HUMAN:MSH6

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MSH6 (synonyms: GTBP)
Protein Name(s)	DNA mismatch repair protein Msh6 hMSH6 G/T mismatch-binding protein GTBP GTMBP MutS-alpha 160 kDa subunit p160
External Links
UniProt	P52701
EMBL	U73737 U73732 U73733 U73734 U73736 D89645 D89646 AK293921 AK304735 AY082894 AC006509 BC004246 U54777 U28946
CCDS	CCDS1836.1 CCDS62906.1 CCDS62907.1
PIR	JC5839
RefSeq	NP_000170.1 NP_001268421.1 NP_001268422.1 NP_001268423.1
UniGene	Hs.445052
PDB	2GFU 2O8B 2O8C 2O8D 2O8E 2O8F
PDBsum	2GFU 2O8B 2O8C 2O8D 2O8E 2O8F
ProteinModelPortal	P52701
SMR	P52701
BioGrid	109211
DIP	DIP-32972N
IntAct	P52701
MINT	MINT-131993
STRING	9606.ENSP00000234420
PhosphoSite	P52701
DMDM	68067672
MaxQB	P52701
PaxDb	P52701
PeptideAtlas	P52701
PRIDE	P52701
DNASU	2956
Ensembl	ENST00000234420 ENST00000538136 ENST00000540021 ENST00000614496
GeneID	2956
KEGG	hsa:2956
UCSC	uc002rwc.2 uc002rwd.4
CTD	2956
GeneCards	GC02P047924
GeneReviews	MSH6
HGNC	HGNC:7329
HPA	CAB009091 HPA028376 HPA028446
MIM	276300 600678 608089 614350
neXtProt	NX_P52701
Orphanet	252202 144 587 99817
PharmGKB	PA184
eggNOG	COG0249
GeneTree	ENSGT00550000075024
HOGENOM	HOG000243127
HOVERGEN	HBG000101
InParanoid	P52701
KO	K08737
OMA	ALKDCMR
OrthoDB	EOG7K9K27
PhylomeDB	P52701
TreeFam	TF105842
Reactome	REACT_228145
ChiTaRS	MSH6
EvolutionaryTrace	P52701
GeneWiki	MSH6
GenomeRNAi	2956
NextBio	11716
PMAP-CutDB	P52701
PRO	PR:P52701
Proteomes	UP000005640
Bgee	P52701
CleanEx	HS_MSH6
ExpressionAtlas	P52701
Genevestigator	P52701
GO	GO:0005737 GO:0005794 GO:0043231 GO:0032301 GO:0000790 GO:0000228 GO:0005634 GO:0005886 GO:0005524 GO:0003682 GO:0003684 GO:0008094 GO:0032137 GO:0035064 GO:0030983 GO:0006200 GO:0008340 GO:0006281 GO:0097193 GO:0008630 GO:0045190 GO:0000710 GO:0006298 GO:0045910 GO:0051096 GO:0007131 GO:0009411 GO:0016446 GO:0016447
Gene3D	3.40.1170.10 3.40.50.300
InterPro	IPR017261 IPR015536 IPR007695 IPR000432 IPR007861 IPR007696 IPR016151 IPR007860 IPR027417 IPR000313
PANTHER	PTHR11361:SF31
Pfam	PF01624 PF05188 PF05192 PF05190 PF00488 PF00855
PIRSF	PIRSF037677
SMART	SM00534 SM00533 SM00293
SUPFAM	SSF48334 SSF52540 SSF55271
PROSITE	PS00486 PS50812

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005634	nucleus	PMID:26300262^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:26300262^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NXL9	F	Seeded From UniProt	complete
involved_in	GO:0097193	intrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P54276	P	Seeded From UniProt	complete
involved_in	GO:0051096	positive regulation of helicase activity	PMID:17715146^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045910	negative regulation of DNA recombination	PMID:17715146^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045190	isotype switching	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P54276	P	Seeded From UniProt	complete
NOT\|involved_in	GO:0043570	maintenance of DNA repeat elements	PMID:16388310^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016447	somatic recombination of immunoglobulin gene segments	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P54276	P	Seeded From UniProt	complete
involved_in	GO:0016446	somatic hypermutation of immunoglobulin genes	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P54276	P	Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P54276	P	Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P54276	P	Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P54276	P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:8942985^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000710	meiotic mismatch repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03834	P	Seeded From UniProt	complete
contributes_to	GO:0043531	ADP binding	PMID:15105434^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0032405	MutLalpha complex binding	PMID:16403449^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0032357	oxidized purine DNA binding	PMID:11801590^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0032357	oxidized purine DNA binding	PMID:11756455^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0032301	MutSalpha complex	PMID:8942985^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
contributes_to	GO:0032143	single thymine insertion binding	PMID:8942985^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0032142	single guanine insertion binding	PMID:8942985^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0032137	guanine/thymine mispair binding	PMID:11809883^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0032137	guanine/thymine mispair binding	PMID:8942985^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0030983	mismatched DNA binding	PMID:11801590^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0030983	mismatched DNA binding	PMID:11756455^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0030983	mismatched DNA binding	PMID:8942985^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0016887	ATPase activity	PMID:16403449^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:8782829^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:10871409^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
contributes_to	GO:0005524	ATP binding	PMID:15105434^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0003690	double-stranded DNA binding	PMID:11809883^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0000400	four-way junction DNA binding	PMID:12034830^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0000287	magnesium ion binding	PMID:16403449^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
NOT\|enables	GO:0042803	protein homodimerization activity	PMID:8942985^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P52701	F	Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	PMID:23622243^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0032301	MutSalpha complex	PMID:23622243^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0030983	mismatched DNA binding	PMID:23622243^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:23622243^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051096	positive regulation of helicase activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145560 UniProtKB:P52701	P	Seeded From UniProt	complete
involved_in	GO:0045910	negative regulation of DNA recombination	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1343961 PANTHER:PTN000145560 UniProtKB:P52701	P	Seeded From UniProt	complete
involved_in	GO:0043570	maintenance of DNA repeat elements	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145560 PomBase:SPCC285.16c WB:WBGene00003422	P	Seeded From UniProt	complete
contributes_to	GO:0043531	ADP binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145560 UniProtKB:P52701	F	Seeded From UniProt	complete
involved_in	GO:0043111	replication fork arrest	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145560 SGD:S000002504	P	Seeded From UniProt	complete
involved_in	GO:0036297	interstrand cross-link repair	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145560 SGD:S000002504	P	Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145560 UniProtKB:P52701	F	Seeded From UniProt	complete
involved_in	GO:0032876	negative regulation of DNA endoreduplication	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145560 UniProtKB:E1BYJ2	P	Seeded From UniProt	complete
contributes_to	GO:0032405	MutLalpha complex binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145560 UniProtKB:P52701	F	Seeded From UniProt	complete
part_of	GO:0032301	MutSalpha complex	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1343961 PANTHER:PTN000145560 SGD:S000002504 UniProtKB:P52701	C	Seeded From UniProt	complete
part_of	GO:0032300	mismatch repair complex	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779	C	Seeded From UniProt	complete
contributes_to	GO:0032143	single thymine insertion binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002260779 UniProtKB:P43246 UniProtKB:P52701	F	Seeded From UniProt	complete
contributes_to	GO:0032137	guanine/thymine mispair binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 MGI:MGI:1343961 PANTHER:PTN002260779 SGD:S000001162 SGD:S000002504 SGD:S000005450 UniProtKB:P43246 UniProtKB:P52701	F	Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1343961 PANTHER:PTN000145560	P	Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1343961 PANTHER:PTN000145563	P	Seeded From UniProt	complete
enables	GO:0008094	DNA-dependent ATPase activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002260779 SGD:S000001162	F	Seeded From UniProt	complete
involved_in	GO:0007095	mitotic G2 DNA damage checkpoint	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145560 UniProtKB:E1BYJ2	P	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 FB:FBgn0015546 MGI:MGI:101816 MGI:MGI:109519 MGI:MGI:1343961 PANTHER:PTN000145505 PomBase:SPBC19G7.01c PomBase:SPCC285.16c SGD:S000000688 SGD:S000001162 SGD:S000002504 SGD:S000005450 TAIR:locus:2095097 UniProtKB:P20585 UniProtKB:P43246 UniProtKB:P52701 WB:WBGene00003418 WB:WBGene00003422	P	Seeded From UniProt	complete
involved_in	GO:0006290	pyrimidine dimer repair	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145560 UniProtKB:O04716	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779 SGD:S000002504 SGD:S000005450 UniProtKB:P43246 UniProtKB:P52701	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779 SGD:S000002504 SGD:S000005450	F	Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 MGI:MGI:109519 MGI:MGI:1343961 PANTHER:PTN002260779 TAIR:locus:2095097 TAIR:locus:2131829 UniProtKB:O04716	F	Seeded From UniProt	complete
involved_in	GO:0000710	meiotic mismatch repair	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0036486 PANTHER:PTN000145560 SGD:S000002504	P	Seeded From UniProt	complete
enables	GO:0000400	four-way junction DNA binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145560 SGD:S000002504 UniProtKB:P52701	F	Seeded From UniProt	complete
enables	GO:0000400	four-way junction DNA binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145560 SGD:S000002504	F	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:23603115^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P43246	P	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:23603115^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P40692	P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0097193	intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54276 ensembl:ENSMUSP00000005503	P	Seeded From UniProt	complete
involved_in	GO:0045910	negative regulation of DNA recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54276 ensembl:ENSMUSP00000005503	P	Seeded From UniProt	complete
involved_in	GO:0045190	isotype switching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54276 ensembl:ENSMUSP00000005503	P	Seeded From UniProt	complete
part_of	GO:0032301	MutSalpha complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54276 ensembl:ENSMUSP00000005503	C	Seeded From UniProt	complete
enables	GO:0032137	guanine/thymine mispair binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54276 ensembl:ENSMUSP00000005503	F	Seeded From UniProt	complete
involved_in	GO:0016447	somatic recombination of immunoglobulin gene segments	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54276 ensembl:ENSMUSP00000005503	P	Seeded From UniProt	complete
involved_in	GO:0016446	somatic hypermutation of immunoglobulin genes	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54276 ensembl:ENSMUSP00000005503	P	Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54276 ensembl:ENSMUSP00000005503	P	Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54276 ensembl:ENSMUSP00000005503	P	Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54276 ensembl:ENSMUSP00000005503	P	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54276 ensembl:ENSMUSP00000005503	P	Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54276 ensembl:ENSMUSP00000005503	F	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54276 ensembl:ENSMUSP00000005503	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54276 ensembl:ENSMUSP00000005503	F	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54276 ensembl:ENSMUSP00000005503	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR007861 InterPro:IPR016151 InterPro:IPR036678	F	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR007861 InterPro:IPR015536 InterPro:IPR016151 InterPro:IPR017261 InterPro:IPR036678	P	Seeded From UniProt	complete
enables	GO:0030983	mismatched DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR007861 InterPro:IPR016151 InterPro:IPR017261 InterPro:IPR036678	F	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	Reactome:R-HSA-5358565	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5632970 Reactome:R-HSA-5577244 Reactome:R-HSA-5444516 Reactome:R-HSA-5358912 Reactome:R-HSA-5358599 Reactome:R-HSA-5358597 Reactome:R-HSA-5358525 Reactome:R-HSA-5358518 Reactome:R-HSA-5358510	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Traver, S et al. (2015) MCM9 Is Required for Mammalian DNA Mismatch Repair. Mol. Cell 59 831-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Saydam, N et al. (2007) Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors. Nucleic Acids Res. 35 5706-16 PubMed GONUTS page
↑ Lin, Y et al. (2006) Transcription promotes contraction of CAG repeat tracts in human cells. Nat. Struct. Mol. Biol. 13 179-80 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Acharya, S et al. (1996) hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. Proc. Natl. Acad. Sci. U.S.A. 93 13629-34 PubMed GONUTS page
↑ ^5.0 ^5.1 Martik, D et al. (2004) Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites. J. Biol. Chem. 279 28402-10 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Plotz, G et al. (2006) Analysis of the human MutLalpha.MutSalpha complex. Biochem. Biophys. Res. Commun. 340 852-9 PubMed GONUTS page
↑ ^7.0 ^7.1 Gu, Y et al. (2002) Human MutY homolog, a DNA glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6. J. Biol. Chem. 277 11135-42 PubMed GONUTS page
↑ ^8.0 ^8.1 Mazurek, A et al. (2002) Activation of human MutS homologs by 8-oxo-guanine DNA damage. J. Biol. Chem. 277 8260-6 PubMed GONUTS page
↑ ^9.0 ^9.1 Plotz, G et al. (2002) hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA. Nucleic Acids Res. 30 711-8 PubMed GONUTS page
↑ Risinger, JI et al. (1996) Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Nat. Genet. 14 102-5 PubMed GONUTS page
↑ Ceccotti, S et al. (2000) Multiple mutations and frameshifts are the hallmark of defective hPMS2 in pZ189-transfected human tumor cells. Nucleic Acids Res. 28 2577-84 PubMed GONUTS page
↑ Subramanian, D & Griffith, JD (2002) Interactions between p53, hMSH2-hMSH6 and HMG I(Y) on Holliday junctions and bulged bases. Nucleic Acids Res. 30 2427-34 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Li, F et al. (2013) The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell 153 590-600 PubMed GONUTS page
↑ ^14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 ^14.13 ^14.14 ^14.15 ^14.16 ^14.17 ^14.18 ^14.19 ^14.20 ^14.21 ^14.22 ^14.23 ^14.24 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^15.0 ^15.1 Ghodgaonkar, MM et al. (2013) Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol. Cell 50 323-32 PubMed GONUTS page

[PMID:26300262-1] 1.0 ^1.1 Traver, S et al. (2015) MCM9 Is Required for Mammalian DNA Mismatch Repair. Mol. Cell 59 831-9 PubMed GONUTS page

[PMID:17715146-2] 2.0 ^2.1 Saydam, N et al. (2007) Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors. Nucleic Acids Res. 35 5706-16 PubMed GONUTS page

[PMID:16388310-3] Lin, Y et al. (2006) Transcription promotes contraction of CAG repeat tracts in human cells. Nat. Struct. Mol. Biol. 13 179-80 PubMed GONUTS page

[PMID:8942985-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Acharya, S et al. (1996) hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. Proc. Natl. Acad. Sci. U.S.A. 93 13629-34 PubMed GONUTS page

[PMID:15105434-5] 5.0 ^5.1 Martik, D et al. (2004) Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites. J. Biol. Chem. 279 28402-10 PubMed GONUTS page

[PMID:16403449-6] 6.0 ^6.1 ^6.2 Plotz, G et al. (2006) Analysis of the human MutLalpha.MutSalpha complex. Biochem. Biophys. Res. Commun. 340 852-9 PubMed GONUTS page

[PMID:11801590-7] 7.0 ^7.1 Gu, Y et al. (2002) Human MutY homolog, a DNA glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6. J. Biol. Chem. 277 11135-42 PubMed GONUTS page

[PMID:11756455-8] 8.0 ^8.1 Mazurek, A et al. (2002) Activation of human MutS homologs by 8-oxo-guanine DNA damage. J. Biol. Chem. 277 8260-6 PubMed GONUTS page

[PMID:11809883-9] 9.0 ^9.1 Plotz, G et al. (2002) hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA. Nucleic Acids Res. 30 711-8 PubMed GONUTS page

[PMID:8782829-10] Risinger, JI et al. (1996) Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Nat. Genet. 14 102-5 PubMed GONUTS page

[PMID:10871409-11] Ceccotti, S et al. (2000) Multiple mutations and frameshifts are the hallmark of defective hPMS2 in pZ189-transfected human tumor cells. Nucleic Acids Res. 28 2577-84 PubMed GONUTS page

[PMID:12034830-12] Subramanian, D & Griffith, JD (2002) Interactions between p53, hMSH2-hMSH6 and HMG I(Y) on Holliday junctions and bulged bases. Nucleic Acids Res. 30 2427-34 PubMed GONUTS page

[PMID:23622243-13] 13.0 ^13.1 ^13.2 ^13.3 Li, F et al. (2013) The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell 153 590-600 PubMed GONUTS page

[PMID:21873635-14] 14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 ^14.13 ^14.14 ^14.15 ^14.16 ^14.17 ^14.18 ^14.19 ^14.20 ^14.21 ^14.22 ^14.23 ^14.24 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23603115-15] 15.0 ^15.1 Ghodgaonkar, MM et al. (2013) Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol. Cell 50 323-32 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

HUMAN:MSH6

Contents

Annotations

Notes

References

a

c

d

e

f

g

h

i

m

n

o

p

r

s

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools