HUMAN:TERT

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TERT (synonyms: EST2, TCS1, TRT)
Protein Name(s)	Telomerase reverse transcriptase HEST2 Telomerase catalytic subunit Telomerase-associated protein 2 TP2
External Links
UniProt	O14746
EMBL	AF018167 AF015950 AF128894 AF128893 AB085628 AB086379 AB086950 AY007685 DQ264729 AC114291 CH471102
CCDS	CCDS3861.2 CCDS54831.1
PIR	T03844
RefSeq	NP_001180305.1 NP_937983.2
UniGene	Hs.492203
PDB	2BCK 4B18 4MNQ
PDBsum	2BCK 4B18 4MNQ
ProteinModelPortal	O14746
SMR	O14746
BioGrid	112874
DIP	DIP-40646N
IntAct	O14746
MINT	MINT-133963
STRING	9606.ENSP00000309572
BindingDB	O14746
ChEMBL	CHEMBL2916
DrugBank	DB00495
PhosphoSite	O14746
PaxDb	O14746
PRIDE	O14746
DNASU	7015
Ensembl	ENST00000310581 ENST00000334602 ENST00000460137 ENST00000508104
GeneID	7015
KEGG	hsa:7015
UCSC	uc003jca.1 uc003jcc.1
CTD	7015
GeneCards	GC05M001253
GeneReviews	TERT
HGNC	HGNC:11730
MIM	178500 187270 609135 613989 614742 615134
neXtProt	NX_O14746
Orphanet	1775 618 3322 88 2032
PharmGKB	PA36447
eggNOG	NOG276584
GeneTree	ENSGT00390000018531
HOGENOM	HOG000148780
HOVERGEN	HBG000460
InParanoid	O14746
KO	K11126
OMA	WLCYHAF
OrthoDB	EOG744TB3
PhylomeDB	O14746
TreeFam	TF329048
Reactome	REACT_200753 REACT_7974
EvolutionaryTrace	O14746
GeneWiki	Telomerase_reverse_transcriptase
GenomeRNAi	7015
NextBio	13641567
PRO	PR:O14746
Proteomes	UP000005640
Bgee	O14746
CleanEx	HS_TERT
ExpressionAtlas	O14746
Genevestigator	O14746
GO	GO:0000781 GO:0042645 GO:0000783 GO:0005730 GO:0005654 GO:0016605 GO:0005697 GO:0003677 GO:0046872 GO:0042803 GO:0003968 GO:0003720 GO:0042162 GO:0070034 GO:0003721 GO:0001223 GO:0000049 GO:0022616 GO:2001240 GO:0030177 GO:0090399 GO:0032203 GO:0000723 GO:0007004 GO:0001172
InterPro	IPR000477 IPR021891 IPR003545
Pfam	PF00078 PF12009
PRINTS	PR01365
SMART	SM00975
PROSITE	PS50878

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006915	apoptotic process	PMID:23326372^[1]	ECO:0000314			P		Nuclear localization of telomerase is correlated with higher amounts of DNA damage and apoptosis. (refer to Figure 2)	complete CACAO 9513
	GO:0060218	hematopoietic stem cell differentiation	PMID:23585473^[2]	ECO:0000315			P		Telomerase-mutant ipscs caused impaired hematopoietic differentiation in vitro. Ref to figure 6	complete CACAO 9530
enables	GO:0003720	telomerase activity	PMID:29695869^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007004	telomere maintenance via telomerase	PMID:29695869^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005697	telomerase holoenzyme complex	PMID:29695869^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:11701125^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96BK5	F	part_of:(GO:0032211)	Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:10197982^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9R0Q7	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:19701182^[6]	ECO:0000353	physical interaction evidence used in manual assertion	RNAcentral:URS00004416C5_9606	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:20351177^[7]	ECO:0000353	physical interaction evidence used in manual assertion	RNAcentral:URS00004416C5_9606	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:18082603^[8]	ECO:0000353	physical interaction evidence used in manual assertion	RNAcentral:URS00004416C5_9606	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:17940095^[9]	ECO:0000353	physical interaction evidence used in manual assertion	RNAcentral:URS00004416C5_9606	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:16507993^[10]	ECO:0000353	physical interaction evidence used in manual assertion	RNAcentral:URS00004416C5_9606	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:23474713^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14746	F		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:10197982^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:G1TGF1	F		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:19751963^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P07900	F		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:19751963^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15185	F		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:19751963^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08238	F		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:10197982^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P07900	F		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:10197982^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08238	F		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:10197982^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15185	F		Seeded From UniProt	complete
involved_in	GO:2000648	positive regulation of stem cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70372	P	occurs_in:(CL:1000428)	Seeded From UniProt	complete
involved_in	GO:0042635	positive regulation of hair cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70372	P		Seeded From UniProt	complete
enables	GO:0003720	telomerase activity	PMID:18082603^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000333	telomerase catalytic core complex	PMID:18082603^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0070034	telomerase RNA binding	PMID:18082603^[8]	ECO:0000353	physical interaction evidence used in manual assertion	RNAcentral:URS00004A7003_9606	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:11701125^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96BK5	F	part_of:(GO:0032211)	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:26194824^[13]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0070034	telomerase RNA binding	PMID:20351177^[7]	ECO:0000353	physical interaction evidence used in manual assertion	RNAcentral:URS00004A7003_9606	F		Seeded From UniProt	complete
involved_in	GO:0007004	telomere maintenance via telomerase	PMID:9443919^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003720	telomerase activity	PMID:9443919^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007004	telomere maintenance via telomerase	PMID:21531765^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003720	telomerase activity	PMID:21531765^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	PMID:26194824^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q96BK5)	Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	PMID:26194824^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q96BK5)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21829167^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005697	telomerase holoenzyme complex	PMID:18082603^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000333	telomerase catalytic core complex	PMID:9443919^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	PMID:24415760^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P54274)	Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	PMID:24415760^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q96BK5) has_regulation_target:(UniProtKB:P54274)	Seeded From UniProt	complete
involved_in	GO:1904751	positive regulation of protein localization to nucleolus	PMID:24415760^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P54274)	Seeded From UniProt	complete
enables	GO:0070034	telomerase RNA binding	PMID:16507993^[10]	ECO:0000353	physical interaction evidence used in manual assertion	RNAcentral:URS00004A7003_9606	F		Seeded From UniProt	complete
part_of	GO:0000333	telomerase catalytic core complex	PMID:17940095^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007004	telomere maintenance via telomerase	PMID:17940095^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003721	telomerase RNA reverse transcriptase activity	PMID:17940095^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070200	establishment of protein localization to telomere	PMID:25589350^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	transports_or_maintains_localization_of:(UniProtKB:Q9BQ15)	Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:25589350^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0000084)	Seeded From UniProt	complete
part_of	GO:0000333	telomerase catalytic core complex	PMID:16507993^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003720	telomerase activity	PMID:16507993^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070034	telomerase RNA binding	PMID:17940095^[9]	ECO:0000353	physical interaction evidence used in manual assertion	RNAcentral:URS00004A7003_9606	F		Seeded From UniProt	complete
enables	GO:0003720	telomerase activity	PMID:17940095^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:22226966^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007004	telomere maintenance via telomerase	PMID:19701182^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:19701182^[6]	ECO:0000353	physical interaction evidence used in manual assertion	RNAcentral:URS000075C8FA_9606	F		Seeded From UniProt	complete
part_of	GO:0000333	telomerase catalytic core complex	PMID:11313459^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003721	telomerase RNA reverse transcriptase activity	PMID:11313459^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071897	DNA biosynthetic process	PMID:19701182^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070034	telomerase RNA binding	PMID:19701182^[6]	ECO:0000353	physical interaction evidence used in manual assertion	RNAcentral:URS00004A7003_9606	F		Seeded From UniProt	complete
involved_in	GO:0062103	double-stranded RNA biosynthetic process	PMID:19701182^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005697	telomerase holoenzyme complex	PMID:19701182^[6]	ECO:0000353	physical interaction evidence used in manual assertion	RNAcentral:URS00004A7003_9606	C		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:11927518^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002544) has_regulation_target:(UniProtKB:P05362)	Seeded From UniProt	complete
involved_in	GO:2000773	negative regulation of cellular senescence	PMID:11927518^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002544)	Seeded From UniProt	complete
involved_in	GO:0071897	DNA biosynthetic process	PMID:9398860^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003721	telomerase RNA reverse transcriptase activity	PMID:9398860^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	PMID:25569094^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:11313459^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
involved_in	GO:2000773	negative regulation of cellular senescence	PMID:11313459^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000359) part_of:(GO:0071456)	Seeded From UniProt	complete
involved_in	GO:0051000	positive regulation of nitric-oxide synthase activity	PMID:11927518^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0090398) occurs_in:(CL:0002544)	Seeded From UniProt	complete
involved_in	GO:0006278	RNA-dependent DNA biosynthetic process	PMID:9398860^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031379	RNA-directed RNA polymerase complex	PMID:19701182^[6]	ECO:0000353	physical interaction evidence used in manual assertion	RNAcentral:URS000075C8FA_9606	C		Seeded From UniProt	complete
involved_in	GO:0001172	transcription, RNA-templated	PMID:19701182^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(RNAcentral:URS000075C8FA_9606)	Seeded From UniProt	complete
enables	GO:0003721	telomerase RNA reverse transcriptase activity	PMID:19701182^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000333	telomerase catalytic core complex	PMID:9398860^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000333	telomerase catalytic core complex	PMID:19701182^[6]	ECO:0000353	physical interaction evidence used in manual assertion	RNAcentral:URS00004A7003_9606	C		Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	PMID:19701182^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(RNAcentral:URS000075C8FA_9606)	Seeded From UniProt	complete
part_of	GO:1990572	TERT-RMRP complex	PMID:19701182^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1903704	negative regulation of production of siRNA involved in RNA interference	PMID:19701182^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(RNAcentral:URS000075C8FA_9606)	Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	PMID:21937513^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003964	RNA-directed DNA polymerase activity	PMID:21937513^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007004	telomere maintenance via telomerase	PMID:2805070^[25]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030177	positive regulation of Wnt signaling pathway	PMID:19571879^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O70372	P		Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	PMID:19571879^[26]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P51532	F		Seeded From UniProt	complete
enables	GO:0000049	tRNA binding	PMID:21937513^[24]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(GO:0005759)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21937513^[24]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(GO:0042645)	Seeded From UniProt	complete
part_of	GO:0042645	mitochondrial nucleoid	PMID:21937513^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24415760^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003720	telomerase activity	PMID:9398860^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	PMID:19701182^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(RNAcentral:URS000075C8FA_9606)	Seeded From UniProt	complete
involved_in	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	PMID:10449030^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090399	replicative senescence	PMID:9454332^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070034	telomerase RNA binding	PMID:11432839^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:11432839^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007004	telomere maintenance via telomerase	PMID:16043710^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0022616	DNA strand elongation	PMID:16043710^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007004	telomere maintenance via telomerase	PMID:9454332^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003721	telomerase RNA reverse transcriptase activity	PMID:15632080^[31]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003720	telomerase activity	PMID:16043710^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000783	nuclear telomere cap complex	PMID:15632080^[31]	ECO:0000305	curator inference used in manual assertion	GO:0003721	C		Seeded From UniProt	complete
colocalizes_with	GO:0016605	PML body	PMID:19567472^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005697	telomerase holoenzyme complex	PMID:12135483^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:19567472^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003720	telomerase activity	PMID:12135483^[33]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	PMID:12135483^[33]	ECO:0000305	curator inference used in manual assertion	GO:0003720	C		Seeded From UniProt	complete
enables	GO:0098680	template-free RNA nucleotidyltransferase	PMID:19701182^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070034	telomerase RNA binding	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202709 PANTHER:PTN000249074 PomBase:SPBC29A3.14c UniProtKB:O14746	F		Seeded From UniProt	complete
enables	GO:0042162	telomeric DNA binding	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000249074 SGD:S000004310	F		Seeded From UniProt	complete
involved_in	GO:0007004	telomere maintenance via telomerase	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000249074 PomBase:SPBC29A3.14c SGD:S000004310 TAIR:locus:2148975 UniProtKB:A0A1D8PEA0 UniProtKB:O14746 UniProtKB:Q8IEH2 WB:WBGene00006618	P		Seeded From UniProt	complete
enables	GO:0003721	telomerase RNA reverse transcriptase activity	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000249074 PomBase:SPBC29A3.14c UniProtKB:A0A1D8PEA0 UniProtKB:O14746 UniProtKB:Q1PS67	F		Seeded From UniProt	complete
part_of	GO:0000333	telomerase catalytic core complex	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202709 PANTHER:PTN000249074 PomBase:SPBC29A3.14c SGD:S000004310 UniProtKB:A0A1D8PEA0 UniProtKB:O14746 UniProtKB:Q1PS67	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23474713^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14746	F		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000648	positive regulation of stem cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70372 ensembl:ENSMUSP00000022104	P		Seeded From UniProt	complete
enables	GO:0070034	telomerase RNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70372 ensembl:ENSMUSP00000022104	F		Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70372 ensembl:ENSMUSP00000022104	P		Seeded From UniProt	complete
involved_in	GO:0042635	positive regulation of hair cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70372 ensembl:ENSMUSP00000022104	P		Seeded From UniProt	complete
involved_in	GO:0030177	positive regulation of Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70372 ensembl:ENSMUSP00000022104	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70372 ensembl:ENSMUSP00000022104	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70372 ensembl:ENSMUSP00000022104	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70372 ensembl:ENSMUSP00000022104	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70372 ensembl:ENSMUSP00000022104	F		Seeded From UniProt	complete
enables	GO:0003720	telomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70372 ensembl:ENSMUSP00000022104	F		Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70372 ensembl:ENSMUSP00000022104	F		Seeded From UniProt	complete
part_of	GO:0000333	telomerase catalytic core complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70372 ensembl:ENSMUSP00000022104	C		Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:1903620	positive regulation of transdifferentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:0060253	negative regulation of glial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:0046686	response to cadmium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003545	F		Seeded From UniProt	complete
enables	GO:0003721	telomerase RNA reverse transcriptase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003545	F		Seeded From UniProt	complete
enables	GO:0003964	RNA-directed DNA polymerase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR021891	F		Seeded From UniProt	complete
enables	GO:0003964	RNA-directed DNA polymerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.7.49	F		Seeded From UniProt	complete
enables	GO:0003720	telomerase activity	PMID:11927518^[21] PMID:23474713^[11] PMID:23784080^[35] Reactome:R-HSA-164617 Reactome:R-HSA-163090	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005697	telomerase holoenzyme complex	PMID:10757788^[36] PMID:22527283^[37]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003964	RNA-directed DNA polymerase activity	PMID:25569094^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042162	telomeric DNA binding	PMID:9288757^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003721	telomerase RNA reverse transcriptase activity	PMID:14991929^[39]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:12135483^[33]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904837	beta-catenin-TCF complex assembly	Reactome:R-HSA-201722	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007004	telomere maintenance via telomerase	Reactome:R-HSA-164620 Reactome:R-HSA-164617 Reactome:R-HSA-164616 Reactome:R-HSA-163120 Reactome:R-HSA-163099 Reactome:R-HSA-163096 Reactome:R-HSA-163090	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-3322422 Reactome:R-HSA-164620 Reactome:R-HSA-164617 Reactome:R-HSA-164616 Reactome:R-HSA-163120 Reactome:R-HSA-163099 Reactome:R-HSA-163096 Reactome:R-HSA-163090	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0779 UniProtKB-SubCell:SL-0276	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0016779	nucleotidyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0548	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0003964	RNA-directed DNA polymerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0695	F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Singhapol, C et al. (2013) Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis. PLoS ONE 8 e52989 PubMed GONUTS page
↑ Winkler, T et al. (2013) Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs. J. Clin. Invest. 123 1952-63 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Nguyen, THD et al. (2018) Cryo-EM structure of substrate-bound human telomerase holoenzyme. Nature 557 190-195 PubMed GONUTS page
↑ ^4.0 ^4.1 Zhou, XZ & Lu, KP (2001) The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107 347-59 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Holt, SE et al. (1999) Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev. 13 817-26 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 Maida, Y et al. (2009) An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. Nature 461 230-5 PubMed GONUTS page
↑ ^7.0 ^7.1 Egan, ED & Collins, K (2010) Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. Mol. Cell. Biol. 30 2775-86 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Fu, D & Collins, K (2007) Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. Mol. Cell 28 773-85 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Redon, S et al. (2007) Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase. Nucleic Acids Res. 35 7011-22 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Middleman, EJ et al. (2006) Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain. Mol. Cell. Biol. 26 2146-59 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Sauerwald, A et al. (2013) Structure of active dimeric human telomerase. Nat. Struct. Mol. Biol. 20 454-60 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Lee, JH & Chung, IK (2010) Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. Cancer Lett. 290 76-86 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Keo, P et al. (2015) Increased Stability of Nucleolar PinX1 in the Presence of TERT. Mol. Cells 38 814-20 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Beattie, TL et al. (1998) Reconstitution of human telomerase activity in vitro. Curr. Biol. 8 177-80 PubMed GONUTS page
↑ ^15.0 ^15.1 Cerone, MA et al. (2011) High-throughput RNAi screening reveals novel regulators of telomerase. Cancer Res. 71 3328-40 PubMed GONUTS page
↑ Chawla, R et al. (2011) Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication. EMBO J. 30 4047-58 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Yoo, JE et al. (2014) PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles. J. Biol. Chem. 289 6886-98 PubMed GONUTS page
↑ ^18.0 ^18.1 Pandita, RK et al. (2015) Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. Cancer Res. 75 858-69 PubMed GONUTS page
↑ Her, J & Chung, IK (2012) The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly. Biochem. Biophys. Res. Commun. 417 1086-92 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Minamino, T et al. (2001) Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol. Cell. Biol. 21 3336-42 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Minamino, T et al. (2002) Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation 105 1541-4 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 Weinrich, SL et al. (1997) Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 17 498-502 PubMed GONUTS page
↑ ^23.0 ^23.1 Lassmann, T et al. (2015) Telomerase reverse transcriptase regulates microRNAs. Int J Mol Sci 16 1192-208 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 Sharma, NK et al. (2012) Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Res. 40 712-25 PubMed GONUTS page
↑ Morin, GB (1989) The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59 521-9 PubMed GONUTS page
↑ ^26.0 ^26.1 Park, JI et al. (2009) Telomerase modulates Wnt signalling by association with target gene chromatin. Nature 460 66-72 PubMed GONUTS page
↑ Holt, SE et al. (1999) Resistance to apoptosis in human cells conferred by telomerase function and telomere stability. Mol. Carcinog. 25 241-8 PubMed GONUTS page
↑ ^28.0 ^28.1 Bodnar, AG et al. (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279 349-52 PubMed GONUTS page
↑ ^29.0 ^29.1 Wenz, C et al. (2001) Human telomerase contains two cooperating telomerase RNA molecules. EMBO J. 20 3526-34 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Zaug, AJ et al. (2005) Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proc. Natl. Acad. Sci. U.S.A. 102 10864-9 PubMed GONUTS page
↑ ^31.0 ^31.1 Kelleher, C et al. (2005) Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro. Mol. Cell. Biol. 25 808-18 PubMed GONUTS page
↑ ^32.0 ^32.1 Oh, W et al. (2009) PML-IV functions as a negative regulator of telomerase by interacting with TERT. J. Cell. Sci. 122 2613-22 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 ^33.3 Chang, JT et al. (2002) Differential regulation of telomerase activity by six telomerase subunits. Eur. J. Biochem. 269 3442-50 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 ^34.3 ^34.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Borowiak, M et al. (2013) HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene. Carcinogenesis 34 2664-72 PubMed GONUTS page
↑ Dragon, F et al. (2000) In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs. Mol. Cell. Biol. 20 3037-48 PubMed GONUTS page
↑ Egan, ED & Collins, K (2012) An enhanced H/ACA RNP assembly mechanism for human telomerase RNA. Mol. Cell. Biol. 32 2428-39 PubMed GONUTS page
↑ Meyerson, M et al. (1997) hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90 785-95 PubMed GONUTS page
↑ Chen, CJ et al. (2004) Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma. World J. Gastroenterol. 10 638-42 PubMed GONUTS page

[PMID:23326372-1] Singhapol, C et al. (2013) Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis. PLoS ONE 8 e52989 PubMed GONUTS page

[PMID:23585473-2] Winkler, T et al. (2013) Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs. J. Clin. Invest. 123 1952-63 PubMed GONUTS page

[PMID:29695869-3] 3.0 ^3.1 ^3.2 Nguyen, THD et al. (2018) Cryo-EM structure of substrate-bound human telomerase holoenzyme. Nature 557 190-195 PubMed GONUTS page

[PMID:11701125-4] 4.0 ^4.1 Zhou, XZ & Lu, KP (2001) The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107 347-59 PubMed GONUTS page

[PMID:10197982-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Holt, SE et al. (1999) Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev. 13 817-26 PubMed GONUTS page

[PMID:19701182-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 Maida, Y et al. (2009) An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. Nature 461 230-5 PubMed GONUTS page

[PMID:20351177-7] 7.0 ^7.1 Egan, ED & Collins, K (2010) Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. Mol. Cell. Biol. 30 2775-86 PubMed GONUTS page

[PMID:18082603-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Fu, D & Collins, K (2007) Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. Mol. Cell 28 773-85 PubMed GONUTS page

[PMID:17940095-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Redon, S et al. (2007) Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase. Nucleic Acids Res. 35 7011-22 PubMed GONUTS page

[PMID:16507993-10] 10.0 ^10.1 ^10.2 ^10.3 Middleman, EJ et al. (2006) Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain. Mol. Cell. Biol. 26 2146-59 PubMed GONUTS page

[PMID:23474713-11] 11.0 ^11.1 ^11.2 Sauerwald, A et al. (2013) Structure of active dimeric human telomerase. Nat. Struct. Mol. Biol. 20 454-60 PubMed GONUTS page

[PMID:19751963-12] 12.0 ^12.1 ^12.2 Lee, JH & Chung, IK (2010) Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. Cancer Lett. 290 76-86 PubMed GONUTS page

[PMID:26194824-13] 13.0 ^13.1 ^13.2 Keo, P et al. (2015) Increased Stability of Nucleolar PinX1 in the Presence of TERT. Mol. Cells 38 814-20 PubMed GONUTS page

[PMID:9443919-14] 14.0 ^14.1 ^14.2 Beattie, TL et al. (1998) Reconstitution of human telomerase activity in vitro. Curr. Biol. 8 177-80 PubMed GONUTS page

[PMID:21531765-15] 15.0 ^15.1 Cerone, MA et al. (2011) High-throughput RNAi screening reveals novel regulators of telomerase. Cancer Res. 71 3328-40 PubMed GONUTS page

[PMID:21829167-16] Chawla, R et al. (2011) Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication. EMBO J. 30 4047-58 PubMed GONUTS page

[PMID:24415760-17] 17.0 ^17.1 ^17.2 ^17.3 Yoo, JE et al. (2014) PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles. J. Biol. Chem. 289 6886-98 PubMed GONUTS page

[PMID:25589350-18] 18.0 ^18.1 Pandita, RK et al. (2015) Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. Cancer Res. 75 858-69 PubMed GONUTS page

[PMID:22226966-19] Her, J & Chung, IK (2012) The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly. Biochem. Biophys. Res. Commun. 417 1086-92 PubMed GONUTS page

[PMID:11313459-20] 20.0 ^20.1 ^20.2 ^20.3 Minamino, T et al. (2001) Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol. Cell. Biol. 21 3336-42 PubMed GONUTS page

[PMID:11927518-21] 21.0 ^21.1 ^21.2 ^21.3 Minamino, T et al. (2002) Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation 105 1541-4 PubMed GONUTS page

[PMID:9398860-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 Weinrich, SL et al. (1997) Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 17 498-502 PubMed GONUTS page

[PMID:25569094-23] 23.0 ^23.1 Lassmann, T et al. (2015) Telomerase reverse transcriptase regulates microRNAs. Int J Mol Sci 16 1192-208 PubMed GONUTS page

[PMID:21937513-24] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 Sharma, NK et al. (2012) Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Res. 40 712-25 PubMed GONUTS page

[PMID:2805070-25] Morin, GB (1989) The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59 521-9 PubMed GONUTS page

[PMID:19571879-26] 26.0 ^26.1 Park, JI et al. (2009) Telomerase modulates Wnt signalling by association with target gene chromatin. Nature 460 66-72 PubMed GONUTS page

[PMID:10449030-27] Holt, SE et al. (1999) Resistance to apoptosis in human cells conferred by telomerase function and telomere stability. Mol. Carcinog. 25 241-8 PubMed GONUTS page

[PMID:9454332-28] 28.0 ^28.1 Bodnar, AG et al. (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279 349-52 PubMed GONUTS page

[PMID:11432839-29] 29.0 ^29.1 Wenz, C et al. (2001) Human telomerase contains two cooperating telomerase RNA molecules. EMBO J. 20 3526-34 PubMed GONUTS page

[PMID:16043710-30] 30.0 ^30.1 ^30.2 Zaug, AJ et al. (2005) Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proc. Natl. Acad. Sci. U.S.A. 102 10864-9 PubMed GONUTS page

[PMID:15632080-31] 31.0 ^31.1 Kelleher, C et al. (2005) Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro. Mol. Cell. Biol. 25 808-18 PubMed GONUTS page

[PMID:19567472-32] 32.0 ^32.1 Oh, W et al. (2009) PML-IV functions as a negative regulator of telomerase by interacting with TERT. J. Cell. Sci. 122 2613-22 PubMed GONUTS page

[PMID:12135483-33] 33.0 ^33.1 ^33.2 ^33.3 Chang, JT et al. (2002) Differential regulation of telomerase activity by six telomerase subunits. Eur. J. Biochem. 269 3442-50 PubMed GONUTS page

[PMID:21873635-34] 34.0 ^34.1 ^34.2 ^34.3 ^34.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23784080-35] Borowiak, M et al. (2013) HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene. Carcinogenesis 34 2664-72 PubMed GONUTS page

[PMID:10757788-36] Dragon, F et al. (2000) In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs. Mol. Cell. Biol. 20 3037-48 PubMed GONUTS page

[PMID:22527283-37] Egan, ED & Collins, K (2012) An enhanced H/ACA RNP assembly mechanism for human telomerase RNA. Mol. Cell. Biol. 32 2428-39 PubMed GONUTS page

[PMID:9288757-38] Meyerson, M et al. (1997) hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90 785-95 PubMed GONUTS page

[PMID:14991929-39] Chen, CJ et al. (2004) Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma. World J. Gastroenterol. 10 638-42 PubMed GONUTS page

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