HUMAN:KPCD2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PRKD2 (synonyms: PKD2)
Protein Name(s)	Serine/threonine-protein kinase D2 nPKC-D2
External Links
UniProt	Q9BZL6
EMBL	AF309082 AK074673 AK095884 AC008635 AC093503 KC877745 AL050147 AF151021
CCDS	CCDS12689.1
PIR	T08777
RefSeq	NP_001073349.1 NP_001073350.1 NP_001073351.1 NP_057541.2
UniGene	Hs.466987
PDB	2COA 3BGM
PDBsum	2COA 3BGM
ProteinModelPortal	Q9BZL6
SMR	Q9BZL6
BioGrid	117384
IntAct	Q9BZL6
MINT	MINT-1179710
STRING	9606.ENSP00000291281
BindingDB	Q9BZL6
ChEMBL	CHEMBL4900
GuidetoPHARMACOLOGY	2173
PhosphoSite	Q9BZL6
DMDM	296434570
MaxQB	Q9BZL6
PaxDb	Q9BZL6
PRIDE	Q9BZL6
DNASU	25865
Ensembl	ENST00000291281 ENST00000433867
GeneID	25865
KEGG	hsa:25865
UCSC	uc002pfh.3
CTD	25865
GeneCards	GC19M047177
HGNC	HGNC:17293
HPA	HPA021490
MIM	607074
neXtProt	NX_Q9BZL6
PharmGKB	PA134903505
eggNOG	COG0515
GeneTree	ENSGT00770000120480
HOGENOM	HOG000015135
HOVERGEN	HBG003564
InParanoid	Q9BZL6
KO	K06070
OrthoDB	EOG75B84N
PhylomeDB	Q9BZL6
TreeFam	TF314320
BRENDA	2.7.11.13
SignaLink	Q9BZL6
ChiTaRS	PRKD2
EvolutionaryTrace	Q9BZL6
GeneWiki	PRKD2
GenomeRNAi	25865
NextBio	47239
PRO	PR:Q9BZL6
Proteomes	UP000005640
Bgee	Q9BZL6
CleanEx	HS_PKD2 HS_PRKD2
ExpressionAtlas	Q9BZL6
Genevestigator	Q9BZL6
GO	GO:0005737 GO:0005794 GO:0005634 GO:0005886 GO:0005524 GO:0046872 GO:0004672 GO:0004697 GO:0004674 GO:0001525 GO:0007155 GO:0008219 GO:0035924 GO:0061154 GO:0035556 GO:0018105 GO:0045766 GO:0043536 GO:0045785 GO:0032793 GO:2000573 GO:2001028 GO:0038033 GO:0010595 GO:0001938 GO:0070374 GO:0045743 GO:1901727 GO:0032743 GO:0032757 GO:1902533 GO:0051092 GO:0033138 GO:0051091 GO:0050862 GO:0045944 GO:0030949 GO:0046777 GO:0089700 GO:0006468 GO:0050852 GO:0048010
Gene3D	2.30.29.30
InterPro	IPR020454 IPR011009 IPR002219 IPR001849 IPR011993 IPR000719 IPR017441 IPR015727 IPR002290 IPR008271
PANTHER	PTHR22968
Pfam	PF00130 PF00169 PF00069
PIRSF	PIRSF000552
PRINTS	PR00008
SMART	SM00109 SM00233 SM00220
SUPFAM	SSF56112
PROSITE	PS50003 PS00107 PS50011 PS00108 PS00479 PS50081

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0019976	interleukin-2 binding	PMID:17077180^[1]	ECO:0000314			F		Figure (4) IL-2 promoter activation upon TCR stimulation in Jurkat cells introduced with WT-PKD2 gene using a lentiviral system.	complete
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:17077180^[1]	ECO:0000314			P		Figure (4) IL-2 promoter activation (which leads to positive regulation of transcription)	complete
	GO:0046777	protein autophosphorylation	PMID:17077180^[1]	ECO:0000314			P		Figure (3) Endogenous PKD2 immunoprecipitated from the cell lysates using anti-PKCµ antibody was subjected to in vitro kinase assay to detect autophosphorylation of PKD2 in the presence or absence of the 3 µM of the indicated inhibitors.	complete
	GO:0033674	positive regulation of kinase activity	PMID:17077180^[1]	ECO:0000314			P		Figure (3) Endogenous PKD2 kinase activity is up-regulated with TCR stimulation in a ZAP-70-independent manner.	complete
	GO:0008219	cell death	PMID:17077180^[1]	ECO:0000314			P		Figure (5) CA-PKD2 expression induced cell death after TCR stimulation. Jurkat cells expressing WT-PKD2-GFP and CA-PKD2-GFP together with uninfected Jurkat cells were stimulated with anti-CD3 mAb. (A) After stimulation at the indicated time, cells were recovered, stained with propidium iodide and subjected to FACS analyses to estimate the proportion of the dead cells. Open and closed symbols represent the percentages of dead cells in the unstimulated or anti-CD3 mAb-stimulated cells, respectively.	complete
	GO:0006468	protein phosphorylation	PMID:22228765^[2]	ECO:0000314			P		Figure 1	complete CACAO 3702
enables	GO:0005080	protein kinase C binding	PMID:28428613^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q05655	F		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:28428613^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:28428613^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:28428613^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:28428613^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:22228765^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001028	positive regulation of endothelial cell chemotaxis	PMID:18440775^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:1902533	positive regulation of intracellular signal transduction	PMID:18440775^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:1901727	positive regulation of histone deacetylase activity	PMID:20497126^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15139	P	has_input:(UniProtKB:Q9UQL6) occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	PMID:17077180^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:18059339^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:17077180^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18059339^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17077180^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:20497126^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15139	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:18440775^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:20497126^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15139	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:18440775^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	PMID:20497126^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15139	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	PMID:18440775^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:20497126^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15139	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:18440775^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:18059339^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0089700	protein kinase D signaling	PMID:20497126^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15139	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:18440775^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:18059339^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:20497126^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15139	P	occurs_in:(CL:0002618) has_input:(UniProtKB:P04792)\|occurs_in(CL:0002618) has_input:(UniProtKB:Q9UQL6)	Seeded From UniProt	complete
involved_in	GO:0032793	positive regulation of CREB transcription factor activity	PMID:20497126^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15139	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:18440775^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0008219	cell death	PMID:17077180^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17077180^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17077180^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18440775^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0002618) has_direct_input:(UniProtKB:P04792)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:17077180^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:20497126^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15139	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BZ03	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BZ03	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:16928771^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:15604256^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:19192391^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050862	positive regulation of T cell receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BZ03	P		Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	PMID:17951978^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:19001381^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	PMID:19001381^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032757	positive regulation of interleukin-8 production	PMID:16928771^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032743	positive regulation of interleukin-2 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BZ03	P		Seeded From UniProt	complete
involved_in	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	PMID:19001381^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:19001381^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:11062248^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11062248^[12]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:19001381^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0089700	protein kinase D signaling	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000540182 UniProtKB:Q15139 UniProtKB:Q9BZL6	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BZ03 ensembl:ENSMUSP00000083273	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BZ03 ensembl:ENSMUSP00000083273	P		Seeded From UniProt	complete
involved_in	GO:0050862	positive regulation of T cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BZ03 ensembl:ENSMUSP00000083273	P		Seeded From UniProt	complete
involved_in	GO:0032743	positive regulation of interleukin-2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BZ03 ensembl:ENSMUSP00000083273	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015727	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR015727 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR015727	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002219	P		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.13	F		Seeded From UniProt	complete
involved_in	GO:0061154	endothelial tube morphogenesis	PMID:21488147^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:21488147^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030148	sphingolipid biosynthetic process	Reactome:R-HSA-1660661	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-429698	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Irie, A et al. (2006) Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells. Int. Immunol. 18 1737-47 PubMed GONUTS page
↑ ^2.0 ^2.1 Pusapati, GV et al. (2012) Protein kinase D regulates RhoA activity via rhotekin phosphorylation. J. Biol. Chem. 287 9473-83 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Cobbaut, M et al. (2017) Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop. Sci Rep 7 887 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Evans, IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell. Signal. 20 1375-84 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Evans, IM et al. (2010) Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells. Biochem. J. 429 565-72 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Liu, D et al. (2008) The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis. Oncogene 27 2989-98 PubMed GONUTS page
↑ ^7.0 ^7.1 Chiu, TT et al. (2007) Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB. Am. J. Physiol., Cell Physiol. 292 C767-77 PubMed GONUTS page
↑ Mihailovic, T et al. (2004) Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cells. Cancer Res. 64 8939-44 PubMed GONUTS page
↑ Li, Q et al. (2009) PKD2 interacts with Lck and regulates NFAT activity in T cells. BMB Rep 42 35-40 PubMed GONUTS page
↑ Ge, X et al. (2007) Angiotensin II directly triggers endothelial exocytosis via protein kinase C-dependent protein kinase D2 activation. J. Pharmacol. Sci. 105 168-76 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Hao, Q et al. (2009) Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis. J. Biol. Chem. 284 799-806 PubMed GONUTS page
↑ ^12.0 ^12.1 Sturany, S et al. (2001) Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases. J. Biol. Chem. 276 3310-8 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^14.0 ^14.1 Evans, IM & Zachary, IC (2011) Protein kinase D in vascular biology and angiogenesis. IUBMB Life 63 258-63 PubMed GONUTS page

[PMID:17077180-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Irie, A et al. (2006) Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells. Int. Immunol. 18 1737-47 PubMed GONUTS page

[PMID:22228765-2] 2.0 ^2.1 Pusapati, GV et al. (2012) Protein kinase D regulates RhoA activity via rhotekin phosphorylation. J. Biol. Chem. 287 9473-83 PubMed GONUTS page

[PMID:28428613-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Cobbaut, M et al. (2017) Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop. Sci Rep 7 887 PubMed GONUTS page

[PMID:18440775-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Evans, IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell. Signal. 20 1375-84 PubMed GONUTS page

[PMID:20497126-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Evans, IM et al. (2010) Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells. Biochem. J. 429 565-72 PubMed GONUTS page

[PMID:18059339-6] 6.0 ^6.1 ^6.2 ^6.3 Liu, D et al. (2008) The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis. Oncogene 27 2989-98 PubMed GONUTS page

[PMID:16928771-7] 7.0 ^7.1 Chiu, TT et al. (2007) Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB. Am. J. Physiol., Cell Physiol. 292 C767-77 PubMed GONUTS page

[PMID:15604256-8] Mihailovic, T et al. (2004) Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cells. Cancer Res. 64 8939-44 PubMed GONUTS page

[PMID:19192391-9] Li, Q et al. (2009) PKD2 interacts with Lck and regulates NFAT activity in T cells. BMB Rep 42 35-40 PubMed GONUTS page

[PMID:17951978-10] Ge, X et al. (2007) Angiotensin II directly triggers endothelial exocytosis via protein kinase C-dependent protein kinase D2 activation. J. Pharmacol. Sci. 105 168-76 PubMed GONUTS page

[PMID:19001381-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Hao, Q et al. (2009) Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis. J. Biol. Chem. 284 799-806 PubMed GONUTS page

[PMID:11062248-12] 12.0 ^12.1 Sturany, S et al. (2001) Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases. J. Biol. Chem. 276 3310-8 PubMed GONUTS page

[PMID:21873635-13] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21488147-14] 14.0 ^14.1 Evans, IM & Zachary, IC (2011) Protein kinase D in vascular biology and angiogenesis. IUBMB Life 63 258-63 PubMed GONUTS page

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HUMAN:KPCD2

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