MOUSE:BECN1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Becn1
Protein Name(s)	Beclin-1 Coiled-coil myosin-like BCL2-interacting protein
External Links
UniProt	O88597
EMBL	AF077302 AK032176 AK050329 AK083800 AL590969 BC005770
CCDS	CCDS25462.1
RefSeq	NP_062530.2
UniGene	Mm.178947
PDB	3BL2
PDBsum	3BL2
ProteinModelPortal	O88597
SMR	O88597
BioGrid	207843
DIP	DIP-41636N
IntAct	O88597
MINT	MINT-1791911
STRING	10090.ENSMUSP00000119369
PhosphoSite	O88597
MaxQB	O88597
PaxDb	O88597
PRIDE	O88597
Ensembl	ENSMUST00000130916
GeneID	56208
KEGG	mmu:56208
UCSC	uc007loj.1
CTD	8678
MGI	MGI:1891828
eggNOG	NOG285533
GeneTree	ENSGT00390000008164
HOGENOM	HOG000158093
HOVERGEN	HBG003181
InParanoid	O88597
KO	K08334
OMA	FEHYRLV
OrthoDB	EOG7D2FDG
PhylomeDB	O88597
TreeFam	TF314282
ChiTaRS	Becn1
EvolutionaryTrace	O88597
NextBio	312043
PRO	PR:O88597
Proteomes	UP000000589
Bgee	O88597
CleanEx	MM_BECN1
ExpressionAtlas	O88597
Genevestigator	O88597
GO	GO:0005737 GO:0016023 GO:0005856 GO:0030425 GO:0016020 GO:0005634 GO:0045335 GO:0043234 GO:0005802 GO:0000045 GO:0006914 GO:0050435 GO:0071275 GO:0071364 GO:0000910 GO:0051607 GO:0007040 GO:0060548 GO:0008285 GO:0048666 GO:0016239 GO:0050790 GO:0042493 GO:0001666 GO:0051707 GO:0033197
InterPro	IPR007243 IPR029318
PANTHER	PTHR12768
Pfam	PF04111 PF15285

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006914	autophagy	PMID:23364696^[1]	ECO:0000314			P		Autophagy genes have beneficial effects in animal models of certain viral and intracellular bacterial infections, and autophagy-inducing agents inhibit HIV replication in primary human monocyte-derived macrophages. As seen in figure 3, the researchers investigated the effects of the Tat–beclin 1 peptide on the replication of three positive-stranded RNA viruses Sindbis virus (SINV), chikungunya virus (CHIKV), West Nile virus (WNV), HIV-1, and the intracellular bacterium, Listeria monocytogenes. Tat–beclin 1 treatment reduced SINV, CHIKV and WNV titres 10–50-fold in HeLa cells.	complete CACAO 6465
	GO:0010508	positive regulation of autophagy	PMID:24056303^[2]	ECO:0000315			P		In Figure 8d, it is shown that a knockdown mutation in beclin-1 results in the improper autophagy-induced dispersal of fluorescent Atg9, compared to an even dispersal in the control.	complete CACAO 8796
	GO:0043652	engulfment of apoptotic cell	PMID:22393062^[3]	ECO:0000315			P		According to Figure 2B, a knockdown in beclin 1 led to a significant increase in the engulfment of dead Jurkat cells compared to the wild type.	complete CACAO 9047
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91XJ1	P		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14457	P		Seeded From UniProt	complete
involved_in	GO:0045022	early endosome to late endosome transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14457	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:23629966^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:23364696^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000378	negative regulation of reactive oxygen species metabolic process	PMID:18281291^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:Q61221	P	part_of:(GO:0071456)	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:18281291^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071456)	Seeded From UniProt	complete
involved_in	GO:0000422	autophagy of mitochondrion	PMID:18281291^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043652	engulfment of apoptotic cell	PMID:22393062^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14457	P		Seeded From UniProt	complete
involved_in	GO:0016236	macroautophagy	PMID:23332761^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	PMID:23332761^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035032	phosphatidylinositol 3-kinase complex, class III	PMID:23332761^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	PMID:23332761^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14457	P		Seeded From UniProt	complete
involved_in	GO:0006995	cellular response to nitrogen starvation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000298965 dictyBase:DDB_G0269244	P		Seeded From UniProt	complete
part_of	GO:0000407	phagophore assembly site	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000298965 PomBase:SPAC20G8.10c	C		Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1891828 PANTHER:PTN000298965 RGD:620190	P		Seeded From UniProt	complete
involved_in	GO:0045324	late endosome to vacuole transport	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000298965 SGD:S000006041	P		Seeded From UniProt	complete
part_of	GO:0034272	phosphatidylinositol 3-kinase complex, class III, type II	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000298965 SGD:S000006041	C		Seeded From UniProt	complete
part_of	GO:0034271	phosphatidylinositol 3-kinase complex, class III, type I	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0264325 PANTHER:PTN000298965 SGD:S000006041	C		Seeded From UniProt	complete
involved_in	GO:0032258	protein localization by the Cvt pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000298965 SGD:S000006041	P		Seeded From UniProt	complete
part_of	GO:0019898	extrinsic component of membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000298965 SGD:S000006041 UniProtKB:Q14457	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000786	positive regulation of autophagosome assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905672	negative regulation of lysosome organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902902	negative regulation of autophagosome assembly	PMID:27994061^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2683833	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902425	positive regulation of attachment of mitotic spindle microtubules to kinetochore	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098780	response to mitochondrial depolarisation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060548	negative regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060548	negative regulation of cell death	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051707	response to other organism	PMID:9765397^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051020	GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050790	regulation of catalytic activity	PMID:22493499^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2683833	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050435	amyloid-beta metabolic process	PMID:18497889^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2683696	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048666	neuron development	PMID:18497889^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2683696	P		Seeded From UniProt	complete
part_of	GO:0045335	phagocytic vesicle	PMID:22493499^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045022	early endosome to late endosome transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	P		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620190	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:27994061^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88597	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17891140^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032801	receptor catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032465	regulation of cytokinesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620190	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:12372286^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620190	C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	F		Seeded From UniProt	complete
part_of	GO:0019898	extrinsic component of membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016236	macroautophagy	PMID:17468177^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1097712	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016236	macroautophagy	PMID:14657337^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2683833	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:9765397^[9]	ECO:0000250	sequence similarity evidence used in manual assertion		C		Seeded From UniProt	Missing: with/from
acts_upstream_of_or_within	GO:0010613	positive regulation of cardiac muscle hypertrophy	PMID:27994061^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2683833	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010508	positive regulation of autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010507	negative regulation of autophagy	PMID:27994061^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:17589504^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007080	mitotic metaphase plate congression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007040	lysosome organization	PMID:18497889^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2683696	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006914	autophagy	PMID:17589504^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006914	autophagy	PMID:12372286^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006914	autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006914	autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620190	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:9765397^[9]	ECO:0000250	sequence similarity evidence used in manual assertion		C		Seeded From UniProt	Missing: with/from
part_of	GO:0005802	trans-Golgi network	PMID:12372286^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005802	trans-Golgi network	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620190	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	C		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	PMID:23798385^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000071)	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	C		Seeded From UniProt	complete
colocalizes_with	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17589504^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620190	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620190	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000423	mitophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000422	autophagy of mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14457	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000045	autophagosome assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620190	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0045022	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0045022	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0045022	C		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	P		Seeded From UniProt	complete
involved_in	GO:1902425	positive regulation of attachment of mitotic spindle microtubules to kinetochore	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	P		Seeded From UniProt	complete
involved_in	GO:0098780	response to mitochondrial depolarisation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	P		Seeded From UniProt	complete
enables	GO:0051020	GTPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	F		Seeded From UniProt	complete
involved_in	GO:0045022	early endosome to late endosome transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	P		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	F		Seeded From UniProt	complete
involved_in	GO:0032801	receptor catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	P		Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	F		Seeded From UniProt	complete
part_of	GO:0019898	extrinsic component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	C		Seeded From UniProt	complete
involved_in	GO:0007080	mitotic metaphase plate congression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	C		Seeded From UniProt	complete
involved_in	GO:0000423	mitophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	P		Seeded From UniProt	complete
involved_in	GO:0000422	autophagy of mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14457 ensembl:ENSP00000355231	P		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:2000786	positive regulation of autophagosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:1905672	negative regulation of lysosome organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0071280	cellular response to copper ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0071275	cellular response to aluminum ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0033197	response to vitamin E	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	C		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0010288	response to lead ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0010040	response to iron(II) ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91XJ1 ensembl:ENSRNOP00000071966	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032913	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007243 InterPro:IPR032913	P		Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032913	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:23184933^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0023	C		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0171	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Shoji-Kawata, S et al. (2013) Identification of a candidate therapeutic autophagy-inducing peptide. Nature 494 201-6 PubMed GONUTS page
↑ He, S et al. (2013) PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex. Nat. Cell Biol. 15 1206-19 PubMed GONUTS page
↑ ^3.0 ^3.1 Konishi, A et al. (2012) Involvement of Beclin 1 in engulfment of apoptotic cells. J. Biol. Chem. 287 13919-29 PubMed GONUTS page
↑ Contreras, AU et al. (2013) Deacetylation of p53 induces autophagy by suppressing Bmf expression. J. Cell Biol. 201 427-37 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Zhang, H et al. (2008) Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J. Biol. Chem. 283 10892-903 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Kim, J et al. (2013) Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152 290-303 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Cheng, Z et al. (2017) Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth. J. Biol. Chem. 292 2065-2079 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Liang, XH et al. (1998) Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J. Virol. 72 8586-96 PubMed GONUTS page
↑ ^10.0 ^10.1 Ma, C et al. (2012) Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex. J. Biol. Chem. 287 18359-65 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Pickford, F et al. (2008) The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J. Clin. Invest. 118 2190-9 PubMed GONUTS page
↑ Takahashi, Y et al. (2007) Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat. Cell Biol. 9 1142-51 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Yue, Z et al. (2002) A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. Neuron 35 921-33 PubMed GONUTS page
↑ Pacheco, CD et al. (2007) Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects. Hum. Mol. Genet. 16 1495-503 PubMed GONUTS page
↑ Yue, Z et al. (2003) Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. U.S.A. 100 15077-82 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Fimia, GM et al. (2007) Ambra1 regulates autophagy and development of the nervous system. Nature 447 1121-5 PubMed GONUTS page
↑ Buraschi, S et al. (2013) Decorin causes autophagy in endothelial cells via Peg3. Proc. Natl. Acad. Sci. U.S.A. 110 E2582-91 PubMed GONUTS page
↑ Margariti, A et al. (2013) XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation. J. Biol. Chem. 288 859-72 PubMed GONUTS page

[PMID:23364696-1] 1.0 ^1.1 Shoji-Kawata, S et al. (2013) Identification of a candidate therapeutic autophagy-inducing peptide. Nature 494 201-6 PubMed GONUTS page

[PMID:24056303-2] He, S et al. (2013) PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex. Nat. Cell Biol. 15 1206-19 PubMed GONUTS page

[PMID:22393062-3] 3.0 ^3.1 Konishi, A et al. (2012) Involvement of Beclin 1 in engulfment of apoptotic cells. J. Biol. Chem. 287 13919-29 PubMed GONUTS page

[PMID:23629966-4] Contreras, AU et al. (2013) Deacetylation of p53 induces autophagy by suppressing Bmf expression. J. Cell Biol. 201 427-37 PubMed GONUTS page

[PMID:18281291-5] 5.0 ^5.1 ^5.2 Zhang, H et al. (2008) Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J. Biol. Chem. 283 10892-903 PubMed GONUTS page

[PMID:23332761-6] 6.0 ^6.1 ^6.2 ^6.3 Kim, J et al. (2013) Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152 290-303 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:27994061-8] 8.0 ^8.1 ^8.2 ^8.3 Cheng, Z et al. (2017) Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth. J. Biol. Chem. 292 2065-2079 PubMed GONUTS page

[PMID:9765397-9] 9.0 ^9.1 ^9.2 Liang, XH et al. (1998) Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J. Virol. 72 8586-96 PubMed GONUTS page

[PMID:22493499-10] 10.0 ^10.1 Ma, C et al. (2012) Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex. J. Biol. Chem. 287 18359-65 PubMed GONUTS page

[PMID:18497889-11] 11.0 ^11.1 ^11.2 Pickford, F et al. (2008) The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J. Clin. Invest. 118 2190-9 PubMed GONUTS page

[PMID:17891140-12] Takahashi, Y et al. (2007) Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat. Cell Biol. 9 1142-51 PubMed GONUTS page

[PMID:12372286-13] 13.0 ^13.1 ^13.2 Yue, Z et al. (2002) A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. Neuron 35 921-33 PubMed GONUTS page

[PMID:17468177-14] Pacheco, CD et al. (2007) Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects. Hum. Mol. Genet. 16 1495-503 PubMed GONUTS page

[PMID:14657337-15] Yue, Z et al. (2003) Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. U.S.A. 100 15077-82 PubMed GONUTS page

[PMID:17589504-16] 16.0 ^16.1 ^16.2 Fimia, GM et al. (2007) Ambra1 regulates autophagy and development of the nervous system. Nature 447 1121-5 PubMed GONUTS page

[PMID:23798385-17] Buraschi, S et al. (2013) Decorin causes autophagy in endothelial cells via Peg3. Proc. Natl. Acad. Sci. U.S.A. 110 E2582-91 PubMed GONUTS page

[PMID:23184933-18] Margariti, A et al. (2013) XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation. J. Biol. Chem. 288 859-72 PubMed GONUTS page

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