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Mendiratta, SK, Martin, WD, Hong, S, Boesteanu, A, Joyce, S and Van Kaer, L (1997) CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6:469-77
Murine CD1 has been implicated in the development and function of an unusual subset of T cells, termed natural T (NT) cells, that coexpress the T cell receptor (TCR) and the natural killer cell receptor NK1.1. Activated NT cells promptly produce large amounts of IL-4, suggesting that these cells can influence the differentiation of CD4+ effector T cell subsets. We have generated mice that carry a mutant CD1d1 gene. NT cell numbers in the thymus, spleen, and liver of these mice were dramatically reduced. Activated splenocytes from mutant mice did not produce IL-4, whereas similarly treated wild-type splenocytes secreted large amounts of this cytokine. These results demonstrate a critical role for CD1 in the positive selection and function of NT cells.
Animals; Antigens, CD1/genetics; Cell Differentiation/genetics; Cell Differentiation/immunology; Immunity, Innate/genetics; Immunoglobulin E/biosynthesis; Interleukin-4/biosynthesis; Interleukin-4/secretion; Liver/cytology; Liver/immunology; Lymphocyte Count; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Receptors, Antigen, T-Cell/metabolism; Receptors, Antigen, T-Cell/physiology; Spleen/cytology; Spleen/immunology; T-Lymphocyte Subsets/metabolism; Thymus Gland/cytology; Thymus Gland/immunology; Thymus Gland/metabolism
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