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HUMAN:PO5F1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | POU5F1 (synonyms: OCT3, OCT4, OTF3) | |
Protein Name(s) | POU domain, class 5, transcription factor 1
Octamer-binding protein 3 Oct-3 Octamer-binding protein 4 Oct-4 Octamer-binding transcription factor 3 OTF-3 | |
External Links | ||
UniProt | Q01860 | |
EMBL | Z11898 Z11899 GQ472773 AB088113 AB202105 AB103619 BA000025 AL662833 AL662833 AL662844 AL773544 AL773544 BX088580 BX088580 CR759815 CR759815 CR388229 CR388229 CR847794 CR847794 CH471081 CH471081 BC117435 BC117437 Z21963 Z21964 S81255 | |
CCDS | CCDS34391.1 | |
PIR | S25561 S32652 | |
RefSeq | NP_001272916.1 NP_002692.2 | |
UniGene | Hs.249184 Hs.632482 Hs.646545 | |
ProteinModelPortal | Q01860 | |
SMR | Q01860 | |
BioGrid | 111456 | |
DIP | DIP-33440N | |
IntAct | Q01860 | |
MINT | MINT-87567 | |
DrugBank | DB00988 DB00368 | |
PhosphoSite | Q01860 | |
DMDM | 400659 | |
PaxDb | Q01860 | |
PRIDE | Q01860 | |
DNASU | 5460 | |
Ensembl | ENST00000259915 ENST00000376243 ENST00000383524 ENST00000412166 ENST00000419095 ENST00000429314 ENST00000429603 ENST00000433063 ENST00000433348 ENST00000434616 ENST00000437747 ENST00000451077 ENST00000454714 | |
GeneID | 5460 | |
KEGG | hsa:5460 | |
UCSC | uc003nsu.3 | |
CTD | 5460 | |
GeneCards | GC06M031136 GC06Mj31119 GC06Mk31120 GC06Ml31172 GC06Mm31210 GC06Mn31119 GC06Mo31121 | |
H-InvDB | HIX0159939 HIX0164984 HIX0166817 HIX0167068 HIX0167306 HIX0167552 HIX0168865 HIX0201948 | |
HGNC | HGNC:9221 | |
HPA | CAB025600 CAB026380 | |
MIM | 164177 | |
neXtProt | NX_Q01860 | |
PharmGKB | PA33545 | |
eggNOG | NOG329627 | |
GeneTree | ENSGT00760000118935 | |
HOVERGEN | HBG057998 | |
InParanoid | Q01860 | |
KO | K09367 | |
OMA | LENMFLQ | |
PhylomeDB | Q01860 | |
TreeFam | TF316413 | |
Reactome | REACT_200670 REACT_200759 REACT_200812 | |
SignaLink | Q01860 | |
GenomeRNAi | 5460 | |
NextBio | 21135 | |
PRO | PR:Q01860 | |
Proteomes | UP000005640 UP000005640 | |
Bgee | Q01860 | |
ExpressionAtlas | Q01860 | |
Genevestigator | Q01860 | |
GO | GO:0005737 GO:0005829 GO:0005654 GO:0005634 GO:0005667 GO:0003677 GO:0035198 GO:0044822 GO:0043565 GO:0000981 GO:0003700 GO:0008134 GO:0044212 GO:0031625 GO:0009653 GO:0001824 GO:0003130 GO:0060913 GO:0060795 GO:0001714 GO:0042789 GO:0060965 GO:0035413 GO:0060391 GO:0045944 GO:0009786 GO:0010468 GO:0090081 GO:0090308 GO:0006355 GO:0009611 GO:0035019 GO:0006366 | |
Gene3D | 1.10.10.60 1.10.260.40 | |
InterPro | IPR017970 IPR001356 IPR009057 IPR010982 IPR013847 IPR015585 IPR000327 | |
PANTHER | PTHR11636:SF15 | |
Pfam | PF00046 PF00157 | |
PRINTS | PR00028 | |
SMART | SM00389 SM00352 | |
SUPFAM | SSF46689 SSF47413 | |
PROSITE | PS00027 PS50071 PS00035 PS00465 PS51179 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000255 |
match to sequence model evidence used in manual assertion |
InterPro:IPR000327 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_regulation_target:(RNAcentral:URS0000527F89_9606) |
Seeded From UniProt |
complete | ||
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(RNAcentral:URS0000527F89_9606) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042789 |
mRNA transcription by RNA polymerase II |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009786 |
regulation of asymmetric cell division |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006366 |
transcription by RNA polymerase II |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002322) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002322) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001824 |
blastocyst development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000305 |
curator inference used in manual assertion |
GO:0003677 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060965 |
negative regulation of gene silencing by miRNA |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0035198 |
miRNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0035198 |
miRNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035019 |
somatic stem cell population maintenance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035019 |
somatic stem cell population maintenance |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010468 |
regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009611 |
response to wounding |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001714 |
endodermal cell fate specification |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001356 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090308 |
regulation of methylation-dependent chromatin silencing |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090081 |
regulation of heart induction by regulation of canonical Wnt signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060913 |
cardiac cell fate determination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060795 |
cell fate commitment involved in formation of primary germ layer |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060391 |
positive regulation of SMAD protein signal transduction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090263 |
positive regulation of canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035019 |
somatic stem cell population maintenance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008134 |
transcription factor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005667 |
transcription factor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003130 |
BMP signaling pathway involved in heart induction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009653 |
anatomical structure morphogenesis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035019 |
somatic stem cell population maintenance |
Reactome:R-HSA-452723 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-6800120 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Xu, N et al. (2009) MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 137 647-58 PubMed GONUTS page
- ↑ 3.0 3.1 Xu, H et al. (2009) WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells. Cell Res. 19 561-73 PubMed GONUTS page
- ↑ 4.0 4.1 Yoon, SJ et al. (2011) HEB and E2A function as SMAD/FOXH1 cofactors. Genes Dev. 25 1654-61 PubMed GONUTS page
- ↑ 5.0 5.1 Trubiani, O et al. (2010) Expression profile of the embryonic markers nanog, OCT-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mesenchymal stem cells. J. Cell. Physiol. 225 123-31 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Boyer, LA et al. (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122 947-56 PubMed GONUTS page
- ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
- ↑ Card, DA et al. (2008) Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol. Cell. Biol. 28 6426-38 PubMed GONUTS page
- ↑ 9.0 9.1 Fong, H et al. (2008) Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. Stem Cells 26 1931-8 PubMed GONUTS page
- ↑ McGowan, SL et al. (2007) Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas. Mol. Vis. 13 1984-2000 PubMed GONUTS page
- ↑ 11.0 11.1 Zhao, M et al. (2007) Evidence for the presence of stem cell-like progenitor cells in human adult pancreas. J. Endocrinol. 195 407-14 PubMed GONUTS page
- ↑ Kristensen, DM et al. (2008) Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. Hum. Reprod. 23 775-82 PubMed GONUTS page
- ↑ Lee, J et al. (2008) Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. Int. J. Biochem. Cell Biol. 40 1043-54 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Zhang, Y et al. (2010) Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes Dev. 24 1746-57 PubMed GONUTS page
- ↑ 15.00 15.01 15.02 15.03 15.04 15.05 15.06 15.07 15.08 15.09 15.10 15.11 Stefanovic, S et al. (2009) Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. J. Cell Biol. 186 665-73 PubMed GONUTS page
- ↑ 16.0 16.1 Nichols, J et al. (1998) Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95 379-91 PubMed GONUTS page
- ↑ Crouau-Roy, B et al. (1994) Localization of the OTF3 gene within the human MHC class I region by physical and meiotic mapping. Genomics 21 241-3 PubMed GONUTS page
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