HUMAN:NRAM2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SLC11A2 (synonyms: DCT1, DMT1, NRAMP2)
Protein Name(s)	Natural resistance-associated macrophage protein 2 NRAMP 2 Divalent cation transporter 1 Divalent metal transporter 1 DMT-1 Solute carrier family 11 member 2
External Links
UniProt	P49281
EMBL	AB004857 AB015355 AF064482 AF064476 AF064477 AF064478 AF064479 AF064480 AF064481 AF064483 AF064476 AF064477 AF064478 AF064479 AF064480 AF064481 AF064482 AF064484 AJ493662 AF046997 AK094735 AK296445 AK316507 AB062284 AC087884 CH471111 BC002592 BC100014 L37347
CCDS	CCDS53791.1 CCDS53792.1 CCDS53793.1 CCDS8805.1
PIR	I57022
RefSeq	NP_000608.1 NP_001167596.1 NP_001167597.1 NP_001167598.1 NP_001167599.1 NP_001167600.1 NP_001167601.1 XP_005268968.1
UniGene	Hs.505545
ProteinModelPortal	P49281
BioGrid	110950
DIP	DIP-48957N
IntAct	P49281
STRING	9606.ENSP00000262052
BindingDB	P49281
ChEMBL	CHEMBL1932895
TCDB	2.A.55.2.1
PhosphoSite	P49281
DMDM	8247934
MaxQB	P49281
PaxDb	P49281
PRIDE	P49281
DNASU	4891
Ensembl	ENST00000262051 ENST00000262052 ENST00000394904 ENST00000541174 ENST00000545993 ENST00000546636 ENST00000547198 ENST00000547688
GeneID	4891
KEGG	hsa:4891
UCSC	uc001rxc.4 uc001rxh.2 uc001rxk.2
CTD	4891
GeneCards	GC12M051375
HGNC	HGNC:10908
HPA	HPA032139 HPA032140
MIM	206100 600523
neXtProt	NX_P49281
Orphanet	83642
PharmGKB	PA259
eggNOG	COG1914
GeneTree	ENSGT00390000006526
HOVERGEN	HBG052665
InParanoid	P49281
KO	K12347
OMA	AFHFNGH
OrthoDB	EOG77127K
PhylomeDB	P49281
TreeFam	TF315185
Reactome	REACT_20547 REACT_25060
ChiTaRS	SLC11A2
GeneWiki	DMT1
GenomeRNAi	4891
NextBio	18825
PRO	PR:P49281
Proteomes	UP000005640
Bgee	P49281
CleanEx	HS_SLC11A2
ExpressionAtlas	P49281
Genevestigator	P49281
GO	GO:0045177 GO:0016324 GO:0045178 GO:0005903 GO:0009986 GO:0005737 GO:0031410 GO:0005769 GO:0005887 GO:0005770 GO:0031902 GO:0005765 GO:0005764 GO:0016020 GO:0005634 GO:0070826 GO:0048471 GO:0005886 GO:0055037 GO:0005802 GO:0005773 GO:0046870 GO:0015086 GO:0050897 GO:0015087 GO:0005507 GO:0005375 GO:0015093 GO:0015078 GO:0022890 GO:0005506 GO:0015094 GO:0030145 GO:0005384 GO:0016151 GO:0015099 GO:0015295 GO:0015100 GO:0008270 GO:0005385 GO:0006919 GO:0070574 GO:0098655 GO:0006878 GO:0006879 GO:0071456 GO:0071281 GO:0034599 GO:0071356 GO:0006824 GO:1902861 GO:0035434 GO:0006825 GO:0048813 GO:0003032 GO:0048821 GO:0070627 GO:0015684 GO:0006783 GO:0015692 GO:0007611 GO:0071421 GO:0006828 GO:0060586 GO:0035444 GO:0015675 GO:0046686 GO:0001666 GO:0010039 GO:0010288 GO:0010042 GO:0055085 GO:0015676 GO:0071577
HAMAP	MF_00221
InterPro	IPR001046
PANTHER	PTHR11706
Pfam	PF01566
PRINTS	PR00447
TIGRFAMs	TIGR01197

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001666	response to hypoxia	PMID:18419598^[1]	ECO:0000270			P		for both P49281-1 and P49281-2 isoforms	complete
	GO:0003032	detection of oxygen	PMID:18419598^[1]	ECO:0000270			P		Positive for P49281-1 and a NOT annotation for P49281-2	complete
	GO:0006919	activation of caspase activity	PMID:18082289^[2]	ECO:0000314			P			complete
	GO:0010039	response to iron ion	PMID:15792797^[3],18082289,11943663,17109629,1273410,122090117	ECO:0000270			P			complete
	GO:0005375	copper ion transmembrane transporter activity	PMID:12734107^[4]	ECO:0000314			F			complete
	GO:0005384	manganese ion transmembrane transporter activity	PMID:17293870^[5]	ECO:0000314			F			complete
	GO:0005737	cytoplasm	PMID:11891802^[6]	ECO:0000314			C			complete
	GO:0005765	lysosomal membrane	PMID:10751401^[7]	ECO:0000314			C			complete
	GO:0070574	cadmium ion transmembrane transport	PMID:18082289^[2], PMID:12662899^[8]	ECO:0000314			P			complete
	GO:0005886	plasma membrane	PMID:11891802^[6],17932044	ECO:0000315			C			complete
	GO:0006825	copper ion transport	PMID:12734107^[4]	ECO:0000314			P			complete
	GO:0070826	paraferritin complex	PMID:11842004^[9]	ECO:0000314			C			complete
	GO:0006828	manganese ion transport	PMID:17293870^[5]	ECO:0000314		P	P			complete
	GO:0015086	cadmium ion transmembrane transporter activity	PMID:12662899^[8]	ECO:0000314		F	F			complete
	GO:0015093	ferrous iron transmembrane transporter activity	PMID:17293870^[5]	ECO:0000314			F			complete
	GO:0015094	lead ion transmembrane transporter activity	PMID:12127992^[10]	ECO:0000314			F			complete
	GO:0005384	manganese ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314			F			complete
NOT	GO:0005385	zinc ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314			F			complete
	GO:0005634	nucleus	PMID:15880641^[12]	ECO:0000314			C			complete
	GO:0005769	early endosome	PMID:15880641^[12]	ECO:0000314			C			complete
	GO:0006824	cobalt ion transport	PMID:17109629^[11]	ECO:0000314			P			complete
	GO:0006828	manganese ion transport	PMID:17109629^[11]	ECO:0000314			P		P	complete
NOT	GO:0015085	calcium ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314			F		F	complete
	GO:0015086	cadmium ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314			F			complete
	GO:0015087	cobalt ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314			F			complete
	GO:0015093	ferrous iron transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314			F			complete
	GO:0015094	lead ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314			F			complete
	GO:0015099	nickel ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314			F			complete
	GO:0015100	vanadium ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314			F			complete
	GO:0070627	ferrous iron import	PMID:17109629^[11]	ECO:0000314			P			complete
	GO:0015692	lead ion transport	PMID:12127992^[10]	ECO:0000314			P			complete
	GO:0015295	solute:hydrogen symporter activity	PMID:17109629^[11]	ECO:0000314			F			complete
	GO:0015675	nickel ion transport	PMID:17109629^[11]	ECO:0000314			P			complete
	GO:0015676	vanadium ion transport	PMID:17109629^[11]	ECO:0000314			P			complete
	GO:0015692	lead ion transport	PMID:17109629^[11]	ECO:0000314			P			complete
	GO:0031902	late endosome membrane	PMID:10751401^[7]	ECO:0000314			C			complete
	GO:0031410	cytoplasmic vesicle	PMID:15880641^[12]	ECO:0000314			C			complete
	GO:0048471	perinuclear region of cytoplasm	PMID:10751401^[7]	ECO:0000314			C			complete
	GO:0045178	basal part of cell	PMID:15880641^[12]	ECO:0000314			C			complete
	GO:0055037	recycling endosome	PMID:15880641^[12]	ECO:0000314			C			complete
	GO:0005634	nucleus	PMID:18419598^[1]	ECO:0000314			C			complete
	GO:0005737	cytoplasm	PMID:18419598^[1]	ECO:0000314			C			complete
	GO:0005769	early endosome	PMID:12475959^[13]	ECO:0000314			C			complete
	GO:0005770	late endosome	PMID:18876082^[14]	ECO:0000314			C			complete
	GO:0005802	trans-Golgi network	PMID:18776082^[15]	ECO:0000314			C			complete
	GO:0009986	cell surface	PMID:12475959^[13]	ECO:0000314			C			complete
NOT	GO:0010039	response to iron ion	PMID:15792797^[3]	ECO:0000270		P	P			complete
	GO:0015082	di-, tri-valent inorganic cation transmembrane transporter activity	PMID:12475959^[13]	ECO:0000316		UniProtKB:Q10177	F			complete
	GO:0016324	apical plasma membrane	PMID:12475959^[13], PMID:15880641^[12]	ECO:0000314			C			complete
	GO:0048471	perinuclear region of cytoplasm	PMID:18776082^[15]	ECO:0000314			C			complete
	GO:0005737	cytoplasm	PMID:18419598^[1]	ECO:0000314			C			complete
	GO:0005764	lysosome	PMID:12475959^[13]	ECO:0000314			C			complete
	GO:0005769	early endosome	PMID:18776082^[15]	ECO:0000314			C			complete
	GO:0006915	apoptosis	PMID:18082289^[2]	ECO:0000314			P			complete
	GO:0015082	di-, tri-valent inorganic cation transmembrane transporter activity	PMID:12475959^[13]	ECO:0000316		UniProtKB:Q10177	F		P49281-1	complete
	GO:0048471	perinuclear region of cytoplasm	PMID:12475959^[13]	ECO:0000314			C		P49281-2	complete
	GO:0055037	recycling endosome	PMID:18776082^[15]	ECO:0000314			C			complete
	GO:0034599	cellular response to oxidative stress	PMID:18082289^[2]	ECO:0000314			P			complete
involved_in	GO:0034755	iron ion transmembrane transport	PMID:17293870^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_start_location:(GO:0005768) has_end_location:(GO:0005829) has_direct_input:(CHEBI:29033)	Seeded From UniProt	complete
part_of	GO:1903561	extracellular vesicle	PMID:27462458^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031526	brush border membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49282	C	part_of:(UBERON:0002114)	Seeded From UniProt	complete
involved_in	GO:0033212	iron import into cell	PMID:9990067^[17]	ECO:0000303	author statement without traceable support used in manual assertion		P	occurs_in:(CL:1000338)	Seeded From UniProt	complete
enables	GO:0015093	ferrous iron transmembrane transporter activity	PMID:9990067^[17]	ECO:0000303	author statement without traceable support used in manual assertion		F	part_of:(CL:1000338)	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:25491917^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:25491917^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0015093	ferrous iron transmembrane transporter activity	PMID:25491917^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046870	cadmium ion binding	PMID:25326704^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046915	transition metal ion transmembrane transporter activity	PMID:25326704^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:25326704^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070574	cadmium ion transmembrane transport	PMID:25326704^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[20]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070574	cadmium ion transmembrane transport	PMID:12662899^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060586	multicellular organismal iron ion homeostasis	PMID:15459009^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:10751401^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031902	late endosome membrane	PMID:10751401^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0015692	lead ion transport	PMID:12127992^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006826	iron ion transport	PMID:12734107^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006826	iron ion transport	PMID:17293870^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0015094	lead ion transmembrane transporter activity	PMID:12127992^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015093	ferrous iron transmembrane transporter activity	PMID:12734107^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015093	ferrous iron transmembrane transporter activity	PMID:17293870^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015086	cadmium ion transmembrane transporter activity	PMID:12662899^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006828	manganese ion transport	PMID:17293870^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006825	copper ion transport	PMID:12734107^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17932044^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11891802^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005773	vacuole	PMID:17932044^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	PMID:10751401^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11891802^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005384	manganese ion transmembrane transporter activity	PMID:17293870^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005375	copper ion transmembrane transporter activity	PMID:12734107^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0070826	paraferritin complex	PMID:11842004^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	PMID:15880641^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045178	basal part of cell	PMID:15880641^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:15880641^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:15880641^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:15880641^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0015295	solute:proton symporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010039	response to iron ion	PMID:17109629^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010039	response to iron ion	PMID:12734107^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:15880641^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	PMID:17897319^[23]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15880641^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:1903561	extracellular vesicle	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 UniProtKB:P49281	C		Seeded From UniProt	complete
involved_in	GO:0060586	multicellular organismal iron ion homeostasis	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 UniProtKB:P49281	P		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 UniProtKB:P49281	C		Seeded From UniProt	complete
enables	GO:0050897	cobalt ion binding	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684	F		Seeded From UniProt	complete
enables	GO:0046870	cadmium ion binding	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	F		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	C		Seeded From UniProt	complete
part_of	GO:0031902	late endosome membrane	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	C		Seeded From UniProt	complete
enables	GO:0030145	manganese ion binding	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684	F		Seeded From UniProt	complete
enables	GO:0016151	nickel cation binding	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684	F		Seeded From UniProt	complete
enables	GO:0015295	solute:proton symporter activity	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 UniProtKB:P49281	F		Seeded From UniProt	complete
enables	GO:0015099	nickel cation transmembrane transporter activity	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	F		Seeded From UniProt	complete
enables	GO:0015094	lead ion transmembrane transporter activity	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	F		Seeded From UniProt	complete
enables	GO:0015093	ferrous iron transmembrane transporter activity	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	F		Seeded From UniProt	complete
enables	GO:0015087	cobalt ion transmembrane transporter activity	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	F		Seeded From UniProt	complete
enables	GO:0015086	cadmium ion transmembrane transporter activity	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG14157 PANTHER:PTN000194431 RGD:3684 TAIR:locus:2025677 TAIR:locus:2200437 UniProtKB:P49281 UniProtKB:P51027	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 UniProtKB:P49281	C		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 UniProtKB:P49281	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194437 UniProtKB:P49279 UniProtKB:P49281 UniProtKB:P51027	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 UniProtKB:P49281	C		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	C		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684	F		Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684	F		Seeded From UniProt	complete
enables	GO:0005384	manganese ion transmembrane transporter activity	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG14157 FB:FBgn0011672 MGI:MGI:1345275 PANTHER:PTN000194431 RGD:3684 TAIR:locus:2025677 TAIR:locus:2036751 UniProtKB:P49281 UniProtKB:Q6ZG85	F		Seeded From UniProt	complete
enables	GO:0005384	manganese ion transmembrane transporter activity	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG14157 FB:FBgn0011672 MGI:MGI:1345275 PANTHER:PTN000194431 RGD:3684 TAIR:locus:2025677 TAIR:locus:2036751 UniProtKB:P49281	F		Seeded From UniProt	complete
enables	GO:0005381	iron ion transmembrane transporter activity	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 RGD:3684	F		Seeded From UniProt	complete
enables	GO:0005375	copper ion transmembrane transporter activity	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035434	copper ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005375	P		Seeded From UniProt	complete
involved_in	GO:0035434	copper ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005375	P		Seeded From UniProt	complete
involved_in	GO:0035444	nickel cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015099	P		Seeded From UniProt	complete
involved_in	GO:0071421	manganese ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005384	P		Seeded From UniProt	complete
involved_in	GO:0071421	manganese ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005384	P		Seeded From UniProt	complete
involved_in	GO:0071421	manganese ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005384	P		Seeded From UniProt	complete
involved_in	GO:1902600	proton transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015295	P		Seeded From UniProt	complete
involved_in	GO:1902600	proton transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015295	P		Seeded From UniProt	complete
part_of	GO:1903561	extracellular vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49282 ensembl:ENSMUSP00000023774	C		Seeded From UniProt	complete
involved_in	GO:0060586	multicellular organismal iron ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49282 ensembl:ENSMUSP00000023774	P		Seeded From UniProt	complete
involved_in	GO:0048821	erythrocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49282 ensembl:ENSMUSP00000023774	P		Seeded From UniProt	complete
involved_in	GO:0048813	dendrite morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49282 ensembl:ENSMUSP00000023774	P		Seeded From UniProt	complete
involved_in	GO:0033212	iron import into cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49282 ensembl:ENSMUSP00000023774	P		Seeded From UniProt	complete
part_of	GO:0031526	brush border membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49282 ensembl:ENSMUSP00000023774	C		Seeded From UniProt	complete
enables	GO:0015087	cobalt ion transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49282 ensembl:ENSMUSP00000023774	F		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49282 ensembl:ENSMUSP00000023774	P		Seeded From UniProt	complete
involved_in	GO:0006826	iron ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49282 ensembl:ENSMUSP00000023774	P		Seeded From UniProt	complete
involved_in	GO:0006824	cobalt ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49282 ensembl:ENSMUSP00000023774	P		Seeded From UniProt	complete
involved_in	GO:0006783	heme biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49282 ensembl:ENSMUSP00000023774	P		Seeded From UniProt	complete
involved_in	GO:0006779	porphyrin-containing compound biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49282 ensembl:ENSMUSP00000023774	P		Seeded From UniProt	complete
involved_in	GO:0006778	porphyrin-containing compound metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49282 ensembl:ENSMUSP00000023774	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49282 ensembl:ENSMUSP00000023774	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49282 ensembl:ENSMUSP00000023774	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001046	C		Seeded From UniProt	complete
involved_in	GO:0030001	metal ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001046	P		Seeded From UniProt	complete
enables	GO:0046873	metal ion transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001046	F		Seeded From UniProt	complete
enables	GO:1905394	retromer complex binding	PMID:20164305^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0033212	iron import into cell	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:12475959^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:18776082^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0022890	inorganic cation transmembrane transporter activity	PMID:12475959^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q10177	F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:12475959^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0015093	ferrous iron transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
NOT\|involved_in	GO:0010039	response to iron ion	PMID:15792797^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:12475959^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:18776082^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:18776082^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:15792797^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:12475959^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18419598^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18419598^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
NOT\|involved_in	GO:0003032	detection of oxygen	PMID:18419598^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:18419598^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034755	iron ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015093	P		Seeded From UniProt	complete
involved_in	GO:0072511	divalent inorganic cation transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015093	P		Seeded From UniProt	complete
involved_in	GO:0098655	cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022890	P		Seeded From UniProt	complete
involved_in	GO:0010039	response to iron ion	PMID:12209011^[26]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033212	iron import into cell	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070574	cadmium ion transmembrane transport	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	PMID:18776082^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:12475959^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:18082289^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0022890	inorganic cation transmembrane transporter activity	PMID:12475959^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q10177	F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:12475959^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:15792797^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0015692	lead ion transport	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006826	iron ion transport	PMID:18082289^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0015675	nickel cation transport	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0015100	vanadium ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015099	nickel cation transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015094	lead ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015093	ferrous iron transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015087	cobalt ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015086	cadmium ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010039	response to iron ion	PMID:15792797^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010039	response to iron ion	PMID:18082289^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:18082289^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006828	manganese ion transport	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006824	cobalt ion transport	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15792797^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:18776082^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:15792797^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:18776082^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:12475959^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:18776082^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:12475959^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18419598^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18419598^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005385	zinc ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005384	manganese ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003032	detection of oxygen	PMID:18419598^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:18419598^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0015676	vanadium ion transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015100	P		Seeded From UniProt	complete
involved_in	GO:0034755	iron ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015093	P		Seeded From UniProt	complete
involved_in	GO:0035444	nickel cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015099	P		Seeded From UniProt	complete
involved_in	GO:0071421	manganese ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005384	P		Seeded From UniProt	complete
involved_in	GO:0071577	zinc ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005385	P		Seeded From UniProt	complete
NOT\|enables	GO:0070835	chromium ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0033212	iron import into cell	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070574	cadmium ion transmembrane transport	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0015692	lead ion transport	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0015676	vanadium ion transport	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0015675	nickel cation transport	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0015100	vanadium ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015099	nickel cation transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015094	lead ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015093	ferrous iron transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015087	cobalt ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015086	cadmium ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
NOT\|enables	GO:0015085	calcium ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006828	manganese ion transport	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006824	cobalt ion transport	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
NOT\|enables	GO:0005385	zinc ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005384	manganese ion transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0034755	iron ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015093	P		Seeded From UniProt	complete
involved_in	GO:0035444	nickel cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015099	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015085	P		Seeded From UniProt	complete
involved_in	GO:0071421	manganese ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005384	P		Seeded From UniProt	complete
involved_in	GO:0071577	zinc ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005385	P		Seeded From UniProt	complete
involved_in	GO:0033212	iron import into cell	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0015093	ferrous iron transmembrane transporter activity	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17109629^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034755	iron ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015093	P		Seeded From UniProt	complete
involved_in	GO:0072511	divalent inorganic cation transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015093	P		Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	Reactome:R-HSA-917937	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-435349	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005381	iron ion transmembrane transporter activity	Reactome:R-HSA-435349	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
involved_in	GO:0055072	iron ion homeostasis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0410	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 Li, Z et al. (2008) Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells. J. Cell. Mol. Med. 12 569-79 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Xu, HM et al. (2008) Over-expressed human divalent metal transporter 1 is involved in iron accumulation in MES23.5 cells. Neurochem. Int. 52 1044-51 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Johnson, DM et al. (2005) Regulation of divalent metal transporter expression in human intestinal epithelial cells following exposure to non-haem iron. FEBS Lett. 579 1923-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Arredondo, M et al. (2003) DMT1, a physiologically relevant apical Cu1+ transporter of intestinal cells. Am. J. Physiol., Cell Physiol. 284 C1525-30 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Ludwiczek, S et al. (2007) Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. Nat. Med. 13 448-54 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Simovich, MJ et al. (2002) Cellular location of proteins related to iron absorption and transport. Am. J. Hematol. 69 164-70 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Tabuchi, M et al. (2000) Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells. J. Biol. Chem. 275 22220-8 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Okubo, M et al. (2003) Cadmium transport by human Nramp 2 expressed in Xenopus laevis oocytes. Toxicol. Appl. Pharmacol. 187 162-7 PubMed GONUTS page
↑ ^9.0 ^9.1 Umbreit, JN et al. (2002) The ferrireductase paraferritin contains divalent metal transporter as well as mobilferrin. Am. J. Physiol. Gastrointest. Liver Physiol. 282 G534-9 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 I Bannon, D et al. (2002) Uptake of lead and iron by divalent metal transporter 1 in yeast and mammalian cells. Biochem. Biophys. Res. Commun. 295 978-84 PubMed GONUTS page
↑ ^11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 ^11.14 ^11.15 ^11.16 ^11.17 ^11.18 ^11.19 ^11.20 ^11.21 ^11.22 ^11.23 ^11.24 ^11.25 ^11.26 ^11.27 ^11.28 ^11.29 ^11.30 ^11.31 ^11.32 ^11.33 ^11.34 ^11.35 ^11.36 ^11.37 ^11.38 ^11.39 ^11.40 ^11.41 ^11.42 ^11.43 ^11.44 ^11.45 ^11.46 ^11.47 ^11.48 ^11.49 ^11.50 ^11.51 ^11.52 ^11.53 ^11.54 ^11.55 ^11.56 Mackenzie, B et al. (2007) Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1). Biochem. J. 403 59-69 PubMed GONUTS page
↑ ^12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 Gruper, Y et al. (2005) Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells. J. Cell. Physiol. 204 901-12 PubMed GONUTS page
↑ ^13.00 ^13.01 ^13.02 ^13.03 ^13.04 ^13.05 ^13.06 ^13.07 ^13.08 ^13.09 ^13.10 ^13.11 ^13.12 ^13.13 ^13.14 ^13.15 ^13.16 Tabuchi, M et al. (2002) Alternative splicing regulates the subcellular localization of divalent metal transporter 1 isoforms. Mol. Biol. Cell 13 4371-87 PubMed GONUTS page
↑ TEGLBJAERG, S (1948) [Not Available]. Nord Med 38 849 PubMed GONUTS page
↑ ^15.00 ^15.01 ^15.02 ^15.03 ^15.04 ^15.05 ^15.06 ^15.07 ^15.08 ^15.09 ^15.10 Foot, NJ et al. (2008) Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood 112 4268-75 PubMed GONUTS page
↑ Mackenzie, K et al. (2016) Regulation of the divalent metal ion transporter via membrane budding. Cell Discov 2 16011 PubMed GONUTS page
↑ ^17.0 ^17.1 Waheed, A et al. (1999) Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. Proc. Natl. Acad. Sci. U.S.A. 96 1579-84 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Yanatori, I et al. (2015) Inhibition of iron uptake by ferristatin II is exerted through internalization of DMT1 at the plasma membrane. Cell Biol. Int. 39 427-34 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Ehrnstorfer, IA et al. (2014) Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport. Nat. Struct. Mol. Biol. 21 990-6 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Mims, MP et al. (2005) Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload. Blood 105 1337-42 PubMed GONUTS page
↑ ^22.0 ^22.1 Techau, ME et al. (2007) Evolution of differences in transport function in Slc11a family members. J. Biol. Chem. 282 35646-56 PubMed GONUTS page
↑ Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page
↑ ^24.00 ^24.01 ^24.02 ^24.03 ^24.04 ^24.05 ^24.06 ^24.07 ^24.08 ^24.09 ^24.10 ^24.11 ^24.12 ^24.13 ^24.14 ^24.15 ^24.16 ^24.17 ^24.18 ^24.19 ^24.20 ^24.21 ^24.22 ^24.23 ^24.24 ^24.25 ^24.26 ^24.27 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Tabuchi, M et al. (2010) Retromer-mediated direct sorting is required for proper endosomal recycling of the mammalian iron transporter DMT1. J. Cell. Sci. 123 756-66 PubMed GONUTS page
↑ Hubert, N & Hentze, MW (2002) Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc. Natl. Acad. Sci. U.S.A. 99 12345-50 PubMed GONUTS page

[PMID:18419598-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 Li, Z et al. (2008) Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells. J. Cell. Mol. Med. 12 569-79 PubMed GONUTS page

[PMID:18082289-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Xu, HM et al. (2008) Over-expressed human divalent metal transporter 1 is involved in iron accumulation in MES23.5 cells. Neurochem. Int. 52 1044-51 PubMed GONUTS page

[PMID:15792797-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Johnson, DM et al. (2005) Regulation of divalent metal transporter expression in human intestinal epithelial cells following exposure to non-haem iron. FEBS Lett. 579 1923-9 PubMed GONUTS page

[PMID:12734107-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Arredondo, M et al. (2003) DMT1, a physiologically relevant apical Cu1+ transporter of intestinal cells. Am. J. Physiol., Cell Physiol. 284 C1525-30 PubMed GONUTS page

[PMID:17293870-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Ludwiczek, S et al. (2007) Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. Nat. Med. 13 448-54 PubMed GONUTS page

[PMID:11891802-6] 6.0 ^6.1 ^6.2 ^6.3 Simovich, MJ et al. (2002) Cellular location of proteins related to iron absorption and transport. Am. J. Hematol. 69 164-70 PubMed GONUTS page

[PMID:10751401-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Tabuchi, M et al. (2000) Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells. J. Biol. Chem. 275 22220-8 PubMed GONUTS page

[PMID:12662899-8] 8.0 ^8.1 ^8.2 ^8.3 Okubo, M et al. (2003) Cadmium transport by human Nramp 2 expressed in Xenopus laevis oocytes. Toxicol. Appl. Pharmacol. 187 162-7 PubMed GONUTS page

[PMID:11842004-9] 9.0 ^9.1 Umbreit, JN et al. (2002) The ferrireductase paraferritin contains divalent metal transporter as well as mobilferrin. Am. J. Physiol. Gastrointest. Liver Physiol. 282 G534-9 PubMed GONUTS page

[PMID:12127992-10] 10.0 ^10.1 ^10.2 ^10.3 I Bannon, D et al. (2002) Uptake of lead and iron by divalent metal transporter 1 in yeast and mammalian cells. Biochem. Biophys. Res. Commun. 295 978-84 PubMed GONUTS page

[PMID:17109629-11] 11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 ^11.14 ^11.15 ^11.16 ^11.17 ^11.18 ^11.19 ^11.20 ^11.21 ^11.22 ^11.23 ^11.24 ^11.25 ^11.26 ^11.27 ^11.28 ^11.29 ^11.30 ^11.31 ^11.32 ^11.33 ^11.34 ^11.35 ^11.36 ^11.37 ^11.38 ^11.39 ^11.40 ^11.41 ^11.42 ^11.43 ^11.44 ^11.45 ^11.46 ^11.47 ^11.48 ^11.49 ^11.50 ^11.51 ^11.52 ^11.53 ^11.54 ^11.55 ^11.56 Mackenzie, B et al. (2007) Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1). Biochem. J. 403 59-69 PubMed GONUTS page

[PMID:15880641-12] 12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 Gruper, Y et al. (2005) Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells. J. Cell. Physiol. 204 901-12 PubMed GONUTS page

[PMID:12475959-13] 13.00 ^13.01 ^13.02 ^13.03 ^13.04 ^13.05 ^13.06 ^13.07 ^13.08 ^13.09 ^13.10 ^13.11 ^13.12 ^13.13 ^13.14 ^13.15 ^13.16 Tabuchi, M et al. (2002) Alternative splicing regulates the subcellular localization of divalent metal transporter 1 isoforms. Mol. Biol. Cell 13 4371-87 PubMed GONUTS page

[PMID:18876082-14] TEGLBJAERG, S (1948) [Not Available]. Nord Med 38 849 PubMed GONUTS page

[PMID:18776082-15] 15.00 ^15.01 ^15.02 ^15.03 ^15.04 ^15.05 ^15.06 ^15.07 ^15.08 ^15.09 ^15.10 Foot, NJ et al. (2008) Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood 112 4268-75 PubMed GONUTS page

[PMID:27462458-16] Mackenzie, K et al. (2016) Regulation of the divalent metal ion transporter via membrane budding. Cell Discov 2 16011 PubMed GONUTS page

[PMID:9990067-17] 17.0 ^17.1 Waheed, A et al. (1999) Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. Proc. Natl. Acad. Sci. U.S.A. 96 1579-84 PubMed GONUTS page

[PMID:25491917-18] 18.0 ^18.1 ^18.2 Yanatori, I et al. (2015) Inhibition of iron uptake by ferristatin II is exerted through internalization of DMT1 at the plasma membrane. Cell Biol. Int. 39 427-34 PubMed GONUTS page

[PMID:25326704-19] 19.0 ^19.1 ^19.2 ^19.3 Ehrnstorfer, IA et al. (2014) Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport. Nat. Struct. Mol. Biol. 21 990-6 PubMed GONUTS page

[PMID:19946888-20] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:15459009-21] Mims, MP et al. (2005) Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload. Blood 105 1337-42 PubMed GONUTS page

[PMID:17932044-22] 22.0 ^22.1 Techau, ME et al. (2007) Evolution of differences in transport function in Slc11a family members. J. Biol. Chem. 282 35646-56 PubMed GONUTS page

[PMID:17897319-23] Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page

[PMID:21873635-24] 24.00 ^24.01 ^24.02 ^24.03 ^24.04 ^24.05 ^24.06 ^24.07 ^24.08 ^24.09 ^24.10 ^24.11 ^24.12 ^24.13 ^24.14 ^24.15 ^24.16 ^24.17 ^24.18 ^24.19 ^24.20 ^24.21 ^24.22 ^24.23 ^24.24 ^24.25 ^24.26 ^24.27 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20164305-25] Tabuchi, M et al. (2010) Retromer-mediated direct sorting is required for proper endosomal recycling of the mammalian iron transporter DMT1. J. Cell. Sci. 123 756-66 PubMed GONUTS page

[PMID:12209011-26] Hubert, N & Hentze, MW (2002) Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc. Natl. Acad. Sci. U.S.A. 99 12345-50 PubMed GONUTS page

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HUMAN:NRAM2

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