MOUSE:A4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	App
Protein Name(s)	Amyloid beta A4 protein ABPP APP Alzheimer disease amyloid A4 protein homolog Amyloidogenic glycoprotein AG N-APP Soluble APP-alpha S-APP-alpha Soluble APP-beta S-APP-beta C99 APP-C99 Beta-amyloid protein 42 Beta-APP42 Beta-amyloid protein 40 Beta-APP40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 APP-C59 Amyloid intracellular domain 59 AID(59) Gamma-CTF(59) Gamma-secretase C-terminal fragment 57 APP-C57 Amyloid intracellular domain 57 AID(57) Gamma-CTF(57) Gamma-secretase C-terminal fragment 50 Amyloid intracellular domain 50 AID(50) Gamma-CTF(50) C31
External Links
UniProt	P12023
EMBL	M18373 X59379 U84012 D10603 BC005490 M24397 X15210 U82624
CCDS	CCDS28285.1
PIR	A27485 A32282 S04855
RefSeq	NP_001185752.1
UniGene	Mm.277585 Mm.489029 Mm.490986
PDB	2ROZ 2YSZ 2YT0 2YT1
PDBsum	2ROZ 2YSZ 2YT0 2YT1
ProteinModelPortal	P12023
SMR	P12023
BioGrid	198167
IntAct	P12023
MINT	MINT-208509
MEROPS	I02.015
PhosphoSite	P12023
MaxQB	P12023
PaxDb	P12023
PRIDE	P12023
Ensembl	ENSMUST00000005406
GeneID	11820
KEGG	mmu:11820
UCSC	uc007ztn.2
CTD	351
MGI	MGI:88059
eggNOG	NOG289770
HOGENOM	HOG000232190
HOVERGEN	HBG000051
InParanoid	P12023
KO	K04520
OMA	TKTCIGT
OrthoDB	EOG7RNJZP
PhylomeDB	P12023
TreeFam	TF317274
Reactome	REACT_196606 REACT_198563 REACT_198644 REACT_198647 REACT_202898 REACT_207651 REACT_219800 REACT_222971 REACT_229705 REACT_250376
ChiTaRS	App
EvolutionaryTrace	P12023
NextBio	279717
PRO	PR:P12023
Proteomes	UP000000589
Bgee	P12023
CleanEx	MM_APP
ExpressionAtlas	P12023
Genevestigator	P12023
GO	GO:0045177 GO:0030424 GO:0009986 GO:0005911 GO:0035253 GO:0005905 GO:0005737 GO:0031410 GO:0043198 GO:0043197 GO:0030134 GO:0005615 GO:0070062 GO:0005794 GO:0016021 GO:0016020 GO:0045121 GO:0031594 GO:0043005 GO:0005641 GO:0048471 GO:0005886 GO:0043235 GO:0051233 GO:0003677 GO:0008201 GO:0016504 GO:0004867 GO:0046914 GO:0008344 GO:0008088 GO:0016199 GO:0007409 GO:0007155 GO:0006878 GO:0008203 GO:0048669 GO:0016358 GO:0006897 GO:0030198 GO:0030900 GO:0035235 GO:0007626 GO:0007617 GO:0006378 GO:0045665 GO:0050885 GO:0051402 GO:0031175 GO:0016322 GO:0007219 GO:0010971 GO:0045931 GO:0045944 GO:0051260 GO:0006468 GO:0007176 GO:0010468 GO:0040014 GO:0043393 GO:0050803 GO:0006417 GO:0006979 GO:0051563 GO:0001967 GO:0051124 GO:0008542
Gene3D	3.30.1490.140 3.90.570.10 4.10.230.10 4.10.410.10
InterPro	IPR008155 IPR013803 IPR011178 IPR024329 IPR008154 IPR019744 IPR015849 IPR019745 IPR028866 IPR019543 IPR002223 IPR020901
PANTHER	PTHR23103:SF7
Pfam	PF10515 PF12924 PF12925 PF02177 PF03494 PF00014
PRINTS	PR00203 PR00759 PR00204
SMART	SM00006 SM00131
SUPFAM	SSF109843 SSF56491 SSF57362 SSF89811
PROSITE	PS00319 PS00320 PS00280 PS50279

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045806	negative regulation of endocytosis	PMID:3815101^[1]	ECO:0000315			P		Figure 2B. Fluorescent staining of APP-deficient neurons reveals increased levels of internalized p75NTR. The control group (with higher levels of APP)showed decreased levels of internalized p75NTR.	complete
part_of	GO:0005798	Golgi-associated vesicle	PMID:23931995^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	PMID:23931995^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030546	receptor activator activity	PMID:11316806^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:O88536) positively_regulates:(GO:0007186) occurs_in:(CL:0000129)	Seeded From UniProt	complete
part_of	GO:0048786	presynaptic active zone	PMID:23815291^[4]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0048786	presynaptic active zone	PMID:23815291^[4]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000406	positive regulation of T cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
part_of	GO:1990812	growth cone filopodium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	C		Seeded From UniProt	complete
part_of	GO:1990761	growth cone lamellipodium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990535	neuron projection maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990000	amyloid fibril formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905908	positive regulation of amyloid fibril formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905606	regulation of presynapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904646	cellular response to amyloid-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903980	positive regulation of microglial cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902004	positive regulation of amyloid-beta formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900273	positive regulation of long-term synaptic potentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900272	negative regulation of long-term synaptic potentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0150003	regulation of spontaneous synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098815	modulation of excitatory postsynaptic potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
part_of	GO:0097449	astrocyte projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090647	modulation of age-related behavioral decline	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071874	cellular response to norepinephrine stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	P		Seeded From UniProt	complete
enables	GO:0070851	growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070555	response to interleukin-1	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061890	positive regulation of astrocyte activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis	PMID:12431992^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1202717	P	occurs_in:(EMAPA:32845) occurs_in:(CL:0000117)	Seeded From UniProt	complete
enables	GO:0051425	PTB domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	PMID:16478525^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1202717	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	PMID:23986251^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O35463	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051247	positive regulation of protein metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051247	positive regulation of protein metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	P		Seeded From UniProt	complete
part_of	GO:0051233	spindle midzone	PMID:15561424^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17547) part_of:(CL:0000031)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051124	synaptic growth at neuromuscular junction	PMID:15689559^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050890	cognition	PMID:25592972^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050885	neuromuscular process controlling balance	PMID:9461064^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050808	synapse organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050803	regulation of synapse structure or activity	PMID:10219973^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136847	P	regulates_o_has_participant:(EMAPA:32845) regulates_o_has_participant:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050725	positive regulation of interleukin-1 beta biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048669	collateral sprouting in absence of injury	PMID:15689559^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88047	P	occurs_in:(EMAPA:25137) occurs_in:(CL:0000100)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:8207383^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16531) part_of:(CL:0000540)\|part_of:(EMAPA:16473) part_of:(CL:0000540)\|part_of:(EMAPA:16478) part_of:(CL:0000540)\|part_of:(EMAPA:16659) part_of:(CL:0000540)\|part_of:(EMAPA:16474) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048169	regulation of long-term neuronal synaptic plasticity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048143	astrocyte activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15944124^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107765 MGI:MGI:1932051	P	has_regulation_target:(MGI:MGI:97004)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15944124^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97004)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045931	positive regulation of mitotic cell cycle	PMID:15561424^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154535	P	regulates_o_occurs_in:(EMAPA:17547) regulates_o_occurs_in:(CL:0000031)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	PMID:18278038^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104518	P	occurs_in:(EMAPA:16913) regulates_o_results_in_acquisition_of_features_of:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	PMID:18278038^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045410	positive regulation of interleukin-6 biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:15561424^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17547) part_of:(CL:0000710)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045080	positive regulation of chemokine biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
part_of	GO:0044304	main axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043393	regulation of protein binding	PMID:17920016^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043393	regulation of protein binding	PMID:17920016^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136847	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:23382219^[17]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:16301330^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042327	positive regulation of phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040014	regulation of multicellular organism growth	PMID:9754878^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154522	P		Seeded From UniProt	complete
part_of	GO:0035253	ciliary rootlet	PMID:16018997^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035235	ionotropic glutamate receptor signaling pathway	PMID:16025111^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2652346	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032640	tumor necrosis factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032092	positive regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	PMID:10845772^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35375)	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:15745965^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18577) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:11740561^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18577) part_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	PMID:8083748^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:8001115^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:10200318^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154522 MGI:MGI:2154535	P	results_in_development_of:(EMAPA:32845)\|results_in_development_of:(EMAPA:35253)	Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:15745965^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18577) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:11740561^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18577) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030198	extracellular matrix organization	PMID:15385965^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2137246 MGI:MGI:2154545	P	occurs_in:(EMAPA:17544)	Seeded From UniProt	complete
part_of	GO:0030134	COPII-coated ER to Golgi transport vesicle	PMID:19966784^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0016504	peptidase activator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016358	dendrite development	PMID:15689559^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88047	P	occurs_in:(EMAPA:25137) occurs_in:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016358	dendrite development	PMID:9390996^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136847	P	occurs_in:(EMAPA:19148) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016358	dendrite development	PMID:10188929^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136847	P	occurs_in:(EMAPA:32770) occurs_in:(CL:0000598)\|occurs_in:(EMAPA:35277) occurs_in:(CL:0000598)\|occurs_in:(EMAPA:35255) occurs_in:(CL:0000598)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016322	neuron remodeling	PMID:10219973^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136847	P	occurs_in:(EMAPA:32845) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016199	axon midline choice point recognition	PMID:8001115^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154522	P	occurs_in:(EMAPA:35253) occurs_in:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:12927782^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:9535056^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15886206^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:12927782^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:10845772^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35578) part_of:(CL:0000188)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014005	microglia development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	PMID:15561424^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154535	P	regulates_o_occurs_in:(EMAPA:17547) regulates_o_occurs_in:(CL:0000031)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:12074840^[35]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97004)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009987	cellular process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:16227578^[36]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008542	visual learning	PMID:10338291^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	PMID:9754878^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	PMID:8001115^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	PMID:7758106^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	PMID:10188929^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008203	cholesterol metabolic process	PMID:17920016^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008203	cholesterol metabolic process	PMID:17920016^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008088	axo-dendritic transport	PMID:20829454^[39]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97180	P	occurs_in:(EMAPA:19148) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008088	axo-dendritic transport	PMID:11740561^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136847	P	occurs_in:(EMAPA:18577) occurs_in:(CL:0000540)\|occurs_in:(EMAPA:35253) occurs_in:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:25438880^[40]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:9461064^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007617	mating behavior	PMID:9461064^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007612	learning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007611	learning or memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007409	axonogenesis	PMID:9390996^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136847	P	occurs_in:(EMAPA:19148) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007176	regulation of epidermal growth factor-activated receptor activity	PMID:17556541^[41]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	PMID:16478525^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1202717	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006897	endocytosis	PMID:16025111^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2652346	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006878	cellular copper ion homeostasis	PMID:15447675^[42]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88047	P	occurs_in:(EMAPA:17544) occurs_in:(CL:0000117)\|occurs_in:(EMAPA:16039) occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006878	cellular copper ion homeostasis	PMID:10526140^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136847	P	occurs_in:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:16025111^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2652346	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006417	regulation of translation	PMID:16314516^[44]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006378	mRNA polyadenylation	PMID:16314516^[44]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:23793062^[45]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15009636^[46]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:16018997^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	C		Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:25592972^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10845772^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000188)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	C		Seeded From UniProt	complete
part_of	GO:0005641	nuclear envelope lumen	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2139	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15944124^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:97004)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002265	astrocyte activation involved in immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001967	suckling behavior	PMID:9461064^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
part_of	GO:0005790	smooth endoplasmic reticulum	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0051563	C		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004867	P		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004867	P		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004867	P		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004867	P		Seeded From UniProt	complete
involved_in	GO:0010952	positive regulation of peptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016504	P		Seeded From UniProt	complete
involved_in	GO:0010952	positive regulation of peptidase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016504	P		Seeded From UniProt	complete
involved_in	GO:2000273	positive regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030546	P		Seeded From UniProt	complete
involved_in	GO:2000406	positive regulation of T cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:1990535	neuron projection maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:1990000	amyloid fibril formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:1905908	positive regulation of amyloid fibril formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:1903980	positive regulation of microglial cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:1902004	positive regulation of amyloid-beta formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:1900272	negative regulation of long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0150003	regulation of spontaneous synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0098815	modulation of excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0061890	positive regulation of astrocyte activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
enables	GO:0051425	PTB domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	F		Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0051247	positive regulation of protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0050725	positive regulation of interleukin-1 beta biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	C		Seeded From UniProt	complete
involved_in	GO:0048169	regulation of long-term neuronal synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0048143	astrocyte activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0045410	positive regulation of interleukin-6 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	C		Seeded From UniProt	complete
involved_in	GO:0045080	positive regulation of chemokine biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	C		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	F		Seeded From UniProt	complete
involved_in	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0032640	tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	F		Seeded From UniProt	complete
involved_in	GO:0014005	microglia development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0009987	cellular process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	C		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	C		Seeded From UniProt	complete
part_of	GO:0005641	nuclear envelope lumen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	F		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	F		Seeded From UniProt	complete
involved_in	GO:0002265	astrocyte activation involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05067 ensembl:ENSP00000284981	P		Seeded From UniProt	complete
part_of	GO:1990812	growth cone filopodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:1990761	growth cone lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
part_of	GO:0097449	astrocyte projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
involved_in	GO:0071874	cellular response to norepinephrine stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
involved_in	GO:0071320	cellular response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
involved_in	GO:0071287	cellular response to manganese ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
involved_in	GO:0071280	cellular response to copper ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
enables	GO:0070851	growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	F		Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
involved_in	GO:0051247	positive regulation of protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:0044304	main axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
enables	GO:0016504	peptidase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	F		Seeded From UniProt	complete
involved_in	GO:0010288	response to lead ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002223 InterPro:IPR036880	F		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028866	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015849 InterPro:IPR036454	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008155 InterPro:IPR013803 InterPro:IPR037071	C		Seeded From UniProt	complete
enables	GO:0046914	transition metal ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011178 InterPro:IPR036669	F		Seeded From UniProt	complete
involved_in	GO:1904472	positive regulation of endothelin secretion	PMID:12808450^[47]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q62151	P		Seeded From UniProt	complete
involved_in	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	PMID:12808450^[47]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q62151	P	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:1903523	negative regulation of blood circulation	PMID:12808450^[47]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P22387,UniProtKB:Q62151	P	occurs_in:(UBERON:0000956) regulates_o_occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
enables	GO:0050750	low-density lipoprotein particle receptor binding	PMID:22383525^[48]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35951	F		Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:19118188^[49]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	PMID:19118188^[49]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:11877420^[50]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0030414	peptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	F		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0914	P		Seeded From UniProt	complete
involved_in	GO:0010466	negative regulation of peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0722	F		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0168 UniProtKB-SubCell:SL-0069	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0310	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0288	C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0197	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Fung, SJ et al. (1987) Differential labeling of the vestibular complex following unilateral injections of horseradish peroxidase into the cat and rat locus coeruleus. Brain Res. 401 347-52 PubMed GONUTS page
↑ ^2.0 ^2.1 Das, U et al. (2013) Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron 79 447-60 PubMed GONUTS page
↑ Tiffany, HL et al. (2001) Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain. J. Biol. Chem. 276 23645-52 PubMed GONUTS page
↑ ^4.0 ^4.1 Laßek, M et al. (2013) Amyloid precursor proteins are constituents of the presynaptic active zone. J. Neurochem. 127 48-56 PubMed GONUTS page
↑ Herms, J et al. (2003) Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein. J. Biol. Chem. 278 2484-9 PubMed GONUTS page
↑ ^6.0 ^6.1 Mohmmad Abdul, H et al. (2006) Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease. J. Neurochem. 96 1322-35 PubMed GONUTS page
↑ Nakanishi, N et al. (2013) Synaptic protein α1-takusan mitigates amyloid-β-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites. J. Neurosci. 33 14170-83 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 López-Sánchez, N et al. (2005) Lengthening of G2/mitosis in cortical precursors from mice lacking beta-amyloid precursor protein. Neuroscience 130 51-60 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Wang, P et al. (2005) Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. J. Neurosci. 25 1219-25 PubMed GONUTS page
↑ ^10.0 ^10.1 Kizuka, Y et al. (2015) An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. EMBO Mol Med 7 175-89 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 von Koch, CS et al. () Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol. Aging 18 661-9 PubMed GONUTS page
↑ ^12.0 ^12.1 Seabrook, GR et al. (1999) Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein. Neuropharmacology 38 349-59 PubMed GONUTS page
↑ Salbaum, JM & Ruddle, FH (1994) Embryonic expression pattern of amyloid protein precursor suggests a role in differentiation of specific subsets of neurons. J. Exp. Zool. 269 116-27 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Pardossi-Piquard, R et al. (2005) Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron 46 541-54 PubMed GONUTS page
↑ ^15.0 ^15.1 Ma, QH et al. (2008) A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis. Nat. Cell Biol. 10 283-94 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Liu, Q et al. (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 56 66-78 PubMed GONUTS page
↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
↑ Muresan, Z & Muresan, V (2005) Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. J. Cell Biol. 171 615-25 PubMed GONUTS page
↑ ^19.0 ^19.1 Tremml, P et al. (1998) Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein gene. Behav. Brain Res. 95 65-76 PubMed GONUTS page
↑ ^20.0 ^20.1 Yang, J & Li, T (2005) The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos. Exp. Cell Res. 309 379-89 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Snyder, EM et al. (2005) Regulation of NMDA receptor trafficking by amyloid-beta. Nat. Neurosci. 8 1051-8 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Akaaboune, M et al. (2000) Developmental regulation of amyloid precursor protein at the neuromuscular junction in mouse skeletal muscle. Mol. Cell. Neurosci. 15 355-67 PubMed GONUTS page
↑ ^23.0 ^23.1 Lazarov, O et al. (2005) Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. J. Neurosci. 25 2386-95 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Kamal, A et al. (2001) Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature 414 643-8 PubMed GONUTS page
↑ Jin, LW et al. (1994) Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension. J. Neurosci. 14 5461-70 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Müller, U et al. (1994) Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene. Cell 79 755-65 PubMed GONUTS page
↑ Magara, F et al. (1999) Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein. Proc. Natl. Acad. Sci. U.S.A. 96 4656-61 PubMed GONUTS page
↑ Herms, J et al. (2004) Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members. EMBO J. 23 4106-15 PubMed GONUTS page
↑ Merte, J et al. (2010) Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure. Nat. Cell Biol. 12 41-6; sup pp 1-8 PubMed GONUTS page
↑ ^30.0 ^30.1 Perez, RG et al. (1997) The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. J. Neurosci. 17 9407-14 PubMed GONUTS page
↑ ^31.0 ^31.1 Dawson, GR et al. (1999) Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein. Neuroscience 90 1-13 PubMed GONUTS page
↑ ^32.0 ^32.1 Rouvinski, A et al. (2003) Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes. Biochem. Biophys. Res. Commun. 308 750-8 PubMed GONUTS page
↑ Apert, C et al. (1998) Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus. J. Neuroendocrinol. 10 101-9 PubMed GONUTS page
↑ Vetrivel, KS et al. (2005) Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J. Biol. Chem. 280 25892-900 PubMed GONUTS page
↑ Fukami, S et al. (2002) Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci. Res. 43 39-56 PubMed GONUTS page
↑ Hoe, HS et al. (2005) F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein. Mol. Cell. Biol. 25 9259-68 PubMed GONUTS page
↑ Phinney, AL et al. (1999) No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice. Neuroscience 90 1207-16 PubMed GONUTS page
↑ Zheng, H et al. (1995) beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81 525-31 PubMed GONUTS page
↑ Vossel, KA et al. (2010) Tau reduction prevents Abeta-induced defects in axonal transport. Science 330 198 PubMed GONUTS page
↑ Liu, L et al. (2015) Pre-synaptic localization of the γ-secretase-inhibiting protein p24α2 in the mammalian brain. J. Neurochem. 133 422-31 PubMed GONUTS page
↑ Zhang, YW et al. (2007) Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc. Natl. Acad. Sci. U.S.A. 104 10613-8 PubMed GONUTS page
↑ Bellingham, SA et al. (2004) Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts. J. Neurochem. 91 423-8 PubMed GONUTS page
↑ White, AR et al. (1999) Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice. Brain Res. 842 439-44 PubMed GONUTS page
↑ ^44.0 ^44.1 Cao, Q et al. (2005) Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation. Mol. Cell. Biol. 25 10930-9 PubMed GONUTS page
↑ Liang, Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat. Immunol. 14 858-66 PubMed GONUTS page
↑ Yang, Y et al. (2004) Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake. J. Neurochem. 88 1361-72 PubMed GONUTS page
↑ ^47.0 ^47.1 ^47.2 Deane, R et al. (2003) RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat. Med. 9 907-13 PubMed GONUTS page
↑ Basak, JM et al. (2012) Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes. J. Biol. Chem. 287 13959-71 PubMed GONUTS page
↑ ^49.0 ^49.1 Puzzo, D et al. (2008) Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J. Neurosci. 28 14537-45 PubMed GONUTS page
↑ Tarr, PE et al. (2002) Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. J. Biol. Chem. 277 16798-804 PubMed GONUTS page

[PMID:3815101-1] Fung, SJ et al. (1987) Differential labeling of the vestibular complex following unilateral injections of horseradish peroxidase into the cat and rat locus coeruleus. Brain Res. 401 347-52 PubMed GONUTS page

[PMID:23931995-2] 2.0 ^2.1 Das, U et al. (2013) Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron 79 447-60 PubMed GONUTS page

[PMID:11316806-3] Tiffany, HL et al. (2001) Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain. J. Biol. Chem. 276 23645-52 PubMed GONUTS page

[PMID:23815291-4] 4.0 ^4.1 Laßek, M et al. (2013) Amyloid precursor proteins are constituents of the presynaptic active zone. J. Neurochem. 127 48-56 PubMed GONUTS page

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