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PMID:18391107

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Citation

Seddon, MD, Chowienczyk, PJ, Brett, SE, Casadei, B and Shah, AM (2008) Neuronal nitric oxide synthase regulates basal microvascular tone in humans in vivo. Circulation 117:1991-6

Abstract

Nitric oxide (NO) has a pivotal role in the regulation of vascular tone and blood flow, with dysfunctional release contributing to disease pathophysiology. These effects have been attributed to NO production by the endothelial NO synthase (eNOS); however, recent evidence suggests that a neuronal NO synthase (nNOS) may also be expressed in arterial vessels.

Links

PubMed Online version:10.1161/CIRCULATIONAHA.107.744540

Keywords

Acetylcholine/pharmacology; Acetylcholine/physiology; Adult; Arginine/pharmacology; Brachial Artery/drug effects; Brachial Artery/enzymology; Brachial Artery/physiology; Citrulline/analogs & derivatives; Citrulline/pharmacology; Forearm/blood supply; Humans; Male; Nitric Oxide/physiology; Nitric Oxide Synthase Type I/antagonists & inhibitors; Nitric Oxide Synthase Type I/physiology; Nitric Oxide Synthase Type III/physiology; Stress, Psychological/physiopathology; Thiourea/analogs & derivatives; Thiourea/pharmacology; Vasodilation; Vasomotor System/drug effects; Vasomotor System/physiology; omega-N-Methylarginine/pharmacology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:NOS1

involved_in

GO:0042311: vasodilation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:NOS1

involved_in

GO:0033555: multicellular organismal response to stress

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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