HUMAN:RL3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RPL3
Protein Name(s)	60S ribosomal protein L3 HIV-1 TAR RNA-binding protein B TARBP-B
External Links
UniProt	P39023
EMBL	X73460 AB062291 CR456566 AK315693 AL022326 BC002408 BC006483 BC008003 BC012146 BC012786 BC013674 BC014017 BC015032 BC015767 BC063662 BC088373 BC107711 M90054 L22453 AB007166
CCDS	CCDS13988.1
PIR	S34195
RefSeq	NP_000958.1
UniGene	Hs.119598
PDB	3J3B
PDBsum	3J3B
ProteinModelPortal	P39023
SMR	P39023
BioGrid	112042
IntAct	P39023
MINT	MINT-1145548
STRING	9606.ENSP00000346001
DrugBank	DB04865
PhosphoSite	P39023
DMDM	730565
SWISS-2DPAGE	P39023
MaxQB	P39023
PaxDb	P39023
PRIDE	P39023
DNASU	6122
Ensembl	ENST00000216146
GeneID	6122
KEGG	hsa:6122
UCSC	uc003axh.3
CTD	6122
GeneCards	GC22M040108
H-InvDB	HIX0172339
HGNC	HGNC:10332
HPA	HPA003365 HPA055361
MIM	604163
neXtProt	NX_P39023
PharmGKB	PA34713
eggNOG	COG0087
GeneTree	ENSGT00390000017606
HOGENOM	HOG000107319
HOVERGEN	HBG001864
InParanoid	P39023
KO	K02925
OMA	THVIMID
PhylomeDB	P39023
TreeFam	TF300555
Reactome	REACT_115902 REACT_1404 REACT_1797 REACT_1986 REACT_2085 REACT_75768 REACT_75822 REACT_79 REACT_9491
ChiTaRS	RPL3
GeneWiki	RPL3
GenomeRNAi	6122
NextBio	23777
PRO	PR:P39023
Proteomes	UP000005640
Bgee	P39023
CleanEx	HS_RPL3
ExpressionAtlas	P39023
Genevestigator	P39023
GO	GO:0005737 GO:0005829 GO:0022625 GO:0070062 GO:0005925 GO:0005730 GO:0005634 GO:0044822 GO:0003723 GO:0003735 GO:0044267 GO:0071353 GO:0010467 GO:0016071 GO:0000184 GO:0016070 GO:0006614 GO:0006412 GO:0006414 GO:0006413 GO:0006415 GO:0019058 GO:0016032 GO:0019083
InterPro	IPR000597 IPR019926 IPR009000
Pfam	PF00297
SUPFAM	SSF50447
PROSITE	PS00474

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0032991	protein-containing complex	PMID:23349634^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16791210^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:16791210^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21630459^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22681889^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0022625	cytosolic large ribosomal subunit	PMID:12962325^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006412	translation	PMID:12962325^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:16963496^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003735	structural constituent of ribosome	PMID:12962325^[8]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0022625	cytosolic large ribosomal subunit	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000146039 RGD:735105 SGD:S000005589 TAIR:locus:2018605 TAIR:locus:2200873 UniProtKB:Q8IJC6	C		Seeded From UniProt	complete
enables	GO:0003735	structural constituent of ribosome	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000146039 UniProtKB:Q8IJC6	F		Seeded From UniProt	complete
involved_in	GO:0000027	ribosomal large subunit assembly	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000146039 SGD:S000005589	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21531 ensembl:ENSRNOP00000060662	C		Seeded From UniProt	complete
part_of	GO:0022625	cytosolic large ribosomal subunit	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21531 ensembl:ENSRNOP00000060662	C		Seeded From UniProt	complete
enables	GO:0008097	5S rRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21531 ensembl:ENSRNOP00000060662	F		Seeded From UniProt	complete
part_of	GO:0005840	ribosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21531 ensembl:ENSRNOP00000060662	C		Seeded From UniProt	complete
involved_in	GO:0071353	cellular response to interleukin-4	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27659 ensembl:ENSMUSP00000080354	P		Seeded From UniProt	complete
enables	GO:0003735	structural constituent of ribosome	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000597	F		Seeded From UniProt	complete
part_of	GO:0005840	ribosome	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000597	C		Seeded From UniProt	complete
involved_in	GO:0006412	translation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000597	P		Seeded From UniProt	complete
part_of	GO:0022625	cytosolic large ribosomal subunit	PMID:2891103^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006412	translation	PMID:2891103^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:2891103^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003735	structural constituent of ribosome	PMID:2891103^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:2891103^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0019083	viral transcription	Reactome:R-HSA-168273	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	Reactome:R-HSA-1799339	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006413	translational initiation	Reactome:R-HSA-72613	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-927889 Reactome:R-HSA-927836 Reactome:R-HSA-927832 Reactome:R-HSA-927813 Reactome:R-HSA-927789 Reactome:R-HSA-72673 Reactome:R-HSA-72672 Reactome:R-HSA-72671 Reactome:R-HSA-6791218 Reactome:R-HSA-192841 Reactome:R-HSA-192704 Reactome:R-HSA-1799335 Reactome:R-HSA-1799332 Reactome:R-HSA-156826	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	Reactome:R-HSA-927802	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
part_of	GO:0005840	ribosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0689	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Cloutier, P et al. (2013) A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. PLoS Genet. 9 e1003210 PubMed GONUTS page
↑ ^2.0 ^2.1 Sigal, A et al. (2006) Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat. Methods 3 525-31 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Odintsova, TI et al. (2003) Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. J. Protein Chem. 22 249-58 PubMed GONUTS page
↑ Sekiguchi, T et al. (2006) NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. Nucleic Acids Res. 34 4593-608 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Ou, JH et al. (1987) Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells. Nucleic Acids Res. 15 8919-34 PubMed GONUTS page

[PMID:23349634-1] Cloutier, P et al. (2013) A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. PLoS Genet. 9 e1003210 PubMed GONUTS page

[PMID:16791210-2] 2.0 ^2.1 Sigal, A et al. (2006) Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat. Methods 3 525-31 PubMed GONUTS page

[PMID:21423176-3] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:20458337-4] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:21630459-5] Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page

[PMID:22681889-6] Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page

[PMID:22658674-7] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:12962325-8] 8.0 ^8.1 ^8.2 Odintsova, TI et al. (2003) Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. J. Protein Chem. 22 249-58 PubMed GONUTS page

[PMID:16963496-9] Sekiguchi, T et al. (2006) NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. Nucleic Acids Res. 34 4593-608 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:2891103-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Ou, JH et al. (1987) Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells. Nucleic Acids Res. 15 8919-34 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

HUMAN:RL3

Contents

Annotations

Notes

References

5

c

e

f

h

m

n

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools