HUMAN:P73

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TP73 (synonyms: P73)
Protein Name(s)	Tumor protein p73 p53-like transcription factor p53-related protein
External Links
UniProt	O15350
EMBL	Y11416 Y11416 Y11416 AF079094 AF079082 AF079083 AF079084 AF079085 AF079086 AF079087 AF079088 AF079089 AF079090 AF079091 AF079092 AF079093 AF077628 AF077616 AF077617 AF077618 AF077619 AF077620 AF077621 AF077624 AF077625 AF077626 AF077627 AY040827 AY040828 AY040829 AB055065 AB055066 AK302118 AK304177 AK304784 AL136528 AL136528 AL136528 AL136528 AL136528 CH471130 BC117251 BC117253
CCDS	CCDS44049.1 CCDS44050.1 CCDS49.1 CCDS55566.1 CCDS55567.1 CCDS55568.1 CCDS55569.1 CCDS59965.1
RefSeq	NP_001119712.1 NP_001119713.1 NP_001119714.1 NP_001191113.1 NP_001191114.1 NP_001191115.1 NP_001191116.1 NP_001191117.1 NP_001191118.1 NP_001191119.1 NP_001191120.1 NP_001191121.1 NP_005418.1
UniGene	Hs.192132
PDB	1COK 1DXS 2KBY 2WQI 2WQJ 2WTT 2XWC 3VD0 3VD1 3VD2 4A63 4G82 4G83 4GUO 4GUQ
PDBsum	1COK 1DXS 2KBY 2WQI 2WQJ 2WTT 2XWC 3VD0 3VD1 3VD2 4A63 4G82 4G83 4GUO 4GUQ
DisProt	DP00319
ProteinModelPortal	O15350
SMR	O15350
BioGrid	113014
DIP	DIP-24202N
IntAct	O15350
MINT	MINT-97729
PhosphoSite	O15350
MaxQB	O15350
PaxDb	O15350
PRIDE	O15350
DNASU	7161
Ensembl	ENST00000346387 ENST00000354437 ENST00000357733 ENST00000378280 ENST00000378285 ENST00000378288 ENST00000378290 ENST00000378295 ENST00000603362 ENST00000604074 ENST00000604479
GeneID	7161
KEGG	hsa:7161
UCSC	uc001akp.3 uc001akr.3 uc001aks.3 uc009vlk.2 uc021ofb.1 uc021ofc.1 uc021ofd.1 uc021ofe.1
CTD	7161
GeneCards	GC01P003592
HGNC	HGNC:12003
HPA	CAB002514 CAB003022
MIM	601990
neXtProt	NX_O15350
PharmGKB	PA36684
eggNOG	NOG80479
GeneTree	ENSGT00390000015092
HOVERGEN	HBG005201
InParanoid	O15350
KO	K10148
OMA	NEGQSAP
OrthoDB	EOG7JQBNW
PhylomeDB	O15350
TreeFam	TF106101
SignaLink	O15350
ChiTaRS	TP73
EvolutionaryTrace	O15350
GeneWiki	P73
GenomeRNAi	7161
NextBio	28022
PMAP-CutDB	O15350
PRO	PR:O15350
Proteomes	UP000005640
Bgee	O15350
ExpressionAtlas	O15350
Genevestigator	O15350
GO	GO:0000785 GO:0005829 GO:0005634 GO:0005667 GO:0003682 GO:0003684 GO:0003690 GO:0042802 GO:0046872 GO:0002039 GO:0019901 GO:0043565 GO:0003700 GO:0008134 GO:0044212 GO:0000187 GO:0007050 GO:0006974 GO:0034644 GO:0033326 GO:0048546 GO:0006978 GO:0021766 GO:0006954 GO:0008630 GO:0042771 GO:0001822 GO:0006298 GO:0031571 GO:0060044 GO:0043508 GO:0043524 GO:0045665 GO:0000122 GO:0048666 GO:0045793 GO:1902167 GO:0048714 GO:0045944 GO:0045893 GO:0009791 GO:0051262 GO:0010468 GO:0007346 GO:0001836 GO:0010332 GO:0010243 GO:0010165 GO:0006351
Gene3D	1.10.150.50 2.60.40.720 4.10.170.10
InterPro	IPR008967 IPR012346 IPR011615 IPR010991 IPR002117 IPR001660 IPR013761 IPR011510
PANTHER	PTHR11447
Pfam	PF00870 PF07710 PF07647
PRINTS	PR00386
SMART	SM00454
SUPFAM	SSF47719 SSF47769 SSF49417
PROSITE	PS00348

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR002117 InterPro:IPR008967 InterPro:IPR011615 InterPro:IPR012346	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P10361	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:25417702^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:25417702^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0097371	MDM2/MDM4 family protein binding	PMID:25417702^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:25417702^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18421303^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P38936)\|has_regulation_target:(UniProtKB:Q07812)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:18421303^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17208	F		Seeded From UniProt	complete
involved_in	GO:0071158	positive regulation of cell cycle arrest	PMID:18421303^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:24652652^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24652652^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:16343436^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16343436^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:16343436^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18174154^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19490146^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16343436^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:16343436^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:18174154^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:19490146^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:18174154^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P53350	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:19490146^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9H4B4	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:18174154^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19490146^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060044	negative regulation of cardiac muscle cell proliferation	PMID:18634800^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15678106^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:18634800^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007346	regulation of mitotic cell cycle	PMID:18634800^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15678106^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22474346^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15350	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22340593^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15350	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19815500^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15350	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1900740	C		Seeded From UniProt	complete
involved_in	GO:0048714	positive regulation of oligodendrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AA88 ensembl:ENSRNOP00000052265	P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AA88 ensembl:ENSRNOP00000052265	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AA88 ensembl:ENSRNOP00000052265	F		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AA88 ensembl:ENSRNOP00000052265	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AA88 ensembl:ENSRNOP00000052265	P		Seeded From UniProt	complete
involved_in	GO:0010243	response to organonitrogen compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AA88 ensembl:ENSRNOP00000052265	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AA88 ensembl:ENSRNOP00000052265	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AA88 ensembl:ENSRNOP00000052265	C		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AA88 ensembl:ENSRNOP00000052265	P		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AA88 ensembl:ENSRNOP00000052265	C		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4AA88 ensembl:ENSRNOP00000052265	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR012346 InterPro:IPR032646	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR008967 InterPro:IPR012346	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR012346 InterPro:IPR032646	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR008967 InterPro:IPR012346 InterPro:IPR032646	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR032646	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032646	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011615	F		Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010991 InterPro:IPR036674	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:12730672^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12730672^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:12730672^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12730672^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:11748232^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09429	F		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:10391251^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:10391249^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:10802655^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1902036	regulation of hematopoietic stem cell differentiation	Reactome:R-HSA-8939236	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	Reactome:R-HSA-139915	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	Reactome:R-HSA-5633008	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8957265 Reactome:R-HSA-8957241 Reactome:R-HSA-8956684	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8957241 Reactome:R-HSA-8956676 Reactome:R-HSA-6799815 Reactome:R-HSA-6799777 Reactome:R-HSA-6799761 Reactome:R-HSA-6799462 Reactome:R-HSA-6798082 Reactome:R-HSA-4331340 Reactome:R-HSA-3700981	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
	GO:0006915	apoptosis	PMID:14634023^[18]	ECO:0000314			P		Figure 6 - Bar graph showing measured levels of cell death where p73 is shown to induces apoptosis (cell death) through PUMA Transactivation.	complete CACAO 3318
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Stindt, MH et al. (2015) Functional interplay between MDM2, p63/p73 and mutant p53. Oncogene 34 4300-10 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Hudson, CD et al. (2008) Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription. Cell Death Differ. 15 1266-78 PubMed GONUTS page
↑ ^4.0 ^4.1 Polato, F et al. (2014) DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]. J. Natl. Cancer Inst. 106 dju053 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Osada, M et al. (2006) A novel response element confers p63- and p73-specific activation of the WNT4 promoter. Biochem. Biophys. Res. Commun. 339 1120-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Koida, N et al. (2008) Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation. J. Biol. Chem. 283 8555-63 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Sang, M et al. (2009) Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation. Genes Cells 14 775-88 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Ebelt, H et al. (2008) Directed expression of dominant-negative p73 enables proliferation of cardiomyocytes in mice. J. Mol. Cell. Cardiol. 45 411-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Rossi, M et al. (2005) The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J. 24 836-48 PubMed GONUTS page
↑ Ethayathulla, AS et al. (2012) Structure of p73 DNA-binding domain tetramer modulates p73 transactivation. Proc. Natl. Acad. Sci. U.S.A. 109 6066-71 PubMed GONUTS page
↑ Katayama, H et al. (2012) Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73. Cancer Cell 21 196-211 PubMed GONUTS page
↑ Joerger, AC et al. (2009) Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proc. Natl. Acad. Sci. U.S.A. 106 17705-10 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Alisi, A et al. (2003) Physical and functional interaction between HCV core protein and the different p73 isoforms. Oncogene 22 2573-80 PubMed GONUTS page
↑ Stros, M et al. (2002) HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter. J. Biol. Chem. 277 7157-64 PubMed GONUTS page
↑ Yuan, ZM et al. (1999) p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature 399 814-7 PubMed GONUTS page
↑ Gong, JG et al. (1999) The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399 806-9 PubMed GONUTS page
↑ Marin, MC et al. (2000) A common polymorphism acts as an intragenic modifier of mutant p53 behaviour. Nat. Genet. 25 47-54 PubMed GONUTS page
↑ Melino, G et al. (2004) p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J. Biol. Chem. 279 8076-83 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:25417702-2] 2.0 ^2.1 ^2.2 ^2.3 Stindt, MH et al. (2015) Functional interplay between MDM2, p63/p73 and mutant p53. Oncogene 34 4300-10 PubMed GONUTS page

[PMID:18421303-3] 3.0 ^3.1 ^3.2 Hudson, CD et al. (2008) Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription. Cell Death Differ. 15 1266-78 PubMed GONUTS page

[PMID:24652652-4] 4.0 ^4.1 Polato, F et al. (2014) DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]. J. Natl. Cancer Inst. 106 dju053 PubMed GONUTS page

[PMID:16343436-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Osada, M et al. (2006) A novel response element confers p63- and p73-specific activation of the WNT4 promoter. Biochem. Biophys. Res. Commun. 339 1120-8 PubMed GONUTS page

[PMID:18174154-6] 6.0 ^6.1 ^6.2 ^6.3 Koida, N et al. (2008) Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation. J. Biol. Chem. 283 8555-63 PubMed GONUTS page

[PMID:19490146-7] 7.0 ^7.1 ^7.2 ^7.3 Sang, M et al. (2009) Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation. Genes Cells 14 775-88 PubMed GONUTS page

[PMID:18634800-8] 8.0 ^8.1 ^8.2 Ebelt, H et al. (2008) Directed expression of dominant-negative p73 enables proliferation of cardiomyocytes in mice. J. Mol. Cell. Cardiol. 45 411-9 PubMed GONUTS page

[PMID:15678106-9] 9.0 ^9.1 Rossi, M et al. (2005) The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J. 24 836-48 PubMed GONUTS page

[PMID:22474346-10] Ethayathulla, AS et al. (2012) Structure of p73 DNA-binding domain tetramer modulates p73 transactivation. Proc. Natl. Acad. Sci. U.S.A. 109 6066-71 PubMed GONUTS page

[PMID:22340593-11] Katayama, H et al. (2012) Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73. Cancer Cell 21 196-211 PubMed GONUTS page

[PMID:19815500-12] Joerger, AC et al. (2009) Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proc. Natl. Acad. Sci. U.S.A. 106 17705-10 PubMed GONUTS page

[PMID:12730672-13] 13.0 ^13.1 ^13.2 ^13.3 Alisi, A et al. (2003) Physical and functional interaction between HCV core protein and the different p73 isoforms. Oncogene 22 2573-80 PubMed GONUTS page

[PMID:11748232-14] Stros, M et al. (2002) HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter. J. Biol. Chem. 277 7157-64 PubMed GONUTS page

[PMID:10391251-15] Yuan, ZM et al. (1999) p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature 399 814-7 PubMed GONUTS page

[PMID:10391249-16] Gong, JG et al. (1999) The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399 806-9 PubMed GONUTS page

[PMID:10802655-17] Marin, MC et al. (2000) A common polymorphism acts as an intragenic modifier of mutant p53 behaviour. Nat. Genet. 25 47-54 PubMed GONUTS page

[PMID:14634023-18] Melino, G et al. (2004) p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J. Biol. Chem. 279 8076-83 PubMed GONUTS page

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HUMAN:P73

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