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PMID:8769481
| Citation |
Hazenbos, WL, Gessner, JE, Hofhuis, FM, Kuipers, H, Meyer, D, Heijnen, IA, Schmidt, RE, Sandor, M, Capel, PJ, Daëron, M, van de Winkel, JG and Verbeek, JS (1996) Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity 5:181-8 |
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| Abstract |
The family of receptors for IgG (Fc gamma R) plays an essential role in antibody-mediated effector functions of the immune system. However, the specific contribution of each of the Fc gamma R classes to in vivo immune reactions is still unclear. Here, we demonstrate that mice deficient for the ligand-binding alpha chain of Fc gamma RIII lack NK cell-mediated antibody-dependent cytotoxicity and phagocytosis of IgG1-coated particles by macrophages. Strikingly, these mice lack IgG-mediated mast cell degranulation, are resistant to IgG-dependent passive cutaneous anaphylaxis, and exhibit an impaired Arthus reaction. These results indicate a prominent role for Fc gamma RIII in inflammatory and anaphylactic responses, making this receptor a potential target in immunotherapy. |
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| Keywords |
Animals; Antibody-Dependent Cell Cytotoxicity; Arthus Reaction/immunology; Cell Degranulation/immunology; Erythrocytes/immunology; Female; Immunoglobulin G/blood; Immunoglobulin G/physiology; Killer Cells, Natural/immunology; Male; Mast Cells/immunology; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Passive Cutaneous Anaphylaxis/immunology; Phagocytosis/immunology; Receptors, IgG/deficiency; Receptors, IgG/genetics; Sheep/immunology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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