HUMAN:NOS1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NOS1
Protein Name(s)	Nitric oxide synthase, brain Constitutive NOS NC-NOS NOS type I Neuronal NOS N-NOS nNOS Peptidyl-cysteine S-nitrosylase NOS1 bNOS
External Links
UniProt	P29475
EMBL	U17327 U17326 U17299 U17300 U17301 U17302 U17303 U17304 U17305 U17307 U17308 U17309 U17310 U17311 U17312 U17313 U17314 U17315 U17316 U17317 U17318 U17319 U17320 U17321 U17322 U17323 U17324 U17325 D16408 L02881 U31466 U66362 AY445095 AC026364 AC068799 AC073864 AJ004918
CCDS	CCDS41842.1 CCDS55890.1
PIR	G01946
RefSeq	NP_000611.1 NP_001191142.1 NP_001191143.1 NP_001191147.1 XP_006719489.1 XP_006719490.1 XP_006719491.1
UniGene	Hs.654410 Hs.684465 Hs.684466 Hs.684467 Hs.735734
PDB	4D1N
PDBsum	4D1N
ProteinModelPortal	P29475
SMR	P29475
BioGrid	110905
DIP	DIP-40999N
IntAct	P29475
MINT	MINT-122019
STRING	9606.ENSP00000320758
BindingDB	P29475
ChEMBL	CHEMBL2096621
DrugBank	DB00997 DB03147 DB00155
GuidetoPHARMACOLOGY	1251
PhosphoSite	P29475
DMDM	1709333
MaxQB	P29475
PaxDb	P29475
PRIDE	P29475
DNASU	4842
Ensembl	ENST00000317775 ENST00000338101 ENST00000618760
GeneID	4842
KEGG	hsa:4842
UCSC	uc001twm.2
CTD	4842
GeneCards	GC12M117636
HGNC	HGNC:7872
HPA	CAB002167
MIM	163731
neXtProt	NX_P29475
PharmGKB	PA252
eggNOG	COG4362
GeneTree	ENSGT00620000087711
HOGENOM	HOG000220884
HOVERGEN	HBG000159
InParanoid	P29475
KO	K13240
OMA	DPANVQF
OrthoDB	EOG79SDW7
PhylomeDB	P29475
TreeFam	TF324410
BioCyc	MetaCyc:HS01647-MONOMER
Reactome	REACT_121256 REACT_23862
ChiTaRS	NOS1
GeneWiki	NOS1
GenomeRNAi	4842
NextBio	18658
PMAP-CutDB	P29475
PRO	PR:P29475
Proteomes	UP000005640
Bgee	P29475
CleanEx	HS_NOS1
ExpressionAtlas	P29475
Genevestigator	P29475
GO	GO:0005737 GO:0005856 GO:0005829 GO:0043197 GO:0045121 GO:0005739 GO:0048471 GO:0001917 GO:0043234 GO:0042383 GO:0016529 GO:0045202 GO:0034618 GO:0046870 GO:0050660 GO:0010181 GO:0020037 GO:0044325 GO:0005506 GO:0050661 GO:0003958 GO:0004517 GO:0016491 GO:0097110 GO:0017080 GO:0034617 GO:0006527 GO:0007596 GO:0071363 GO:0042738 GO:0051701 GO:0033555 GO:0007520 GO:0045776 GO:0051926 GO:0010523 GO:0051346 GO:0043267 GO:0051612 GO:0042136 GO:0006809 GO:0007263 GO:0018119 GO:0090382 GO:0031284 GO:0035066 GO:1902307 GO:0098735 GO:0045944 GO:0045893 GO:0045909 GO:0055117 GO:0002028 GO:0009408 GO:0001666 GO:0006941
Gene3D	1.20.990.10 2.30.42.10 3.40.50.360 3.90.340.10
InterPro	IPR003097 IPR017927 IPR001094 IPR008254 IPR001709 IPR029039 IPR023173 IPR012144 IPR004030 IPR001433 IPR001478 IPR017938
Pfam	PF00667 PF00258 PF00175 PF02898 PF00595
PIRSF	PIRSF000333
PRINTS	PR00369 PR00371
SMART	SM00228
SUPFAM	SSF50156 SSF52218 SSF56512 SSF63380
PROSITE	PS51384 PS50902 PS60001 PS50106

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004517	nitric-oxide synthase activity	PMID:1689048^[1]	ECO:0000314			F		figure 3	complete CACAO 4515
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:28089352^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P10636) occurs_in:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:27225184^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002129)	Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:1689048^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29476	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	C		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	F		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	P		Seeded From UniProt	complete
involved_in	GO:0051926	negative regulation of calcium ion transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	P		Seeded From UniProt	complete
involved_in	GO:0051612	negative regulation of serotonin uptake	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	P		Seeded From UniProt	complete
involved_in	GO:0051346	negative regulation of hydrolase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	P		Seeded From UniProt	complete
involved_in	GO:0043267	negative regulation of potassium ion transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	P		Seeded From UniProt	complete
involved_in	GO:0042738	exogenous drug catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	P		Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	P		Seeded From UniProt	complete
involved_in	GO:0018119	peptidyl-cysteine S-nitrosylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	P		Seeded From UniProt	complete
involved_in	GO:0006941	striated muscle contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	P		Seeded From UniProt	complete
involved_in	GO:0002028	regulation of sodium ion transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	P		Seeded From UniProt	complete
involved_in	GO:0098735	positive regulation of the force of heart contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	P		Seeded From UniProt	complete
involved_in	GO:1902307	positive regulation of sodium ion transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29476	P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29476	F		Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29476	F		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29476	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:17027776^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29476	C		Seeded From UniProt	complete
enables	GO:0046870	cadmium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29476	F		Seeded From UniProt	complete
involved_in	GO:0042311	vasodilation	PMID:18391107^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042311	vasodilation	PMID:18048451^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29476	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29476	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:7545544^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0034617	tetrahydrobiopterin binding	PMID:7488039^[8]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0033555	multicellular organismal response to stress	PMID:18391107^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29476	F		Seeded From UniProt	complete
involved_in	GO:0018119	peptidyl-cysteine S-nitrosylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29476	P		Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29476	F		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:9892689^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0010181	FMN binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29476	F		Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	PMID:18048451^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	PMID:7545544^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	P		Seeded From UniProt	complete
involved_in	GO:0006527	arginine catabolic process	PMID:7545544^[7]	ECO:0000305	curator inference used in manual assertion	GO:0004517	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:7545544^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	C		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:7545544^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0J4	F		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29476	F		Seeded From UniProt	complete
part_of	GO:0001917	photoreceptor inner segment	PMID:17027776^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29476	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:16276418^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0098924	retrograde trans-synaptic signaling by nitric oxide	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97360 PANTHER:PTN000454042	P		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10191 MGI:MGI:97361 PANTHER:PTN000453956 RGD:3184 RGD:68335 UniProtKB:O08336 UniProtKB:O08394 UniProtKB:Q9UBK8 UniProtKB:Q9UHB4	F		Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453988 RGD:3184	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97361 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186 ZFIN:ZDB-GENE-040305-1	P		Seeded From UniProt	complete
involved_in	GO:0031284	positive regulation of guanylate cyclase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 UniProtKB:P29473 UniProtKB:P29474	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97744 PANTHER:PTN000453956 UniProtKB:Q9UHB4	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000454042 RGD:3184	C		Seeded From UniProt	complete
part_of	GO:0012506	vesicle membrane	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186	C		Seeded From UniProt	complete
enables	GO:0010181	FMN binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10191 MGI:MGI:97361 PANTHER:PTN000453956 RGD:3184 RGD:68335 UniProtKB:O08336 UniProtKB:O08394 UniProtKB:Q9UBK8 UniProtKB:Q9UHB4	F		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002322100 RGD:3185	P		Seeded From UniProt	complete
involved_in	GO:0007263	nitric oxide mediated signal transduction	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 RGD:3184 ZFIN:ZDB-GENE-001101-1	P		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97360 MGI:MGI:97361 MGI:MGI:97362 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P29473 UniProtKB:P29474 UniProtKB:P35228	P		Seeded From UniProt	complete
involved_in	GO:0006527	arginine catabolic process	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97361 PANTHER:PTN001066032 RGD:3184 UniProtKB:P29473 UniProtKB:P29474 UniProtKB:P35228	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 RGD:3184 RGD:3186 UniProtKB:P29475	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453956 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P35228 UniProtKB:Q9SB48 UniProtKB:Q9UHB4	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453765 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P35228	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97362 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186	C		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011676 MGI:MGI:97360 MGI:MGI:97361 MGI:MGI:97362 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P29473 UniProtKB:P29474 UniProtKB:P29475 UniProtKB:P35228	F		Seeded From UniProt	complete
enables	GO:0003958	NADPH-hemoprotein reductase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453763 PomBase:SPBC29A10.01 RGD:68335 SGD:S000001084 TAIR:locus:2128951 UniProtKB:A0A1D8PLR7 UniProtKB:O08336 UniProtKB:O08394 UniProtKB:P16435 UniProtKB:Q9UBK8	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0140196	positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
involved_in	GO:0099163	synaptic signaling by nitric oxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
involved_in	GO:0098924	retrograde trans-synaptic signaling by nitric oxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
involved_in	GO:0098735	positive regulation of the force of heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
involved_in	GO:0051926	negative regulation of calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
involved_in	GO:0051612	negative regulation of serotonin uptake	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
involved_in	GO:0051346	negative regulation of hydrolase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
involved_in	GO:0050767	regulation of neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	C		Seeded From UniProt	complete
part_of	GO:0044305	calyx of Held	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	C		Seeded From UniProt	complete
involved_in	GO:0043267	negative regulation of potassium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
involved_in	GO:0042738	exogenous drug catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	C		Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	C		Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	C		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	C		Seeded From UniProt	complete
involved_in	GO:0018119	peptidyl-cysteine S-nitrosylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
involved_in	GO:0006941	striated muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	C		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	F		Seeded From UniProt	complete
involved_in	GO:0002028	regulation of sodium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0J4 ensembl:ENSMUSP00000120421	P		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004030 InterPro:IPR012144 InterPro:IPR036119	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004030 InterPro:IPR012144 InterPro:IPR036119	P		Seeded From UniProt	complete
enables	GO:0010181	FMN binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001094 InterPro:IPR008254 InterPro:IPR012144	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001433 InterPro:IPR001709 InterPro:IPR003097 InterPro:IPR017927 InterPro:IPR023173	F		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F		Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001094 InterPro:IPR001433 InterPro:IPR001709 InterPro:IPR003097 InterPro:IPR004030 InterPro:IPR017927 InterPro:IPR023173 InterPro:IPR036119	P		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.13.39	F		Seeded From UniProt	complete
involved_in	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	PMID:21536106^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(UBERON:0002349) occurs_in:(GO:0016529)	Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:21536106^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	occurs_in:(UBERON:0000948) has_direct_input:(UniProtKB:Q92736) occurs_in:(GO:0016529)	Seeded From UniProt	complete
involved_in	GO:1902514	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	PMID:21536106^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0002098)	Seeded From UniProt	complete
colocalizes_with	GO:1990425	ryanodine receptor complex	PMID:21536106^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	part_of:(UBERON:0002349) part_of:(GO:0016529)	Seeded From UniProt	complete
involved_in	GO:0055117	regulation of cardiac muscle contraction	PMID:9892689^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042136	neurotransmitter biosynthetic process	PMID:7545544^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0034618	arginine binding	PMID:17029414^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010523	negative regulation of calcium ion transport into cytosol	PMID:17568574^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007520	myoblast fusion	PMID:7545544^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17892502^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1903779	regulation of cardiac conduction	Reactome:R-HSA-5578775	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	Reactome:R-HSA-1222556	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5617178 Reactome:R-HSA-418436	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0284	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0238	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Bredt, DS & Snyder, SH (1990) Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc. Natl. Acad. Sci. U.S.A. 87 682-5 PubMed GONUTS page
↑ Wang, Y et al. (2017) Downregulation of miR-132/212 impairs S-nitrosylation balance and induces tau phosphorylation in Alzheimer's disease. Neurobiol. Aging 51 156-166 PubMed GONUTS page
↑ Reilly, SN et al. (2016) Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase. Sci Transl Med 8 340ra74 PubMed GONUTS page
↑ ^4.0 ^4.1 Vidal, L et al. (2006) Nitric oxide synthase in retina and optic nerve head of rat with increased intraocular pressure and effect of timolol. Brain Res. Bull. 70 406-13 PubMed GONUTS page
↑ ^5.0 ^5.1 Seddon, MD et al. (2008) Neuronal nitric oxide synthase regulates basal microvascular tone in humans in vivo. Circulation 117 1991-6 PubMed GONUTS page
↑ ^6.0 ^6.1 Kellogg, DL Jr et al. (2008) Neuronal nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo. J. Physiol. (Lond.) 586 847-57 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Brenman, JE et al. (1995) Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy. Cell 82 743-52 PubMed GONUTS page
↑ Chen, PF et al. (1995) Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity. Biochem. Biophys. Res. Commun. 215 1119-29 PubMed GONUTS page
↑ ^9.0 ^9.1 Xu, KY et al. (1999) Nitric oxide synthase in cardiac sarcoplasmic reticulum. Proc. Natl. Acad. Sci. U.S.A. 96 657-62 PubMed GONUTS page
↑ Ward, ME et al. (2005) Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant. J. Clin. Invest. 115 3128-39 PubMed GONUTS page
↑ ^11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 ^11.14 ^11.15 ^11.16 ^11.17 ^11.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Schulman, IH & Hare, JM (2012) Regulation of cardiovascular cellular processes by S-nitrosylation. Biochim. Biophys. Acta 1820 752-62 PubMed GONUTS page
↑ Konas, DW et al. (2006) Role of Asp1393 in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein. Biochemistry 45 12596-609 PubMed GONUTS page
↑ Seddon, M et al. (2007) Cardiomyocytes as effectors of nitric oxide signalling. Cardiovasc. Res. 75 315-26 PubMed GONUTS page
↑ Sullivan, JC et al. (2008) Influence of salt on subcellular localization of nitric oxide synthase activity and expression in the renal inner medulla. Clin. Exp. Pharmacol. Physiol. 35 120-5 PubMed GONUTS page

[PMID:1689048-1] 1.0 ^1.1 Bredt, DS & Snyder, SH (1990) Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc. Natl. Acad. Sci. U.S.A. 87 682-5 PubMed GONUTS page

[PMID:28089352-2] Wang, Y et al. (2017) Downregulation of miR-132/212 impairs S-nitrosylation balance and induces tau phosphorylation in Alzheimer's disease. Neurobiol. Aging 51 156-166 PubMed GONUTS page

[PMID:27225184-3] Reilly, SN et al. (2016) Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase. Sci Transl Med 8 340ra74 PubMed GONUTS page

[PMID:17027776-4] 4.0 ^4.1 Vidal, L et al. (2006) Nitric oxide synthase in retina and optic nerve head of rat with increased intraocular pressure and effect of timolol. Brain Res. Bull. 70 406-13 PubMed GONUTS page

[PMID:18391107-5] 5.0 ^5.1 Seddon, MD et al. (2008) Neuronal nitric oxide synthase regulates basal microvascular tone in humans in vivo. Circulation 117 1991-6 PubMed GONUTS page

[PMID:18048451-6] 6.0 ^6.1 Kellogg, DL Jr et al. (2008) Neuronal nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo. J. Physiol. (Lond.) 586 847-57 PubMed GONUTS page

[PMID:7545544-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Brenman, JE et al. (1995) Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy. Cell 82 743-52 PubMed GONUTS page

[PMID:7488039-8] Chen, PF et al. (1995) Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity. Biochem. Biophys. Res. Commun. 215 1119-29 PubMed GONUTS page

[PMID:9892689-9] 9.0 ^9.1 Xu, KY et al. (1999) Nitric oxide synthase in cardiac sarcoplasmic reticulum. Proc. Natl. Acad. Sci. U.S.A. 96 657-62 PubMed GONUTS page

[PMID:16276418-10] Ward, ME et al. (2005) Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant. J. Clin. Invest. 115 3128-39 PubMed GONUTS page

[PMID:21873635-11] 11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 ^11.14 ^11.15 ^11.16 ^11.17 ^11.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21536106-12] 12.0 ^12.1 ^12.2 ^12.3 Schulman, IH & Hare, JM (2012) Regulation of cardiovascular cellular processes by S-nitrosylation. Biochim. Biophys. Acta 1820 752-62 PubMed GONUTS page

[PMID:17029414-13] Konas, DW et al. (2006) Role of Asp1393 in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein. Biochemistry 45 12596-609 PubMed GONUTS page

[PMID:17568574-14] Seddon, M et al. (2007) Cardiomyocytes as effectors of nitric oxide signalling. Cardiovasc. Res. 75 315-26 PubMed GONUTS page

[PMID:17892502-15] Sullivan, JC et al. (2008) Influence of salt on subcellular localization of nitric oxide synthase activity and expression in the renal inner medulla. Clin. Exp. Pharmacol. Physiol. 35 120-5 PubMed GONUTS page

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