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PMID:23201774

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Citation

Cardus, A, Uryga, AK, Walters, G and Erusalimsky, JD (2013) SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence. Cardiovasc. Res. 97:571-9

Abstract

Although endothelial cell senescence is known to play an important role in the development of cardiovascular pathologies, mechanisms that attenuate this process have not been extensively investigated. The aim of this study was to investigate whether SIRT6, a member of the sirtuin family of NAD(+)-dependent protein deacetylases/ADP-ribosyltransferases, protects endothelial cells from premature senescence and dysfunction, and if so which is its mode of action.

Links

PubMed PMC3567786 Online version:10.1093/cvr/cvs352

Keywords

Aorta/cytology; Aorta/metabolism; Cell Proliferation; Cells, Cultured; Cellular Senescence/physiology; DNA Damage/physiology; Endothelium, Vascular/cytology; Endothelium, Vascular/metabolism; Homeostasis/physiology; Humans; Intercellular Adhesion Molecule-1/metabolism; Nitric Oxide Synthase Type III/metabolism; Plasminogen Activator Inhibitor 1/metabolism; RNA Interference/physiology; Sirtuins/deficiency; Sirtuins/genetics; Sirtuins/metabolism; Telomere/physiology; Umbilical Veins/cytology; Umbilical Veins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:SIR6

involved_in

GO:1905555: positive regulation of blood vessel branching

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:SIR6

involved_in

GO:1905555: positive regulation blood vessel branching

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:SIR6

involved_in

GO:0032206: positive regulation of telomere maintenance

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:SIR6

involved_in

GO:1905564: positive regulation of vascular endothelial cell proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

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