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MOUSE:A4

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) App
Protein Name(s) Amyloid beta A4 protein

ABPP APP Alzheimer disease amyloid A4 protein homolog Amyloidogenic glycoprotein AG N-APP Soluble APP-alpha S-APP-alpha Soluble APP-beta S-APP-beta C99 APP-C99 Beta-amyloid protein 42 Beta-APP42 Beta-amyloid protein 40 Beta-APP40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 APP-C59 Amyloid intracellular domain 59 AID(59) Gamma-CTF(59) Gamma-secretase C-terminal fragment 57 APP-C57 Amyloid intracellular domain 57 AID(57) Gamma-CTF(57) Gamma-secretase C-terminal fragment 50 Amyloid intracellular domain 50 AID(50) Gamma-CTF(50) C31

External Links
UniProt P12023
EMBL M18373
X59379
U84012
D10603
BC005490
M24397
X15210
U82624
CCDS CCDS28285.1
PIR A27485
A32282
S04855
RefSeq NP_001185752.1
UniGene Mm.277585
Mm.489029
Mm.490986
PDB 2ROZ
2YSZ
2YT0
2YT1
PDBsum 2ROZ
2YSZ
2YT0
2YT1
ProteinModelPortal P12023
SMR P12023
BioGrid 198167
IntAct P12023
MINT MINT-208509
MEROPS I02.015
PhosphoSite P12023
MaxQB P12023
PaxDb P12023
PRIDE P12023
Ensembl ENSMUST00000005406
GeneID 11820
KEGG mmu:11820
UCSC uc007ztn.2
CTD 351
MGI MGI:88059
eggNOG NOG289770
HOGENOM HOG000232190
HOVERGEN HBG000051
InParanoid P12023
KO K04520
OMA TKTCIGT
OrthoDB EOG7RNJZP
PhylomeDB P12023
TreeFam TF317274
Reactome REACT_196606
REACT_198563
REACT_198644
REACT_198647
REACT_202898
REACT_207651
REACT_219800
REACT_222971
REACT_229705
REACT_250376
ChiTaRS App
EvolutionaryTrace P12023
NextBio 279717
PRO PR:P12023
Proteomes UP000000589
Bgee P12023
CleanEx MM_APP
ExpressionAtlas P12023
Genevestigator P12023
GO GO:0045177
GO:0030424
GO:0009986
GO:0005911
GO:0035253
GO:0005905
GO:0005737
GO:0031410
GO:0043198
GO:0043197
GO:0030134
GO:0005615
GO:0070062
GO:0005794
GO:0016021
GO:0016020
GO:0045121
GO:0031594
GO:0043005
GO:0005641
GO:0048471
GO:0005886
GO:0043235
GO:0051233
GO:0003677
GO:0008201
GO:0016504
GO:0004867
GO:0046914
GO:0008344
GO:0008088
GO:0016199
GO:0007409
GO:0007155
GO:0006878
GO:0008203
GO:0048669
GO:0016358
GO:0006897
GO:0030198
GO:0030900
GO:0035235
GO:0007626
GO:0007617
GO:0006378
GO:0045665
GO:0050885
GO:0051402
GO:0031175
GO:0016322
GO:0007219
GO:0010971
GO:0045931
GO:0045944
GO:0051260
GO:0006468
GO:0007176
GO:0010468
GO:0040014
GO:0043393
GO:0050803
GO:0006417
GO:0006979
GO:0051563
GO:0001967
GO:0051124
GO:0008542
Gene3D 3.30.1490.140
3.90.570.10
4.10.230.10
4.10.410.10
InterPro IPR008155
IPR013803
IPR011178
IPR024329
IPR008154
IPR019744
IPR015849
IPR019745
IPR028866
IPR019543
IPR002223
IPR020901
PANTHER PTHR23103:SF7
Pfam PF10515
PF12924
PF12925
PF02177
PF03494
PF00014
PRINTS PR00203
PR00759
PR00204
SMART SM00006
SM00131
SUPFAM SSF109843
SSF56491
SSF57362
SSF89811
PROSITE PS00319
PS00320
PS00280
PS50279

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0045806

negative regulation of endocytosis

PMID:3815101[1]

ECO:0000315

P

Figure 2B. Fluorescent staining of APP-deficient neurons reveals increased levels of internalized p75NTR. The control group (with higher levels of APP)showed decreased levels of internalized p75NTR.

complete

part_of

GO:0005798

Golgi-associated vesicle

PMID:23931995[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0055037

recycling endosome

PMID:23931995[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0030546

receptor activator activity

PMID:11316806[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0048786

presynaptic active zone

PMID:23815291[4]

ECO:0006042

cell fractionation evidence used in manual assertion

C

part_of:(UBERON:0000955)

Seeded From UniProt

complete

part_of

GO:0048786

presynaptic active zone

PMID:23815291[4]

ECO:0000279

western blot evidence used in manual assertion

C

part_of:(UBERON:0000955)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000406

positive regulation of T cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

part_of

GO:1990812

growth cone filopodium

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

C

Seeded From UniProt

complete

part_of

GO:1990761

growth cone lamellipodium

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1990535

neuron projection maintenance

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1990000

amyloid fibril formation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1905908

positive regulation of amyloid fibril formation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1905606

regulation of presynapse assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1904646

cellular response to amyloid-beta

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903980

positive regulation of microglial cell activation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902004

positive regulation of amyloid-beta formation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901224

positive regulation of NIK/NF-kappaB signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1900273

positive regulation of long-term synaptic potentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1900272

negative regulation of long-term synaptic potentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0150003

regulation of spontaneous synaptic transmission

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0098815

modulation of excitatory postsynaptic potential

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

part_of

GO:0097449

astrocyte projection

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090647

modulation of age-related behavioral decline

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071874

cellular response to norepinephrine stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

P

Seeded From UniProt

complete

enables

GO:0070851

growth factor receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070555

response to interleukin-1

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061890

positive regulation of astrocyte activation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051563

smooth endoplasmic reticulum calcium ion homeostasis

PMID:12431992[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1202717

P

  • occurs_in:(EMAPA:32845)
  • occurs_in:(CL:0000117)

Seeded From UniProt

complete

enables

GO:0051425

PTB domain binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051402

neuron apoptotic process

PMID:16478525[6]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1202717

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051402

neuron apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051260

protein homooligomerization

PMID:23986251[7]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O35463

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051247

positive regulation of protein metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051247

positive regulation of protein metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

P

Seeded From UniProt

complete

part_of

GO:0051233

spindle midzone

PMID:15561424[8]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17547)
  • part_of:(CL:0000031)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051124

synaptic growth at neuromuscular junction

PMID:15689559[9]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88047

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051091

positive regulation of DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050890

cognition

PMID:25592972[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050885

neuromuscular process controlling balance

PMID:9461064[11]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88047

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050808

synapse organization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050803

regulation of synapse structure or activity

PMID:10219973[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2136847

P

  • regulates_o_has_participant:(EMAPA:32845)
  • regulates_o_has_participant:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050730

regulation of peptidyl-tyrosine phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050725

positive regulation of interleukin-1 beta biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048669

collateral sprouting in absence of injury

PMID:15689559[9]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88047

P

  • occurs_in:(EMAPA:25137)
  • occurs_in:(CL:0000100)

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:8207383[13]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16531)
  • part_of:(CL:0000540)|part_of:(EMAPA:16473)
  • part_of:(CL:0000540)|part_of:(EMAPA:16478)
  • part_of:(CL:0000540)|part_of:(EMAPA:16659)
  • part_of:(CL:0000540)|part_of:(EMAPA:16474)
  • part_of:(CL:0000540)

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048169

regulation of long-term neuronal synaptic plasticity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048143

astrocyte activation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046330

positive regulation of JNK cascade

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:15944124[14]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:107765
MGI:MGI:1932051

P

has_regulation_target:(MGI:MGI:97004)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:15944124[14]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:97004)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045931

positive regulation of mitotic cell cycle

PMID:15561424[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154535

P

  • regulates_o_occurs_in:(EMAPA:17547)
  • regulates_o_occurs_in:(CL:0000031)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045665

negative regulation of neuron differentiation

PMID:18278038[15]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:104518

P

  • occurs_in:(EMAPA:16913)
  • regulates_o_results_in_acquisition_of_features_of:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045665

negative regulation of neuron differentiation

PMID:18278038[15]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_results_in_acquisition_of_features_of:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045410

positive regulation of interleukin-6 biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

part_of

GO:0045177

apical part of cell

PMID:15561424[8]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17547)
  • part_of:(CL:0000710)

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

C

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045080

positive regulation of chemokine biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

part_of

GO:0044304

main axon

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043393

regulation of protein binding

PMID:17920016[16]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88047

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043393

regulation of protein binding

PMID:17920016[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2136847

P

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

PMID:23382219[17]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:16301330[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042535

positive regulation of tumor necrosis factor biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042327

positive regulation of phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0040014

regulation of multicellular organism growth

PMID:9754878[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154522

P

Seeded From UniProt

complete

part_of

GO:0035253

ciliary rootlet

PMID:16018997[20]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035235

ionotropic glutamate receptor signaling pathway

PMID:16025111[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2652346

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033138

positive regulation of peptidyl-serine phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032640

tumor necrosis factor production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032092

positive regulation of protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

part_of

GO:0031594

neuromuscular junction

PMID:10845772[22]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:35375)

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

PMID:15745965[23]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:18577)
  • part_of:(CL:0000540)

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

PMID:11740561[24]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:18577)
  • part_of:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031175

neuron projection development

PMID:8083748[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030900

forebrain development

PMID:8001115[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154522

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030900

forebrain development

PMID:10200318[27]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154522
MGI:MGI:2154535

P

results_in_development_of:(EMAPA:32845)|results_in_development_of:(EMAPA:35253)

Seeded From UniProt

complete

part_of

GO:0030426

growth cone

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:15745965[23]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:18577)
  • part_of:(CL:0000540)

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:11740561[24]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:18577)
  • part_of:(CL:0000540)

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030198

extracellular matrix organization

PMID:15385965[28]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2137246
MGI:MGI:2154545

P

occurs_in:(EMAPA:17544)

Seeded From UniProt

complete

part_of

GO:0030134

COPII-coated ER to Golgi transport vesicle

PMID:19966784[29]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

F

Seeded From UniProt

complete

enables

GO:0016504

peptidase activator activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016358

dendrite development

PMID:15689559[9]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88047

P

  • occurs_in:(EMAPA:25137)
  • occurs_in:(CL:0000100)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016358

dendrite development

PMID:9390996[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2136847

P

  • occurs_in:(EMAPA:19148)
  • occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016358

dendrite development

PMID:10188929[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2136847

P

  • occurs_in:(EMAPA:32770)
  • occurs_in:(CL:0000598)|occurs_in:(EMAPA:35277)
  • occurs_in:(CL:0000598)|occurs_in:(EMAPA:35255)
  • occurs_in:(CL:0000598)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016322

neuron remodeling

PMID:10219973[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2136847

P

  • occurs_in:(EMAPA:32845)
  • occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016199

axon midline choice point recognition

PMID:8001115[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154522

P

  • occurs_in:(EMAPA:35253)
  • occurs_in:(CL:0000117)

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:12927782[32]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:9535056[33]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:15886206[34]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:12927782[32]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:10845772[22]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:35578)
  • part_of:(CL:0000188)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0014005

microglia development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010971

positive regulation of G2/M transition of mitotic cell cycle

PMID:15561424[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154535

P

  • regulates_o_occurs_in:(EMAPA:17547)
  • regulates_o_occurs_in:(CL:0000031)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010629

negative regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010468

regulation of gene expression

PMID:12074840[35]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:97004)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010468

regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009987

cellular process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:16227578[36]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

C

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008542

visual learning

PMID:10338291[37]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2136847

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008344

adult locomotory behavior

PMID:9754878[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154522

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008344

adult locomotory behavior

PMID:8001115[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154522

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008344

adult locomotory behavior

PMID:7758106[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2136847

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008344

adult locomotory behavior

PMID:10188929[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2136847

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008203

cholesterol metabolic process

PMID:17920016[16]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88047

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008203

cholesterol metabolic process

PMID:17920016[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2136847

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008088

axo-dendritic transport

PMID:20829454[39]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97180

P

  • occurs_in:(EMAPA:19148)
  • occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008088

axo-dendritic transport

PMID:11740561[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2136847

P

  • occurs_in:(EMAPA:18577)
  • occurs_in:(CL:0000540)|occurs_in:(EMAPA:35253)
  • occurs_in:(CL:0000540)

Seeded From UniProt

complete

part_of

GO:0008021

synaptic vesicle

PMID:25438880[40]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:9461064[11]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88047

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007617

mating behavior

PMID:9461064[11]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88047

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007612

learning

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007611

learning or memory

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007409

axonogenesis

PMID:9390996[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2136847

P

  • occurs_in:(EMAPA:19148)
  • occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007176

regulation of epidermal growth factor-activated receptor activity

PMID:17556541[41]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88047

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006979

response to oxidative stress

PMID:16478525[6]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1202717

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006897

endocytosis

PMID:16025111[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2652346

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006878

cellular copper ion homeostasis

PMID:15447675[42]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88047

P

  • occurs_in:(EMAPA:17544)
  • occurs_in:(CL:0000117)|occurs_in:(EMAPA:16039)
  • occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006878

cellular copper ion homeostasis

PMID:10526140[43]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2136847

P

occurs_in:(EMAPA:17544)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006468

protein phosphorylation

PMID:16025111[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2652346

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006417

regulation of translation

PMID:16314516[44]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006378

mRNA polyadenylation

PMID:16314516[44]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005911

cell-cell junction

PMID:23793062[45]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15009636[46]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:16018997[20]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

C

Seeded From UniProt

complete

part_of

GO:0005791

rough endoplasmic reticulum

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:25592972[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:10845772[22]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000188)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

C

Seeded From UniProt

complete

part_of

GO:0005641

nuclear envelope lumen

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2139

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

F

Seeded From UniProt

complete

enables

GO:0004867

serine-type endopeptidase inhibitor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:15944124[14]

ECO:0000314

direct assay evidence used in manual assertion

F

has_participant:(MGI:MGI:97004)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002265

astrocyte activation involved in immune response

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001967

suckling behavior

PMID:9461064[11]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88047

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P05067

P

Seeded From UniProt

complete

part_of

GO:0005790

smooth endoplasmic reticulum

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0051563

C

Seeded From UniProt

complete

involved_in

GO:0010951

negative regulation of endopeptidase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004867

P

Seeded From UniProt

complete

involved_in

GO:0010951

negative regulation of endopeptidase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004867

P

Seeded From UniProt

complete

involved_in

GO:0010951

negative regulation of endopeptidase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004867

P

Seeded From UniProt

complete

involved_in

GO:0010951

negative regulation of endopeptidase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004867

P

Seeded From UniProt

complete

involved_in

GO:0010952

positive regulation of peptidase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016504

P

Seeded From UniProt

complete

involved_in

GO:0010952

positive regulation of peptidase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016504

P

Seeded From UniProt

complete

involved_in

GO:2000273

positive regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0030546

P

Seeded From UniProt

complete

involved_in

GO:2000406

positive regulation of T cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:1990535

neuron projection maintenance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:1990000

amyloid fibril formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:1905908

positive regulation of amyloid fibril formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:1905606

regulation of presynapse assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:1904646

cellular response to amyloid-beta

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:1903980

positive regulation of microglial cell activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:1902004

positive regulation of amyloid-beta formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:1901224

positive regulation of NIK/NF-kappaB signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:1900273

positive regulation of long-term synaptic potentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:1900272

negative regulation of long-term synaptic potentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0150003

regulation of spontaneous synaptic transmission

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0098815

modulation of excitatory postsynaptic potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0090647

modulation of age-related behavioral decline

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0061890

positive regulation of astrocyte activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

enables

GO:0051425

PTB domain binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

F

Seeded From UniProt

complete

involved_in

GO:0051402

neuron apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0051247

positive regulation of protein metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0050808

synapse organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0050730

regulation of peptidyl-tyrosine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0050725

positive regulation of interleukin-1 beta biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

C

Seeded From UniProt

complete

involved_in

GO:0048169

regulation of long-term neuronal synaptic plasticity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0048143

astrocyte activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0046330

positive regulation of JNK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0045410

positive regulation of interleukin-6 biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

C

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

C

Seeded From UniProt

complete

involved_in

GO:0045080

positive regulation of chemokine biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

C

Seeded From UniProt

complete

part_of

GO:0043198

dendritic shaft

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

C

Seeded From UniProt

complete

part_of

GO:0043197

dendritic spine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

F

Seeded From UniProt

complete

involved_in

GO:0042535

positive regulation of tumor necrosis factor biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0042327

positive regulation of phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0032640

tumor necrosis factor production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0032092

positive regulation of protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

F

Seeded From UniProt

complete

involved_in

GO:0014005

microglia development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0010468

regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0009987

cellular process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

C

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0007612

learning

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0007611

learning or memory

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

C

Seeded From UniProt

complete

part_of

GO:0005641

nuclear envelope lumen

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

F

Seeded From UniProt

complete

enables

GO:0004867

serine-type endopeptidase inhibitor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

F

Seeded From UniProt

complete

involved_in

GO:0002265

astrocyte activation involved in immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

involved_in

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P05067
ensembl:ENSP00000284981

P

Seeded From UniProt

complete

part_of

GO:1990812

growth cone filopodium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

C

Seeded From UniProt

complete

part_of

GO:1990761

growth cone lamellipodium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

C

Seeded From UniProt

complete

involved_in

GO:1990090

cellular response to nerve growth factor stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

P

Seeded From UniProt

complete

part_of

GO:0097449

astrocyte projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

C

Seeded From UniProt

complete

involved_in

GO:0071874

cellular response to norepinephrine stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

P

Seeded From UniProt

complete

involved_in

GO:0071320

cellular response to cAMP

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

P

Seeded From UniProt

complete

involved_in

GO:0071287

cellular response to manganese ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

P

Seeded From UniProt

complete

involved_in

GO:0071280

cellular response to copper ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

P

Seeded From UniProt

complete

enables

GO:0070851

growth factor receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

F

Seeded From UniProt

complete

involved_in

GO:0070555

response to interleukin-1

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

P

Seeded From UniProt

complete

involved_in

GO:0051247

positive regulation of protein metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

P

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

C

Seeded From UniProt

complete

part_of

GO:0044304

main axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

C

Seeded From UniProt

complete

part_of

GO:0030426

growth cone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

C

Seeded From UniProt

complete

enables

GO:0016504

peptidase activator activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

F

Seeded From UniProt

complete

involved_in

GO:0010288

response to lead ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

C

Seeded From UniProt

complete

involved_in

GO:0009314

response to radiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

C

Seeded From UniProt

complete

part_of

GO:0005791

rough endoplasmic reticulum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08592
ensembl:ENSRNOP00000041613

C

Seeded From UniProt

complete

enables

GO:0004867

serine-type endopeptidase inhibitor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002223
InterPro:IPR036880

F

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028866

P

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015849
InterPro:IPR036454

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008155
InterPro:IPR013803
InterPro:IPR037071

C

Seeded From UniProt

complete

enables

GO:0046914

transition metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011178
InterPro:IPR036669

F

Seeded From UniProt

complete

involved_in

GO:1904472

positive regulation of endothelin secretion

PMID:12808450[47]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q62151

P

Seeded From UniProt

complete

involved_in

GO:0042535

positive regulation of tumor necrosis factor biosynthetic process

PMID:12808450[47]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q62151

P

occurs_in:(UBERON:0000955)

Seeded From UniProt

complete

involved_in

GO:1903523

negative regulation of blood circulation

PMID:12808450[47]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P22387,UniProtKB:Q62151

P

  • occurs_in:(UBERON:0000956)
  • regulates_o_occurs_in:(UBERON:0000956)

Seeded From UniProt

complete

enables

GO:0050750

low-density lipoprotein particle receptor binding

PMID:22383525[48]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P35951

F

Seeded From UniProt

complete

involved_in

GO:0007613

memory

PMID:19118188[49]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060291

long-term synaptic potentiation

PMID:19118188[49]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:11877420[50]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

involved_in

GO:0006897

endocytosis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0254

P

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0358

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0030414

peptidase inhibitor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0646

F

Seeded From UniProt

complete

involved_in

GO:0007219

Notch signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0914

P

Seeded From UniProt

complete

involved_in

GO:0010466

negative regulation of peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0646

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0004867

serine-type endopeptidase inhibitor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0722

F

Seeded From UniProt

complete

part_of

GO:0005905

clathrin-coated pit

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0168
UniProtKB-SubCell:SL-0069

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0310

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0094

C

Seeded From UniProt

complete

part_of

GO:0030426

growth cone

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0288

C

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0197

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Fung, SJ et al. (1987) Differential labeling of the vestibular complex following unilateral injections of horseradish peroxidase into the cat and rat locus coeruleus. Brain Res. 401 347-52 PubMed GONUTS page
  2. 2.0 2.1 Das, U et al. (2013) Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron 79 447-60 PubMed GONUTS page
  3. Tiffany, HL et al. (2001) Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain. J. Biol. Chem. 276 23645-52 PubMed GONUTS page
  4. 4.0 4.1 Laßek, M et al. (2013) Amyloid precursor proteins are constituents of the presynaptic active zone. J. Neurochem. 127 48-56 PubMed GONUTS page
  5. Herms, J et al. (2003) Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein. J. Biol. Chem. 278 2484-9 PubMed GONUTS page
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