GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:21488147

From GONUTS
Jump to: navigation, search
Citation

Evans, IM and Zachary, IC (2011) Protein kinase D in vascular biology and angiogenesis. IUBMB Life 63:258-63

Abstract

The Protein Kinase D (PKD) family comprises diacylglycerol stimulated serine/threonine protein kinases that participate in many key signaling pathways in a diverse range of cells. Recent studies show that PKD isoforms 1 and 2 play critical roles in vascular biology and angiogenesis and there has been considerable progress in determining some of the key angiogenic signaling pathways mediated by PKD in endothelial cells. Less is currently known regarding the specific roles of PKD isoforms in endothelial cells and the role of PKD in smooth muscle cells. PKD is also emerging as a potentially important mediator of tumor growth and tumor angiogenesis and there is growing interest in PKD as a novel therapeutic target in cancer.

Links

PubMed Online version:10.1002/iub.456

Keywords

Animals; Endothelial Cells/metabolism; Humans; Isoenzymes/metabolism; Muscle, Smooth, Vascular/metabolism; Muscle, Smooth, Vascular/physiology; Neoplasms/blood supply; Neovascularization, Pathologic/metabolism; Protein Kinase C/metabolism; Signal Transduction

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:ITB3

involved_in

GO:0007229: integrin-mediated signaling pathway

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KPCD2

involved_in

GO:0061154: endothelial tube morphogenesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KPCD2

involved_in

GO:0046777: protein autophosphorylation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KPCD1

involved_in

GO:2001044: regulation of integrin-mediated signaling pathway

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KPCD1

involved_in

GO:0046777: protein autophosphorylation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KPCD1

involved_in

GO:0045806: negative regulation of endocytosis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KPCD1

involved_in

GO:0007229: integrin-mediated signaling pathway

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.