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HUMAN:REL

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) REL
Protein Name(s) Proto-oncogene c-Rel
External Links
UniProt Q04864
EMBL X75042
DQ314888
AC010733
BC117191
BC143885
M11595
CCDS CCDS1864.1
CCDS74515.1
PIR A60646
RefSeq NP_001278675.1
NP_002899.1
UniGene Hs.631886
Hs.633256
ProteinModelPortal Q04864
SMR Q04864
BioGrid 111898
DIP DIP-301N
IntAct Q04864
MINT MINT-1137552
STRING 9606.ENSP00000295025
PhosphoSite Q04864
DMDM 548720
MaxQB Q04864
PaxDb Q04864
PRIDE Q04864
DNASU 5966
Ensembl ENST00000295025
ENST00000394479
GeneID 5966
KEGG hsa:5966
UCSC uc002sam.1
uc002san.1
CTD 5966
GeneCards GC02P061108
HGNC HGNC:9954
HPA CAB004404
MIM 164910
neXtProt NX_Q04864
PharmGKB PA34321
eggNOG NOG119056
GeneTree ENSGT00500000044765
HOGENOM HOG000264257
HOVERGEN HBG017916
InParanoid Q04864
KO K09254
OMA WEAKGIF
OrthoDB EOG7VHSWT
PhylomeDB Q04864
TreeFam TF325632
Reactome REACT_118656
SignaLink Q04864
GeneWiki REL
GenomeRNAi 5966
NextBio 23226
PRO PR:Q04864
Proteomes UP000005640
Bgee Q04864
CleanEx HS_REL
ExpressionAtlas Q04864
Genevestigator Q04864
GO GO:0005829
GO:0005654
GO:0005667
GO:0000980
GO:0001205
GO:0003700
GO:0001816
GO:0007249
GO:1901215
GO:0043123
GO:0045084
GO:0045944
Gene3D 2.60.40.10
2.60.40.340
InterPro IPR013783
IPR014756
IPR002909
IPR000451
IPR008967
IPR011539
Pfam PF00554
PRINTS PR00057
SMART SM00429
SUPFAM SSF49417
SSF81296
PROSITE PS01204
PS50254

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0032688

negative regulation of interferon-beta production

PMID:22065573[1]

ECO:0000314

P

Fig. 4

complete
CACAO 3243

GO:0005634

nucleus

PMID:22065573[1]

ECO:0000315

C

Fig. 3D

complete
CACAO 3244

GO:0010629

negative regulation of gene expression

PMID:22065573[1]

ECO:0000314

P

Fig. 4C

complete
CACAO 3245

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[2]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[2]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR000451
InterPro:IPR002909
InterPro:IPR008967
InterPro:IPR011539

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:Q04207

F

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:22065573[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22065573[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032688

negative regulation of interferon-beta production

PMID:22065573[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:1406630[3]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(NCBI_Gene:50802)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:1406630[3]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0000165)

Seeded From UniProt

complete

enables

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

PMID:1406630[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:8423996[4]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:12761501[5]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011274
FB:FBgn0260632
MGI:MGI:103289
PANTHER:PTN000652441
UniProtKB:Q04206
UniProtKB:Q04864

P

Seeded From UniProt

complete

involved_in

GO:0038061

NIK/NF-kappaB signaling

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103289
PANTHER:PTN000652441

P

Seeded From UniProt

complete

involved_in

GO:0034097

response to cytokine

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
RGD:727889

P

Seeded From UniProt

complete

involved_in

GO:0007249

I-kappaB kinase/NF-kappaB signaling

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
RGD:1311231

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
UniProtKB:Q04206

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103289
MGI:MGI:103290
PANTHER:PTN000652441
RGD:727889
UniProtKB:Q01201
UniProtKB:Q04206

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
UniProtKB:Q01201

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103290
PANTHER:PTN000652441
UniProtKB:Q04206

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
ZFIN:ZDB-GENE-040825-4

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0260632
MGI:MGI:103290
PANTHER:PTN000652441
UniProtKB:Q04206

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103290
PANTHER:PTN000652441
UniProtKB:Q04206

P

Seeded From UniProt

complete

involved_in

GO:1901215

negative regulation of neuron death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M5R1
ensembl:ENSRNOP00000072332

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M5R1
ensembl:ENSRNOP00000072332

F

Seeded From UniProt

complete

involved_in

GO:0007249

I-kappaB kinase/NF-kappaB signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M5R1
ensembl:ENSRNOP00000072332

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M5R1
ensembl:ENSRNOP00000072332

C

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M5R1
ensembl:ENSRNOP00000072332

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M5R1
ensembl:ENSRNOP00000072332

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M5R1
ensembl:ENSRNOP00000072332

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011539
InterPro:IPR037059

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR008967
InterPro:IPR011539
InterPro:IPR030505
InterPro:IPR037059

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR030505

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR030505

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR008967
InterPro:IPR011539
InterPro:IPR037059

P

Seeded From UniProt

complete

involved_in

GO:0007249

I-kappaB kinase/NF-kappaB signaling

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030505

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030505

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-1168643
Reactome:R-HSA-1168642
Reactome:R-HSA-1168640
Reactome:R-HSA-1168638
Reactome:R-HSA-1168633

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-1168633

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Siednienko, J et al. (2011) Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1. J. Biol. Chem. 286 44750-63 PubMed GONUTS page
  2. ↑ 2.0 2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Kunsch, C et al. (1992) Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation. Mol. Cell. Biol. 12 4412-21 PubMed GONUTS page
  4. ↑ Mathew, S et al. (1993) Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization. Oncogene 8 191-3 PubMed GONUTS page
  5. ↑ Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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