HUMAN:GRAB

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	GZMB (synonyms: CGL1, CSPB, CTLA1, GRB)
Protein Name(s)	Granzyme B C11 CTLA-1 Cathepsin G-like 1 CTSGL1 Cytotoxic T-lymphocyte proteinase 2 Lymphocyte protease Fragmentin-2 Granzyme-2 Human lymphocyte protein HLP SECT T-cell serine protease 1-3E
External Links
UniProt	P10144
EMBL	M17016 J03189 J04071 J03072 M38193 M28879 AL136018 BC030195
CCDS	CCDS9633.1
PIR	A61021
RefSeq	NP_004122.2
UniGene	Hs.1051
PDB	1FQ3 1IAU
PDBsum	1FQ3 1IAU
ProteinModelPortal	P10144
SMR	P10144
BioGrid	109257
IntAct	P10144
MINT	MINT-4528791
STRING	9606.ENSP00000216341
BindingDB	P10144
ChEMBL	CHEMBL2316
MEROPS	S01.010
PhosphoSite	P10144
DMDM	317373361
PaxDb	P10144
PRIDE	P10144
DNASU	3002
Ensembl	ENST00000216341
GeneID	3002
KEGG	hsa:3002
UCSC	uc001wps.2
CTD	3002
GeneCards	GC14M025100
H-InvDB	HIX0011578
HGNC	HGNC:4709
HPA	CAB000376 HPA003418
MIM	123910
neXtProt	NX_P10144
eggNOG	COG5640
GeneTree	ENSGT00760000118895
HOGENOM	HOG000251820
HOVERGEN	HBG013304
InParanoid	P10144
KO	K01353
PhylomeDB	P10144
TreeFam	TF333630
Reactome	REACT_163910 REACT_701
ChiTaRS	GZMB
EvolutionaryTrace	P10144
GeneWiki	GZMB
GenomeRNAi	3002
NextBio	11904
PMAP-CutDB	P10144
PRO	PR:P10144
Proteomes	UP000005640
Bgee	P10144
CleanEx	HS_GZMB
ExpressionAtlas	P10144
Genevestigator	P10144
GO	GO:0005737 GO:0005829 GO:0001772 GO:0043231 GO:0016020 GO:0005634 GO:0004252 GO:0008236 GO:0006915 GO:0019835 GO:0097193 GO:0007219 GO:1900740
InterPro	IPR001254 IPR018114 IPR001314 IPR009003
Pfam	PF00089
PRINTS	PR00722
SMART	SM00020
SUPFAM	SSF50494
PROSITE	PS50240 PS00134 PS00135

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0017148	negative regulation of translation	PMID:29107333^[1]	ECO:0000314			P		Fig 3B shows that luminescence decreases of luciferase reporter gene with prolonged exposure to GZMB. This assay was performed with human GZMB exposed to E.Coli.	complete CACAO 13147
involved_in	GO:0042267	natural killer cell mediated cytotoxicity	PMID:21795594^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	PMID:11331782^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P20700) occurs_in:(GO:0005634)	Seeded From UniProt	complete
involved_in	GO:0008626	granzyme-mediated apoptotic signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109267 PANTHER:PTN000668323	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109267 PANTHER:PTN000668264	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1900740	C		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001254 InterPro:IPR001314 InterPro:IPR018114 InterPro:IPR037553	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001254 InterPro:IPR001314 InterPro:IPR018114	P		Seeded From UniProt	complete
involved_in	GO:0008626	granzyme-mediated apoptotic signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037553	P		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037553	C		Seeded From UniProt	complete
involved_in	GO:0042267	natural killer cell mediated cytotoxicity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037553	P		Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	PMID:2402757^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	PMID:2049336^[7] PMID:12524539^[8] Reactome:R-HSA-139893	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:12524539^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11909973^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001772	immunological synapse	PMID:12524539^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	Reactome:R-HSA-75108	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-139893	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0720	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
involved_in	GO:0019835	cytolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0204	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Dotiwala, F et al. (2017) Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program. Cell 171 1125-1137.e11 PubMed GONUTS page
↑ El Haddad, N et al. (2011) The novel role of SERPINB9 in cytotoxic protection of human mesenchymal stem cells. J. Immunol. 187 2252-60 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Zhang, D et al. (2001) Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis. Proc. Natl. Acad. Sci. U.S.A. 98 5746-51 PubMed GONUTS page
↑ ^5.0 ^5.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Klein, JL et al. (1990) Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C). Tissue Antigens 35 220-8 PubMed GONUTS page
↑ Haddad, P et al. (1991) Structure and evolutionary origin of the human granzyme H gene. Int. Immunol. 3 57-66 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Fan, Z et al. (2003) Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Nat. Immunol. 4 145-53 PubMed GONUTS page
↑ Fan, Z et al. (2002) HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Mol. Cell. Biol. 22 2810-20 PubMed GONUTS page

[PMID:29107333-1] Dotiwala, F et al. (2017) Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program. Cell 171 1125-1137.e11 PubMed GONUTS page

[PMID:21795594-2] El Haddad, N et al. (2011) The novel role of SERPINB9 in cytotoxic protection of human mesenchymal stem cells. J. Immunol. 187 2252-60 PubMed GONUTS page

[PMID:19946888-3] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:11331782-4] Zhang, D et al. (2001) Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis. Proc. Natl. Acad. Sci. U.S.A. 98 5746-51 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:2402757-6] Klein, JL et al. (1990) Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C). Tissue Antigens 35 220-8 PubMed GONUTS page

[PMID:2049336-7] Haddad, P et al. (1991) Structure and evolutionary origin of the human granzyme H gene. Int. Immunol. 3 57-66 PubMed GONUTS page

[PMID:12524539-8] 8.0 ^8.1 ^8.2 Fan, Z et al. (2003) Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Nat. Immunol. 4 145-53 PubMed GONUTS page

[PMID:11909973-9] Fan, Z et al. (2002) HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Mol. Cell. Biol. 22 2810-20 PubMed GONUTS page

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HUMAN:GRAB

Contents

Annotations

Notes

References

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