PMID:7753802

Citation	González-García, M, García, I, Ding, L, O'Shea, S, Boise, LH, Thompson, CB and Núñez, G (1995) bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death. Proc. Natl. Acad. Sci. U.S.A. 92:4304-8
Abstract	Previous studies have implicated the bcl-2 protooncogene as a potential regulator of neuronal survival. However, mice lacking functional bcl-2 exhibited normal development and maintenance of the central nervous system (CNS). Since bcl-2 appears dispensable for neuronal survival, we have examined the expression and function of bcl-x, another member of the bcl-2 family of death regulatory genes. Bcl-2 is expressed in neuronal tissues during embryonic development but is down-regulated in the adult CNS. In contrast, Bcl-xL expression is retained in neurons of the adult CNS. Two different forms of bcl-x mRNA and their corresponding products, Bcl-xL and Bcl-x beta, were expressed in embryonic and adult neurons of the CNS. Microinjection of bcl-xL and bcl-x beta cDNAs into primary sympathetic neurons inhibited their death induced by nerve growth factor withdrawal. Thus, Bcl-x proteins appear to play an important role in the regulation of neuronal survival in the adult CNS.
Links	PubMed PMC41932
Keywords	Aging/metabolism; Animals; Animals, Newborn; Brain/embryology; Brain/growth & development; Brain/metabolism; Cell Death/physiology; Cells, Cultured; DNA, Complementary; Embryonic and Fetal Development; In Situ Hybridization; Liver/metabolism; Microinjections; Neurons/cytology; Neurons/metabolism; Organ Specificity; Proto-Oncogene Proteins/biosynthesis; Proto-Oncogene Proteins c-bcl-2; Rats; Spinal Cord/growth & development; Spinal Cord/metabolism; Superior Cervical Ganglion/cytology; Superior Cervical Ganglion/physiology; bcl-X Protein
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