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HUMAN:TERT

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TERT (synonyms: EST2, TCS1, TRT)
Protein Name(s) Telomerase reverse transcriptase

HEST2 Telomerase catalytic subunit Telomerase-associated protein 2 TP2

External Links
UniProt O14746
EMBL AF018167
AF015950
AF128894
AF128893
AB085628
AB086379
AB086950
AY007685
DQ264729
AC114291
CH471102
CCDS CCDS3861.2
CCDS54831.1
PIR T03844
RefSeq NP_001180305.1
NP_937983.2
UniGene Hs.492203
PDB 2BCK
4B18
4MNQ
PDBsum 2BCK
4B18
4MNQ
ProteinModelPortal O14746
SMR O14746
BioGrid 112874
DIP DIP-40646N
IntAct O14746
MINT MINT-133963
STRING 9606.ENSP00000309572
BindingDB O14746
ChEMBL CHEMBL2916
DrugBank DB00495
PhosphoSite O14746
PaxDb O14746
PRIDE O14746
DNASU 7015
Ensembl ENST00000310581
ENST00000334602
ENST00000460137
ENST00000508104
GeneID 7015
KEGG hsa:7015
UCSC uc003jca.1
uc003jcc.1
CTD 7015
GeneCards GC05M001253
GeneReviews TERT
HGNC HGNC:11730
MIM 178500
187270
609135
613989
614742
615134
neXtProt NX_O14746
Orphanet 1775
618
3322
88
2032
PharmGKB PA36447
eggNOG NOG276584
GeneTree ENSGT00390000018531
HOGENOM HOG000148780
HOVERGEN HBG000460
InParanoid O14746
KO K11126
OMA WLCYHAF
OrthoDB EOG744TB3
PhylomeDB O14746
TreeFam TF329048
Reactome REACT_200753
REACT_7974
EvolutionaryTrace O14746
GeneWiki Telomerase_reverse_transcriptase
GenomeRNAi 7015
NextBio 13641567
PRO PR:O14746
Proteomes UP000005640
Bgee O14746
CleanEx HS_TERT
ExpressionAtlas O14746
Genevestigator O14746
GO GO:0000781
GO:0042645
GO:0000783
GO:0005730
GO:0005654
GO:0016605
GO:0005697
GO:0003677
GO:0046872
GO:0042803
GO:0003968
GO:0003720
GO:0042162
GO:0070034
GO:0003721
GO:0001223
GO:0000049
GO:0022616
GO:2001240
GO:0030177
GO:0090399
GO:0032203
GO:0000723
GO:0007004
GO:0001172
InterPro IPR000477
IPR021891
IPR003545
Pfam PF00078
PF12009
PRINTS PR01365
SMART SM00975
PROSITE PS50878

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006915

apoptotic process

PMID:23326372[1]

ECO:0000314

P

Nuclear localization of telomerase is correlated with higher amounts of DNA damage and apoptosis. (refer to Figure 2)

complete
CACAO 9513

GO:0060218

hematopoietic stem cell differentiation

PMID:23585473[2]

ECO:0000315

P

Telomerase-mutant ipscs caused impaired hematopoietic differentiation in vitro. Ref to figure 6

complete
CACAO 9530

enables

GO:0003720

telomerase activity

PMID:29695869[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007004

telomere maintenance via telomerase

PMID:29695869[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005697

telomerase holoenzyme complex

PMID:29695869[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0047485

protein N-terminus binding

PMID:11701125[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q96BK5

F

part_of:(GO:0032211)

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

PMID:10197982[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9R0Q7

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:19701182[6]

ECO:0000353

physical interaction evidence used in manual assertion

RNAcentral:URS00004416C5_9606

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:20351177[7]

ECO:0000353

physical interaction evidence used in manual assertion

RNAcentral:URS00004416C5_9606

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:18082603[8]

ECO:0000353

physical interaction evidence used in manual assertion

RNAcentral:URS00004416C5_9606

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:17940095[9]

ECO:0000353

physical interaction evidence used in manual assertion

RNAcentral:URS00004416C5_9606

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:16507993[10]

ECO:0000353

physical interaction evidence used in manual assertion

RNAcentral:URS00004416C5_9606

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:23474713[11]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O14746

F

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

PMID:10197982[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:G1TGF1

F

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

PMID:19751963[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P07900

F

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

PMID:19751963[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q15185

F

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

PMID:19751963[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P08238

F

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

PMID:10197982[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P07900

F

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

PMID:10197982[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P08238

F

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

PMID:10197982[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q15185

F

Seeded From UniProt

complete

involved_in

GO:2000648

positive regulation of stem cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O70372

P

occurs_in:(CL:1000428)

Seeded From UniProt

complete

involved_in

GO:0042635

positive regulation of hair cycle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O70372

P

Seeded From UniProt

complete

enables

GO:0003720

telomerase activity

PMID:18082603[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000333

telomerase catalytic core complex

PMID:18082603[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0070034

telomerase RNA binding

PMID:18082603[8]

ECO:0000353

physical interaction evidence used in manual assertion

RNAcentral:URS00004A7003_9606

F

Seeded From UniProt

complete

enables

GO:0008022

protein C-terminus binding

PMID:11701125[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q96BK5

F

part_of:(GO:0032211)

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:26194824[13]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0070034

telomerase RNA binding

PMID:20351177[7]

ECO:0000353

physical interaction evidence used in manual assertion

RNAcentral:URS00004A7003_9606

F

Seeded From UniProt

complete

involved_in

GO:0007004

telomere maintenance via telomerase

PMID:9443919[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003720

telomerase activity

PMID:9443919[14]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007004

telomere maintenance via telomerase

PMID:21531765[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003720

telomerase activity

PMID:21531765[15]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0031647

regulation of protein stability

PMID:26194824[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q96BK5)

Seeded From UniProt

complete

involved_in

GO:0031647

regulation of protein stability

PMID:26194824[13]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q96BK5)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21829167[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005697

telomerase holoenzyme complex

PMID:18082603[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000333

telomerase catalytic core complex

PMID:9443919[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0031647

regulation of protein stability

PMID:24415760[17]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P54274)

Seeded From UniProt

complete

involved_in

GO:0032092

positive regulation of protein binding

PMID:24415760[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1904751

positive regulation of protein localization to nucleolus

PMID:24415760[17]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P54274)

Seeded From UniProt

complete

enables

GO:0070034

telomerase RNA binding

PMID:16507993[10]

ECO:0000353

physical interaction evidence used in manual assertion

RNAcentral:URS00004A7003_9606

F

Seeded From UniProt

complete

part_of

GO:0000333

telomerase catalytic core complex

PMID:17940095[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007004

telomere maintenance via telomerase

PMID:17940095[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003721

telomerase RNA reverse transcriptase activity

PMID:17940095[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0070200

establishment of protein localization to telomere

PMID:25589350[18]

ECO:0000314

direct assay evidence used in manual assertion

P

transports_or_maintains_localization_of:(UniProtKB:Q9BQ15)

Seeded From UniProt

complete

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:25589350[18]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0000084)

Seeded From UniProt

complete

part_of

GO:0000333

telomerase catalytic core complex

PMID:16507993[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003720

telomerase activity

PMID:16507993[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0070034

telomerase RNA binding

PMID:17940095[9]

ECO:0000353

physical interaction evidence used in manual assertion

RNAcentral:URS00004A7003_9606

F

Seeded From UniProt

complete

enables

GO:0003720

telomerase activity

PMID:17940095[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:22226966[19]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007004

telomere maintenance via telomerase

PMID:19701182[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:19701182[6]

ECO:0000353

physical interaction evidence used in manual assertion

RNAcentral:URS000075C8FA_9606

F

Seeded From UniProt

complete

part_of

GO:0000333

telomerase catalytic core complex

PMID:11313459[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003721

telomerase RNA reverse transcriptase activity

PMID:11313459[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0071897

DNA biosynthetic process

PMID:19701182[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070034

telomerase RNA binding

PMID:19701182[6]

ECO:0000353

physical interaction evidence used in manual assertion

RNAcentral:URS00004A7003_9606

F

Seeded From UniProt

complete

involved_in

GO:0062103

double-stranded RNA biosynthetic process

PMID:19701182[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005697

telomerase holoenzyme complex

PMID:19701182[6]

ECO:0000353

physical interaction evidence used in manual assertion

RNAcentral:URS00004A7003_9606

C

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:11927518[21]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000773

negative regulation of cellular senescence

PMID:11927518[21]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0002544)

Seeded From UniProt

complete

involved_in

GO:0071897

DNA biosynthetic process

PMID:9398860[22]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003721

telomerase RNA reverse transcriptase activity

PMID:9398860[22]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

PMID:25569094[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071456

cellular response to hypoxia

PMID:11313459[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000359)

Seeded From UniProt

complete

involved_in

GO:2000773

negative regulation of cellular senescence

PMID:11313459[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051000

positive regulation of nitric-oxide synthase activity

PMID:11927518[21]

ECO:0000314

direct assay evidence used in manual assertion

P

  • happens_during:(GO:0090398)
  • occurs_in:(CL:0002544)

Seeded From UniProt

complete

involved_in

GO:0006278

RNA-dependent DNA biosynthetic process

PMID:9398860[22]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031379

RNA-directed RNA polymerase complex

PMID:19701182[6]

ECO:0000353

physical interaction evidence used in manual assertion

RNAcentral:URS000075C8FA_9606

C

Seeded From UniProt

complete

involved_in

GO:0001172

transcription, RNA-templated

PMID:19701182[6]

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(RNAcentral:URS000075C8FA_9606)

Seeded From UniProt

complete

enables

GO:0003721

telomerase RNA reverse transcriptase activity

PMID:19701182[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000333

telomerase catalytic core complex

PMID:9398860[22]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000333

telomerase catalytic core complex

PMID:19701182[6]

ECO:0000353

physical interaction evidence used in manual assertion

RNAcentral:URS00004A7003_9606

C

Seeded From UniProt

complete

involved_in

GO:0030422

production of siRNA involved in RNA interference

PMID:19701182[6]

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(RNAcentral:URS000075C8FA_9606)

Seeded From UniProt

complete

part_of

GO:1990572

TERT-RMRP complex

PMID:19701182[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1903704

negative regulation of production of siRNA involved in RNA interference

PMID:19701182[6]

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(RNAcentral:URS000075C8FA_9606)

Seeded From UniProt

complete

involved_in

GO:0007005

mitochondrion organization

PMID:21937513[24]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003964

RNA-directed DNA polymerase activity

PMID:21937513[24]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007004

telomere maintenance via telomerase

PMID:2805070[25]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030177

positive regulation of Wnt signaling pathway

PMID:19571879[26]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O70372

P

Seeded From UniProt

complete

enables

GO:0001223

transcription coactivator binding

PMID:19571879[26]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P51532

F

Seeded From UniProt

complete

enables

GO:0000049

tRNA binding

PMID:21937513[24]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(GO:0005759)

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:21937513[24]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(GO:0042645)

Seeded From UniProt

complete

part_of

GO:0042645

mitochondrial nucleoid

PMID:21937513[24]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24415760[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003720

telomerase activity

PMID:9398860[22]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003968

RNA-directed 5'-3' RNA polymerase activity

PMID:19701182[6]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(RNAcentral:URS000075C8FA_9606)

Seeded From UniProt

complete

involved_in

GO:2001240

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

PMID:10449030[27]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090399

replicative senescence

PMID:9454332[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070034

telomerase RNA binding

PMID:11432839[29]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:11432839[29]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007004

telomere maintenance via telomerase

PMID:16043710[30]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0022616

DNA strand elongation

PMID:16043710[30]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007004

telomere maintenance via telomerase

PMID:9454332[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003721

telomerase RNA reverse transcriptase activity

PMID:15632080[31]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003720

telomerase activity

PMID:16043710[30]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000783

nuclear telomere cap complex

PMID:15632080[31]

ECO:0000305

curator inference used in manual assertion

GO:0003721

C

Seeded From UniProt

complete

colocalizes_with

GO:0016605

PML body

PMID:19567472[32]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005697

telomerase holoenzyme complex

PMID:12135483[33]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:19567472[32]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003720

telomerase activity

PMID:12135483[33]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000781

chromosome, telomeric region

PMID:12135483[33]

ECO:0000305

curator inference used in manual assertion

GO:0003720

C

Seeded From UniProt

complete

enables

GO:0098680

template-free RNA nucleotidyltransferase

PMID:19701182[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0070034

telomerase RNA binding

PMID:21873635[34]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1202709
PANTHER:PTN000249074
PomBase:SPBC29A3.14c
UniProtKB:O14746

F

Seeded From UniProt

complete

enables

GO:0042162

telomeric DNA binding

PMID:21873635[34]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000249074
SGD:S000004310

F

Seeded From UniProt

complete

involved_in

GO:0007004

telomere maintenance via telomerase

PMID:21873635[34]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000249074
PomBase:SPBC29A3.14c
SGD:S000004310
TAIR:locus:2148975
UniProtKB:A0A1D8PEA0
UniProtKB:O14746
UniProtKB:Q8IEH2
WB:WBGene00006618

P

Seeded From UniProt

complete

enables

GO:0003721

telomerase RNA reverse transcriptase activity

PMID:21873635[34]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000249074
PomBase:SPBC29A3.14c
UniProtKB:A0A1D8PEA0
UniProtKB:O14746
UniProtKB:Q1PS67

F

Seeded From UniProt

complete

part_of

GO:0000333

telomerase catalytic core complex

PMID:21873635[34]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1202709
PANTHER:PTN000249074
PomBase:SPBC29A3.14c
SGD:S000004310
UniProtKB:A0A1D8PEA0
UniProtKB:O14746
UniProtKB:Q1PS67

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:23474713[11]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O14746

F

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:2000648

positive regulation of stem cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70372
ensembl:ENSMUSP00000022104

P

Seeded From UniProt

complete

enables

GO:0070034

telomerase RNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70372
ensembl:ENSMUSP00000022104

F

Seeded From UniProt

complete

involved_in

GO:0046326

positive regulation of glucose import

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70372
ensembl:ENSMUSP00000022104

P

Seeded From UniProt

complete

involved_in

GO:0042635

positive regulation of hair cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70372
ensembl:ENSMUSP00000022104

P

Seeded From UniProt

complete

involved_in

GO:0030177

positive regulation of Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70372
ensembl:ENSMUSP00000022104

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70372
ensembl:ENSMUSP00000022104

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70372
ensembl:ENSMUSP00000022104

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70372
ensembl:ENSMUSP00000022104

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70372
ensembl:ENSMUSP00000022104

F

Seeded From UniProt

complete

enables

GO:0003720

telomerase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70372
ensembl:ENSMUSP00000022104

F

Seeded From UniProt

complete

enables

GO:0001223

transcription coactivator binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70372
ensembl:ENSMUSP00000022104

F

Seeded From UniProt

complete

part_of

GO:0000333

telomerase catalytic core complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70372
ensembl:ENSMUSP00000022104

C

Seeded From UniProt

complete

involved_in

GO:2000352

negative regulation of endothelial cell apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q673L6
ensembl:ENSRNOP00000022683

P

Seeded From UniProt

complete

involved_in

GO:1904754

positive regulation of vascular associated smooth muscle cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q673L6
ensembl:ENSRNOP00000022683

P

Seeded From UniProt

complete

involved_in

GO:1904707

positive regulation of vascular smooth muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q673L6
ensembl:ENSRNOP00000022683

P

Seeded From UniProt

complete

involved_in

GO:1903620

positive regulation of transdifferentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q673L6
ensembl:ENSRNOP00000022683

P

Seeded From UniProt

complete

involved_in

GO:1900087

positive regulation of G1/S transition of mitotic cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q673L6
ensembl:ENSRNOP00000022683

P

Seeded From UniProt

complete

involved_in

GO:0071456

cellular response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q673L6
ensembl:ENSRNOP00000022683

P

Seeded From UniProt

complete

involved_in

GO:0060253

negative regulation of glial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q673L6
ensembl:ENSRNOP00000022683

P

Seeded From UniProt

complete

involved_in

GO:0046686

response to cadmium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q673L6
ensembl:ENSRNOP00000022683

P

Seeded From UniProt

complete

involved_in

GO:0045766

positive regulation of angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q673L6
ensembl:ENSRNOP00000022683

P

Seeded From UniProt

complete

involved_in

GO:0043524

negative regulation of neuron apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q673L6
ensembl:ENSRNOP00000022683

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q673L6
ensembl:ENSRNOP00000022683

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q673L6
ensembl:ENSRNOP00000022683

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q673L6
ensembl:ENSRNOP00000022683

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q673L6
ensembl:ENSRNOP00000022683

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003545

F

Seeded From UniProt

complete

enables

GO:0003721

telomerase RNA reverse transcriptase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003545

F

Seeded From UniProt

complete

enables

GO:0003964

RNA-directed DNA polymerase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021891

F

Seeded From UniProt

complete

enables

GO:0003964

RNA-directed DNA polymerase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.7.49

F

Seeded From UniProt

complete

enables

GO:0003720

telomerase activity

PMID:11927518[21]
PMID:23474713[11]
PMID:23784080[35]
Reactome:R-HSA-164617
Reactome:R-HSA-163090

ECO:0000304

author statement supported by traceable reference used in manual assertion





F

Seeded From UniProt

complete

part_of

GO:0005697

telomerase holoenzyme complex

PMID:10757788[36]
PMID:22527283[37]

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0003964

RNA-directed DNA polymerase activity

PMID:25569094[23]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042162

telomeric DNA binding

PMID:9288757[38]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003721

telomerase RNA reverse transcriptase activity

PMID:14991929[39]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000723

telomere maintenance

PMID:12135483[33]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1904837

beta-catenin-TCF complex assembly

Reactome:R-HSA-201722

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007004

telomere maintenance via telomerase

Reactome:R-HSA-164620
Reactome:R-HSA-164617
Reactome:R-HSA-164616
Reactome:R-HSA-163120
Reactome:R-HSA-163099
Reactome:R-HSA-163096
Reactome:R-HSA-163090

ECO:0000304

author statement supported by traceable reference used in manual assertion







P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-3322422
Reactome:R-HSA-164620
Reactome:R-HSA-164617
Reactome:R-HSA-164616
Reactome:R-HSA-163120
Reactome:R-HSA-163099
Reactome:R-HSA-163096
Reactome:R-HSA-163090

ECO:0000304

author statement supported by traceable reference used in manual assertion








C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0000781

chromosome, telomeric region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0779
UniProtKB-SubCell:SL-0276

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016779

nucleotidyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0548

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0003964

RNA-directed DNA polymerase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0695

F

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0190

C

Seeded From UniProt

complete

part_of

GO:0016605

PML body

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0465

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Singhapol, C et al. (2013) Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis. PLoS ONE 8 e52989 PubMed GONUTS page
  2. Winkler, T et al. (2013) Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs. J. Clin. Invest. 123 1952-63 PubMed GONUTS page
  3. 3.0 3.1 3.2 Nguyen, THD et al. (2018) Cryo-EM structure of substrate-bound human telomerase holoenzyme. Nature 557 190-195 PubMed GONUTS page
  4. 4.0 4.1 Zhou, XZ & Lu, KP (2001) The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107 347-59 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 Holt, SE et al. (1999) Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev. 13 817-26 PubMed GONUTS page
  6. 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 Maida, Y et al. (2009) An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. Nature 461 230-5 PubMed GONUTS page
  7. 7.0 7.1 Egan, ED & Collins, K (2010) Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. Mol. Cell. Biol. 30 2775-86 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 Fu, D & Collins, K (2007) Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. Mol. Cell 28 773-85 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 9.5 Redon, S et al. (2007) Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase. Nucleic Acids Res. 35 7011-22 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 Middleman, EJ et al. (2006) Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain. Mol. Cell. Biol. 26 2146-59 PubMed GONUTS page
  11. 11.0 11.1 11.2 Sauerwald, A et al. (2013) Structure of active dimeric human telomerase. Nat. Struct. Mol. Biol. 20 454-60 PubMed GONUTS page
  12. 12.0 12.1 12.2 Lee, JH & Chung, IK (2010) Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. Cancer Lett. 290 76-86 PubMed GONUTS page
  13. 13.0 13.1 13.2 Keo, P et al. (2015) Increased Stability of Nucleolar PinX1 in the Presence of TERT. Mol. Cells 38 814-20 PubMed GONUTS page
  14. 14.0 14.1 14.2 Beattie, TL et al. (1998) Reconstitution of human telomerase activity in vitro. Curr. Biol. 8 177-80 PubMed GONUTS page
  15. 15.0 15.1 Cerone, MA et al. (2011) High-throughput RNAi screening reveals novel regulators of telomerase. Cancer Res. 71 3328-40 PubMed GONUTS page
  16. Chawla, R et al. (2011) Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication. EMBO J. 30 4047-58 PubMed GONUTS page
  17. 17.0 17.1 17.2 17.3 Yoo, JE et al. (2014) PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles. J. Biol. Chem. 289 6886-98 PubMed GONUTS page
  18. 18.0 18.1 Pandita, RK et al. (2015) Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. Cancer Res. 75 858-69 PubMed GONUTS page
  19. Her, J & Chung, IK (2012) The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly. Biochem. Biophys. Res. Commun. 417 1086-92 PubMed GONUTS page
  20. 20.0 20.1 20.2 20.3 Minamino, T et al. (2001) Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol. Cell. Biol. 21 3336-42 PubMed GONUTS page
  21. 21.0 21.1 21.2 21.3 Minamino, T et al. (2002) Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation 105 1541-4 PubMed GONUTS page
  22. 22.0 22.1 22.2 22.3 22.4 Weinrich, SL et al. (1997) Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 17 498-502 PubMed GONUTS page
  23. 23.0 23.1 Lassmann, T et al. (2015) Telomerase reverse transcriptase regulates microRNAs. Int J Mol Sci 16 1192-208 PubMed GONUTS page
  24. 24.0 24.1 24.2 24.3 24.4 Sharma, NK et al. (2012) Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Res. 40 712-25 PubMed GONUTS page
  25. Morin, GB (1989) The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59 521-9 PubMed GONUTS page
  26. 26.0 26.1 Park, JI et al. (2009) Telomerase modulates Wnt signalling by association with target gene chromatin. Nature 460 66-72 PubMed GONUTS page
  27. Holt, SE et al. (1999) Resistance to apoptosis in human cells conferred by telomerase function and telomere stability. Mol. Carcinog. 25 241-8 PubMed GONUTS page
  28. 28.0 28.1 Bodnar, AG et al. (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279 349-52 PubMed GONUTS page
  29. 29.0 29.1 Wenz, C et al. (2001) Human telomerase contains two cooperating telomerase RNA molecules. EMBO J. 20 3526-34 PubMed GONUTS page
  30. 30.0 30.1 30.2 Zaug, AJ et al. (2005) Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proc. Natl. Acad. Sci. U.S.A. 102 10864-9 PubMed GONUTS page
  31. 31.0 31.1 Kelleher, C et al. (2005) Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro. Mol. Cell. Biol. 25 808-18 PubMed GONUTS page
  32. 32.0 32.1 Oh, W et al. (2009) PML-IV functions as a negative regulator of telomerase by interacting with TERT. J. Cell. Sci. 122 2613-22 PubMed GONUTS page
  33. 33.0 33.1 33.2 33.3 Chang, JT et al. (2002) Differential regulation of telomerase activity by six telomerase subunits. Eur. J. Biochem. 269 3442-50 PubMed GONUTS page
  34. 34.0 34.1 34.2 34.3 34.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  35. Borowiak, M et al. (2013) HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene. Carcinogenesis 34 2664-72 PubMed GONUTS page
  36. Dragon, F et al. (2000) In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs. Mol. Cell. Biol. 20 3037-48 PubMed GONUTS page
  37. Egan, ED & Collins, K (2012) An enhanced H/ACA RNP assembly mechanism for human telomerase RNA. Mol. Cell. Biol. 32 2428-39 PubMed GONUTS page
  38. Meyerson, M et al. (1997) hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90 785-95 PubMed GONUTS page
  39. Chen, CJ et al. (2004) Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma. World J. Gastroenterol. 10 638-42 PubMed GONUTS page

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[f4171f9f1e4fe818b95e320e] /wiki/index.php/HUMAN:TERT Error from line 252 of /usr/local/github/wiki-extensions/wiki-extensions-hulab/AnnotationLinks/AnnotationLinks.php: Call to a member function getIdentifier() on null

Backtrace:

#0 /usr/local/github/wiki-extensions/wiki-extensions-hulab/AnnotationLinks/AnnotationLinks.php(70): AnnotationLinks::getQuickGOannotations(string, array)
#1 /var/www/html/go/wiki/includes/parser/Parser.php(3888): AnnotationLinks::renderAnnotations(NULL, array, Parser, PPFrame_DOM)
#2 /var/www/html/go/wiki/includes/parser/Preprocessor_DOM.php(1362): Parser->extensionSubstitution(array, PPFrame_DOM)
#3 /var/www/html/go/wiki/includes/parser/Parser.php(2942): PPFrame_DOM->expand(DOMElement, integer)
#4 /var/www/html/go/wiki/includes/parser/Parser.php(1293): Parser->replaceVariables(string)
#5 /var/www/html/go/wiki/includes/parser/Parser.php(443): Parser->internalParse(string)
#6 /var/www/html/go/wiki/includes/content/WikitextContent.php(323): Parser->parse(string, Title, ParserOptions, boolean, boolean, integer)
#7 /var/www/html/go/wiki/includes/content/AbstractContent.php(516): WikitextContent->fillParserOutput(Title, integer, ParserOptions, boolean, ParserOutput)
#8 /var/www/html/go/wiki/includes/content/ContentHandler.php(1324): AbstractContent->getParserOutput(Title, integer, ParserOptions)
#9 /usr/local/github/wiki-extensions/wiki-extensions-hulab/CirrusSearch/includes/Updater.php(348): ContentHandler->getParserOutputForIndexing(WikiPage, ParserCache)
#10 /usr/local/github/wiki-extensions/wiki-extensions-hulab/CirrusSearch/includes/Updater.php(407): CirrusSearch\Updater::buildDocument(CirrusSearch, WikiPage, CirrusSearch\Connection, integer, integer, integer)
#11 /usr/local/github/wiki-extensions/wiki-extensions-hulab/CirrusSearch/includes/Updater.php(205): CirrusSearch\Updater->buildDocumentsForPages(array, integer)
#12 /usr/local/github/wiki-extensions/wiki-extensions-hulab/CirrusSearch/includes/Updater.php(83): CirrusSearch\Updater->updatePages(array, integer)
#13 /usr/local/github/wiki-extensions/wiki-extensions-hulab/CirrusSearch/includes/Job/LinksUpdate.php(52): CirrusSearch\Updater->updateFromTitle(Title)
#14 /usr/local/github/wiki-extensions/wiki-extensions-hulab/CirrusSearch/includes/Job/Job.php(99): CirrusSearch\Job\LinksUpdate->doJob()
#15 /var/www/html/go/wiki/includes/jobqueue/JobRunner.php(296): CirrusSearch\Job\Job->run()
#16 /var/www/html/go/wiki/includes/jobqueue/JobRunner.php(193): JobRunner->executeJob(CirrusSearch\Job\LinksUpdate, Wikimedia\Rdbms\LBFactorySimple, BufferingStatsdDataFactory, integer)
#17 /var/www/html/go/wiki/includes/MediaWiki.php(1002): JobRunner->run(array)
#18 /var/www/html/go/wiki/includes/MediaWiki.php(988): MediaWiki->triggerSyncJobs(integer, MediaWiki\Logger\LegacyLogger)
#19 /var/www/html/go/wiki/includes/MediaWiki.php(912): MediaWiki->triggerJobs()
#20 /var/www/html/go/wiki/includes/MediaWiki.php(727): MediaWiki->restInPeace(string, boolean)
#21 /var/www/html/go/wiki/includes/MediaWiki.php(750): MediaWiki->{closure}()
#22 /var/www/html/go/wiki/includes/MediaWiki.php(557): MediaWiki->doPostOutputShutdown(string)
#23 /var/www/html/go/wiki/index.php(42): MediaWiki->run()
#24 {main}

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