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PMID:18281244

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Citation

Kristensen, DM, Nielsen, JE, Skakkebaek, NE, Graem, N, Jacobsen, GK, Rajpert-De Meyts, E and Leffers, H (2008) Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. Hum. Reprod. 23:775-82

Abstract

UTF-1 and REX-1/ZFP42 are transcription factors involved in pluripotency. Because of phenotypic similarities between pluripotent embryonic stem cells and testicular germ cell tumours (TGCT) and the derivation of pluripotent cells from testes, we investigated the expression of UTF-1 and REX-1 during human gonadal development and in TGCT.

Links

PubMed Online version:10.1093/humrep/den010

Keywords

Child; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Gestational Age; Humans; Immunohistochemistry; In Situ Hybridization; Infant; Kruppel-Like Transcription Factors/biosynthesis; Male; Neoplasms, Germ Cell and Embryonal/metabolism; Nuclear Proteins/biosynthesis; Ovary/metabolism; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; Testis/metabolism; Trans-Activators/biosynthesis

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:PO5F1

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:UTF1

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:UTF1

involved_in

GO:0008584: male gonad development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ZFP42

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:ZFP42

involved_in

GO:0008585: female gonad development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ZFP42

involved_in

GO:0008584: male gonad development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ZFP42

involved_in

GO:0051321: meiotic cell cycle

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PO5F1

part_of

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

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