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PMID:21536106

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Citation

Schulman, IH and Hare, JM (2012) Regulation of cardiovascular cellular processes by S-nitrosylation. Biochim. Biophys. Acta 1820:752-62

Abstract

Nitric oxide (NO), a highly versatile signaling molecule, exerts a broad range of regulatory influences in the cardiovascular system that extends from vasodilation to myocardial contractility, angiogenesis, inflammation, and energy metabolism. Considerable attention has been paid to deciphering the mechanisms for such diversity in signaling. S-nitrosylation of cysteine thiols is a major signaling pathway through which NO exerts its actions. An emerging concept of NO pathophysiology is that the interplay between NO and reactive oxygen species (ROS), the nitroso/redox balance, is an important regulator of cardiovascular homeostasis.

Links

PubMed Online version:10.1016/j.bbagen.2011.04.002

Keywords

Animals; Calcium/metabolism; Cardiovascular Diseases/metabolism; Cardiovascular Diseases/physiopathology; Cardiovascular System/metabolism; Cardiovascular System/physiopathology; Cell Physiological Phenomena; Cysteine/chemistry; Cysteine/metabolism; Heart Failure/metabolism; Humans; Myocardium/metabolism; Nitric Oxide/metabolism; Nitric Oxide Synthase/metabolism; Nitrosation; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species/metabolism; Signal Transduction

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:NOS1

enables

GO:0044325: transmembrane transporter binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

  • occurs_in:(UBERON:0000948)
  • has_input:(UniProtKB:Q92736)
  • occurs_in:(GO:0016529)

Seeded From UniProt

complete

HUMAN:NOS1

involved_in

GO:1902514: regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

  • occurs_in:(CL:0002098)

Seeded From UniProt

complete

HUMAN:NOS1

colocalizes_with

GO:1990425: ryanodine receptor complex

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:NOS1

involved_in

GO:1902514: regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

occurs_in:(CL:0002098)

Seeded From UniProt

complete

HUMAN:NOS1

enables

GO:0044325: ion channel binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

  • occurs_in:(UBERON:0000948)
  • has_direct_input:(UniProtKB:Q92736)
  • occurs_in:(GO:0016529)

Seeded From UniProt

complete

HUMAN:NOS1

involved_in

GO:0060314: regulation of ryanodine-sensitive calcium-release channel activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

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