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HUMAN:PO5F1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) POU5F1 (synonyms: OCT3, OCT4, OTF3)
Protein Name(s) POU domain, class 5, transcription factor 1

Octamer-binding protein 3 Oct-3 Octamer-binding protein 4 Oct-4 Octamer-binding transcription factor 3 OTF-3

External Links
UniProt Q01860
EMBL Z11898
Z11899
GQ472773
AB088113
AB202105
AB103619
BA000025
AL662833
AL662833
AL662844
AL773544
AL773544
BX088580
BX088580
CR759815
CR759815
CR388229
CR388229
CR847794
CR847794
CH471081
CH471081
BC117435
BC117437
Z21963
Z21964
S81255
CCDS CCDS34391.1
PIR S25561
S32652
RefSeq NP_001272916.1
NP_002692.2
UniGene Hs.249184
Hs.632482
Hs.646545
ProteinModelPortal Q01860
SMR Q01860
BioGrid 111456
DIP DIP-33440N
IntAct Q01860
MINT MINT-87567
DrugBank DB00988
DB00368
PhosphoSite Q01860
DMDM 400659
PaxDb Q01860
PRIDE Q01860
DNASU 5460
Ensembl ENST00000259915
ENST00000376243
ENST00000383524
ENST00000412166
ENST00000419095
ENST00000429314
ENST00000429603
ENST00000433063
ENST00000433348
ENST00000434616
ENST00000437747
ENST00000451077
ENST00000454714
GeneID 5460
KEGG hsa:5460
UCSC uc003nsu.3
CTD 5460
GeneCards GC06M031136
GC06Mj31119
GC06Mk31120
GC06Ml31172
GC06Mm31210
GC06Mn31119
GC06Mo31121
H-InvDB HIX0159939
HIX0164984
HIX0166817
HIX0167068
HIX0167306
HIX0167552
HIX0168865
HIX0201948
HGNC HGNC:9221
HPA CAB025600
CAB026380
MIM 164177
neXtProt NX_Q01860
PharmGKB PA33545
eggNOG NOG329627
GeneTree ENSGT00760000118935
HOVERGEN HBG057998
InParanoid Q01860
KO K09367
OMA LENMFLQ
PhylomeDB Q01860
TreeFam TF316413
Reactome REACT_200670
REACT_200759
REACT_200812
SignaLink Q01860
GenomeRNAi 5460
NextBio 21135
PRO PR:Q01860
Proteomes UP000005640
UP000005640
Bgee Q01860
ExpressionAtlas Q01860
Genevestigator Q01860
GO GO:0005737
GO:0005829
GO:0005654
GO:0005634
GO:0005667
GO:0003677
GO:0035198
GO:0044822
GO:0043565
GO:0000981
GO:0003700
GO:0008134
GO:0044212
GO:0031625
GO:0009653
GO:0001824
GO:0003130
GO:0060913
GO:0060795
GO:0001714
GO:0042789
GO:0060965
GO:0035413
GO:0060391
GO:0045944
GO:0009786
GO:0010468
GO:0090081
GO:0090308
GO:0006355
GO:0009611
GO:0035019
GO:0006366
Gene3D 1.10.10.60
1.10.260.40
InterPro IPR017970
IPR001356
IPR009057
IPR010982
IPR013847
IPR015585
IPR000327
PANTHER PTHR11636:SF15
Pfam PF00046
PF00157
PRINTS PR00028
SMART SM00389
SM00352
SUPFAM SSF46689
SSF47413
PROSITE PS00027
PS50071
PS00035
PS00465
PS51179

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR000327
InterPro:IPR001356
InterPro:IPR009057
InterPro:IPR010982
InterPro:IPR013847
InterPro:IPR015585

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:19409607[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0001227

DNA-binding transcription repressor activity, RNA polymerase II-specific

PMID:19409607[2]

ECO:0000314

direct assay evidence used in manual assertion

F

has_regulation_target:(RNAcentral:URS0000527F89_9606)

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:19409607[2]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(RNAcentral:URS0000527F89_9606)

Seeded From UniProt

complete

involved_in

GO:0042789

mRNA transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20263

P

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

PMID:19274063[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O00308

F

Seeded From UniProt

complete

involved_in

GO:0009786

regulation of asymmetric cell division

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20263

P

Seeded From UniProt

complete

involved_in

GO:0006366

transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20263

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21828274[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002322)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:20458727[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:20458727[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21828274[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002322)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:19274063[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001824

blastocyst development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20263

P

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P20263

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:16153702[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16153702[6]

ECO:0000305

curator inference used in manual assertion

GO:0003677

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:16153702[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:16153702[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0060965

negative regulation of gene silencing by miRNA

PMID:19409607[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0035198

miRNA binding

PMID:18710938[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0035198

miRNA binding

PMID:19409607[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0035019

somatic stem cell population maintenance

PMID:18388306[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035019

somatic stem cell population maintenance

PMID:19409607[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010468

regulation of gene expression

PMID:18388306[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009611

response to wounding

PMID:17982423[10]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18000303[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:18281244[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18000303[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18191611[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20713518[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:20713518[14]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001714

endodermal cell fate specification

PMID:20713518[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001356
InterPro:IPR009057
InterPro:IPR010982
InterPro:IPR013847

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000327

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000327
InterPro:IPR017970

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017970

F

Seeded From UniProt

complete

involved_in

GO:0090308

regulation of methylation-dependent chromatin silencing

PMID:19736317[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090081

regulation of heart induction by regulation of canonical Wnt signaling pathway

PMID:19736317[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060913

cardiac cell fate determination

PMID:19736317[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060795

cell fate commitment involved in formation of primary germ layer

PMID:19736317[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060391

positive regulation of SMAD protein signal transduction

PMID:19736317[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:19736317[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

PMID:19736317[15]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0090263

positive regulation of canonical Wnt signaling pathway

PMID:19736317[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035019

somatic stem cell population maintenance

PMID:19736317[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:19736317[15]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9H6I2

F

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

PMID:19736317[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0003130

BMP signaling pathway involved in heart induction

PMID:19736317[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009653

anatomical structure morphogenesis

PMID:9814708[16]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:9814708[16]
PMID:8088794[17]

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

involved_in

GO:0035019

somatic stem cell population maintenance

Reactome:R-HSA-452723

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-6800120
Reactome:R-HSA-480685
Reactome:R-HSA-480204
Reactome:R-HSA-2972979
Reactome:R-HSA-2972978
Reactome:R-HSA-2972977
Reactome:R-HSA-2972975
Reactome:R-HSA-2972967
Reactome:R-HSA-2972966
Reactome:R-HSA-2972965
Reactome:R-HSA-2972964
Reactome:R-HSA-2972962
Reactome:R-HSA-2972960
Reactome:R-HSA-2972956
Reactome:R-HSA-2972952
Reactome:R-HSA-2972949
Reactome:R-HSA-2972948
Reactome:R-HSA-2895778
Reactome:R-HSA-2889036
Reactome:R-HSA-1112609

ECO:0000304

author statement supported by traceable reference used in manual assertion




















C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238
UniProtKB-KW:KW-0371

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Xu, N et al. (2009) MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 137 647-58 PubMed GONUTS page
  3. 3.0 3.1 Xu, H et al. (2009) WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells. Cell Res. 19 561-73 PubMed GONUTS page
  4. 4.0 4.1 Yoon, SJ et al. (2011) HEB and E2A function as SMAD/FOXH1 cofactors. Genes Dev. 25 1654-61 PubMed GONUTS page
  5. 5.0 5.1 Trubiani, O et al. (2010) Expression profile of the embryonic markers nanog, OCT-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mesenchymal stem cells. J. Cell. Physiol. 225 123-31 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Boyer, LA et al. (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122 947-56 PubMed GONUTS page
  7. Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  8. Card, DA et al. (2008) Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol. Cell. Biol. 28 6426-38 PubMed GONUTS page
  9. 9.0 9.1 Fong, H et al. (2008) Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. Stem Cells 26 1931-8 PubMed GONUTS page
  10. McGowan, SL et al. (2007) Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas. Mol. Vis. 13 1984-2000 PubMed GONUTS page
  11. 11.0 11.1 Zhao, M et al. (2007) Evidence for the presence of stem cell-like progenitor cells in human adult pancreas. J. Endocrinol. 195 407-14 PubMed GONUTS page
  12. Kristensen, DM et al. (2008) Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. Hum. Reprod. 23 775-82 PubMed GONUTS page
  13. Lee, J et al. (2008) Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. Int. J. Biochem. Cell Biol. 40 1043-54 PubMed GONUTS page
  14. 14.0 14.1 14.2 Zhang, Y et al. (2010) Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes Dev. 24 1746-57 PubMed GONUTS page
  15. 15.00 15.01 15.02 15.03 15.04 15.05 15.06 15.07 15.08 15.09 15.10 15.11 Stefanovic, S et al. (2009) Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. J. Cell Biol. 186 665-73 PubMed GONUTS page
  16. 16.0 16.1 Nichols, J et al. (1998) Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95 379-91 PubMed GONUTS page
  17. Crouau-Roy, B et al. (1994) Localization of the OTF3 gene within the human MHC class I region by physical and meiotic mapping. Genomics 21 241-3 PubMed GONUTS page