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HUMAN:SIR6
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SIRT6 (synonyms: SIR2L6) | |
| Protein Name(s) | NAD-dependent protein deacetylase sirtuin-6
Regulatory protein SIR2 homolog 6 SIR2-like protein 6 | |
| External Links | ||
| UniProt | Q8N6T7 | |
| EMBL | AF233396 AK074810 AK315048 CR457200 AC005620 AC006930 CH471139 BC004218 BC005026 BC028220 | |
| CCDS | CCDS12122.1 CCDS54199.1 | |
| RefSeq | NP_001180214.1 NP_057623.2 | |
| UniGene | Hs.423756 | |
| PDB | 3K35 3PKI 3PKJ 3ZG6 | |
| PDBsum | 3K35 3PKI 3PKJ 3ZG6 | |
| ProteinModelPortal | Q8N6T7 | |
| SMR | Q8N6T7 | |
| BioGrid | 119603 | |
| DIP | DIP-47346N | |
| IntAct | Q8N6T7 | |
| MINT | MINT-1374731 | |
| STRING | 9606.ENSP00000337332 | |
| BindingDB | Q8N6T7 | |
| ChEMBL | CHEMBL2163182 | |
| GuidetoPHARMACOLOGY | 2712 | |
| iPTMnet | Q8N6T7 | |
| PhosphoSite | Q8N6T7 | |
| BioMuta | SIRT6 | |
| DMDM | 38258612 | |
| EPD | Q8N6T7 | |
| MaxQB | Q8N6T7 | |
| PaxDb | Q8N6T7 | |
| PRIDE | Q8N6T7 | |
| DNASU | 51548 | |
| Ensembl | ENST00000305232 ENST00000337491 | |
| GeneID | 51548 | |
| KEGG | hsa:51548 | |
| UCSC | uc002lzo.4 | |
| CTD | 51548 | |
| GeneCards | SIRT6 | |
| H-InvDB | HIX0014654 | |
| HGNC | HGNC:14934 | |
| MIM | 606211 | |
| neXtProt | NX_Q8N6T7 | |
| PharmGKB | PA37939 | |
| eggNOG | KOG1905 COG0846 | |
| GeneTree | ENSGT00530000063706 | |
| HOVERGEN | HBG060028 | |
| InParanoid | Q8N6T7 | |
| KO | K11416 | |
| OMA | NVLDWEH | |
| PhylomeDB | Q8N6T7 | |
| TreeFam | TF106184 | |
| Reactome | [www.reactome.org/content/detail/R-HSA-5693607 R-HSA-5693607] | |
| SIGNOR | Q8N6T7 | |
| ChiTaRS | SIRT6 | |
| EvolutionaryTrace | Q8N6T7 | |
| GeneWiki | SIRT6 | |
| GenomeRNAi | 51548 | |
| PRO | PR:Q8N6T7 | |
| Proteomes | UP000005640 | |
| Bgee | Q8N6T7 | |
| ExpressionAtlas | Q8N6T7 | |
| Genevisible | Q8N6T7 | |
| GO | GO:0005737 GO:0005724 GO:0005654 GO:0005634 GO:0003682 GO:0003956 GO:0003950 GO:0070403 GO:0017136 GO:0046969 GO:0034979 GO:0003714 GO:0008270 GO:0006284 GO:0042593 GO:0016575 GO:1990619 GO:0061647 GO:0008285 GO:0046325 GO:0045820 GO:0045892 GO:0048146 GO:2000648 GO:0003247 GO:0006471 GO:0006476 GO:0031648 GO:0010569 GO:0031667 | |
| Gene3D | 3.40.50.1220 | |
| InterPro | IPR029035 IPR003000 IPR026590 | |
| PANTHER | PTHR11085 | |
| Pfam | PF02146 | |
| SUPFAM | SSF52467 | |
| PROSITE | PS50305 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:1901485 |
positive regulation of transcription factor catabolic process |
ECO:0000315 |
P |
Figure 4B-F: FOXO1 is trafficked from nucleus to cytoplasm in cells expressing Sirt6, followed by degradation in the proteasome. When proteasome activity is inhibited, FOXO1 continues to be trafficked from nucleus to cytoplasm. In cells expressing inactive Sirt6, FOXO1 remains in the nucleus. Sirt6 expression increases ubiquitination and subsequent degradation of FOXO1. |
complete | |||||
| GO:0006476 |
protein deacetylation |
ECO:0000315 |
P |
Figure 3D |
complete | |||||
| GO:0000209 |
protein polyubiquitination |
ECO:0000315 |
P |
Figure 4F: expression of Sirt6 increases FOXO1 ubiquitination as compared to mutant Sirt6 |
complete | |||||
|
involved_in |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1905564 |
positive regulation of vascular endothelial cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032206 |
positive regulation of telomere maintenance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032206 |
positive regulation of telomere maintenance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1905549 |
positive regulation of telomeric heterochromatin assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031940 |
positive regulation of chromatin silencing at telomere |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
regulates_expression_of:(ENSEMBL:ENSG00000187608) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902732 |
positive regulation of chondrocyte proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1905555 |
positive regulation blood vessel branching |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070403 |
NAD+ binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046969 |
NAD-dependent histone deacetylase activity (H3-K9 specific) |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017136 |
NAD-dependent histone deacetylase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010569 |
regulation of double-strand break repair via homologous recombination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006471 |
protein ADP-ribosylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
NOT|part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005724 |
nuclear telomeric heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003956 |
NAD(P)+-protein-arginine ADP-ribosyltransferase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006476 |
protein deacetylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0033558 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006476 |
protein deacetylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0034979 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016575 |
histone deacetylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0017136 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061647 |
histone H3-K9 modification |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0046969 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061647 |
histone H3-K9 modification |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046969 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1990619 |
histone H3-K9 deacetylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0046969 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1990619 |
histone H3-K9 deacetylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046969 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000648 |
positive regulation of stem cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P59941 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P59941 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048146 |
positive regulation of fibroblast proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P59941 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046969 |
NAD-dependent histone deacetylase activity (H3-K9 specific) |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P59941 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046325 |
negative regulation of glucose import |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P59941 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P59941 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045820 |
negative regulation of glycolytic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P59941 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042593 |
glucose homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P59941 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031648 |
protein destabilization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P59941 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P59941 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006471 |
protein ADP-ribosylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P59941 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006284 |
base-excision repair |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P59941 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P59941 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003956 |
NAD(P)+-protein-arginine ADP-ribosyltransferase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P59941 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003714 |
transcription corepressor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P59941 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P59941 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0033558 |
protein deacetylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q4FZY2 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031667 |
response to nutrient levels |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q4FZY2 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q4FZY2 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q4FZY2 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0003247 |
post-embryonic cardiac muscle cell growth involved in heart morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q4FZY2 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0070403 |
NAD+ binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006471 |
protein ADP-ribosylation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003950 |
NAD+ ADP-ribosyltransferase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034979 |
NAD-dependent protein deacetylase activity |
Reactome:R-HSA-5685953 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-5685953 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Song, MY et al. (2016) Insulin secretion impairment in Sirt6 knockout pancreatic β cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway. Sci Rep 6 30321 PubMed GONUTS page
- ↑ Yao, L et al. (2017) Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat. Cell Rep 20 641-654 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Cardus, A et al. (2013) SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence. Cardiovasc. Res. 97 571-9 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Nagai, K et al. (2015) Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes. Osteoarthr. Cartil. 23 1412-20 PubMed GONUTS page
- ↑ 5.0 5.1 Tennen, RI et al. (2011) SIRT6 is required for maintenance of telomere position effect in human cells. Nat Commun 2 433 PubMed GONUTS page
- ↑ 6.0 6.1 Michishita, E et al. (2008) SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 452 492-6 PubMed GONUTS page
- ↑ Kawahara, TL et al. (2009) SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 136 62-74 PubMed GONUTS page
- ↑ 8.0 8.1 Michishita, E et al. (2005) Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol. Biol. Cell 16 4623-35 PubMed GONUTS page
- ↑ 9.0 9.1 Yamamoto, H et al. (2007) Sirtuin functions in health and disease. Mol. Endocrinol. 21 1745-55 PubMed GONUTS page
h
n
- GO:0003956 ! NAD(P)+-protein-arginine ADP-ribosyltransferase activity
- GO:0003950 ! NAD+-protein poly-ADP-ribosyltransferase activity
- GO:0070403 ! NAD+ binding
- GO:0034979 ! NAD-dependent protein lysine deacetylase activity
- GO:0045820 ! negative regulation of glycolytic process
- GO:0008285 ! negative regulation of cell population proliferation
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0046325 ! negative regulation of D-glucose import
- GO:0005730 ! nucleolus
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
o
- GO:1990619 ! obsolete histone H3-K9 deacetylation
- GO:0061647 ! obsolete histone H3-K9 modification
- GO:0016575 ! obsolete histone deacetylation
- GO:0005724 ! obsolete nuclear telomeric heterochromatin
- GO:1905549 ! obsolete positive regulation of subtelomeric heterochromatin assembly
- GO:0031940 ! obsolete positive regulation of chromatin silencing at telomere
- GO:1901485 ! obsolete positive regulation of transcription factor catabolic process
- GO:0006471 ! obsolete protein ADP-ribosylation
p
- GO:1902732 ! positive regulation of chondrocyte proliferation
- GO:0120162 ! positive regulation of cold-induced thermogenesis
- GO:1905564 ! positive regulation of vascular endothelial cell proliferation
- GO:0032206 ! positive regulation of telomere maintenance
- GO:0048146 ! positive regulation of fibroblast proliferation
- GO:2000648 ! positive regulation of stem cell proliferation
- GO:1905555 ! positive regulation of blood vessel branching
- GO:0003247 ! post-embryonic cardiac muscle cell growth involved in heart morphogenesis
- Primates
- GO:0006476 ! protein deacetylation
- GO:0031648 ! protein destabilization
- GO:0033558 ! protein lysine deacetylase activity
- GO:0000209 ! protein polyubiquitination
r
