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PMID:19486527

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Citation

Souza, PP, Völkel, P, Trinel, D, Vandamme, J, Rosnoblet, C, Héliot, L and Angrand, PO (2009) The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours. BMC Cell Biol. 10:41

Abstract

Histone lysine methylation plays a fundamental role in chromatin organization and marks distinct chromatin regions. In particular, trimethylation at lysine 9 of histone H3 (H3K9) and at lysine 20 of histone H4 (H4K20) governed by the histone methyltransferases SUV39H1/2 and SUV420H1/2 respectively, have emerged as a hallmark of pericentric heterochromatin. Controlled chromatin organization is crucial for gene expression regulation and genome stability. Therefore, it is essential to analyze mechanisms responsible for high order chromatin packing and in particular the interplay between enzymes involved in histone modifications, such as histone methyltransferases and proteins that recognize these epigenetic marks.

Links

PubMed PMC2701926 Online version:10.1186/1471-2121-10-41

Keywords

Amino Acid Sequence; Animals; Cell Cycle; Cell Line; Chromosomal Proteins, Non-Histone/metabolism; HeLa Cells; Heterochromatin/chemistry; Histone-Lysine N-Methyltransferase/isolation & purification; Histone-Lysine N-Methyltransferase/metabolism; Humans; Mice; Molecular Sequence Data; Nuclear Proteins/metabolism; Protein Interaction Domains and Motifs/physiology; Protein Interaction Mapping/methods

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:H2AY

located_in

GO:0001739: sex chromatin

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:H2AY

located_in

GO:0005721: pericentric heterochromatin

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:5HT7R

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P43243

F

Seeded From UniProt

complete

HUMAN:MATR3

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P34969

F

Seeded From UniProt

complete

HUMAN:CBX1

enables

GO:0019899: enzyme binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q86Y97

F

Seeded From UniProt

complete

HUMAN:CBX1

enables

GO:1990226: histone methyltransferase binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q86Y97

F

Seeded From UniProt

complete

HUMAN:CBX3

enables

GO:0042802: identical protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q13185

F

Seeded From UniProt

complete

HUMAN:CBX3

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q86Y97

F

Seeded From UniProt

complete

HUMAN:KMT5C

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q13185

F

Seeded From UniProt

complete

HUMAN:KMT5C

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P83916

F

Seeded From UniProt

complete

HUMAN:KMT5C

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q13185

F

Seeded From UniProt

complete

HUMAN:KMT5C

located_in

GO:0000792: heterochromatin

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:KMT5C

located_in

GO:0005721: pericentric heterochromatin

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:H2AY

part_of

GO:0005721: pericentric heterochromatin

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:H2AY

part_of

GO:0001739: sex chromatin

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:CBX3

enables

GO:0019899: enzyme binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q86Y97

F

Seeded From UniProt

complete

HUMAN:CBX3

enables

GO:1990226: histone methyltransferase binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q86Y97

F

Seeded From UniProt

complete

HUMAN:CBX3

enables

GO:0042802: identical protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q13185

F

occurs_in:(GO:0005634)

Seeded From UniProt

complete


See also

References

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