HUMAN:RS7

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RPS7
Protein Name(s)	40S ribosomal protein S7
External Links
UniProt	P62081
EMBL	M77233 Z25749 AK311794 AC108488 CH471053 CH471053 CH471053 BC002866 BC061901 BC071919
CCDS	CCDS1648.1
PIR	JC4388
RefSeq	NP_001002.1
UniGene	Hs.534346 Hs.546287 Hs.646582
PDB	3J3A
PDBsum	3J3A
ProteinModelPortal	P62081
SMR	P62081
BioGrid	112115
IntAct	P62081
MINT	MINT-5001160
STRING	9606.ENSP00000339095
PhosphoSite	P62081
DMDM	49065831
MaxQB	P62081
PaxDb	P62081
PeptideAtlas	P62081
PRIDE	P62081
DNASU	6201
Ensembl	ENST00000304921 ENST00000403564 ENST00000406376
GeneID	6201
KEGG	hsa:6201
UCSC	uc002qxw.3
CTD	6201
GeneCards	GC02P003622
GeneReviews	RPS7
HGNC	HGNC:10440
HPA	HPA056586
MIM	603658 612563
neXtProt	NX_P62081
Orphanet	124
PharmGKB	PA34855
eggNOG	NOG280542
GeneTree	ENSGT00390000014122
HOGENOM	HOG000197237
HOVERGEN	HBG001698
InParanoid	P62081
KO	K02993
OrthoDB	EOG74J997
PhylomeDB	P62081
TreeFam	TF343364
Reactome	REACT_1079 REACT_115902 REACT_1404 REACT_1797 REACT_1979 REACT_1986 REACT_2085 REACT_75768 REACT_75822 REACT_79 REACT_931 REACT_9491
ChiTaRS	RPS7
GeneWiki	RPS7
GenomeRNAi	6201
NextBio	24083
PMAP-CutDB	P62081
PRO	PR:P62081
Proteomes	UP000005640
Bgee	P62081
CleanEx	HS_RPS7
ExpressionAtlas	P62081
Genevestigator	P62081
GO	GO:0030686 GO:0005737 GO:0005829 GO:0022627 GO:0070062 GO:0005925 GO:0016020 GO:0005815 GO:0005730 GO:0005634 GO:0030529 GO:0005840 GO:0032040 GO:0044822 GO:0003723 GO:0003735 GO:0044267 GO:0002181 GO:0010467 GO:0016071 GO:0000184 GO:0042274 GO:0016070 GO:0006364 GO:0006614 GO:0006412 GO:0006414 GO:0006413 GO:0006415 GO:0019058 GO:0016032 GO:0019083
InterPro	IPR000554
PANTHER	PTHR11278
Pfam	PF01251
PROSITE	PS00948

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
colocalizes_with	GO:0005813	centrosome	PMID:20873783^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:20873783^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:20873783^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HC98	F		Seeded From UniProt	complete
involved_in	GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	PMID:17310983^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17310983^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:1990948	ubiquitin ligase inhibitor activity	PMID:17310983^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	PMID:17310983^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904667	negative regulation of ubiquitin protein ligase activity	PMID:17310983^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:1901976	regulation of cell cycle checkpoint	PMID:23563151^[3]	ECO:0000315			P		Figure 3 shows that overexpression of the ribosomal protein S7 resulted in overproduced expression of GADD45alpha, a known cell checkpoint protein. Therefore the S7 ribosomal protein helps to regulate cell cycle checkpoints.	complete CACAO 7552
involved_in	GO:0010628	positive regulation of gene expression	PMID:17310983^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:17310983^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048027	mRNA 5'-UTR binding	PMID:16213212^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	PMID:16213212^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21630459^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22681889^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042274	ribosomal small subunit biogenesis	PMID:18697920^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0022627	cytosolic small ribosomal subunit	PMID:8706699^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0022627	cytosolic small ribosomal subunit	PMID:15883184^[12]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0022627	cytosolic small ribosomal subunit	PMID:8522193^[13]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006412	translation	PMID:8706699^[11]	ECO:0000305	curator inference used in manual assertion	GO:0022627	P		Seeded From UniProt	complete
involved_in	GO:0006412	translation	PMID:15883184^[12]	ECO:0000305	curator inference used in manual assertion	GO:0022627	P		Seeded From UniProt	complete
involved_in	GO:0006412	translation	PMID:8522193^[13]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006364	rRNA processing	PMID:18697920^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005840	ribosome	PMID:15883184^[12]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:11823430^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9687515^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:8522193^[13]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042274	ribosomal small subunit biogenesis	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000138848 UniProtKB:P62081	P		Seeded From UniProt	complete
part_of	GO:0032040	small-subunit processome	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000138848 SGD:S000005040 SGD:S000005622	C		Seeded From UniProt	complete
part_of	GO:0022627	cytosolic small ribosomal subunit	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000138848 RGD:61907 TAIR:locus:2076839 TAIR:locus:2181402 TAIR:locus:2200839 UniProtKB:P62081	C		Seeded From UniProt	complete
involved_in	GO:0006364	rRNA processing	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000138848 UniProtKB:P62081	P		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	PMID:18809582^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0022627	cytosolic small ribosomal subunit	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62083 ensembl:ENSRNOP00000075995	C		Seeded From UniProt	complete
enables	GO:0008266	poly(U) RNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62083 ensembl:ENSRNOP00000075995	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62082 ensembl:ENSMUSP00000073880	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62082 ensembl:ENSMUSP00000073880	P		Seeded From UniProt	complete
involved_in	GO:0001843	neural tube closure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62082 ensembl:ENSMUSP00000073880	P		Seeded From UniProt	complete
enables	GO:0003735	structural constituent of ribosome	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000554	F		Seeded From UniProt	complete
part_of	GO:0005840	ribosome	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000554	C		Seeded From UniProt	complete
involved_in	GO:0006412	translation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000554	P		Seeded From UniProt	complete
involved_in	GO:0019083	viral transcription	Reactome:R-HSA-168273	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	Reactome:R-HSA-1799339	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006413	translational initiation	Reactome:R-HSA-72613	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006364	rRNA processing	Reactome:R-HSA-6791226	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-927889 Reactome:R-HSA-927836 Reactome:R-HSA-927832 Reactome:R-HSA-927813 Reactome:R-HSA-927789 Reactome:R-HSA-72697 Reactome:R-HSA-72691 Reactome:R-HSA-72676 Reactome:R-HSA-72673 Reactome:R-HSA-72672 Reactome:R-HSA-72671 Reactome:R-HSA-72621 Reactome:R-HSA-72619 Reactome:R-HSA-6791223 Reactome:R-HSA-192841 Reactome:R-HSA-192704 Reactome:R-HSA-1799335 Reactome:R-HSA-1799332 Reactome:R-HSA-157849 Reactome:R-HSA-156823 Reactome:R-HSA-156808	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6791228 Reactome:R-HSA-6791227 Reactome:R-HSA-6791223 Reactome:R-HSA-6791222 Reactome:R-HSA-6791221	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	Reactome:R-HSA-927802	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
part_of	GO:0005840	ribosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0689	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Vaz Meirelles, G et al. (2010) Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. J. Proteome Res. 9 6298-316 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Chen, D et al. (2007) Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene 26 5029-37 PubMed GONUTS page
↑ Gao, M et al. (2013) Ribosomal protein S7 regulates arsenite-induced GADD45α expression by attenuating MDM2-mediated GADD45α ubiquitination and degradation. Nucleic Acids Res. 41 5210-22 PubMed GONUTS page
↑ ^4.0 ^4.1 Takagi, M et al. (2005) Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 123 49-63 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^10.0 ^10.1 Robledo, S et al. (2008) The role of human ribosomal proteins in the maturation of rRNA and ribosome production. RNA 14 1918-29 PubMed GONUTS page
↑ ^11.0 ^11.1 Vladimirov, SN et al. (1996) Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. Eur. J. Biochem. 239 144-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Yu, Y et al. (2005) Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes. Protein Sci. 14 1438-46 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Annilo, T et al. (1995) The human ribosomal protein S7-encoding gene: isolation, structure and localization in 2p25. Gene 165 297-302 PubMed GONUTS page
↑ Jäkel, S et al. (2002) Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. EMBO J. 21 377-86 PubMed GONUTS page
↑ Jäkel, S & Görlich, D (1998) Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. EMBO J. 17 4491-502 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Maggi, LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol. Cell. Biol. 28 7050-65 PubMed GONUTS page

[PMID:20873783-1] 1.0 ^1.1 ^1.2 Vaz Meirelles, G et al. (2010) Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. J. Proteome Res. 9 6298-316 PubMed GONUTS page

[PMID:17310983-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Chen, D et al. (2007) Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene 26 5029-37 PubMed GONUTS page

[PMID:23563151-3] Gao, M et al. (2013) Ribosomal protein S7 regulates arsenite-induced GADD45α expression by attenuating MDM2-mediated GADD45α ubiquitination and degradation. Nucleic Acids Res. 41 5210-22 PubMed GONUTS page

[PMID:16213212-4] 4.0 ^4.1 Takagi, M et al. (2005) Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 123 49-63 PubMed GONUTS page

[PMID:21423176-5] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:19946888-6] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:21630459-7] Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page

[PMID:22681889-8] Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page

[PMID:22658674-9] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:18697920-10] 10.0 ^10.1 Robledo, S et al. (2008) The role of human ribosomal proteins in the maturation of rRNA and ribosome production. RNA 14 1918-29 PubMed GONUTS page

[PMID:8706699-11] 11.0 ^11.1 Vladimirov, SN et al. (1996) Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. Eur. J. Biochem. 239 144-9 PubMed GONUTS page

[PMID:15883184-12] 12.0 ^12.1 ^12.2 Yu, Y et al. (2005) Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes. Protein Sci. 14 1438-46 PubMed GONUTS page

[PMID:8522193-13] 13.0 ^13.1 ^13.2 Annilo, T et al. (1995) The human ribosomal protein S7-encoding gene: isolation, structure and localization in 2p25. Gene 165 297-302 PubMed GONUTS page

[PMID:11823430-14] Jäkel, S et al. (2002) Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. EMBO J. 21 377-86 PubMed GONUTS page

[PMID:9687515-15] Jäkel, S & Görlich, D (1998) Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. EMBO J. 17 4491-502 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18809582-17] Maggi, LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol. Cell. Biol. 28 7050-65 PubMed GONUTS page

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HUMAN:RS7

Contents

Annotations

Notes

References

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