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MOUSE:B2CL1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Bcl2l1 (synonyms: Bcl2l, Bclx)
Protein Name(s) Bcl-2-like protein 1

Bcl2-L-1 Apoptosis regulator Bcl-X

External Links
UniProt Q64373
EMBL X83574
L35049
L35048
U10102
U10101
U10100
U51278
U51279
U78031
U78030
CCDS CCDS16899.1
PIR I49055
I49056
I49057
RefSeq NP_001276645.1
NP_001276646.1
NP_033873.3
XP_006498672.1
XP_006498674.1
XP_006498675.1
UniGene Mm.238213
PDB 1PQ0
1PQ1
2BZW
3IHC
3IHD
3IHE
3IHF
3IIG
3IIH
3ILB
3ILC
PDBsum 1PQ0
1PQ1
2BZW
3IHC
3IHD
3IHE
3IHF
3IIG
3IIH
3ILB
3ILC
ProteinModelPortal Q64373
SMR Q64373
BioGrid 198323
IntAct Q64373
MINT MINT-87027
PhosphoSite Q64373
MaxQB Q64373
PaxDb Q64373
PRIDE Q64373
Ensembl ENSMUST00000007803
ENSMUST00000109820
ENSMUST00000134902
ENSMUST00000140436
GeneID 12048
KEGG mmu:12048
UCSC uc008ngi.1
uc008ngj.1
uc008ngn.1
CTD 598
MGI MGI:88139
eggNOG NOG300479
GeneTree ENSGT00530000062935
HOGENOM HOG000056452
InParanoid Q64373
KO K04570
OMA NGSPSWH
OrthoDB EOG70GMGD
TreeFam TF315834
Reactome REACT_198658
REACT_223399
EvolutionaryTrace Q64373
NextBio 280335
PMAP-CutDB Q64373
PRO PR:Q64373
Proteomes UP000000589
Bgee Q64373
CleanEx MM_BCL2L1
ExpressionAtlas Q64373
Genevestigator Q64373
GO GO:0097136
GO:0030054
GO:0005813
GO:0005829
GO:0016021
GO:0005622
GO:0005743
GO:0005759
GO:0031966
GO:0005741
GO:0005739
GO:0031965
GO:0005730
GO:0030672
GO:0046982
GO:0042803
GO:0071839
GO:0008283
GO:0060154
GO:0071312
GO:0071230
GO:0071480
GO:0000910
GO:0097192
GO:0009566
GO:0007281
GO:0040007
GO:0097284
GO:0001701
GO:0008630
GO:0008584
GO:0070584
GO:0007093
GO:2000811
GO:0043066
GO:0090005
GO:1900118
GO:2001243
GO:1902230
GO:0043524
GO:0090201
GO:0051402
GO:0001541
GO:0043065
GO:0008284
GO:0046902
GO:0051881
GO:0001836
GO:0046898
GO:0034097
GO:0009314
GO:0009615
GO:0007283
GO:0019050
InterPro IPR013279
IPR002475
IPR004725
IPR020717
IPR020726
IPR020728
IPR003093
IPR020731
IPR026298
PANTHER PTHR11256
PTHR11256:SF12
Pfam PF00452
PF02180
PRINTS PR01864
PR01862
SMART SM00265
TIGRFAMs TIGR00865
PROSITE PS50062
PS01080
PS01258
PS01259
PS01260
PS50063

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

involved_in

GO:1900118

negative regulation of execution phase of apoptosis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

involved_in

GO:0007093

mitotic cell cycle checkpoint

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07817

C

Seeded From UniProt

complete

involved_in

GO:0032465

regulation of cytokinesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

involved_in

GO:2001243

negative regulation of intrinsic apoptotic signaling pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000135647
UniProtKB:P10415
UniProtKB:Q07817
ZFIN:ZDB-GENE-010730-1

P

Seeded From UniProt

complete

involved_in

GO:0097192

extrinsic apoptotic signaling pathway in absence of ligand

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101769
MGI:MGI:108052
MGI:MGI:1097161
MGI:MGI:88138
MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648
UniProtKB:Q07820

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88138
MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648
RGD:2192
RGD:2199
RGD:2200
RGD:620525
RGD:620621
RGD:620717
RGD:621635
RGD:70984
UniProtKB:P10415
UniProtKB:Q07812
UniProtKB:Q07820
UniProtKB:Q16611
UniProtKB:Q92843
ZFIN:ZDB-GENE-000511-7
ZFIN:ZDB-GENE-030825-1
ZFIN:ZDB-GENE-051012-1

F

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101769
MGI:MGI:102687
MGI:MGI:88138
MGI:MGI:88139
PANTHER:PTN000135647
RGD:2199
RGD:2200
RGD:620525
UniProtKB:P10415
UniProtKB:Q07817
UniProtKB:Q07820
UniProtKB:Q92843
WB:WBGene00000423
ZFIN:ZDB-GENE-000511-7
ZFIN:ZDB-GENE-010730-1

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1330841
MGI:MGI:1858494
MGI:MGI:99702
PANTHER:PTN000135648
RGD:621635
UniProtKB:P10415
UniProtKB:Q07812
UniProtKB:Q16611

F

Seeded From UniProt

complete

involved_in

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0029131
MGI:MGI:101769
MGI:MGI:1097161
MGI:MGI:88138
MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648

P

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648
RGD:2192
RGD:2200
UniProtKB:P10415
UniProtKB:Q07817
WB:WBGene00000423

C

Seeded From UniProt

complete

enables

GO:0043027

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042981

regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0040008

regulation of growth

PMID:10894153[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2176699

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0036466

synaptic vesicle recycling via endosome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034097

response to cytokine

PMID:9184696[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032465

regulation of cytokinesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

part_of

GO:0031966

mitochondrial membrane

PMID:11980919[4]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16985)
  • part_of:(CL:0000540)

Seeded From UniProt

complete

colocalizes_with

GO:0031966

mitochondrial membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

C

Seeded From UniProt

complete

colocalizes_with

GO:0030672

synaptic vesicle membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

C

Seeded From UniProt

complete

enables

GO:0030276

clathrin binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019050

suppression by virus of host apoptotic process

PMID:15231831[5]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:26582200[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009615

response to virus

PMID:15231831[5]

ECO:0000314

direct assay evidence used in manual assertion

P

has_participant:(EMAPA:32845)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009566

fertilization

PMID:10894153[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009314

response to radiation

PMID:14517295[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158303

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:14517295[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158303

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008584

male gonad development

PMID:10894153[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2176699

P

results_in_development_of:(EMAPA:17972)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

PMID:17267035[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008283

cell population proliferation

PMID:9176392[9]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(EMAPA:16846)
  • acts_on_population_of:(CL:0000182)

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007283

spermatogenesis

PMID:10894153[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007281

germ cell development

PMID:10894153[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

results_in_development_of:(CL:0000020)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007281

germ cell development

PMID:10894153[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2176699

P

results_in_development_of:(CL:0000670)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007093

mitotic cell cycle checkpoint

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

colocalizes_with

GO:0005905

clathrin-coated pit

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:11980919[4]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16985)
  • part_of:(CL:0000540)

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:26582200[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:23530063[10]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:16105)

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

C

Seeded From UniProt

complete

part_of

GO:0005740

mitochondrial envelope

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:14651853[11]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(EMAPA:16846)|part_of:(EMAPA:16894)|part_of:(EMAPA:17373)

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:7607090[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:20671748[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:12931191[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002931

response to ischemia

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001836

release of cytochrome c from mitochondria

PMID:17052454[15]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001836

release of cytochrome c from mitochondria

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001701

in utero embryonic development

PMID:10618441[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158303

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001541

ovarian follicle development

PMID:10894153[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

results_in_development_of:(EMAPA:30755)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001541

ovarian follicle development

PMID:10894153[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2176699

P

results_in_development_of:(EMAPA:30755)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001541

ovarian follicle development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001243

negative regulation of intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001171

positive regulation of ATP biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000811

negative regulation of anoikis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000809

positive regulation of synaptic vesicle clustering

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000302

positive regulation of synaptic vesicle exocytosis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903077

negative regulation of protein localization to plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902230

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

PMID:26582200[6]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1900452

regulation of long-term synaptic depression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1900244

positive regulation of synaptic vesicle endocytosis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1900118

negative regulation of execution phase of apoptosis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

part_of

GO:0098793

presynapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

C

Seeded From UniProt

complete

enables

GO:0097371

MDM2/MDM4 family protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097284

hepatocyte apoptotic process

PMID:10618441[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158303

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097192

extrinsic apoptotic signaling pathway in absence of ligand

PMID:12115603[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0097136

Bcl-2 family protein complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090201

negative regulation of release of cytochrome c from mitochondria

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071839

apoptotic process in bone marrow cell

PMID:10618441[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158303

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071480

cellular response to gamma radiation

PMID:15231831[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071312

cellular response to alkaloid

PMID:15231831[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071230

cellular response to amino acid stimulus

PMID:15231831[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2675966

P

occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070584

mitochondrion morphogenesis

PMID:20671748[13]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060154

cellular process regulating host cell cycle in response to virus

PMID:15231831[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2675966

P

occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051881

regulation of mitochondrial membrane potential

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

enables

GO:0051434

BH3 domain binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051402

neuron apoptotic process

PMID:10618441[16]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:107739

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051402

neuron apoptotic process

PMID:10618441[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158303

P

Seeded From UniProt

complete

enables

GO:0051400

BH domain binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

F

Seeded From UniProt

complete

enables

GO:0051020

GTPase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:8918887[18]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P70444

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:7834748[19]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q07813
UniProtKB:Q61337

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:7650488[20]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q07813

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046902

regulation of mitochondrial membrane permeability

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046898

response to cycloheximide

PMID:9176392[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:9096145[21]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

  • occurs_in:(EMAPA:16910)
  • regulates_o_occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:11150333[22]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1277950

P

  • occurs_in:(EMAPA:16469)
  • regulates_o_occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:11150333[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158303

P

  • occurs_in:(EMAPA:16469)
  • regulates_o_occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:8625820[23]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:7753802[24]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:15231831[5]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(EMAPA:32845)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:8798452[25]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:14517295[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:10894153[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2176699

P

  • regulates_o_occurs_in:(EMAPA:17962)
  • regulates_o_occurs_in:(CL:0000586)|regulates_o_occurs_in:(EMAPA:17972)
  • regulates_o_occurs_in:(CL:0000586)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:9867803[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:17267035[8]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_occurs_in:(CL:0000451)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:11717309[27]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:7650367[28]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07817

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2200

P

Seeded From UniProt

complete

involved_in

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0043027

P

Seeded From UniProt

complete

involved_in

GO:2001243

negative regulation of intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

P

Seeded From UniProt

complete

involved_in

GO:1903077

negative regulation of protein localization to plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

P

Seeded From UniProt

complete

involved_in

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

P

Seeded From UniProt

complete

involved_in

GO:1902230

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

P

Seeded From UniProt

complete

involved_in

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

P

Seeded From UniProt

complete

involved_in

GO:1900118

negative regulation of execution phase of apoptosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

P

Seeded From UniProt

complete

part_of

GO:0097136

Bcl-2 family protein complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

C

Seeded From UniProt

complete

involved_in

GO:0051881

regulation of mitochondrial membrane potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

P

Seeded From UniProt

complete

enables

GO:0051434

BH3 domain binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

F

Seeded From UniProt

complete

involved_in

GO:0046902

regulation of mitochondrial membrane permeability

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

F

Seeded From UniProt

complete

involved_in

GO:0034097

response to cytokine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

P

Seeded From UniProt

complete

involved_in

GO:0032465

regulation of cytokinesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

F

Seeded From UniProt

complete

involved_in

GO:0019050

suppression by virus of host apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

P

Seeded From UniProt

complete

involved_in

GO:0007093

mitotic cell cycle checkpoint

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

C

Seeded From UniProt

complete

involved_in

GO:0001836

release of cytochrome c from mitochondria

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07817
ensembl:ENSP00000365230

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004725

C

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003093
InterPro:IPR004725
InterPro:IPR013279
InterPro:IPR020717
InterPro:IPR020726
InterPro:IPR020728
InterPro:IPR020731
InterPro:IPR026298
InterPro:IPR036834

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:8798452[25]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q07813

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:8798158[29]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:7607090[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

PMID:8798158[29]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0999
UniProtKB-SubCell:SL-0168

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0770

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1000
UniProtKB-SubCell:SL-0172

C

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

part_of

GO:0030672

synaptic vesicle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0260

C

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0182

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

part_of

GO:0031966

mitochondrial membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0171

C

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Rucker, EB 3rd et al. (2000) Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Mol. Endocrinol. 14 1038-52 PubMed GONUTS page
  3. Li, L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell. Immunol. 178 33-41 PubMed GONUTS page
  4. 4.0 4.1 Putcha, GV et al. (2002) Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J. Cell Biol. 157 441-53 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Seo, SY et al. (2004) BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J. Biol. Chem. 279 42240-9 PubMed GONUTS page
  6. 6.0 6.1 6.2 Urresti, J et al. (2016) Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells. J. Biol. Chem. 291 1221-34 PubMed GONUTS page
  7. 7.0 7.1 7.2 Maclean, KH et al. (2003) c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL. Mol. Cell. Biol. 23 7256-70 PubMed GONUTS page
  8. 8.0 8.1 Chen, M et al. (2007) Regulation of the lifespan in dendritic cell subsets. Mol. Immunol. 44 2558-65 PubMed GONUTS page
  9. 9.0 9.1 Tzung, SP et al. (1997) Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene. Am. J. Pathol. 150 1985-95 PubMed GONUTS page
  10. Hatle, KM et al. (2013) MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations. Mol. Cell. Biol. 33 2302-14 PubMed GONUTS page
  11. Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
  12. 12.0 12.1 González-García, M et al. (1994) bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development 120 3033-42 PubMed GONUTS page
  13. 13.0 13.1 Cleland, MM et al. (2011) Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cell Death Differ. 18 235-47 PubMed GONUTS page
  14. Danial, NN et al. (2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424 952-6 PubMed GONUTS page
  15. Walensky, LD et al. (2006) A stapled BID BH3 helix directly binds and activates BAX. Mol. Cell 24 199-210 PubMed GONUTS page
  16. 16.0 16.1 16.2 16.3 16.4 Roth, KA et al. (2000) Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death. Proc. Natl. Acad. Sci. U.S.A. 97 466-71 PubMed GONUTS page
  17. Ayllón, V et al. (2002) The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad. Eur. J. Immunol. 32 1847-55 PubMed GONUTS page
  18. Wang, K et al. (1996) BID: a novel BH3 domain-only death agonist. Genes Dev. 10 2859-69 PubMed GONUTS page
  19. Yang, E et al. (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80 285-91 PubMed GONUTS page
  20. Chao, DT et al. (1995) Bcl-XL and Bcl-2 repress a common pathway of cell death. J. Exp. Med. 182 821-8 PubMed GONUTS page
  21. Shindler, KS et al. (1997) Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice. J. Neurosci. 17 3112-9 PubMed GONUTS page
  22. 22.0 22.1 Zaidi, AU et al. (2001) Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways. J. Neurosci. 21 169-75 PubMed GONUTS page
  23. Middleton, G et al. (1996) Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors. Development 122 695-701 PubMed GONUTS page
  24. González-García, M et al. (1995) bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death. Proc. Natl. Acad. Sci. U.S.A. 92 4304-8 PubMed GONUTS page
  25. 25.0 25.1 Simonian, PL et al. (1996) Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL. J. Biol. Chem. 271 22764-72 PubMed GONUTS page
  26. Chen, G et al. (1999) Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J. Biol. Chem. 274 7-10 PubMed GONUTS page
  27. Dramsi, S et al. (2002) Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity. J. Biol. Chem. 277 6399-405 PubMed GONUTS page
  28. Broome, HE et al. (1995) Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal. J. Immunol. 155 2311-7 PubMed GONUTS page
  29. 29.0 29.1 Heermeier, K et al. (1996) Bax and Bcl-xs are induced at the onset of apoptosis in involuting mammary epithelial cells. Mech. Dev. 56 197-207 PubMed GONUTS page