HUMAN:MK14

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MAPK14 (synonyms: CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A)
Protein Name(s)	Mitogen-activated protein kinase 14 MAP kinase 14 MAPK 14 Cytokine suppressive anti-inflammatory drug-binding protein CSAID-binding protein CSBP MAP kinase MXI2 MAX-interacting protein 2 Mitogen-activated protein kinase p38 alpha MAP kinase p38 alpha Stress-activated protein kinase 2a SAPK2a
External Links
UniProt	Q16539
EMBL	L35263 L35264 L35253 U19775 AF100544 AB074150 FJ032367 AK291709 BT006933 CR536505 EU332860 Z95152 CH471081 BC000092 BC031574
CCDS	CCDS4815.1 CCDS4816.1 CCDS4817.1
PIR	S53536
RefSeq	NP_001306.1 NP_620581.1 NP_620582.1 NP_620583.1
UniGene	Hs.485233
PDB	1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBS 1WBT 1WBV 1WBW 1WFC 1YQJ 1ZYJ 1ZZ2 1ZZL 2BAJ 2BAK 2BAL 2BAQ 2FSL 2FSM 2FSO 2FST 2GFS 2I0H 2LGC 2NPQ 2OKR 2ONL 2QD9 2RG5 2RG6 2Y8O 2YIS 2YIW 2YIX 2ZAZ 2ZB0 2ZB1 3BV2 3BV3 3BX5 3C5U 3CTQ 3D7Z 3D83 3DS6 3DT1 3E92 3E93 3FC1 3FI4 3FKL 3FKN 3FKO 3FL4 3FLN 3FLQ 3FLS 3FLW 3FLY 3FLZ 3FMH 3FMJ 3FMK 3FML 3FMM 3FMN 3FSF 3FSK 3GC7 3GCP 3GCQ 3GCS 3GCU 3GCV 3GFE 3GI3 3HA8 3HEC 3HEG 3HL7 3HLL 3HP2 3HP5 3HRB 3HUB 3HUC 3HV3 3HV4 3HV5 3HV6 3HV7 3HVC 3IPH 3ITZ 3IW5 3IW6 3IW7 3IW8 3K3I 3K3J 3KF7 3KQ7 3L8S 3L8X 3LFA 3LFB 3LFC 3LFD 3LFE 3LFF 3LHJ 3MGY 3MH0 3MH1 3MH2 3MH3 3MPA 3MPT 3MVL 3MVM 3MW1 3NEW 3NNU 3NNV 3NNW 3NNX 3NWW 3O8P 3O8T 3O8U 3OBG 3OBJ 3OC1 3OCG 3OD6 3ODY 3ODZ 3OEF 3PG3 3QUD 3QUE 3RIN 3ROC 3S3I 3S4Q 3U8W 3UVP 3UVQ 3UVR 3ZS5 3ZSG 3ZSH 3ZSI 3ZYA 4A9Y 4AA0 4AA4 4AA5 4AAC 4DLI 4DLJ 4E5A 4E5B 4E6A 4E6C 4E8A 4EH2 4EH3 4EH4 4EH5 4EH6 4EH7 4EH8 4EH9 4EHV 4EWQ 4F9W 4F9Y 4FA2 4GEO 4KIN 4KIP 4KIQ 4L8M
PDBsum	1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBS 1WBT 1WBV 1WBW 1WFC 1YQJ 1ZYJ 1ZZ2 1ZZL 2BAJ 2BAK 2BAL 2BAQ 2FSL 2FSM 2FSO 2FST 2GFS 2I0H 2LGC 2NPQ 2OKR 2ONL 2QD9 2RG5 2RG6 2Y8O 2YIS 2YIW 2YIX 2ZAZ 2ZB0 2ZB1 3BV2 3BV3 3BX5 3C5U 3CTQ 3D7Z 3D83 3DS6 3DT1 3E92 3E93 3FC1 3FI4 3FKL 3FKN 3FKO 3FL4 3FLN 3FLQ 3FLS 3FLW 3FLY 3FLZ 3FMH 3FMJ 3FMK 3FML 3FMM 3FMN 3FSF 3FSK 3GC7 3GCP 3GCQ 3GCS 3GCU 3GCV 3GFE 3GI3 3HA8 3HEC 3HEG 3HL7 3HLL 3HP2 3HP5 3HRB 3HUB 3HUC 3HV3 3HV4 3HV5 3HV6 3HV7 3HVC 3IPH 3ITZ 3IW5 3IW6 3IW7 3IW8 3K3I 3K3J 3KF7 3KQ7 3L8S 3L8X 3LFA 3LFB 3LFC 3LFD 3LFE 3LFF 3LHJ 3MGY 3MH0 3MH1 3MH2 3MH3 3MPA 3MPT 3MVL 3MVM 3MW1 3NEW 3NNU 3NNV 3NNW 3NNX 3NWW 3O8P 3O8T 3O8U 3OBG 3OBJ 3OC1 3OCG 3OD6 3ODY 3ODZ 3OEF 3PG3 3QUD 3QUE 3RIN 3ROC 3S3I 3S4Q 3U8W 3UVP 3UVQ 3UVR 3ZS5 3ZSG 3ZSH 3ZSI 3ZYA 4A9Y 4AA0 4AA4 4AA5 4AAC 4DLI 4DLJ 4E5A 4E5B 4E6A 4E6C 4E8A 4EH2 4EH3 4EH4 4EH5 4EH6 4EH7 4EH8 4EH9 4EHV 4EWQ 4F9W 4F9Y 4FA2 4GEO 4KIN 4KIP 4KIQ 4L8M
ProteinModelPortal	Q16539
SMR	Q16539
BioGrid	107819
DIP	DIP-30987N
IntAct	Q16539
MINT	MINT-126546
STRING	9606.ENSP00000229794
BindingDB	Q16539
ChEMBL	CHEMBL2094115
GuidetoPHARMACOLOGY	1499
PhosphoSite	Q16539
OGP	Q16539
MaxQB	Q16539
PaxDb	Q16539
PRIDE	Q16539
DNASU	1432
Ensembl	ENST00000229794 ENST00000229795 ENST00000310795
GeneID	1432
KEGG	hsa:1432
UCSC	uc003olo.3 uc003olp.3 uc003olq.3 uc003olr.3
CTD	1432
GeneCards	GC06P035995
HGNC	HGNC:6876
HPA	CAB010285 CAB040578
MIM	600289
neXtProt	NX_Q16539
PharmGKB	PA30621
eggNOG	COG0515
GeneTree	ENSGT00550000074271
HOVERGEN	HBG014652
InParanoid	Q16539
KO	K04441
OMA	FETTERY
OrthoDB	EOG7PCJGV
PhylomeDB	Q16539
TreeFam	TF105100
BioCyc	MetaCyc:HS03507-MONOMER
Reactome	REACT_12065 REACT_12599 REACT_169436 REACT_19140 REACT_200686 REACT_21326 REACT_21399 REACT_21402 REACT_228166 REACT_23879 REACT_25042 REACT_25299 REACT_75776
SignaLink	Q16539
ChiTaRS	MAPK14
EvolutionaryTrace	Q16539
GeneWiki	MAPK14
GenomeRNAi	1432
NextBio	35478285
PRO	PR:Q16539
Proteomes	UP000005640
Bgee	Q16539
CleanEx	HS_MAPK14
ExpressionAtlas	Q16539
Genevestigator	Q16539
GO	GO:0005737 GO:0005829 GO:0070062 GO:0005739 GO:0005654 GO:0005634 GO:0000922 GO:0005524 GO:0004707 GO:0004708 GO:0051525 GO:0004674 GO:0070935 GO:0000187 GO:0001525 GO:0006915 GO:0007596 GO:0001502 GO:0000902 GO:0007166 GO:0006928 GO:0071479 GO:0071222 GO:0035924 GO:0006935 GO:0002062 GO:0000077 GO:0019395 GO:0010467 GO:0006006 GO:0045087 GO:0035556 GO:0031663 GO:0016071 GO:0042692 GO:0002755 GO:0002756 GO:0014835 GO:0090090 GO:0048011 GO:0030316 GO:0038066 GO:0018105 GO:0030168 GO:0045648 GO:0051149 GO:0045663 GO:1901741 GO:0010831 GO:0042307 GO:2000379 GO:0045944 GO:0007265 GO:0051090 GO:0006357 GO:0032495 GO:0016070 GO:0007165 GO:0042770 GO:0007519 GO:0051403 GO:0090400 GO:0051146 GO:0034166 GO:0034134 GO:0034138 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0006351 GO:0007178 GO:0035666 GO:0048010
InterPro	IPR011009 IPR003527 IPR008352 IPR000719 IPR017441 IPR002290
Pfam	PF00069
PRINTS	PR01773
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS01351 PS00107 PS50011

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010628	positive regulation of gene expression	PMID:24299952^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P01375	P	regulates_expression_of:(ENSEMBL:ENSG00000207611) occurs_in:(CL:0002618)	Seeded From UniProt	complete
enables	GO:0048273	mitogen-activated protein kinase p38 binding	PMID:11035004^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P52564	F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:26649771^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P59861) happens_during:(GO:0071223)	Seeded From UniProt	complete
involved_in	GO:0071223	cellular response to lipoteichoic acid	PMID:26649771^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:10391943^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y6W6	F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:25754930^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O00182) occurs_in:(CL:0001056) happens_during:(GO:0098586) has_regulation_target:(UniProtKB:P29460)	Seeded From UniProt	complete
involved_in	GO:0098586	cellular response to virus	PMID:25754930^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0001056) causally_upstream_of:(GO:0010628)	Seeded From UniProt	complete
involved_in	GO:2001184	positive regulation of interleukin-12 secretion	PMID:25754930^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0001056) happens_during:(GO:0098586) has_regulation_target:(UniProtKB:P29460)	Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	PMID:23483889^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:23483889^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99873	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:21283629^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15297	F		Seeded From UniProt	complete
involved_in	GO:0031281	positive regulation of cyclase activity	PMID:22027397^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900015	regulation of cytokine production involved in inflammatory response	PMID:15251176^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000379	positive regulation of reactive oxygen species metabolic process	PMID:20160708^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090400	stress-induced premature senescence	PMID:20160708^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071479	cellular response to ionizing radiation	PMID:20160708^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051525	NFAT protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P47811	F		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:18440775^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
NOT\|involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:18440775^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042770	signal transduction in response to DNA damage	PMID:20160708^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:18440775^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618) has_input:(UniProtKB:P15692)	Seeded From UniProt	complete
involved_in	GO:0030316	osteoclast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P47811	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P47811	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P47811	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P47811	C		Seeded From UniProt	complete
involved_in	GO:1901741	positive regulation of myoblast fusion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P47811	P		Seeded From UniProt	complete
involved_in	GO:0045663	positive regulation of myoblast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P47811	P		Seeded From UniProt	complete
involved_in	GO:0038066	p38MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P47811	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:10838079^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010831	positive regulation of myotube differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P47811	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P47811	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P47811	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P47811	C		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:20932473^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:10330143^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:7997261^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001172432 RGD:70500	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1346865 PANTHER:PTN000622075 RGD:3046 RGD:70500 RGD:71050 UniProtKB:P78362 UniProtKB:Q16539 UniProtKB:Q96SB4 UniProtKB:Q9UPZ9 WB:WBGene00004055 WB:WBGene00004056	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346861 PANTHER:PTN000622075 UniProtKB:A9T142	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0052703 FB:FBgn0267339 MGI:MGI:1201408 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346862 MGI:MGI:1346863 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:2444559 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:621506 RGD:628847 RGD:70500 RGD:70975 RGD:71050 SGD:S000000112 SGD:S000004103 SGD:S000004829 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P28482 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q96SB4 WB:WBGene00002178 WB:WBGene00002187 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004056 WB:WBGene00004057	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003256 FB:FBgn0015765 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1336881 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:1934157 MGI:MGI:2444559 MGI:MGI:96913 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPAC31G5.09c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:3663 RGD:621505 RGD:621506 RGD:628675 RGD:628847 RGD:70496 RGD:70500 SGD:S000000112 SGD:S000001072 SGD:S000003272 SGD:S000003642 SGD:S000004103 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P20794 UniProtKB:P28482 UniProtKB:P45983 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q5AZN7 UniProtKB:Q8GYQ5 UniProtKB:Q96SB4 UniProtKB:Q9LV37 UniProtKB:Q9P419 WB:WBGene00002178 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004057 dictyBase:DDB_G0283903 dictyBase:DDB_G0286353	C		Seeded From UniProt	complete
	GO:0051247	positive regulation of protein metabolic process	PMID:22027397^[8]	ECO:0000315			P		Fig. 5A	complete CACAO 2993
	GO:0051247	positive regulation of protein metabolic process	PMID:22027397^[8]	ECO:0000315			P		Fig. 5A	complete CACAO 2997
enables	GO:0004707	MAP kinase activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN001172432 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
	GO:0031281	positive regulation of cyclase activity	PMID:22027397^[8]	ECO:0000315			P		Fig. 5D	complete CACAO 2994
	GO:0031281	positive regulation of cyclase activity	PMID:22027397^[8]	ECO:0000315			P		Fig. 5D	complete CACAO 2998
enables	GO:0004707	MAP kinase activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000183747 FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN002372889 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:23776175^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
	GO:1900015	regulation of cytokine production involved in inflammatory response	PMID:15251176^[9]	ECO:0000314			P		All four parts of Fig 4 show that the addition of the MAPK14 inhibitor SB203580 reduces the levels of different inflammatory cytokines, proving that MAPK14 plays a role in the regulation of the production of some of the cytokines that play an inflammatory role.	complete CACAO 5324
involved_in	GO:1905050	positive regulation of metallopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:1901741	positive regulation of myoblast fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0099179	regulation of synaptic membrane adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	C		Seeded From UniProt	complete
involved_in	GO:0090336	positive regulation of brown fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0060045	positive regulation of cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
enables	GO:0051525	NFAT protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	F		Seeded From UniProt	complete
involved_in	GO:0051146	striated muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0045663	positive regulation of myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0038066	p38MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0035994	response to muscle stretch	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0032495	response to muramyl dipeptide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0030316	osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0030278	regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0019395	fatty acid oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	F		Seeded From UniProt	complete
involved_in	GO:0010831	positive regulation of myotube differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0010759	positive regulation of macrophage chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0007519	skeletal muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	C		Seeded From UniProt	complete
part_of	GO:0005623	cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	C		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	F		Seeded From UniProt	complete
involved_in	GO:0002741	positive regulation of cytokine secretion involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0001890	placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0001502	cartilage condensation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	C		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47811 ensembl:ENSMUSP00000004990	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003527 InterPro:IPR008352 InterPro:IPR038784	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008352 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008352	P		Seeded From UniProt	complete
involved_in	GO:0038066	p38MAPK cascade	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR038784	P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.24	F		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:10706854^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10706854^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:10706854^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004708	MAP kinase kinase activity	PMID:10706854^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070935	3'-UTR-mediated mRNA stabilization	PMID:20932473^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1904813	ficolin-1-rich granule lumen	Reactome:R-HSA-6800434	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051149	positive regulation of muscle cell differentiation	Reactome:R-HSA-375170	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051090	regulation of DNA-binding transcription factor activity	Reactome:R-HSA-450341	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Reactome:R-HSA-194138	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0034774	secretory granule lumen	Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007265	Ras protein signal transduction	Reactome:R-HSA-167044	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-9626880 Reactome:R-HSA-5218804 Reactome:R-HSA-451366 Reactome:R-HSA-450257 Reactome:R-HSA-448958 Reactome:R-HSA-432148 Reactome:R-HSA-428961 Reactome:R-HSA-428941 Reactome:R-HSA-187688	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-450333 Reactome:R-HSA-450257 Reactome:R-HSA-450222 Reactome:R-HSA-448958 Reactome:R-HSA-448955 Reactome:R-HSA-3239019 Reactome:R-HSA-3239014 Reactome:R-HSA-3238999 Reactome:R-HSA-3229102 Reactome:R-HSA-198669 Reactome:R-HSA-168053	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6800434 Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-HSA-450222 Reactome:R-HSA-428961	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	Reactome:R-HSA-450302	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Palmieri, D et al. (2014) TNFα induces the expression of genes associated with endothelial dysfunction through p38MAPK-mediated down-regulation of miR-149. Biochem. Biophys. Res. Commun. 443 246-51 PubMed GONUTS page
↑ Tomás-Zuber, M et al. (2001) C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB). J. Biol. Chem. 276 5892-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Kim, JH et al. (2015) Expression of Beta-Defensin 131 Promotes an Innate Immune Response in Human Prostate Epithelial Cells. PLoS ONE 10 e0144776 PubMed GONUTS page
↑ Tanoue, T et al. (1999) Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. J. Biol. Chem. 274 19949-56 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Hsu, YL et al. (2015) Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus. J. Cell. Mol. Med. 19 1065-76 PubMed GONUTS page
↑ ^6.0 ^6.1 Hua, WK et al. (2013) Protein arginine methyltransferase 1 interacts with and activates p38α to facilitate erythroid differentiation. PLoS ONE 8 e56715 PubMed GONUTS page
↑ An, H et al. (2011) LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1). PLoS ONE 6 e16427 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Mamik, MK et al. (2011) HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms. J Neuroinflammation 8 145 PubMed GONUTS page
↑ ^9.0 ^9.1 Dillman, JF 3rd et al. (2004) An inhibitor of p38 MAP kinase downregulates cytokine release induced by sulfur mustard exposure in human epidermal keratinocytes. Toxicol In Vitro 18 593-9 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Passos, JF et al. (2010) Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol. Syst. Biol. 6 347 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Evans, IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell. Signal. 20 1375-84 PubMed GONUTS page
↑ Sanz, V et al. (2000) Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2. FEBS Lett. 474 169-74 PubMed GONUTS page
↑ ^13.0 ^13.1 Reinhardt, HC et al. (2010) DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Mol. Cell 40 34-49 PubMed GONUTS page
↑ Yang, SH et al. (1999) Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. Mol. Cell. Biol. 19 4028-38 PubMed GONUTS page
↑ Lee, JC et al. () A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372 739-46 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Kampen, GT et al. (2000) Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. Blood 95 1911-7 PubMed GONUTS page

[PMID:24299952-1] Palmieri, D et al. (2014) TNFα induces the expression of genes associated with endothelial dysfunction through p38MAPK-mediated down-regulation of miR-149. Biochem. Biophys. Res. Commun. 443 246-51 PubMed GONUTS page

[PMID:11035004-2] Tomás-Zuber, M et al. (2001) C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB). J. Biol. Chem. 276 5892-9 PubMed GONUTS page

[PMID:26649771-3] 3.0 ^3.1 Kim, JH et al. (2015) Expression of Beta-Defensin 131 Promotes an Innate Immune Response in Human Prostate Epithelial Cells. PLoS ONE 10 e0144776 PubMed GONUTS page

[PMID:10391943-4] Tanoue, T et al. (1999) Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. J. Biol. Chem. 274 19949-56 PubMed GONUTS page

[PMID:25754930-5] 5.0 ^5.1 ^5.2 Hsu, YL et al. (2015) Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus. J. Cell. Mol. Med. 19 1065-76 PubMed GONUTS page

[PMID:23483889-6] 6.0 ^6.1 Hua, WK et al. (2013) Protein arginine methyltransferase 1 interacts with and activates p38α to facilitate erythroid differentiation. PLoS ONE 8 e56715 PubMed GONUTS page

[PMID:21283629-7] An, H et al. (2011) LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1). PLoS ONE 6 e16427 PubMed GONUTS page

[PMID:22027397-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Mamik, MK et al. (2011) HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms. J Neuroinflammation 8 145 PubMed GONUTS page

[PMID:15251176-9] 9.0 ^9.1 Dillman, JF 3rd et al. (2004) An inhibitor of p38 MAP kinase downregulates cytokine release induced by sulfur mustard exposure in human epidermal keratinocytes. Toxicol In Vitro 18 593-9 PubMed GONUTS page

[PMID:20160708-10] 10.0 ^10.1 ^10.2 ^10.3 Passos, JF et al. (2010) Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol. Syst. Biol. 6 347 PubMed GONUTS page

[PMID:18440775-11] 11.0 ^11.1 ^11.2 Evans, IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell. Signal. 20 1375-84 PubMed GONUTS page

[PMID:10838079-12] Sanz, V et al. (2000) Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2. FEBS Lett. 474 169-74 PubMed GONUTS page

[PMID:20932473-13] 13.0 ^13.1 Reinhardt, HC et al. (2010) DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Mol. Cell 40 34-49 PubMed GONUTS page

[PMID:10330143-14] Yang, SH et al. (1999) Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. Mol. Cell. Biol. 19 4028-38 PubMed GONUTS page

[PMID:7997261-15] Lee, JC et al. () A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372 739-46 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23776175-17] Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page

[PMID:10706854-18] 18.0 ^18.1 ^18.2 ^18.3 Kampen, GT et al. (2000) Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. Blood 95 1911-7 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

HUMAN:MK14

Contents

Annotations

Notes

References

3

a

c

d

e

f

g

h

i

k

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools