MOUSE:BAG3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Bag3 (synonyms: Bis)
Protein Name(s)	BAG family molecular chaperone regulator 3 BAG-3 Bcl-2-associated athanogene 3 Bcl-2-binding protein Bis
External Links
UniProt	Q9JLV1
EMBL	AF130471 AB041583 AK007414 AK016510 AK036675 CH466531
CCDS	CCDS21898.1
RefSeq	NP_038891.4
UniGene	Mm.84073
PDB	1UK5
PDBsum	1UK5
ProteinModelPortal	Q9JLV1
SMR	Q9JLV1
BioGrid	205891
IntAct	Q9JLV1
MINT	MINT-4124913
PhosphoSite	Q9JLV1
MaxQB	Q9JLV1
PaxDb	Q9JLV1
PRIDE	Q9JLV1
Ensembl	ENSMUST00000033136
GeneID	29810
KEGG	mmu:29810
UCSC	uc009jzb.2
CTD	9531
MGI	MGI:1352493
eggNOG	NOG238690
GeneTree	ENSGT00530000063256
HOGENOM	HOG000050234
HOVERGEN	HBG003419
InParanoid	Q9JLV1
KO	K09557
OMA	VYPQLRP
OrthoDB	EOG75B85S
TreeFam	TF102013
EvolutionaryTrace	Q9JLV1
NextBio	306958
PRO	PR:Q9JLV1
Proteomes	UP000000589
Bgee	Q9JLV1
CleanEx	MM_BAG3
Genevestigator	Q9JLV1
GO	GO:0005829 GO:0043005 GO:0005886 GO:0030018 GO:0032403 GO:0007420 GO:0071260 GO:0097192 GO:0008625 GO:0010664 GO:0050821 GO:0021510
Gene3D	1.20.58.120
InterPro	IPR003103 IPR001202
Pfam	PF02179 PF00397
SMART	SM00264 SM00456
SUPFAM	SSF51045
PROSITE	PS51035 PS01159 PS50020

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0046716	muscle cell cellular homeostasis	PMID:16936253^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0018254)\|occurs_in:(UBERON:0001133)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95817	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95817	C		Seeded From UniProt	complete
involved_in	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95817	P		Seeded From UniProt	complete
involved_in	GO:0046827	positive regulation of protein export from nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95817	P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95817	P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95817	P		Seeded From UniProt	complete
enables	GO:0000774	adenyl-nucleotide exchange factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95817	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905337	positive regulation of aggrephagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903215	negative regulation of protein targeting to mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307794	P		Seeded From UniProt	complete
part_of	GO:0101031	chaperone complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:11527400^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071260	cellular response to mechanical stimulus	PMID:16936253^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3530294	P	occurs_in:(EMAPA:32688)\|occurs_in:(EMAPA:32716)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061684	chaperone-mediated autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307794	P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	PMID:20884878^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3530294	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046827	positive regulation of protein export from nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046716	muscle cell cellular homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:20884878^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307794	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307794	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307794	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034620	cellular response to unfolded protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034605	cellular response to heat	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	P		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	PMID:20060297^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35786)	Seeded From UniProt	complete
part_of	GO:0030018	Z disc	PMID:16936253^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:36390)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010664	negative regulation of striated muscle cell apoptotic process	PMID:16936253^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3530294	P	regulates_o_occurs_in:(EMAPA:32688)\|regulates_o_occurs_in:(EMAPA:32716)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010664	negative regulation of striated muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:10597216^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:10597216^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	C		Seeded From UniProt	complete
part_of	GO:0001725	stress fiber	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307794	C		Seeded From UniProt	complete
enables	GO:0000774	adenyl-nucleotide exchange factor activity	PMID:20060297^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	F		Seeded From UniProt	complete
enables	GO:0000774	adenyl-nucleotide exchange factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95817	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000045	autophagosome assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307794	P		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0000774	P		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0000774	P		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0000774	P		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0000774	P		Seeded From UniProt	complete
involved_in	GO:1905337	positive regulation of aggrephagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95817 ensembl:ENSP00000358081	P		Seeded From UniProt	complete
part_of	GO:0101031	chaperone complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95817 ensembl:ENSP00000358081	C		Seeded From UniProt	complete
involved_in	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95817 ensembl:ENSP00000358081	P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95817 ensembl:ENSP00000358081	F		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95817 ensembl:ENSP00000358081	P		Seeded From UniProt	complete
involved_in	GO:0046827	positive regulation of protein export from nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95817 ensembl:ENSP00000358081	P		Seeded From UniProt	complete
involved_in	GO:0046716	muscle cell cellular homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95817 ensembl:ENSP00000358081	P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95817 ensembl:ENSP00000358081	P		Seeded From UniProt	complete
involved_in	GO:0034620	cellular response to unfolded protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95817 ensembl:ENSP00000358081	P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95817 ensembl:ENSP00000358081	P		Seeded From UniProt	complete
involved_in	GO:0010664	negative regulation of striated muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95817 ensembl:ENSP00000358081	P		Seeded From UniProt	complete
involved_in	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95817 ensembl:ENSP00000358081	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95817 ensembl:ENSP00000358081	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95817 ensembl:ENSP00000358081	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95817 ensembl:ENSP00000358081	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95817 ensembl:ENSP00000358081	C		Seeded From UniProt	complete
enables	GO:0000774	adenyl-nucleotide exchange factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95817 ensembl:ENSP00000358081	F		Seeded From UniProt	complete
involved_in	GO:1903215	negative regulation of protein targeting to mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	P		Seeded From UniProt	complete
involved_in	GO:0061684	chaperone-mediated autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	C		Seeded From UniProt	complete
involved_in	GO:0021510	spinal cord development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	P		Seeded From UniProt	complete
part_of	GO:0001725	stress fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	C		Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003103 InterPro:IPR036533 InterPro:IPR039773	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Homma, S et al. (2006) BAG3 deficiency results in fulminant myopathy and early lethality. Am. J. Pathol. 169 761-73 PubMed GONUTS page
↑ Antoku, K et al. (2001) Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein. Biochem. Biophys. Res. Commun. 286 1003-10 PubMed GONUTS page
↑ ^3.0 ^3.1 Hishiya, A et al. (2010) BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress. Circ. Res. 107 1220-31 PubMed GONUTS page
↑ ^4.0 ^4.1 Arndt, V et al. (2010) Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr. Biol. 20 143-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Lee, JH et al. (1999) Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene 18 6183-90 PubMed GONUTS page

[PMID:16936253-1] 1.0 ^1.1 ^1.2 ^1.3 Homma, S et al. (2006) BAG3 deficiency results in fulminant myopathy and early lethality. Am. J. Pathol. 169 761-73 PubMed GONUTS page

[PMID:11527400-2] Antoku, K et al. (2001) Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein. Biochem. Biophys. Res. Commun. 286 1003-10 PubMed GONUTS page

[PMID:20884878-3] 3.0 ^3.1 Hishiya, A et al. (2010) BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress. Circ. Res. 107 1220-31 PubMed GONUTS page

[PMID:20060297-4] 4.0 ^4.1 Arndt, V et al. (2010) Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr. Biol. 20 143-8 PubMed GONUTS page

[PMID:10597216-5] 5.0 ^5.1 Lee, JH et al. (1999) Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene 18 6183-90 PubMed GONUTS page

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MOUSE:BAG3

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