HUMAN:PRS4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PSMC1
Protein Name(s)	26S protease regulatory subunit 4 P26s4 26S proteasome AAA-ATPase subunit RPT2 Proteasome 26S subunit ATPase 1
External Links
UniProt	P62191
EMBL	L02426 AK299121 CR457044 AL161662 AL355074 BC000512 BC016368 BC067741 BC073818
CCDS	CCDS32139.1
PIR	A44468
RefSeq	NP_002793.2
UniGene	Hs.356654 Hs.476697
ProteinModelPortal	P62191
SMR	P62191
BioGrid	111673
IntAct	P62191
MINT	MINT-1141832
STRING	9606.ENSP00000261303
iPTMnet	P62191
PhosphoSite	P62191
SwissPalm	P62191
BioMuta	PSMC1
DMDM	49065817
EPD	P62191
PaxDb	P62191
PeptideAtlas	P62191
PRIDE	P62191
DNASU	5700
Ensembl	ENST00000261303 ENST00000543772
GeneID	5700
KEGG	hsa:5700
UCSC	uc001xyg.4
CTD	5700
GeneCards	PSMC1
H-InvDB	HIX0030744
HGNC	HGNC:9547
HPA	HPA000872 HPA016885
MIM	602706
neXtProt	NX_P62191
PharmGKB	PA33892
eggNOG	KOG0726 COG1222
GeneTree	ENSGT00550000074818
HOGENOM	HOG000225143
HOVERGEN	HBG000109
InParanoid	P62191
KO	K03062
OMA	VLLHHKN
OrthoDB	EOG7F24ST
PhylomeDB	P62191
TreeFam	TF106226
Reactome	R-HSA-1169091 R-HSA-1236974 R-HSA-1236978 R-HSA-174084 R-HSA-174113 R-HSA-174154 R-HSA-174178 R-HSA-174184 R-HSA-180534 R-HSA-180585 R-HSA-187577 R-HSA-195253 R-HSA-202424 R-HSA-211733 R-HSA-2467813 R-HSA-2871837 R-HSA-349425 R-HSA-350562 R-HSA-450408 R-HSA-4608870 R-HSA-4641257 R-HSA-4641258 R-HSA-5358346 R-HSA-5362768 R-HSA-5607761 R-HSA-5607764 R-HSA-5610780 R-HSA-5610783 R-HSA-5610785 R-HSA-5632684 R-HSA-5658442 R-HSA-5668541 R-HSA-5676590 R-HSA-5687128 R-HSA-68827 R-HSA-68949 R-HSA-69017 R-HSA-69229 R-HSA-69601 R-HSA-983168
ChiTaRS	PSMC1
GeneWiki	PSMC1
GenomeRNAi	5700
NextBio	22146
PRO	PR:P62191
Proteomes	UP000005640
Bgee	P62191
CleanEx	HS_PSMC1
ExpressionAtlas	P62191
Genevisible	P62191
GO	GO:0005737 GO:0005829 GO:0031597 GO:0016020 GO:0031595 GO:0005654 GO:0005634 GO:0022624 GO:0000502 GO:0008540 GO:0005524 GO:0016887 GO:0044822 GO:0036402 GO:0017025 GO:0000186 GO:0031145 GO:0042590 GO:0002479 GO:0002474 GO:0006915 GO:0007411 GO:0034641 GO:0006977 GO:0007173 GO:0030433 GO:0038095 GO:0008543 GO:0000082 GO:0010467 GO:0045087 GO:0008286 GO:0000165 GO:0000278 GO:0043066 GO:0090090 GO:0051436 GO:0048011 GO:0038061 GO:0006595 GO:0090263 GO:1901800 GO:0045899 GO:0051437 GO:0012501 GO:0000209 GO:0007265 GO:0042981 GO:0006521 GO:0043488 GO:0051439 GO:0007264 GO:0044281 GO:0002223 GO:0050852 GO:0033209 GO:0048010 GO:0016032
Gene3D	3.40.50.300
InterPro	IPR005937 IPR003593 IPR003959 IPR003960 IPR027417
Pfam	PF00004
SMART	SM00382
SUPFAM	SSF52540
TIGRFAMs	TIGR01242
PROSITE	PS00674

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Colocalizes with	GO:0005814	centriole	PMID:26872363^[1]	ECO:0000314			C		Figure 2 shows localization of P26s4 at one of the centrioles in dividing cells. The experiments revealed that P26s4 co-localised with both: TOPORS and centriolar markers in dividing (Fig 3), but not in ciliated cells (S2 Fig).	complete CACAO 11770
part_of	GO:0000502	proteasome complex	PMID:17323924^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21630459^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
part_of	GO:0000502	proteasome complex	PMID:8811196^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0022624	proteasome accessory complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P62192	C		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:1429620^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35998	F		Seeded From UniProt	complete
enables	GO:0036402	proteasome-activating ATPase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000553258 SGD:S000002165	F		Seeded From UniProt	complete
enables	GO:0017025	TBP-class protein binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000553258 RGD:621097	F		Seeded From UniProt	complete
part_of	GO:0008540	proteasome regulatory particle, base subcomplex	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015282 PANTHER:PTN000553258 PomBase:SPBC4.07c SGD:S000002165 TAIR:locus:2119926	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1901800	positive regulation of proteasomal protein catabolic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0036402	P		Seeded From UniProt	complete
involved_in	GO:1901800	positive regulation of proteasomal protein catabolic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0036402	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62192 ensembl:ENSMUSP00000021595	P		Seeded From UniProt	complete
part_of	GO:0022624	proteasome accessory complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62192 ensembl:ENSMUSP00000021595	C		Seeded From UniProt	complete
part_of	GO:0005838	proteasome regulatory particle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62192 ensembl:ENSMUSP00000021595	C		Seeded From UniProt	complete
enables	GO:0017025	TBP-class protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62193 ensembl:ENSRNOP00000005329	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62193 ensembl:ENSRNOP00000005329	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003959 InterPro:IPR003960	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005937	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005937	F		Seeded From UniProt	complete
involved_in	GO:0030163	protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005937	P		Seeded From UniProt	complete
enables	GO:0036402	proteasome-activating ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR035244	F		Seeded From UniProt	complete
involved_in	GO:1902036	regulation of hematopoietic stem cell differentiation	Reactome:R-HSA-8939236	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901990	regulation of mitotic cell cycle phase transition	Reactome:R-HSA-174113	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	Reactome:R-HSA-4641257	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	Reactome:R-HSA-4641258	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	Reactome:R-HSA-9020702	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	Reactome:R-HSA-1234174	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	Reactome:R-HSA-4086400	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	Reactome:R-HSA-382556	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	Reactome:R-HSA-202403	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043488	regulation of mRNA stability	Reactome:R-HSA-450408	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Reactome:R-HSA-8852354 Reactome:R-HSA-2130282 Reactome:R-HSA-174255	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038061	NIK/NF-kappaB signaling	Reactome:R-HSA-5676590	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	Reactome:R-HSA-5668541	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Reactome:R-HSA-8854071	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031145	anaphase-promoting complex-dependent catabolic process	Reactome:R-HSA-174178 Reactome:R-HSA-174154 Reactome:R-HSA-174143	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	Reactome:R-HSA-8854044	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006521	regulation of cellular amino acid metabolic process	Reactome:R-HSA-350562	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006457	protein folding	Reactome:R-HSA-532668	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-9011324 Reactome:R-NUL-5610751 Reactome:R-NUL-212917 Reactome:R-HSA-983150 Reactome:R-HSA-8957265 Reactome:R-HSA-8956184 Reactome:R-HSA-8956140 Reactome:R-HSA-8866858 Reactome:R-HSA-8866553 Reactome:R-HSA-8854071 Reactome:R-HSA-8854044 Reactome:R-HSA-8852354 Reactome:R-HSA-8850992 Reactome:R-HSA-8850594 Reactome:R-HSA-75825 Reactome:R-HSA-69600 Reactome:R-HSA-69016 Reactome:R-HSA-68948 Reactome:R-HSA-68825 Reactome:R-HSA-5689539 Reactome:R-HSA-5687112 Reactome:R-HSA-5668520 Reactome:R-HSA-5668481 Reactome:R-HSA-5665871 Reactome:R-HSA-5665854 Reactome:R-HSA-5658430 Reactome:R-HSA-5635868 Reactome:R-HSA-5610760 Reactome:R-HSA-5610758 Reactome:R-HSA-5610754 Reactome:R-HSA-5607731 Reactome:R-HSA-5607724 Reactome:R-HSA-5387392 Reactome:R-HSA-5362448 Reactome:R-HSA-4641260 Reactome:R-HSA-4641256 Reactome:R-HSA-4608855 Reactome:R-HSA-450466 Reactome:R-HSA-3640874 Reactome:R-HSA-353125 Reactome:R-HSA-264458 Reactome:R-HSA-2130282 Reactome:R-HSA-209061 Reactome:R-HSA-188191 Reactome:R-HSA-180603 Reactome:R-HSA-180573 Reactome:R-HSA-174255 Reactome:R-HSA-174203 Reactome:R-HSA-174202 Reactome:R-HSA-174105 Reactome:R-HSA-1504193 Reactome:R-HSA-1236970 Reactome:R-HSA-1234159 Reactome:R-HSA-1168640	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-9604648 Reactome:R-HSA-8952408 Reactome:R-HSA-8939801 Reactome:R-HSA-5635854 Reactome:R-HSA-187574 Reactome:R-HSA-174058	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	Reactome:R-HSA-1236978	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Reactome:R-HSA-5621481	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	Reactome:R-HSA-983168	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0000502	proteasome complex	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0647	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Czub, B et al. (2016) TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene. PLoS ONE 11 e0148678 PubMed GONUTS page
↑ Wang, X et al. (2007) Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Biochemistry 46 3553-65 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
↑ Coux, O et al. (1996) Structure and functions of the 20S and 26S proteasomes. Annu. Rev. Biochem. 65 801-47 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ Dubiel, W et al. (1992) Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family. J. Biol. Chem. 267 22699-702 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26872363-1] Czub, B et al. (2016) TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene. PLoS ONE 11 e0148678 PubMed GONUTS page

[PMID:17323924-2] Wang, X et al. (2007) Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Biochemistry 46 3553-65 PubMed GONUTS page

[PMID:19946888-3] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:21630459-4] Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page

[PMID:8811196-5] Coux, O et al. (1996) Structure and functions of the 20S and 26S proteasomes. Annu. Rev. Biochem. 65 801-47 PubMed GONUTS page

[PMID:22658674-6] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:1429620-7] Dubiel, W et al. (1992) Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family. J. Biol. Chem. 267 22699-702 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

HUMAN:PRS4

Contents

Annotations

Notes

References

a

c

e

f

h

i

m

n

o

p

r

s

t

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools