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PMID:25819580

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Citation

Nagai, K, Matsushita, T, Matsuzaki, T, Takayama, K, Matsumoto, T, Kuroda, R and Kurosaka, M (2015) Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes. Osteoarthr. Cartil. 23:1412-20

Abstract

SIRT6, a member of the sirtuin family of nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylases, has been implicated as a key factor in aging-related diseases. However, the role of SIRT6 in chondrocytes has not been fully explored. The purpose of this study was to examine the role of SIRT6 in human chondrocytes by inhibiting SIRT6 in vitro.

Links

PubMed Online version:10.1016/j.joca.2015.03.024

Keywords

Cell Proliferation; Cells, Cultured; Cellular Senescence; Chondrocytes/metabolism; Chondrocytes/pathology; DNA Damage; Histones/metabolism; Humans; Matrix Metalloproteinase 1/genetics; Matrix Metalloproteinase 1/metabolism; Matrix Metalloproteinase 13/genetics; Matrix Metalloproteinase 13/metabolism; Osteoarthritis, Knee/pathology; RNA Interference; RNA, Messenger/metabolism; Real-Time Polymerase Chain Reaction; Sirtuins/deficiency; Sirtuins/genetics; Telomere; Up-Regulation; beta-Galactosidase/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:SIR6

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:SIR6

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:SIR6

involved_in

GO:1902732: positive regulation of chondrocyte proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:SIR6

involved_in

GO:0032206: positive regulation of telomere maintenance

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

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