MOUSE:CADH2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cdh2
Protein Name(s)	Cadherin-2 Neural cadherin N-cadherin
External Links
UniProt	P15116
EMBL	M31131 AB008811 S45011 CH466557 BC022107
CCDS	CCDS29076.1
PIR	A32759
RefSeq	NP_031690.3
UniGene	Mm.257437
PDB	1NCG 1NCH 1NCI 1NCJ 1OP4 2QVI 3Q2W 4NUM 4NUP 4NUQ
PDBsum	1NCG 1NCH 1NCI 1NCJ 1OP4 2QVI 3Q2W 4NUM 4NUP 4NUQ
ProteinModelPortal	P15116
SMR	P15116
BioGrid	198637
DIP	DIP-31564N
IntAct	P15116
MINT	MINT-4089694
PhosphoSite	P15116
MaxQB	P15116
PaxDb	P15116
PRIDE	P15116
Ensembl	ENSMUST00000025166
GeneID	12558
KEGG	mmu:12558
UCSC	uc008edx.2
CTD	1000
MGI	MGI:88355
eggNOG	NOG251747
GeneTree	ENSGT00760000118906
HOGENOM	HOG000231254
HOVERGEN	HBG106438
InParanoid	P15116
KO	K06736
OMA	HSGHLQR
OrthoDB	EOG7RJPQM
TreeFam	TF316817
Reactome	REACT_230395 REACT_258600
EvolutionaryTrace	P15116
NextBio	281622
PRO	PR:P15116
Proteomes	UP000000589
Bgee	P15116
CleanEx	MM_CDH2
ExpressionAtlas	P15116
Genevestigator	P15116
GO	GO:0005912 GO:0016324 GO:0016342 GO:0005911 GO:0070062 GO:0005916 GO:0016021 GO:0014704 GO:0030027 GO:0016020 GO:0045202 GO:0005509 GO:0019899 GO:0019903 GO:0048514 GO:0016339 GO:0007155 GO:0016477 GO:0044331 GO:0010001 GO:0007157 GO:0007156 GO:0090090 GO:0097150 GO:0043410 GO:0051146
Gene3D	2.60.40.60 4.10.900.10
InterPro	IPR002126 IPR015919 IPR020894 IPR000233 IPR014868 IPR027397 IPR030051
PANTHER	PTHR24027:SF79
Pfam	PF00028 PF01049 PF08758
PRINTS	PR00205
SMART	SM00112 SM01055
SUPFAM	SSF49313
PROSITE	PS00232 PS50268

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005911	cell-cell junction	PMID:24338362^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9655503^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:9655503^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:9655503^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:25232112^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:20668183^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:23392350^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:23392350^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:23392350^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:A2AAJ9	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:26403541^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:26403541^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044853	plasma membrane raft	PMID:24046456^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	PMID:24046456^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:O08917)	Seeded From UniProt	complete
involved_in	GO:1902897	regulation of postsynaptic density protein 95 clustering	PMID:20534458^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly	PMID:20534458^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1001571) occurs_in:(UBERON:0003883)	Seeded From UniProt	complete
involved_in	GO:2000809	positive regulation of synaptic vesicle clustering	PMID:20534458^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0048786) occurs_in:(CL:0000540) occurs_in:(GO:0030425)	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:24952463^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9R0S2	F		Seeded From UniProt	complete
involved_in	GO:0044331	cell-cell adhesion mediated by cadherin	PMID:24952463^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010001	glial cell differentiation	PMID:24952463^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097150	neuronal stem cell population maintenance	PMID:24952463^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:17884088^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:16973135^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14522	F		Seeded From UniProt	complete
part_of	GO:0099060	integral component of postsynaptic specialization membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001167473 RGD:69280	C		Seeded From UniProt	complete
part_of	GO:0099059	integral component of presynaptic active zone membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001167473 RGD:69280	C		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105057 MGI:MGI:88354 MGI:MGI:88356 PANTHER:PTN000616280 RGD:69280 UniProtKB:O93319 UniProtKB:P12830 UniProtKB:Q86UP0	P		Seeded From UniProt	complete
involved_in	GO:0051966	regulation of synaptic transmission, glutamatergic	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001167473 RGD:69280	P		Seeded From UniProt	complete
involved_in	GO:0050770	regulation of axonogenesis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001167473 RGD:69280	P		Seeded From UniProt	complete
involved_in	GO:0048514	blood vessel morphogenesis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88355 PANTHER:PTN001167473	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000616280 UniProtKB:P10288 UniProtKB:P55290	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88355 PANTHER:PTN001167473 RGD:69280	C		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001167473 UniProtKB:P10288	C		Seeded From UniProt	complete
involved_in	GO:0044331	cell-cell adhesion mediated by cadherin	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88355 PANTHER:PTN000616280 UniProtKB:P10288	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001167473 UniProtKB:P10288	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99551 PANTHER:PTN000616280	F		Seeded From UniProt	complete
involved_in	GO:0034332	adherens junction organization	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000616280 UniProtKB:P12830 ZFIN:ZDB-GENE-990415-171	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88355 PANTHER:PTN001167473 UniProtKB:P19022	C		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88354 PANTHER:PTN000616280 UniProtKB:P12830 UniProtKB:P19022 ZFIN:ZDB-GENE-990415-171	C		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1095414 MGI:MGI:88354 MGI:MGI:88355 PANTHER:PTN000616280 RGD:2321 RGD:69280 UniProtKB:P55290	P		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88355 PANTHER:PTN001167473 RGD:69280	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88355 PANTHER:PTN001167473	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1095414 MGI:MGI:88354 MGI:MGI:88355 PANTHER:PTN000616280 UniProtKB:P10288 UniProtKB:P33150 UniProtKB:P33151	C		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88354 PANTHER:PTN000616280	F		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001167473 RGD:69280	P		Seeded From UniProt	complete
involved_in	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1095414 MGI:MGI:88355 MGI:MGI:99218 PANTHER:PTN000616280 UniProtKB:P55290	P		Seeded From UniProt	complete
involved_in	GO:0007043	cell-cell junction assembly	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000616280 UniProtKB:P33151	P		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105057 MGI:MGI:88354 MGI:MGI:88356 PANTHER:PTN000616280 RGD:69280 UniProtKB:P10288 UniProtKB:P12830 UniProtKB:P19022 UniProtKB:P33151	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105057 MGI:MGI:107435 MGI:MGI:1095414 MGI:MGI:88354 MGI:MGI:88355 MGI:MGI:88356 MGI:MGI:99217 MGI:MGI:99551 PANTHER:PTN000616280 RGD:619745 RGD:621089 RGD:69279 RGD:69280 UniProtKB:O93319 UniProtKB:P10288 UniProtKB:P12830 UniProtKB:P19022 UniProtKB:P22223 UniProtKB:P33151 UniProtKB:P55283 UniProtKB:P55290 UniProtKB:Q6ZTQ4 UniProtKB:Q90763 ZFIN:ZDB-GENE-010606-1	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001167473 UniProtKB:P19022	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88354 PANTHER:PTN000616280 UniProtKB:Q86UP0	F		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000616280 ZFIN:ZDB-GENE-990415-171	P		Seeded From UniProt	complete
part_of	GO:0099060	integral component of postsynaptic specialization membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	C		Seeded From UniProt	complete
part_of	GO:0099059	integral component of presynaptic active zone membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098609	cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:19075000^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1278315 MGI:MGI:98956	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070445	regulation of oligodendrocyte progenitor proliferation	PMID:25100583^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95387	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060563	neuroepithelial cell differentiation	PMID:25100583^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95387	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060019	radial glial cell differentiation	PMID:25100583^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95387	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051966	regulation of synaptic transmission, glutamatergic	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051291	protein heterooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051146	striated muscle cell differentiation	PMID:20160094^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109327 MGI:MGI:1346865 MGI:MGI:1918084 MGI:MGI:1926387	P		Seeded From UniProt	complete
enables	GO:0050998	nitric-oxide synthase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050770	regulation of axonogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048872	homeostasis of number of cells	PMID:25100583^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95387	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048854	brain morphogenesis	PMID:25100583^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95387	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048514	blood vessel morphogenesis	PMID:15809310^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3522469	P		Seeded From UniProt	complete
enables	GO:0045295	gamma-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19022	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19022	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:14622577^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	PMID:20160094^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109327 MGI:MGI:1918084 MGI:MGI:1926387	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035023	regulation of Rho protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032880	regulation of protein localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031641	regulation of myelination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	P		Seeded From UniProt	complete
colocalizes_with	GO:0030864	cortical actin cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19022	C		Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19022	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:14657280^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19022	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021987	cerebral cortex development	PMID:25100583^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95387	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021537	telencephalon development	PMID:25100583^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95387	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	PMID:14561752^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19022	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:14561752^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:21947081^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544) part_of:(CL:0000047)	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:25512490^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:30445)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19723622^[22]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Z1Y3	C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:26187182^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	C		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19022	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007416	synapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:8270638^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	PMID:8270638^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	PMID:14561752^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007155	cell adhesion	PMID:14657280^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007155	cell adhesion	PMID:12738802^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005916	fascia adherens	PMID:11732910^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005916	fascia adherens	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19022	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	PMID:18239929^[27]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16530) part_of:(CL:0000710)	Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	PMID:16892058^[28]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000710)	Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	PMID:12695331^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	PMID:12203715^[30]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	PMID:12052883^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:21296051^[32]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16105) part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19022	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19022	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69280	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19022	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21572446^[33]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15116	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21300292^[34]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15116	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20190754^[35]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15116	F		Seeded From UniProt	complete
enables	GO:0045295	gamma-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	F		Seeded From UniProt	complete
part_of	GO:0030864	cortical actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	C		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	C		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	F		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000233 InterPro:IPR002126 InterPro:IPR015919 InterPro:IPR030051	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020894	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020894 InterPro:IPR030051	P		Seeded From UniProt	complete
involved_in	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000233 InterPro:IPR002126	P		Seeded From UniProt	complete
involved_in	GO:0009966	regulation of signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030051	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002126 InterPro:IPR015919	C		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039808	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965 UniProtKB-SubCell:SL-0038	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0238	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0310	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Phang, HQ et al. (2014) POPX2 phosphatase regulates the KIF3 kinesin motor complex. J. Cell. Sci. 127 727-39 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Tamura, K et al. (1998) Structure-function analysis of cell adhesion by neural (N-) cadherin. Neuron 20 1153-63 PubMed GONUTS page
↑ Wang, SH et al. (2014) Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization. J. Neurosci. 34 12745-61 PubMed GONUTS page
↑ Bozdagi, O et al. (2010) Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin. J. Neurosci. 30 9984-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Hu, LY & Kontrogianni-Konstantopoulos, A (2013) The kinase domains of obscurin interact with intercellular adhesion proteins. FASEB J. 27 2001-12 PubMed GONUTS page
↑ ^6.0 ^6.1 Sharma, P et al. (2015) Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nat Commun 6 8391 PubMed GONUTS page
↑ ^7.0 ^7.1 Guillaume, E et al. (2013) Flotillin microdomains stabilize cadherins at cell-cell junctions. J. Cell. Sci. 126 5293-304 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Stan, A et al. (2010) Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation. Proc. Natl. Acad. Sci. U.S.A. 107 11116-21 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Porlan, E et al. (2014) MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin. Nat. Cell Biol. 16 629-38 PubMed GONUTS page
↑ Lopez-Santiago, LF et al. (2007) Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. J. Mol. Cell. Cardiol. 43 636-47 PubMed GONUTS page
↑ Besco, JA et al. (2006) Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT). Brain Res. 1116 50-7 PubMed GONUTS page
↑ ^12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 ^12.17 ^12.18 ^12.19 ^12.20 ^12.21 ^12.22 ^12.23 ^12.24 ^12.25 ^12.26 ^12.27 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Haÿ, E et al. (2009) N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation. Mol. Cell. Biol. 29 953-64 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Gil-Sanz, C et al. (2014) Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon. J. Neurosci. 34 10475-87 PubMed GONUTS page
↑ ^15.0 ^15.1 Lu, M & Krauss, RS (2010) N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts. Proc. Natl. Acad. Sci. U.S.A. 107 4212-7 PubMed GONUTS page
↑ Luo, Y & Radice, GL (2005) N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis. J. Cell Biol. 169 29-34 PubMed GONUTS page
↑ Bamji, SX et al. (2003) Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron 40 719-31 PubMed GONUTS page
↑ ^18.0 ^18.1 Gavard, J et al. (2004) Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J. Cell. Sci. 117 257-70 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Guo, HB et al. (2003) N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways. J. Biol. Chem. 278 52412-24 PubMed GONUTS page
↑ Gruber, R et al. (2011) MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway. Nat. Cell Biol. 13 1325-34 PubMed GONUTS page
↑ Xu, B et al. (2014) PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility. Proc. Natl. Acad. Sci. U.S.A. 111 18643-8 PubMed GONUTS page
↑ Sato, M et al. (2009) Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). J. Biol. Chem. 284 31431-40 PubMed GONUTS page
↑ Glynn, P et al. (2015) Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo. Circulation 132 567-77 PubMed GONUTS page
↑ ^24.0 ^24.1 Matsunami, H et al. (1993) Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene. J. Cell. Sci. 106 ( Pt 1) 401-9 PubMed GONUTS page
↑ Iijima, Y et al. (2003) Beating is necessary for transdifferentiation of skeletal muscle-derived cells into cardiomyocytes. FASEB J. 17 1361-3 PubMed GONUTS page
↑ Zhang, JQ et al. (2001) Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart. Biochemistry 40 14898-906 PubMed GONUTS page
↑ Manning, JA et al. (2008) Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development. Histochem. Cell Biol. 129 751-64 PubMed GONUTS page
↑ Cappello, S et al. (2006) The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat. Neurosci. 9 1099-107 PubMed GONUTS page
↑ Lallemand, D et al. (2003) NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev. 17 1090-100 PubMed GONUTS page
↑ Sinn, HW et al. (2002) Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development. Dev. Dyn. 225 1-13 PubMed GONUTS page
↑ Hollnagel, A et al. (2002) The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration. Mol. Cell. Biol. 22 4760-70 PubMed GONUTS page
↑ Thomas, NM et al. (2011) Sex differences in expression and subcellular localization of heart rhythm determinant proteins. Biochem. Biophys. Res. Commun. 406 117-22 PubMed GONUTS page
↑ Vendome, J et al. (2011) Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Nat. Struct. Mol. Biol. 18 693-700 PubMed GONUTS page
↑ Harrison, OJ et al. (2011) The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure 19 244-56 PubMed GONUTS page
↑ Harrison, OJ et al. (2010) Two-step adhesive binding by classical cadherins. Nat. Struct. Mol. Biol. 17 348-57 PubMed GONUTS page

[PMID:24338362-1] Phang, HQ et al. (2014) POPX2 phosphatase regulates the KIF3 kinesin motor complex. J. Cell. Sci. 127 727-39 PubMed GONUTS page

[PMID:9655503-2] 2.0 ^2.1 ^2.2 Tamura, K et al. (1998) Structure-function analysis of cell adhesion by neural (N-) cadherin. Neuron 20 1153-63 PubMed GONUTS page

[PMID:25232112-3] Wang, SH et al. (2014) Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization. J. Neurosci. 34 12745-61 PubMed GONUTS page

[PMID:20668183-4] Bozdagi, O et al. (2010) Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin. J. Neurosci. 30 9984-9 PubMed GONUTS page

[PMID:23392350-5] 5.0 ^5.1 ^5.2 Hu, LY & Kontrogianni-Konstantopoulos, A (2013) The kinase domains of obscurin interact with intercellular adhesion proteins. FASEB J. 27 2001-12 PubMed GONUTS page

[PMID:26403541-6] 6.0 ^6.1 Sharma, P et al. (2015) Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nat Commun 6 8391 PubMed GONUTS page

[PMID:24046456-7] 7.0 ^7.1 Guillaume, E et al. (2013) Flotillin microdomains stabilize cadherins at cell-cell junctions. J. Cell. Sci. 126 5293-304 PubMed GONUTS page

[PMID:20534458-8] 8.0 ^8.1 ^8.2 Stan, A et al. (2010) Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation. Proc. Natl. Acad. Sci. U.S.A. 107 11116-21 PubMed GONUTS page

[PMID:24952463-9] 9.0 ^9.1 ^9.2 ^9.3 Porlan, E et al. (2014) MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin. Nat. Cell Biol. 16 629-38 PubMed GONUTS page

[PMID:17884088-10] Lopez-Santiago, LF et al. (2007) Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. J. Mol. Cell. Cardiol. 43 636-47 PubMed GONUTS page

[PMID:16973135-11] Besco, JA et al. (2006) Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT). Brain Res. 1116 50-7 PubMed GONUTS page

[PMID:21873635-12] 12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 ^12.17 ^12.18 ^12.19 ^12.20 ^12.21 ^12.22 ^12.23 ^12.24 ^12.25 ^12.26 ^12.27 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19075000-13] Haÿ, E et al. (2009) N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation. Mol. Cell. Biol. 29 953-64 PubMed GONUTS page

[PMID:25100583-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Gil-Sanz, C et al. (2014) Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon. J. Neurosci. 34 10475-87 PubMed GONUTS page

[PMID:20160094-15] 15.0 ^15.1 Lu, M & Krauss, RS (2010) N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts. Proc. Natl. Acad. Sci. U.S.A. 107 4212-7 PubMed GONUTS page

[PMID:15809310-16] Luo, Y & Radice, GL (2005) N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis. J. Cell Biol. 169 29-34 PubMed GONUTS page

[PMID:14622577-17] Bamji, SX et al. (2003) Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron 40 719-31 PubMed GONUTS page

[PMID:14657280-18] 18.0 ^18.1 Gavard, J et al. (2004) Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J. Cell. Sci. 117 257-70 PubMed GONUTS page

[PMID:14561752-19] 19.0 ^19.1 ^19.2 Guo, HB et al. (2003) N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways. J. Biol. Chem. 278 52412-24 PubMed GONUTS page

[PMID:21947081-20] Gruber, R et al. (2011) MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway. Nat. Cell Biol. 13 1325-34 PubMed GONUTS page

[PMID:25512490-21] Xu, B et al. (2014) PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility. Proc. Natl. Acad. Sci. U.S.A. 111 18643-8 PubMed GONUTS page

[PMID:19723622-22] Sato, M et al. (2009) Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). J. Biol. Chem. 284 31431-40 PubMed GONUTS page

[PMID:26187182-23] Glynn, P et al. (2015) Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo. Circulation 132 567-77 PubMed GONUTS page

[PMID:8270638-24] 24.0 ^24.1 Matsunami, H et al. (1993) Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene. J. Cell. Sci. 106 ( Pt 1) 401-9 PubMed GONUTS page

[PMID:12738802-25] Iijima, Y et al. (2003) Beating is necessary for transdifferentiation of skeletal muscle-derived cells into cardiomyocytes. FASEB J. 17 1361-3 PubMed GONUTS page

[PMID:11732910-26] Zhang, JQ et al. (2001) Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart. Biochemistry 40 14898-906 PubMed GONUTS page

[PMID:18239929-27] Manning, JA et al. (2008) Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development. Histochem. Cell Biol. 129 751-64 PubMed GONUTS page

[PMID:16892058-28] Cappello, S et al. (2006) The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat. Neurosci. 9 1099-107 PubMed GONUTS page

[PMID:12695331-29] Lallemand, D et al. (2003) NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev. 17 1090-100 PubMed GONUTS page

[PMID:12203715-30] Sinn, HW et al. (2002) Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development. Dev. Dyn. 225 1-13 PubMed GONUTS page

[PMID:12052883-31] Hollnagel, A et al. (2002) The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration. Mol. Cell. Biol. 22 4760-70 PubMed GONUTS page

[PMID:21296051-32] Thomas, NM et al. (2011) Sex differences in expression and subcellular localization of heart rhythm determinant proteins. Biochem. Biophys. Res. Commun. 406 117-22 PubMed GONUTS page

[PMID:21572446-33] Vendome, J et al. (2011) Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Nat. Struct. Mol. Biol. 18 693-700 PubMed GONUTS page

[PMID:21300292-34] Harrison, OJ et al. (2011) The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure 19 244-56 PubMed GONUTS page

[PMID:20190754-35] Harrison, OJ et al. (2010) Two-step adhesive binding by classical cadherins. Nat. Struct. Mol. Biol. 17 348-57 PubMed GONUTS page

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