MOUSE:B2CL1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Bcl2l1 (synonyms: Bcl2l, Bclx)
Protein Name(s)	Bcl-2-like protein 1 Bcl2-L-1 Apoptosis regulator Bcl-X
External Links
UniProt	Q64373
EMBL	X83574 L35049 L35048 U10102 U10101 U10100 U51278 U51279 U78031 U78030
CCDS	CCDS16899.1
PIR	I49055 I49056 I49057
RefSeq	NP_001276645.1 NP_001276646.1 NP_033873.3 XP_006498672.1 XP_006498674.1 XP_006498675.1
UniGene	Mm.238213
PDB	1PQ0 1PQ1 2BZW 3IHC 3IHD 3IHE 3IHF 3IIG 3IIH 3ILB 3ILC
PDBsum	1PQ0 1PQ1 2BZW 3IHC 3IHD 3IHE 3IHF 3IIG 3IIH 3ILB 3ILC
ProteinModelPortal	Q64373
SMR	Q64373
BioGrid	198323
IntAct	Q64373
MINT	MINT-87027
PhosphoSite	Q64373
MaxQB	Q64373
PaxDb	Q64373
PRIDE	Q64373
Ensembl	ENSMUST00000007803 ENSMUST00000109820 ENSMUST00000134902 ENSMUST00000140436
GeneID	12048
KEGG	mmu:12048
UCSC	uc008ngi.1 uc008ngj.1 uc008ngn.1
CTD	598
MGI	MGI:88139
eggNOG	NOG300479
GeneTree	ENSGT00530000062935
HOGENOM	HOG000056452
InParanoid	Q64373
KO	K04570
OMA	NGSPSWH
OrthoDB	EOG70GMGD
TreeFam	TF315834
Reactome	REACT_198658 REACT_223399
EvolutionaryTrace	Q64373
NextBio	280335
PMAP-CutDB	Q64373
PRO	PR:Q64373
Proteomes	UP000000589
Bgee	Q64373
CleanEx	MM_BCL2L1
ExpressionAtlas	Q64373
Genevestigator	Q64373
GO	GO:0097136 GO:0030054 GO:0005813 GO:0005829 GO:0016021 GO:0005622 GO:0005743 GO:0005759 GO:0031966 GO:0005741 GO:0005739 GO:0031965 GO:0005730 GO:0030672 GO:0046982 GO:0042803 GO:0071839 GO:0008283 GO:0060154 GO:0071312 GO:0071230 GO:0071480 GO:0000910 GO:0097192 GO:0009566 GO:0007281 GO:0040007 GO:0097284 GO:0001701 GO:0008630 GO:0008584 GO:0070584 GO:0007093 GO:2000811 GO:0043066 GO:0090005 GO:1900118 GO:2001243 GO:1902230 GO:0043524 GO:0090201 GO:0051402 GO:0001541 GO:0043065 GO:0008284 GO:0046902 GO:0051881 GO:0001836 GO:0046898 GO:0034097 GO:0009314 GO:0009615 GO:0007283 GO:0019050
InterPro	IPR013279 IPR002475 IPR004725 IPR020717 IPR020726 IPR020728 IPR003093 IPR020731 IPR026298
PANTHER	PTHR11256 PTHR11256:SF12
Pfam	PF00452 PF02180
PRINTS	PR01864 PR01862
SMART	SM00265
TIGRFAMs	TIGR00865
PROSITE	PS50062 PS01080 PS01258 PS01259 PS01260 PS50063

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
involved_in	GO:1900118	negative regulation of execution phase of apoptosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
involved_in	GO:0007093	mitotic cell cycle checkpoint	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q07817	C		Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000135647 UniProtKB:P10415 UniProtKB:Q07817 ZFIN:ZDB-GENE-010730-1	P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101769 MGI:MGI:108052 MGI:MGI:1097161 MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 UniProtKB:Q07820	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 RGD:2192 RGD:2199 RGD:2200 RGD:620525 RGD:620621 RGD:620717 RGD:621635 RGD:70984 UniProtKB:P10415 UniProtKB:Q07812 UniProtKB:Q07820 UniProtKB:Q16611 UniProtKB:Q92843 ZFIN:ZDB-GENE-000511-7 ZFIN:ZDB-GENE-030825-1 ZFIN:ZDB-GENE-051012-1	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101769 MGI:MGI:102687 MGI:MGI:88138 MGI:MGI:88139 PANTHER:PTN000135647 RGD:2199 RGD:2200 RGD:620525 UniProtKB:P10415 UniProtKB:Q07817 UniProtKB:Q07820 UniProtKB:Q92843 WB:WBGene00000423 ZFIN:ZDB-GENE-000511-7 ZFIN:ZDB-GENE-010730-1	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1330841 MGI:MGI:1858494 MGI:MGI:99702 PANTHER:PTN000135648 RGD:621635 UniProtKB:P10415 UniProtKB:Q07812 UniProtKB:Q16611	F		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029131 MGI:MGI:101769 MGI:MGI:1097161 MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648	P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 RGD:2192 RGD:2200 UniProtKB:P10415 UniProtKB:Q07817 WB:WBGene00000423	C		Seeded From UniProt	complete
enables	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040008	regulation of growth	PMID:10894153^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176699	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036466	synaptic vesicle recycling via endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034097	response to cytokine	PMID:9184696^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032465	regulation of cytokinesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	PMID:11980919^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16985) part_of:(CL:0000540)	Seeded From UniProt	complete
colocalizes_with	GO:0031966	mitochondrial membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	C		Seeded From UniProt	complete
colocalizes_with	GO:0030672	synaptic vesicle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	C		Seeded From UniProt	complete
enables	GO:0030276	clathrin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019050	suppression by virus of host apoptotic process	PMID:15231831^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:26582200^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009615	response to virus	PMID:15231831^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(EMAPA:32845)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009566	fertilization	PMID:10894153^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99702	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009314	response to radiation	PMID:14517295^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158303	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:14517295^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158303	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008584	male gonad development	PMID:10894153^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176699	P	results_in_development_of:(EMAPA:17972)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:17267035^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	PMID:9176392^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16846) acts_on_population_of:(CL:0000182)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:10894153^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99702	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007281	germ cell development	PMID:10894153^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99702	P	results_in_development_of:(CL:0000020)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007281	germ cell development	PMID:10894153^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176699	P	results_in_development_of:(CL:0000670)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007093	mitotic cell cycle checkpoint	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
colocalizes_with	GO:0005905	clathrin-coated pit	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11980919^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16985) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:26582200^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:23530063^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	C		Seeded From UniProt	complete
part_of	GO:0005740	mitochondrial envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14651853^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:16894)\|part_of:(EMAPA:17373)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:7607090^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:20671748^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:12931191^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002931	response to ischemia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001836	release of cytochrome c from mitochondria	PMID:17052454^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99702	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:10618441^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158303	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001541	ovarian follicle development	PMID:10894153^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99702	P	results_in_development_of:(EMAPA:30755)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001541	ovarian follicle development	PMID:10894153^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176699	P	results_in_development_of:(EMAPA:30755)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001541	ovarian follicle development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001171	positive regulation of ATP biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000811	negative regulation of anoikis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000809	positive regulation of synaptic vesicle clustering	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000302	positive regulation of synaptic vesicle exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903077	negative regulation of protein localization to plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	PMID:26582200^[6]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900452	regulation of long-term synaptic depression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900244	positive regulation of synaptic vesicle endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900118	negative regulation of execution phase of apoptosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	C		Seeded From UniProt	complete
enables	GO:0097371	MDM2/MDM4 family protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097284	hepatocyte apoptotic process	PMID:10618441^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158303	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:12115603^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0097136	Bcl-2 family protein complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090201	negative regulation of release of cytochrome c from mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071839	apoptotic process in bone marrow cell	PMID:10618441^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158303	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071480	cellular response to gamma radiation	PMID:15231831^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071312	cellular response to alkaloid	PMID:15231831^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071230	cellular response to amino acid stimulus	PMID:15231831^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2675966	P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070584	mitochondrion morphogenesis	PMID:20671748^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99702	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060154	cellular process regulating host cell cycle in response to virus	PMID:15231831^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2675966	P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051881	regulation of mitochondrial membrane potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
enables	GO:0051434	BH3 domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	PMID:10618441^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107739	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	PMID:10618441^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158303	P		Seeded From UniProt	complete
enables	GO:0051400	BH domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	F		Seeded From UniProt	complete
enables	GO:0051020	GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:8918887^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P70444	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:7834748^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q07813 UniProtKB:Q61337	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:7650488^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q07813	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046902	regulation of mitochondrial membrane permeability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046898	response to cycloheximide	PMID:9176392^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:9096145^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99702	P	occurs_in:(EMAPA:16910) regulates_o_occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:11150333^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1277950	P	occurs_in:(EMAPA:16469) regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:11150333^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158303	P	occurs_in:(EMAPA:16469) regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:8625820^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:7753802^[24]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:15231831^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:32845)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:8798452^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99702	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:14517295^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:10894153^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176699	P	regulates_o_occurs_in:(EMAPA:17962) regulates_o_occurs_in:(CL:0000586)\|regulates_o_occurs_in:(EMAPA:17972) regulates_o_occurs_in:(CL:0000586)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:9867803^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:17267035^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000451)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:11717309^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:7650367^[28]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q07817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2200	P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0043027	P		Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	P		Seeded From UniProt	complete
involved_in	GO:1903077	negative regulation of protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	P		Seeded From UniProt	complete
involved_in	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	P		Seeded From UniProt	complete
involved_in	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	P		Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	P		Seeded From UniProt	complete
involved_in	GO:1900118	negative regulation of execution phase of apoptosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	P		Seeded From UniProt	complete
part_of	GO:0097136	Bcl-2 family protein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	C		Seeded From UniProt	complete
involved_in	GO:0051881	regulation of mitochondrial membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	P		Seeded From UniProt	complete
enables	GO:0051434	BH3 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	F		Seeded From UniProt	complete
involved_in	GO:0046902	regulation of mitochondrial membrane permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	F		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	P		Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	F		Seeded From UniProt	complete
involved_in	GO:0019050	suppression by virus of host apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	P		Seeded From UniProt	complete
involved_in	GO:0007093	mitotic cell cycle checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	C		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q07817 ensembl:ENSP00000365230	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004725	C		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003093 InterPro:IPR004725 InterPro:IPR013279 InterPro:IPR020717 InterPro:IPR020726 InterPro:IPR020728 InterPro:IPR020731 InterPro:IPR026298 InterPro:IPR036834	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:8798452^[25]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q07813	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:8798158^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:7607090^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	PMID:8798158^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0999 UniProtKB-SubCell:SL-0168	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0260	C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0182	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0171	C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0170	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Rucker, EB 3rd et al. (2000) Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Mol. Endocrinol. 14 1038-52 PubMed GONUTS page
↑ Li, L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell. Immunol. 178 33-41 PubMed GONUTS page
↑ ^4.0 ^4.1 Putcha, GV et al. (2002) Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J. Cell Biol. 157 441-53 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Seo, SY et al. (2004) BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J. Biol. Chem. 279 42240-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Urresti, J et al. (2016) Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells. J. Biol. Chem. 291 1221-34 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Maclean, KH et al. (2003) c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL. Mol. Cell. Biol. 23 7256-70 PubMed GONUTS page
↑ ^8.0 ^8.1 Chen, M et al. (2007) Regulation of the lifespan in dendritic cell subsets. Mol. Immunol. 44 2558-65 PubMed GONUTS page
↑ ^9.0 ^9.1 Tzung, SP et al. (1997) Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene. Am. J. Pathol. 150 1985-95 PubMed GONUTS page
↑ Hatle, KM et al. (2013) MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations. Mol. Cell. Biol. 33 2302-14 PubMed GONUTS page
↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
↑ ^12.0 ^12.1 González-García, M et al. (1994) bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development 120 3033-42 PubMed GONUTS page
↑ ^13.0 ^13.1 Cleland, MM et al. (2011) Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cell Death Differ. 18 235-47 PubMed GONUTS page
↑ Danial, NN et al. (2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424 952-6 PubMed GONUTS page
↑ Walensky, LD et al. (2006) A stapled BID BH3 helix directly binds and activates BAX. Mol. Cell 24 199-210 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 Roth, KA et al. (2000) Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death. Proc. Natl. Acad. Sci. U.S.A. 97 466-71 PubMed GONUTS page
↑ Ayllón, V et al. (2002) The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad. Eur. J. Immunol. 32 1847-55 PubMed GONUTS page
↑ Wang, K et al. (1996) BID: a novel BH3 domain-only death agonist. Genes Dev. 10 2859-69 PubMed GONUTS page
↑ Yang, E et al. (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80 285-91 PubMed GONUTS page
↑ Chao, DT et al. (1995) Bcl-XL and Bcl-2 repress a common pathway of cell death. J. Exp. Med. 182 821-8 PubMed GONUTS page
↑ Shindler, KS et al. (1997) Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice. J. Neurosci. 17 3112-9 PubMed GONUTS page
↑ ^22.0 ^22.1 Zaidi, AU et al. (2001) Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways. J. Neurosci. 21 169-75 PubMed GONUTS page
↑ Middleton, G et al. (1996) Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors. Development 122 695-701 PubMed GONUTS page
↑ González-García, M et al. (1995) bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death. Proc. Natl. Acad. Sci. U.S.A. 92 4304-8 PubMed GONUTS page
↑ ^25.0 ^25.1 Simonian, PL et al. (1996) Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL. J. Biol. Chem. 271 22764-72 PubMed GONUTS page
↑ Chen, G et al. (1999) Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J. Biol. Chem. 274 7-10 PubMed GONUTS page
↑ Dramsi, S et al. (2002) Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity. J. Biol. Chem. 277 6399-405 PubMed GONUTS page
↑ Broome, HE et al. (1995) Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal. J. Immunol. 155 2311-7 PubMed GONUTS page
↑ ^29.0 ^29.1 Heermeier, K et al. (1996) Bax and Bcl-xs are induced at the onset of apoptosis in involuting mammary epithelial cells. Mech. Dev. 56 197-207 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10894153-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Rucker, EB 3rd et al. (2000) Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Mol. Endocrinol. 14 1038-52 PubMed GONUTS page

[PMID:9184696-3] Li, L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell. Immunol. 178 33-41 PubMed GONUTS page

[PMID:11980919-4] 4.0 ^4.1 Putcha, GV et al. (2002) Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J. Cell Biol. 157 441-53 PubMed GONUTS page

[PMID:15231831-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Seo, SY et al. (2004) BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J. Biol. Chem. 279 42240-9 PubMed GONUTS page

[PMID:26582200-6] 6.0 ^6.1 ^6.2 Urresti, J et al. (2016) Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells. J. Biol. Chem. 291 1221-34 PubMed GONUTS page

[PMID:14517295-7] 7.0 ^7.1 ^7.2 Maclean, KH et al. (2003) c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL. Mol. Cell. Biol. 23 7256-70 PubMed GONUTS page

[PMID:17267035-8] 8.0 ^8.1 Chen, M et al. (2007) Regulation of the lifespan in dendritic cell subsets. Mol. Immunol. 44 2558-65 PubMed GONUTS page

[PMID:9176392-9] 9.0 ^9.1 Tzung, SP et al. (1997) Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene. Am. J. Pathol. 150 1985-95 PubMed GONUTS page

[PMID:23530063-10] Hatle, KM et al. (2013) MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations. Mol. Cell. Biol. 33 2302-14 PubMed GONUTS page

[PMID:14651853-11] Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

[PMID:7607090-12] 12.0 ^12.1 González-García, M et al. (1994) bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development 120 3033-42 PubMed GONUTS page

[PMID:20671748-13] 13.0 ^13.1 Cleland, MM et al. (2011) Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cell Death Differ. 18 235-47 PubMed GONUTS page

[PMID:12931191-14] Danial, NN et al. (2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424 952-6 PubMed GONUTS page

[PMID:17052454-15] Walensky, LD et al. (2006) A stapled BID BH3 helix directly binds and activates BAX. Mol. Cell 24 199-210 PubMed GONUTS page

[PMID:10618441-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Roth, KA et al. (2000) Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death. Proc. Natl. Acad. Sci. U.S.A. 97 466-71 PubMed GONUTS page

[PMID:12115603-17] Ayllón, V et al. (2002) The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad. Eur. J. Immunol. 32 1847-55 PubMed GONUTS page

[PMID:8918887-18] Wang, K et al. (1996) BID: a novel BH3 domain-only death agonist. Genes Dev. 10 2859-69 PubMed GONUTS page

[PMID:7834748-19] Yang, E et al. (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80 285-91 PubMed GONUTS page

[PMID:7650488-20] Chao, DT et al. (1995) Bcl-XL and Bcl-2 repress a common pathway of cell death. J. Exp. Med. 182 821-8 PubMed GONUTS page

[PMID:9096145-21] Shindler, KS et al. (1997) Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice. J. Neurosci. 17 3112-9 PubMed GONUTS page

[PMID:11150333-22] 22.0 ^22.1 Zaidi, AU et al. (2001) Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways. J. Neurosci. 21 169-75 PubMed GONUTS page

[PMID:8625820-23] Middleton, G et al. (1996) Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors. Development 122 695-701 PubMed GONUTS page

[PMID:7753802-24] González-García, M et al. (1995) bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death. Proc. Natl. Acad. Sci. U.S.A. 92 4304-8 PubMed GONUTS page

[PMID:8798452-25] 25.0 ^25.1 Simonian, PL et al. (1996) Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL. J. Biol. Chem. 271 22764-72 PubMed GONUTS page

[PMID:9867803-26] Chen, G et al. (1999) Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J. Biol. Chem. 274 7-10 PubMed GONUTS page

[PMID:11717309-27] Dramsi, S et al. (2002) Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity. J. Biol. Chem. 277 6399-405 PubMed GONUTS page

[PMID:7650367-28] Broome, HE et al. (1995) Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal. J. Immunol. 155 2311-7 PubMed GONUTS page

[PMID:8798158-29] 29.0 ^29.1 Heermeier, K et al. (1996) Bax and Bcl-xs are induced at the onset of apoptosis in involuting mammary epithelial cells. Mech. Dev. 56 197-207 PubMed GONUTS page

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MOUSE:B2CL1

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