HUMAN:P63

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TP63 (synonyms: KET, P63, P73H, P73L, TP73L)
Protein Name(s)	Tumor protein 63 p63 Chronic ulcerative stomatitis protein CUSP Keratinocyte transcription factor KET Transformation-related protein 63 TP63 Tumor protein p73-like p73L p40 p51
External Links
UniProt	Q9H3D4
EMBL	AB010153 Y16961 AF075428 AF075429 AF075430 AF075431 AF075432 AF075433 AF124539 AF124528 AF124529 AF124531 AF124532 AF124533 AF124534 AF124535 AF124536 AF124537 AF124538 AF124539 AF124528 AF124529 AF124531 AF124532 AF124533 AF124534 AF124535 AF124536 AF124537 AF124540 AF124528 AF124529 AF124531 AF124532 AF124533 AF124534 AF124535 AF124539 AF124530 AF124531 AF124532 AF124533 AF124534 AF124535 AF124536 AF124537 AF124538 AF124539 AF124530 AF124531 AF124532 AF124533 AF124534 AF124535 AF124536 AF124537 AF124540 AF124531 AF124533 AF124535 AF124534 AF124532 AF124530 AB016072 AB016073 AF091627 AF116770 AF116756 AF116757 AF116759 AF116760 AF116761 AF116762 AF116763 AF116764 AF116765 AF116769 AF116756 AF116757 AF116759 AF116760 AF116761 AF116762 AF116763 AF116764 AF116765 AF116766 AF116767 AF116768 AF116769 AF116756 AF116759 AF116757 AF116762 AF116764 AF116766 AF116767 AF116765 AF116763 AF116761 AF116760 AF116769 AF116756 AF116757 AF116759 AF116760 AF116761 AF116762 AF116763 AF116764 AF116765 AF116766 AF116770 AF116758 AF116760 AF116762 AF116764 AF116765 AF116763 AF116761 AF116759 AF116769 AF116758 AF116759 AF116760 AF116764 AF116766 AF116768 AF116767 AF116765 AF116763 AF116762 AF116761 AF116769 AF116758 AF116760 AF116759 AF116761 AF116763 AF116765 AF116767 AF116766 AF116764 AF116762 AF116769 AF116758 AF116760 AF116759 AF116761 AF116763 AF116765 AF116766 AF116764 AF116762 AF116771 AB042841 BC039815 AF061512 AY342152 AY341145 AY339663 AY341143 AY339664 AY341142 AY341143 AY341142 AY341144 AY342153 AY342154 AJ315499
CCDS	CCDS3293.1 CCDS46976.1 CCDS46977.1 CCDS46978.1 CCDS46979.1 CCDS46980.1
RefSeq	NP_001108450.1 NP_001108451.1 NP_001108452.1 NP_001108453.1 NP_001108454.1 NP_003713.3 XP_005247900.1
UniGene	Hs.137569
PDB	1RG6 2RMN 2Y9T 2Y9U 3QYM 3QYN 3US0 3US1 3US2 3ZY0 3ZY1 4A9Z
PDBsum	1RG6 2RMN 2Y9T 2Y9U 3QYM 3QYN 3US0 3US1 3US2 3ZY0 3ZY1 4A9Z
ProteinModelPortal	Q9H3D4
SMR	Q9H3D4
BioGrid	114181
DIP	DIP-29588N
IntAct	Q9H3D4
MINT	MINT-190238
PhosphoSite	Q9H3D4
DMDM	57013009
MaxQB	Q9H3D4
PaxDb	Q9H3D4
PRIDE	Q9H3D4
DNASU	8626
Ensembl	ENST00000264731 ENST00000320472 ENST00000354600 ENST00000392460 ENST00000392461 ENST00000392463 ENST00000418709 ENST00000437221 ENST00000440651 ENST00000449992 ENST00000456148
GeneID	8626
KEGG	hsa:8626
UCSC	uc003frx.2 uc003fry.2 uc003frz.2 uc003fsb.2 uc003fsc.2 uc003fsd.2 uc010hzc.1 uc010hzd.1
CTD	8626
GeneCards	GC03P189349
GeneReviews	TP63
HGNC	HGNC:15979
HPA	CAB000083 HPA006288 HPA007010
MIM	103285 106260 129400 603273 603543 604292 605289
neXtProt	NX_Q9H3D4
Orphanet	978 1071 93930 1991 1896 69085 2440
PharmGKB	PA162406776
eggNOG	NOG80479
GeneTree	ENSGT00390000015092
HOVERGEN	HBG005201
InParanoid	Q9H3D4
KO	K10149
OMA	VPSSHCT
OrthoDB	EOG7JQBNW
PhylomeDB	Q9H3D4
TreeFam	TF106101
SignaLink	Q9H3D4
ChiTaRS	TP63
EvolutionaryTrace	Q9H3D4
GeneWiki	TP63
GenomeRNAi	8626
NextBio	32339
PRO	PR:Q9H3D4
Proteomes	UP000005640
Bgee	Q9H3D4
ExpressionAtlas	Q9H3D4
Genevestigator	Q9H3D4
GO	GO:0000785 GO:0005737 GO:0005829 GO:0030425 GO:0000790 GO:0005654 GO:0005634 GO:0005791 GO:0005667 GO:0003682 GO:0003684 GO:0003677 GO:0003690 GO:0042802 GO:0046872 GO:0002039 GO:0001077 GO:0043565 GO:0003700 GO:0000989 GO:0044212 GO:0050699 GO:0006915 GO:0006974 GO:0034644 GO:0006338 GO:0060197 GO:0006978 GO:0007499 GO:0030326 GO:0010481 GO:0002064 GO:0001736 GO:0061436 GO:0048807 GO:0031069 GO:0042771 GO:0030216 GO:0043616 GO:0031571 GO:0010259 GO:0043066 GO:2000773 GO:0045617 GO:2000381 GO:0000122 GO:0045892 GO:0051402 GO:0007219 GO:0042475 GO:0030859 GO:2001235 GO:1902808 GO:2000271 GO:0010838 GO:0002053 GO:0045747 GO:0045669 GO:0045944 GO:0045893 GO:0036342 GO:0060513 GO:0051289 GO:0009954 GO:0010482 GO:0043523 GO:0001302 GO:0010332 GO:0010165 GO:0001501 GO:0048745 GO:0007283 GO:0060529 GO:0048485 GO:0060157
Gene3D	1.10.150.50 2.60.40.720 4.10.170.10
InterPro	IPR008967 IPR012346 IPR011615 IPR010991 IPR002117 IPR001660 IPR013761 IPR011510
PANTHER	PTHR11447
Pfam	PF00870 PF07710 PF07647
PRINTS	PR00386
SMART	SM00454
SUPFAM	SSF47719 SSF47769 SSF49417
PROSITE	PS00348

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR002117 InterPro:IPR008967 InterPro:IPR011615 InterPro:IPR012346	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P10361	F	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:25417702^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:25417702^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0097371	MDM2/MDM4 family protein binding	PMID:25417702^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00987	F	Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:25417702^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F	Seeded From UniProt	complete
enables	GO:0050699	WW domain binding	PMID:19451233^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6ZWJ1	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22521434^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	PMID:22521434^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:22521434^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:2000271	positive regulation of fibroblast apoptotic process	PMID:9774969^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0061436	establishment of skin barrier	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88898	P	Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	PMID:10373484^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9H3D4	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16343436^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12446784^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9774969^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:12446784^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045747	positive regulation of Notch signaling pathway	PMID:11641404^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:12446779^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9H3D4	F	Seeded From UniProt	complete
involved_in	GO:0010482	regulation of epidermal cell division	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88898	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12446779^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9774969^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:9662346^[11]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10657951^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11106548^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10657951^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21464285^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9H3D4	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21335238^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9H3D4	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19815500^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9H3D4	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1900740	C	Seeded From UniProt	complete
involved_in	GO:2001235	positive regulation of apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:2000381	negative regulation of mesoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:1904888	cranial skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:1904674	positive regulation of somatic stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0098773	skin epidermis development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0061436	establishment of skin barrier	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0060529	squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0060513	prostatic bud formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0060197	cloacal septation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0048807	female genitalia morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0048646	anatomical structure formation involved in morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0048485	sympathetic nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0045747	positive regulation of Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0045617	negative regulation of keratinocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0043589	skin morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	F	Seeded From UniProt	complete
involved_in	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	F	Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0036342	post-anal tail morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0035116	embryonic hindlimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0035115	embryonic forelimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0031069	hair follicle morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0030859	polarized epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0030855	epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0030216	keratinocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0010838	positive regulation of keratinocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0010482	regulation of epidermal cell division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0010481	epidermal cell division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0010259	multicellular organism aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0009954	proximal/distal pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0009913	epidermal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0008544	epidermis development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0007499	ectoderm and mesoderm interaction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	C	Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	F	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	F	Seeded From UniProt	complete
involved_in	GO:0002064	epithelial cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0001942	hair follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0001738	morphogenesis of a polarized epithelium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0001736	establishment of planar polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88898 ensembl:ENSMUSP00000110965	P	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	C	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	C	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	C	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	F	Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	P	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	P	Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	F	Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	F	Seeded From UniProt	complete
involved_in	GO:0001302	replicative cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JJP6 ensembl:ENSRNOP00000033463	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR012346 InterPro:IPR032645	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR008967 InterPro:IPR012346	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR012346	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR008967 InterPro:IPR012346 InterPro:IPR032645 InterPro:IPR037611	P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR032645	P	Seeded From UniProt	complete
involved_in	GO:0032502	developmental process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032645	P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011615	F	Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010991 InterPro:IPR036674	P	Seeded From UniProt	complete
involved_in	GO:2000773	negative regulation of cellular senescence	PMID:19451233^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1902808	positive regulation of cell cycle G1/S phase transition	PMID:19451233^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:19451233^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20123734^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:20123734^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:20123734^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:9662378^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	Reactome:R-HSA-139915	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	Reactome:R-HSA-5633008	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6800836 Reactome:R-HSA-6799815 Reactome:R-HSA-6799777 Reactome:R-HSA-6799761 Reactome:R-HSA-6799462 Reactome:R-HSA-6798082 Reactome:R-HSA-5632393 Reactome:R-HSA-4331340 Reactome:R-HSA-3700981	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0914	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Stindt, MH et al. (2015) Functional interplay between MDM2, p63/p73 and mutant p53. Oncogene 34 4300-10 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Li, Y et al. (2009) Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation. Mol. Cell. Biol. 29 3953-63 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Chen, K et al. (2012) Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR. Bone 51 69-77 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Yang, A et al. (1998) p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell 2 305-16 PubMed GONUTS page
↑ Davison, TS et al. (1999) p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53. J. Biol. Chem. 274 18709-14 PubMed GONUTS page
↑ Osada, M et al. (2006) A novel response element confers p63- and p73-specific activation of the WNT4 promoter. Biochem. Biophys. Res. Commun. 339 1120-8 PubMed GONUTS page
↑ ^8.0 ^8.1 Ghioni, P et al. (2002) Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains. Mol. Cell. Biol. 22 8659-68 PubMed GONUTS page
↑ Sasaki, Y et al. (2002) The p53 family member genes are involved in the Notch signal pathway. J. Biol. Chem. 277 719-24 PubMed GONUTS page
↑ ^10.0 ^10.1 Serber, Z et al. (2002) A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism. Mol. Cell. Biol. 22 8601-11 PubMed GONUTS page
↑ Trink, B et al. (1998) A new human p53 homologue. Nat. Med. 4 747-8 PubMed GONUTS page
↑ ^12.0 ^12.1 Hall, PA et al. (2000) Expression of the p53 homologue p63alpha and deltaNp63alpha in normal and neoplastic cells. Carcinogenesis 21 153-60 PubMed GONUTS page
↑ Signoretti, S et al. (2000) p63 is a prostate basal cell marker and is required for prostate development. Am. J. Pathol. 157 1769-75 PubMed GONUTS page
↑ Chen, C et al. (2011) Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elements. Proc. Natl. Acad. Sci. U.S.A. 108 6456-61 PubMed GONUTS page
↑ Deutsch, GB et al. (2011) DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer. Cell 144 566-76 PubMed GONUTS page
↑ Joerger, AC et al. (2009) Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proc. Natl. Acad. Sci. U.S.A. 106 17705-10 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Heyne, K et al. (2010) NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle. Nucleic Acids Res. 38 3159-71 PubMed GONUTS page
↑ Osada, M et al. (1998) Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat. Med. 4 839-43 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:25417702-2] 2.0 ^2.1 ^2.2 ^2.3 Stindt, MH et al. (2015) Functional interplay between MDM2, p63/p73 and mutant p53. Oncogene 34 4300-10 PubMed GONUTS page

[PMID:19451233-3] 3.0 ^3.1 ^3.2 ^3.3 Li, Y et al. (2009) Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation. Mol. Cell. Biol. 29 3953-63 PubMed GONUTS page

[PMID:22521434-4] 4.0 ^4.1 ^4.2 Chen, K et al. (2012) Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR. Bone 51 69-77 PubMed GONUTS page

[PMID:9774969-5] 5.0 ^5.1 ^5.2 Yang, A et al. (1998) p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell 2 305-16 PubMed GONUTS page

[PMID:10373484-6] Davison, TS et al. (1999) p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53. J. Biol. Chem. 274 18709-14 PubMed GONUTS page

[PMID:16343436-7] Osada, M et al. (2006) A novel response element confers p63- and p73-specific activation of the WNT4 promoter. Biochem. Biophys. Res. Commun. 339 1120-8 PubMed GONUTS page

[PMID:12446784-8] 8.0 ^8.1 Ghioni, P et al. (2002) Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains. Mol. Cell. Biol. 22 8659-68 PubMed GONUTS page

[PMID:11641404-9] Sasaki, Y et al. (2002) The p53 family member genes are involved in the Notch signal pathway. J. Biol. Chem. 277 719-24 PubMed GONUTS page

[PMID:12446779-10] 10.0 ^10.1 Serber, Z et al. (2002) A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism. Mol. Cell. Biol. 22 8601-11 PubMed GONUTS page

[PMID:9662346-11] Trink, B et al. (1998) A new human p53 homologue. Nat. Med. 4 747-8 PubMed GONUTS page

[PMID:10657951-12] 12.0 ^12.1 Hall, PA et al. (2000) Expression of the p53 homologue p63alpha and deltaNp63alpha in normal and neoplastic cells. Carcinogenesis 21 153-60 PubMed GONUTS page

[PMID:11106548-13] Signoretti, S et al. (2000) p63 is a prostate basal cell marker and is required for prostate development. Am. J. Pathol. 157 1769-75 PubMed GONUTS page

[PMID:21464285-14] Chen, C et al. (2011) Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elements. Proc. Natl. Acad. Sci. U.S.A. 108 6456-61 PubMed GONUTS page

[PMID:21335238-15] Deutsch, GB et al. (2011) DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer. Cell 144 566-76 PubMed GONUTS page

[PMID:19815500-16] Joerger, AC et al. (2009) Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proc. Natl. Acad. Sci. U.S.A. 106 17705-10 PubMed GONUTS page

[PMID:20123734-17] 17.0 ^17.1 ^17.2 Heyne, K et al. (2010) NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle. Nucleic Acids Res. 38 3159-71 PubMed GONUTS page

[PMID:9662378-18] Osada, M et al. (1998) Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat. Med. 4 839-43 PubMed GONUTS page

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HUMAN:P63

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