HUMAN:H2AY

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	H2AFY (synonyms: MACROH2A1)
Protein Name(s)	Core histone macro-H2A.1 Histone macroH2A1 mH2A1 Histone H2A.y H2A/y Medulloblastoma antigen MU-MB-50.205
External Links
UniProt	O75367
EMBL	AF041483 AF044286 AF054174 AK023409 AC026691 BC013331 BC095406 AY134746
CCDS	CCDS4183.1 CCDS4184.1 CCDS4185.1
RefSeq	NP_001035248.1 NP_004884.1 NP_613075.1 NP_613258.2
UniGene	Hs.420272 Hs.599225
PDB	1U35 1ZR3 1ZR5 2F8N 2FXK 3HQH 3HSV 3IID 3IIF 3IVB
PDBsum	1U35 1ZR3 1ZR5 2F8N 2FXK 3HQH 3HSV 3IID 3IIF 3IVB
ProteinModelPortal	O75367
SMR	O75367
BioGrid	114927
DIP	DIP-44283N
IntAct	O75367
MINT	MINT-2866965
STRING	9606.ENSP00000353806
PhosphoSite	O75367
SWISS-2DPAGE	O75367
MaxQB	O75367
PaxDb	O75367
PRIDE	O75367
DNASU	9555
Ensembl	ENST00000304332 ENST00000312469 ENST00000510038 ENST00000511689
GeneID	9555
KEGG	hsa:9555
UCSC	uc003lam.1 uc003lan.1 uc003lao.1
CTD	9555
GeneCards	GC05M134669
HGNC	HGNC:4740
MIM	610054
neXtProt	NX_O75367
PharmGKB	PA29117
eggNOG	COG2110
GeneTree	ENSGT00760000119217
HOVERGEN	HBG009342
InParanoid	O75367
KO	K11251
OMA	QVVQADI
OrthoDB	EOG71G9VP
PhylomeDB	O75367
TreeFam	TF332276
ChiTaRS	H2AFY
EvolutionaryTrace	O75367
GeneWiki	H2AFY
GenomeRNAi	9555
NextBio	35835
PMAP-CutDB	O75367
PRO	PR:O75367
Proteomes	UP000005640
Bgee	O75367
CleanEx	HS_H2AFY
ExpressionAtlas	O75367
Genevestigator	O75367
GO	GO:0001740 GO:0000793 GO:0070062 GO:0000790 GO:0005730 GO:0000786 GO:0005634 GO:0005721 GO:0001739 GO:0031490 GO:0003677 GO:0010385 GO:0019901 GO:0030291 GO:0000182 GO:0044212 GO:0016568 GO:0007549 GO:0071169 GO:1902750 GO:0045814 GO:0033128 GO:0071901 GO:0000122 GO:1901837 GO:0006334
Gene3D	1.10.20.10
InterPro	IPR021171 IPR009072 IPR007125 IPR002119 IPR002589
Pfam	PF00125 PF01661
PIRSF	PIRSF037942
PRINTS	PR00620
SMART	SM00506 SM00414
SUPFAM	SSF47113
PROSITE	PS51154

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1902882	regulation of response to oxidative stress	PMID:23022728^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:19135898^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904815	negative regulation of protein localization to chromosome, telomeric region	PMID:26373281^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	transports_or_maintains_localization_of:(UniProtKB:O95271)	Seeded From UniProt	complete
involved_in	GO:0034184	positive regulation of maintenance of mitotic sister chromatid cohesion	PMID:26373281^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:26373281^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O95271	F		Seeded From UniProt	complete
involved_in	GO:0045814	negative regulation of gene expression, epigenetic	PMID:23595991^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q01860) happens_during:(GO:0035987) has_input:(UniProtKB:P48431)	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:23595991^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:Q01860) has_input:(UniProtKB:Q9H9S0) has_input:(UniProtKB:Q9Y261) has_input:(UniProtKB:Q9H6I2) happens_during:(GO:0035987)	Seeded From UniProt	complete
involved_in	GO:0045618	positive regulation of keratinocyte differentiation	PMID:23595991^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	PMID:25526730^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061086	negative regulation of histone H3-K27 methylation	PMID:25526730^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	causally_upstream_of:(GO:0019216)	Seeded From UniProt	complete
involved_in	GO:0051572	negative regulation of histone H3-K4 methylation	PMID:25526730^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	causally_upstream_of:(GO:0019216)	Seeded From UniProt	complete
involved_in	GO:0045815	positive regulation of gene expression, epigenetic	PMID:25526730^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	causally_upstream_of:(GO:0019216)	Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	PMID:25526730^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000182)	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:20008927^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0040029	regulation of gene expression, epigenetic	PMID:20008927^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031492	nucleosomal DNA binding	PMID:20008927^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0031492	nucleosomal DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZQ8	F		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZQ8	F		Seeded From UniProt	complete
part_of	GO:0000228	nuclear chromosome	PMID:18936163^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001740	Barr body	PMID:18936163^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005721	pericentric heterochromatin	PMID:19486527^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902750	negative regulation of cell cycle G2/M phase transition	PMID:22194607^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901837	negative regulation of transcription of nucleolar large rRNA by RNA polymerase I	PMID:24071584^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9P0M6	P		Seeded From UniProt	complete
involved_in	GO:1901837	negative regulation of transcription of nucleolar large rRNA by RNA polymerase I	PMID:24071584^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071901	negative regulation of protein serine/threonine kinase activity	PMID:22194607^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071169	establishment of protein localization to chromatin	PMID:19734898^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q15910)	Seeded From UniProt	complete
NOT\|involved_in	GO:0061187	regulation of chromatin silencing at rDNA	PMID:24071584^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045814	negative regulation of gene expression, epigenetic	PMID:19734898^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045814	negative regulation of gene expression, epigenetic	PMID:24071584^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:19734898^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0033128	negative regulation of histone phosphorylation	PMID:22194607^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q99986) part_of:(GO:0043987) part_of:(GO:0072355)	Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	PMID:19734898^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	PMID:24071584^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0030291	protein serine/threonine kinase inhibitor activity	PMID:22194607^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_regulation_target:(UniProtKB:Q99986)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:22194607^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99986	F		Seeded From UniProt	complete
enables	GO:0010385	double-stranded methylated DNA binding	PMID:24071584^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:24071584^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21630459^[13]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:19734898^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:24071584^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:22194607^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000182	rDNA binding	PMID:24071584^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19734898^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O43364) has_regulation_target:(UniProtKB:O43365) has_regulation_target:(UniProtKB:P31260)	Seeded From UniProt	complete
involved_in	GO:0006334	nucleosome assembly	PMID:9714746^[14]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:9714746^[14]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000786	nucleosome	PMID:9714746^[14]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2448285 PANTHER:PTN000604564 PomBase:SPBC11B10.10c	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000179664 PANTHER:PTN000604564 UniProtKB:O97320 UniProtKB:Q7L7L0	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102688 PANTHER:PTN000604564 SGD:S000005372 UniProtKB:O75367 UniProtKB:Q9P0M6	C		Seeded From UniProt	complete
involved_in	GO:0007549	dosage compensation	PMID:15053874^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0001740	Barr body	PMID:11331621^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02874 ensembl:ENSRNOP00000049143	C		Seeded From UniProt	complete
part_of	GO:0000786	nucleosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02874 ensembl:ENSRNOP00000049143	C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02874 ensembl:ENSRNOP00000049143	C		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZQ8 ensembl:ENSMUSP00000016081	F		Seeded From UniProt	complete
involved_in	GO:1902882	regulation of response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZQ8 ensembl:ENSMUSP00000016081	P		Seeded From UniProt	complete
involved_in	GO:1901837	negative regulation of transcription of nucleolar large rRNA by RNA polymerase I	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZQ8 ensembl:ENSMUSP00000016081	P		Seeded From UniProt	complete
enables	GO:0031492	nucleosomal DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZQ8 ensembl:ENSMUSP00000016081	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZQ8 ensembl:ENSMUSP00000016081	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZQ8 ensembl:ENSMUSP00000016081	F		Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QZQ8 ensembl:ENSMUSP00000016081	C		Seeded From UniProt	complete
part_of	GO:0000786	nucleosome	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002119 InterPro:IPR007125 InterPro:IPR021171	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002119 InterPro:IPR007125 InterPro:IPR021171	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002119	C		Seeded From UniProt	complete
involved_in	GO:0006334	nucleosome assembly	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR021171	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009072	F		Seeded From UniProt	complete
involved_in	GO:1902883	negative regulation of response to oxidative stress	PMID:23022728^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902884	positive regulation of response to oxidative stress	PMID:23022728^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0001739	sex chromatin	PMID:19486527^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
part_of	GO:0000786	nucleosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0544	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Dardenne, E et al. (2012) Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness. Nat. Struct. Mol. Biol. 19 1139-46 PubMed GONUTS page
↑ Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Ramamoorthy, M & Smith, S (2015) Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells. Cancer Cell 28 357-69 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Barrero, MJ et al. (2013) Macro histone variants are critical for the differentiation of human pluripotent cells. J. Biol. Chem. 288 16110-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Podrini, C et al. (2015) MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis. FASEB J. 29 1676-87 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Gamble, MJ et al. (2010) The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing. Genes Dev. 24 21-32 PubMed GONUTS page
↑ ^7.0 ^7.1 Mietton, F et al. (2009) Weak but uniform enrichment of the histone variant macroH2A1 along the inactive X chromosome. Mol. Cell. Biol. 29 150-6 PubMed GONUTS page
↑ ^8.0 ^8.1 Souza, PP et al. (2009) The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours. BMC Cell Biol. 10 41 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Kim, W et al. (2012) Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase. J. Biol. Chem. 287 5278-89 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 Cong, R et al. (2014) macroH2A1 histone variant represses rDNA transcription. Nucleic Acids Res. 42 181-92 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Buschbeck, M et al. (2009) The histone variant macroH2A is an epigenetic regulator of key developmental genes. Nat. Struct. Mol. Biol. 16 1074-9 PubMed GONUTS page
↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Lee, Y et al. (1998) Isolation of cDNA clones encoding human histone macroH2A1 subtypes. Biochim. Biophys. Acta 1399 73-7 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Acín-Pérez, R et al. (2004) Respiratory complex III is required to maintain complex I in mammalian mitochondria. Mol. Cell 13 805-15 PubMed GONUTS page
↑ Chadwick, BP & Willard, HF (2001) Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. Hum. Mol. Genet. 10 1101-13 PubMed GONUTS page

[PMID:23022728-1] 1.0 ^1.1 ^1.2 Dardenne, E et al. (2012) Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness. Nat. Struct. Mol. Biol. 19 1139-46 PubMed GONUTS page

[PMID:19135898-2] Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page

[PMID:26373281-3] 3.0 ^3.1 ^3.2 Ramamoorthy, M & Smith, S (2015) Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells. Cancer Cell 28 357-69 PubMed GONUTS page

[PMID:23595991-4] 4.0 ^4.1 ^4.2 Barrero, MJ et al. (2013) Macro histone variants are critical for the differentiation of human pluripotent cells. J. Biol. Chem. 288 16110-6 PubMed GONUTS page

[PMID:25526730-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Podrini, C et al. (2015) MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis. FASEB J. 29 1676-87 PubMed GONUTS page

[PMID:20008927-6] 6.0 ^6.1 ^6.2 Gamble, MJ et al. (2010) The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing. Genes Dev. 24 21-32 PubMed GONUTS page

[PMID:18936163-7] 7.0 ^7.1 Mietton, F et al. (2009) Weak but uniform enrichment of the histone variant macroH2A1 along the inactive X chromosome. Mol. Cell. Biol. 29 150-6 PubMed GONUTS page

[PMID:19486527-8] 8.0 ^8.1 Souza, PP et al. (2009) The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours. BMC Cell Biol. 10 41 PubMed GONUTS page

[PMID:23533145-9] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:22194607-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Kim, W et al. (2012) Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase. J. Biol. Chem. 287 5278-89 PubMed GONUTS page

[PMID:24071584-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 Cong, R et al. (2014) macroH2A1 histone variant represses rDNA transcription. Nucleic Acids Res. 42 181-92 PubMed GONUTS page

[PMID:19734898-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Buschbeck, M et al. (2009) The histone variant macroH2A is an epigenetic regulator of key developmental genes. Nat. Struct. Mol. Biol. 16 1074-9 PubMed GONUTS page

[PMID:21630459-13] Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page

[PMID:9714746-14] 14.0 ^14.1 ^14.2 Lee, Y et al. (1998) Isolation of cDNA clones encoding human histone macroH2A1 subtypes. Biochim. Biophys. Acta 1399 73-7 PubMed GONUTS page

[PMID:21873635-15] 15.0 ^15.1 ^15.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15053874-16] Acín-Pérez, R et al. (2004) Respiratory complex III is required to maintain complex I in mammalian mitochondria. Mol. Cell 13 805-15 PubMed GONUTS page

[PMID:11331621-17] Chadwick, BP & Willard, HF (2001) Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. Hum. Mol. Genet. 10 1101-13 PubMed GONUTS page

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HUMAN:H2AY

Contents

Annotations

Notes

References

b

c

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