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HUMAN:HDAC5
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | HDAC5 (synonyms: KIAA0600) | |
Protein Name(s) | Histone deacetylase 5
HD5 Antigen NY-CO-9 | |
External Links | ||
UniProt | Q9UQL6 | |
EMBL | AF132608 AB011172 AC023855 BC013140 BC051824 BX458255 AF039691 BK000028 | |
CCDS | CCDS32663.1 CCDS45696.1 | |
RefSeq | NP_001015053.1 NP_005465.2 XP_005256961.1 XP_005256963.1 | |
UniGene | Hs.438782 | |
ProteinModelPortal | Q9UQL6 | |
SMR | Q9UQL6 | |
BioGrid | 115331 | |
DIP | DIP-38260N | |
IntAct | Q9UQL6 | |
MINT | MINT-1407477 | |
STRING | 9606.ENSP00000225983 | |
BindingDB | Q9UQL6 | |
ChEMBL | CHEMBL3038483 | |
GuidetoPHARMACOLOGY | 2660 | |
PhosphoSite | Q9UQL6 | |
BioMuta | HDAC5 | |
DMDM | 296434519 | |
MaxQB | Q9UQL6 | |
PaxDb | Q9UQL6 | |
PRIDE | Q9UQL6 | |
Ensembl | ENST00000225983 ENST00000336057 ENST00000586802 | |
GeneID | 10014 | |
KEGG | hsa:10014 | |
UCSC | uc002ifd.1 uc002iff.1 uc010czp.1 | |
CTD | 10014 | |
GeneCards | GC17M044076 | |
H-InvDB | HIX0013862 | |
HGNC | HGNC:14068 | |
HPA | CAB019400 HPA030991 | |
MIM | 605315 | |
neXtProt | NX_Q9UQL6 | |
PharmGKB | PA29230 | |
eggNOG | COG0123 | |
GeneTree | ENSGT00530000062809 | |
HOGENOM | HOG000232065 | |
HOVERGEN | HBG057100 | |
InParanoid | Q9UQL6 | |
KO | K11406 | |
OMA | LGPYDSR | |
OrthoDB | EOG7RFTH5 | |
PhylomeDB | Q9UQL6 | |
TreeFam | TF106174 | |
Reactome | R-HSA-2122947 R-HSA-2644606 R-HSA-2894862 | |
ChiTaRS | HDAC5 | |
GeneWiki | Histone_deacetylase_5 | |
GenomeRNAi | 10014 | |
NextBio | 37831 | |
PRO | PR:Q9UQL6 | |
Proteomes | UP000005640 | |
Bgee | Q9UQL6 | |
CleanEx | HS_HDAC5 | |
ExpressionAtlas | Q9UQL6 | |
Genevisible | Q9UQL6 | |
GO | GO:0005737 GO:0005829 GO:0005794 GO:0000118 GO:0016604 GO:0005654 GO:0005634 GO:0003682 GO:0001047 GO:0004407 GO:0042826 GO:0046872 GO:0032041 GO:0033558 GO:0005080 GO:0070491 GO:0001025 GO:0003714 GO:0008134 GO:0042113 GO:0030183 GO:0032869 GO:0071222 GO:0016568 GO:0006325 GO:0006338 GO:0006342 GO:0007507 GO:0016575 GO:0006954 GO:0033555 GO:0090051 GO:0010832 GO:0045668 GO:0000122 GO:0045892 GO:0030182 GO:0007219 GO:0002076 GO:0051091 GO:0045944 GO:0006476 GO:0040029 GO:0010830 GO:0043393 GO:0048742 GO:0014823 GO:0042220 GO:0042493 GO:0006351 | |
Gene3D | 3.40.800.20 | |
InterPro | IPR000286 IPR023801 IPR024643 IPR017320 IPR030703 | |
PANTHER | PTHR10625 PTHR10625:SF57 | |
Pfam | PF12203 PF00850 | |
PIRSF | PIRSF037911 | |
PRINTS | PR01270 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
NOT|involved_in |
GO:2000615 |
regulation of histone H3-K9 acetylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042826 |
histone deacetylase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006476 |
protein deacetylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0033558 |
protein deacetylase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002577)|part_of:(CL:0000371) |
Seeded From UniProt |
complete | ||
enables |
GO:0001085 |
RNA polymerase II transcription factor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0040029 |
regulation of gene expression, epigenetic |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090051 |
negative regulation of cell migration involved in sprouting angiogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0070491 |
repressing transcription factor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043393 |
regulation of protein binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032869 |
cellular response to insulin stimulus |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016575 |
histone deacetylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010832 |
negative regulation of myotube differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010832 |
negative regulation of myotube differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008134 |
transcription factor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004407 |
histone deacetylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010830 |
regulation of myotube differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005080 |
protein kinase C binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
GO:0005737 |
cytoplasm |
ECO:0000314 |
C |
Figure 2C |
complete | |||||
part_of |
GO:0016607 |
nuclear speck |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 2C and F |
complete | |||||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070932 |
histone H3 deacetylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0032041 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LM64 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042493 |
response to drug |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LM64 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042220 |
response to cocaine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LM64 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LM64 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030182 |
neuron differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LM64 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0014823 |
response to activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LM64 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008134 |
transcription factor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LM64 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LM64 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LM64 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003682 |
chromatin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LM64 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0000118 |
histone deacetylase complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004407 |
histone deacetylase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016575 |
histone deacetylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0040029 |
regulation of gene expression, epigenetic |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0032041 |
NAD-dependent histone deacetylase activity (H3-K14 specific) |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004407 |
histone deacetylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006342 |
chromatin silencing |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006338 |
chromatin remodeling |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004407 |
histone deacetylase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042113 |
B cell activation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030183 |
B cell differentiation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0000118 |
histone deacetylase complex |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-2220982 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Chen, H & Qi, L (2010) SUMO modification regulates the transcriptional activity of XBP1. Biochem. J. 429 95-102 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Chang, CW et al. (2013) Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion. Mol. Hum. Reprod. 19 745-55 PubMed GONUTS page
- ↑ 3.0 3.1 Kang, HJ et al. (2014) Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1. Cancer Res. 74 1484-94 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Urbich, C et al. (2009) HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells. Blood 113 5669-79 PubMed GONUTS page
- ↑ Zhang, CL et al. (2002) Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation. Mol. Cell. Biol. 22 7302-12 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Seo, HW et al. (2009) Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1. FEBS Lett. 583 55-60 PubMed GONUTS page
- ↑ McGee, SL et al. (2008) AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5. Diabetes 57 860-7 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 Grozinger, CM & Schreiber, SL (2000) Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc. Natl. Acad. Sci. U.S.A. 97 7835-40 PubMed GONUTS page
- ↑ 9.0 9.1 Lu, J et al. (2000) Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Mol. Cell 6 233-44 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 McKinsey, TA et al. (2000) Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature 408 106-11 PubMed GONUTS page
- ↑ Harrison, BC et al. (2010) Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases. FEBS Lett. 584 1103-10 PubMed GONUTS page
- ↑ McKinsey, TA et al. (2006) Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK. Mol. Biol. Cell 17 438-47 PubMed GONUTS page
- ↑ 13.0 13.1 Cho, Y et al. (2015) Filamin A is required in injured axons for HDAC5 activity and axon regeneration. J. Biol. Chem. 290 22759-70 PubMed GONUTS page
- ↑ 14.0 14.1 Grozinger, CM et al. (1999) Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Natl. Acad. Sci. U.S.A. 96 4868-73 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 15.4 15.5 Verdin, E et al. (2003) Class II histone deacetylases: versatile regulators. Trends Genet. 19 286-93 PubMed GONUTS page
c
- Catarrhini
- GO:0032869 ! cellular response to insulin stimulus
- GO:0071222 ! cellular response to lipopolysaccharide
- Chordata
- GO:0003682 ! chromatin binding
- GO:0006325 ! chromatin organization
- GO:0006338 ! chromatin remodeling
- GO:0006342 ! chromatin silencing
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005829 ! cytosol
e
h
n
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0010832 ! negative regulation of myotube differentiation
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0090051 ! negative regulation of cell migration involved in sprouting angiogenesis
- GO:0030182 ! neuron differentiation
- GO:0016607 ! nuclear speck
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
o
p
- GO:0051091 ! positive regulation of DNA-binding transcription factor activity
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- Primates
- GO:0032991 ! protein-containing complex
- GO:0006476 ! protein deacetylation
- GO:0005080 ! protein kinase C binding
- GO:0033558 ! protein lysine deacetylase activity
r
- GO:0043393 ! regulation of protein binding
- GO:0010830 ! regulation of myotube differentiation
- GO:0070491 ! repressing transcription factor binding
- GO:0042220 ! response to cocaine
- GO:0014823 ! response to activity
- GO:0042493 ! response to drug
- GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding
- GO:0001085 ! RNA polymerase II transcription factor binding
t