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HUMAN:HDAC5

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) HDAC5 (synonyms: KIAA0600)
Protein Name(s) Histone deacetylase 5

HD5 Antigen NY-CO-9

External Links
UniProt Q9UQL6
EMBL AF132608
AB011172
AC023855
BC013140
BC051824
BX458255
AF039691
BK000028
CCDS CCDS32663.1
CCDS45696.1
RefSeq NP_001015053.1
NP_005465.2
XP_005256961.1
XP_005256963.1
UniGene Hs.438782
ProteinModelPortal Q9UQL6
SMR Q9UQL6
BioGrid 115331
DIP DIP-38260N
IntAct Q9UQL6
MINT MINT-1407477
STRING 9606.ENSP00000225983
BindingDB Q9UQL6
ChEMBL CHEMBL3038483
GuidetoPHARMACOLOGY 2660
PhosphoSite Q9UQL6
BioMuta HDAC5
DMDM 296434519
MaxQB Q9UQL6
PaxDb Q9UQL6
PRIDE Q9UQL6
Ensembl ENST00000225983
ENST00000336057
ENST00000586802
GeneID 10014
KEGG hsa:10014
UCSC uc002ifd.1
uc002iff.1
uc010czp.1
CTD 10014
GeneCards GC17M044076
H-InvDB HIX0013862
HGNC HGNC:14068
HPA CAB019400
HPA030991
MIM 605315
neXtProt NX_Q9UQL6
PharmGKB PA29230
eggNOG COG0123
GeneTree ENSGT00530000062809
HOGENOM HOG000232065
HOVERGEN HBG057100
InParanoid Q9UQL6
KO K11406
OMA LGPYDSR
OrthoDB EOG7RFTH5
PhylomeDB Q9UQL6
TreeFam TF106174
Reactome R-HSA-2122947
R-HSA-2644606
R-HSA-2894862
ChiTaRS HDAC5
GeneWiki Histone_deacetylase_5
GenomeRNAi 10014
NextBio 37831
PRO PR:Q9UQL6
Proteomes UP000005640
Bgee Q9UQL6
CleanEx HS_HDAC5
ExpressionAtlas Q9UQL6
Genevisible Q9UQL6
GO GO:0005737
GO:0005829
GO:0005794
GO:0000118
GO:0016604
GO:0005654
GO:0005634
GO:0003682
GO:0001047
GO:0004407
GO:0042826
GO:0046872
GO:0032041
GO:0033558
GO:0005080
GO:0070491
GO:0001025
GO:0003714
GO:0008134
GO:0042113
GO:0030183
GO:0032869
GO:0071222
GO:0016568
GO:0006325
GO:0006338
GO:0006342
GO:0007507
GO:0016575
GO:0006954
GO:0033555
GO:0090051
GO:0010832
GO:0045668
GO:0000122
GO:0045892
GO:0030182
GO:0007219
GO:0002076
GO:0051091
GO:0045944
GO:0006476
GO:0040029
GO:0010830
GO:0043393
GO:0048742
GO:0014823
GO:0042220
GO:0042493
GO:0006351
Gene3D 3.40.800.20
InterPro IPR000286
IPR023801
IPR024643
IPR017320
IPR030703
PANTHER PTHR10625
PTHR10625:SF57
Pfam PF12203
PF00850
PIRSF PIRSF037911
PRINTS PR01270

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0008134

transcription factor binding

PMID:20408817[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O35426-2

F

Seeded From UniProt

complete

NOT|involved_in

GO:2000615

regulation of histone H3-K9 acetylation

PMID:23867755[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

PMID:23867755[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O15379

F

Seeded From UniProt

complete

involved_in

GO:0006476

protein deacetylation

PMID:23867755[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0033558

protein deacetylase activity

PMID:23867755[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:23867755[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:23867755[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002577)|part_of:(CL:0000371)

Seeded From UniProt

complete

enables

GO:0001085

RNA polymerase II transcription factor binding

PMID:23867755[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NP62

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:24413532[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0040029

regulation of gene expression, epigenetic

PMID:24413532[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090051

negative regulation of cell migration involved in sprouting angiogenesis

PMID:19351956[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070491

repressing transcription factor binding

PMID:12242305[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q61686

F

Seeded From UniProt

complete

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

PMID:19071119[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:19071119[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

contributes_to

GO:0044212

transcription regulatory region DNA binding

PMID:19351956[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043393

regulation of protein binding

PMID:19071119[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032869

cellular response to insulin stimulus

PMID:18184930[7]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016575

histone deacetylation

PMID:10869435[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010832

negative regulation of myotube differentiation

PMID:10983972[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010832

negative regulation of myotube differentiation

PMID:11081517[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:19071119[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q61221

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:10869435[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11081517[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10869435[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11081517[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004407

histone deacetylase activity

PMID:10869435[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:10983972[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:19351956[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010830

regulation of myotube differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z2V6

P

Seeded From UniProt

complete

enables

GO:0005080

protein kinase C binding

PMID:20188095[11]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q16512

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:16236793[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:26157139[13]

ECO:0000314

C

Figure 2C

complete
CACAO 11095

part_of

GO:0016607

nuclear speck

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:26157139[13]

ECO:0000314

C

Figure 2C and F

complete
CACAO 11097

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070932

histone H3 deacetylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0032041

P

Seeded From UniProt

complete

involved_in

GO:0071222

cellular response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1LM64
ensembl:ENSRNOP00000052059

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1LM64
ensembl:ENSRNOP00000052059

P

Seeded From UniProt

complete

involved_in

GO:0042220

response to cocaine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1LM64
ensembl:ENSRNOP00000052059

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1LM64
ensembl:ENSRNOP00000052059

C

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1LM64
ensembl:ENSRNOP00000052059

P

Seeded From UniProt

complete

involved_in

GO:0014823

response to activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1LM64
ensembl:ENSRNOP00000052059

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1LM64
ensembl:ENSRNOP00000052059

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1LM64
ensembl:ENSRNOP00000052059

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1LM64
ensembl:ENSRNOP00000052059

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1LM64
ensembl:ENSRNOP00000052059

F

Seeded From UniProt

complete

part_of

GO:0000118

histone deacetylase complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017320

C

Seeded From UniProt

complete

enables

GO:0004407

histone deacetylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017320
InterPro:IPR030703

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030703

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030703

C

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017320

P

Seeded From UniProt

complete

involved_in

GO:0016575

histone deacetylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017320
InterPro:IPR030703

P

Seeded From UniProt

complete

involved_in

GO:0040029

regulation of gene expression, epigenetic

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030703

P

Seeded From UniProt

complete

enables

GO:0032041

NAD-dependent histone deacetylase activity (H3-K14 specific)

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.1.98

F

Seeded From UniProt

complete

enables

GO:0004407

histone deacetylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.1.98

F

Seeded From UniProt

complete

involved_in

GO:0006342

chromatin silencing

PMID:10869435[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006338

chromatin remodeling

PMID:10220385[14]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004407

histone deacetylase activity

PMID:10220385[14]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:12711221[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042113

B cell activation

PMID:12711221[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030183

B cell differentiation

PMID:12711221[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:12711221[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

PMID:12711221[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000118

histone deacetylase complex

PMID:12711221[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-2220982

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Chen, H & Qi, L (2010) SUMO modification regulates the transcriptional activity of XBP1. Biochem. J. 429 95-102 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Chang, CW et al. (2013) Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion. Mol. Hum. Reprod. 19 745-55 PubMed GONUTS page
  3. 3.0 3.1 Kang, HJ et al. (2014) Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1. Cancer Res. 74 1484-94 PubMed GONUTS page
  4. 4.0 4.1 4.2 Urbich, C et al. (2009) HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells. Blood 113 5669-79 PubMed GONUTS page
  5. Zhang, CL et al. (2002) Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation. Mol. Cell. Biol. 22 7302-12 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Seo, HW et al. (2009) Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1. FEBS Lett. 583 55-60 PubMed GONUTS page
  7. McGee, SL et al. (2008) AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5. Diabetes 57 860-7 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 Grozinger, CM & Schreiber, SL (2000) Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc. Natl. Acad. Sci. U.S.A. 97 7835-40 PubMed GONUTS page
  9. 9.0 9.1 Lu, J et al. (2000) Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Mol. Cell 6 233-44 PubMed GONUTS page
  10. 10.0 10.1 10.2 McKinsey, TA et al. (2000) Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature 408 106-11 PubMed GONUTS page
  11. Harrison, BC et al. (2010) Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases. FEBS Lett. 584 1103-10 PubMed GONUTS page
  12. McKinsey, TA et al. (2006) Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK. Mol. Biol. Cell 17 438-47 PubMed GONUTS page
  13. 13.0 13.1 Cho, Y et al. (2015) Filamin A is required in injured axons for HDAC5 activity and axon regeneration. J. Biol. Chem. 290 22759-70 PubMed GONUTS page
  14. 14.0 14.1 Grozinger, CM et al. (1999) Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Natl. Acad. Sci. U.S.A. 96 4868-73 PubMed GONUTS page
  15. 15.0 15.1 15.2 15.3 15.4 15.5 Verdin, E et al. (2003) Class II histone deacetylases: versatile regulators. Trends Genet. 19 286-93 PubMed GONUTS page