HUMAN:TAL1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TAL1 (synonyms: BHLHA17, SCL, TCL5)
Protein Name(s)	T-cell acute lymphocytic leukemia protein 1 TAL-1 Class A basic helix-loop-helix protein 17 bHLHa17 Stem cell protein T-cell leukemia/lymphoma protein 5
External Links
UniProt	P17542
EMBL	M61108 M61103 M61104 M61105 M63572 M63589 M63576 M63584 AL135960 CH471059 CH471059 CH471059 X58621 X58622 M29038 X51990
CCDS	CCDS547.1
PIR	A36358 I38253
RefSeq	NP_001274276.1 NP_001277332.1 NP_001277333.1 NP_001277334.1 NP_001277335.1 NP_003180.1 XP_005271216.1 XP_005271217.1 XP_006710925.1
UniGene	Hs.705618 Hs.737706
PDB	2YPA 2YPB
PDBsum	2YPA 2YPB
ProteinModelPortal	P17542
SMR	P17542
BioGrid	112749
DIP	DIP-40640N
IntAct	P17542
MINT	MINT-2801392
STRING	9606.ENSP00000294339
PhosphoSite	P17542
DMDM	134305
MaxQB	P17542
PaxDb	P17542
PRIDE	P17542
DNASU	6886
Ensembl	ENST00000294339 ENST00000371884
GeneID	6886
KEGG	hsa:6886
UCSC	uc001cqx.2
CTD	6886
GeneCards	GC01M047681
H-InvDB	HIX0029300
HGNC	HGNC:11556
HPA	CAB017805
MIM	187040
neXtProt	NX_P17542
Orphanet	99861
PharmGKB	PA36326
eggNOG	NOG307510
GeneTree	ENSGT00760000119097
HOGENOM	HOG000113414
HOVERGEN	HBG005018
InParanoid	P17542
KO	K09068
OrthoDB	EOG7SN8DF
PhylomeDB	P17542
TreeFam	TF315153
SignaLink	P17542
ChiTaRS	TAL1
GeneWiki	TAL1
GenomeRNAi	6886
NextBio	26909
PMAP-CutDB	P17542
PRO	PR:P17542
Proteomes	UP000005640
Bgee	P17542
CleanEx	HS_TAL1
ExpressionAtlas	P17542
Genevestigator	P17542
GO	GO:0000790 GO:0005634 GO:0005667 GO:0003682 GO:0070888 GO:0019899 GO:0042826 GO:0000979 GO:0000980 GO:0001085 GO:0000981 GO:0003700 GO:0044212 GO:0001525 GO:0060018 GO:0030221 GO:0045165 GO:0060216 GO:0035162 GO:0030218 GO:0043249 GO:0060217 GO:0060218 GO:0030097 GO:0007626 GO:0035855 GO:0030219 GO:0000122 GO:0030220 GO:0051781 GO:0045799 GO:0045648 GO:0045931 GO:0031334 GO:0045944 GO:0045893 GO:0042127 GO:0060375 GO:2000036 GO:0006357 GO:0021527
Gene3D	4.10.280.10
InterPro	IPR011598
Pfam	PF00010
SMART	SM00353
SUPFAM	SSF47459
PROSITE	PS50888

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0051781	positive regulation of cell division	PMID:20855495^[1]	ECO:0000315			P	Fig 1a (bottom). " TAL1 knockdown lengthend the doubling time of cells...".	complete
	GO:0045931	positive regulation of mitotic cell cycle	PMID:20855495^[1]	ECO:0000315			P	Tal-1 knockdown induced a partial blockage of the G2/M to G1 transition (Fig 1 b) and diminished uptake of BrdU in HSB2 cells indicated slow progression in S phase (Fig 1 c).	complete
	GO:0051091	positive regulation of transcription factor activity	PMID:20855495^[1]	ECO:0000315			P	NKX3.1 messenger RNA (mRNA) and NKX3.1 protein levels were three- to fourfold decreased when TAL1 expression was decreased in Jurkat and HSB2 cells using shTAL1 constructs (Fig. 2, b and c.	complete
	GO:0070888	E-box binding	PMID:20855495^[1]	ECO:0000314			F	using oligonucleotides that cover all E-boxes and GATA binding sites present in the −875/−570 human NKX3.1 promoter region, we found that TAL1 and GATA-3 can bind an E-box located at −738 and/or two GATA binding sites at −748 and −697 (Fig. 3 c)	complete
	GO:0010843	promoter binding	PMID:20855495^[1]	ECO:0000314			F	Chromatin immunoprecipitation (ChIP) showed that TAL1 and GATA-3, the only member of the GATA family expressed in T cells, were specifically bound in vivo to the −875/−570 region of the human NKX3.1 gene promoter (Fig. 3 b).	complete
	GO:0031334	positive regulation of protein complex assembly	PMID:20855495^[1]	ECO:0000314			P	Expression of TAL1 led to its recruitment by GATA-3 (Fig. 4 a, top right) and to the formation of a transcriptional complex containing LMO1/2 and Ldb1 proteins on the NKX3.1 promoter (Fig. 4 a, bottom).	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR011598	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q64221	F	Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:20855495^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	PMID:20855495^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20855495^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	PMID:20855495^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045799	positive regulation of chromatin assembly or disassembly	PMID:20855495^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22091	P	Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22091	P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22091	F	Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:19497860^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92769	F	Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:19497860^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13547	F	Seeded From UniProt	complete
colocalizes_with	GO:0033193	Lsd1/2 complex	PMID:19497860^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0031334	positive regulation of protein complex assembly	PMID:20855495^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030221	basophil differentiation	PMID:7678994^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030219	megakaryocyte differentiation	PMID:7678994^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	PMID:1396592^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	PMID:7678994^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030097	hemopoiesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22091	P	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:19497860^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60341	F	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22091	P	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:15920471^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19497860^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:19497860^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:15920471^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8IX07	F	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:20855495^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
colocalizes_with	GO:0000118	histone deacetylase complex	PMID:19497860^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20028976^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	PMID:20028976^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035162	embryonic hemopoiesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22091	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98480 PANTHER:PTN001015390	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98480 PANTHER:PTN001015390 UniProtKB:P17542	C	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98480 PANTHER:PTN001015390	F	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001015390 UniProtKB:Q02575	F	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16763211^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:2000273	positive regulation of signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:2000036	regulation of stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	F	Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0060375	regulation of mast cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0060218	hematopoietic stem cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0060217	hemangioblast cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0060216	definitive hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0060018	astrocyte fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0048699	generation of neurons	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0045647	negative regulation of erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0045637	regulation of myeloid cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	F	Seeded From UniProt	complete
involved_in	GO:0043249	erythrocyte maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0035855	megakaryocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0035162	embryonic hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	C	Seeded From UniProt	complete
involved_in	GO:0030220	platelet formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0030219	megakaryocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0030099	myeloid cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0030097	hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0021527	spinal cord association neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	C	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	F	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	F	Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	F	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22091 ensembl:ENSMUSP00000030489	P	Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011598 InterPro:IPR036638	F	Seeded From UniProt	complete
involved_in	GO:1902036	regulation of hematopoietic stem cell differentiation	Reactome:R-HSA-8939236	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8956586 Reactome:R-HSA-8956568	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 Kusy, S et al. (2010) NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J. Exp. Med. 207 2141-56 PubMed GONUTS page
↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Hu, X et al. (2009) LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc. Natl. Acad. Sci. U.S.A. 106 10141-6 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Mouthon, MA et al. (1993) Expression of tal-1 and GATA-binding proteins during human hematopoiesis. Blood 81 647-55 PubMed GONUTS page
↑ Aplan, PD et al. (1992) The SCL gene product: a positive regulator of erythroid differentiation. EMBO J. 11 4073-81 PubMed GONUTS page
↑ ^6.0 ^6.1 Rodriguez, P et al. (2005) GATA-1 forms distinct activating and repressive complexes in erythroid cells. EMBO J. 24 2354-66 PubMed GONUTS page
↑ ^7.0 ^7.1 Lausen, J et al. (2010) Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1. J. Biol. Chem. 285 5338-46 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ McCormack, MP et al. (2006) A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis. Blood 108 2248-56 PubMed GONUTS page

[PMID:20855495-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 Kusy, S et al. (2010) NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J. Exp. Med. 207 2141-56 PubMed GONUTS page

[PMID:19274049-2] Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:19497860-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Hu, X et al. (2009) LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc. Natl. Acad. Sci. U.S.A. 106 10141-6 PubMed GONUTS page

[PMID:7678994-4] 4.0 ^4.1 ^4.2 Mouthon, MA et al. (1993) Expression of tal-1 and GATA-binding proteins during human hematopoiesis. Blood 81 647-55 PubMed GONUTS page

[PMID:1396592-5] Aplan, PD et al. (1992) The SCL gene product: a positive regulator of erythroid differentiation. EMBO J. 11 4073-81 PubMed GONUTS page

[PMID:15920471-6] 6.0 ^6.1 Rodriguez, P et al. (2005) GATA-1 forms distinct activating and repressive complexes in erythroid cells. EMBO J. 24 2354-66 PubMed GONUTS page

[PMID:20028976-7] 7.0 ^7.1 Lausen, J et al. (2010) Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1. J. Biol. Chem. 285 5338-46 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16763211-9] McCormack, MP et al. (2006) A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis. Blood 108 2248-56 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

HUMAN:TAL1

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools