HUMAN:FOXO3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FOXO3 (synonyms: FKHRL1, FOXO3A)
Protein Name(s)	Forkhead box protein O3 AF6q21 protein Forkhead in rhabdomyosarcoma-like 1
External Links
UniProt	O43524
EMBL	AF032886 AK301304 AL096818 AL391646 AL365509 AL365509 AL391646 CH471051 CH471051 BC020227 BC021224 BC068552 AJ001589 AJ001590
CCDS	CCDS5068.1
RefSeq	NP_001446.1 NP_963853.1 XP_005266925.1
UniGene	Hs.220950
PDB	2K86 2LQH 2LQI 2UZK
PDBsum	2K86 2LQH 2LQI 2UZK
ProteinModelPortal	O43524
SMR	O43524
BioGrid	108598
DIP	DIP-29723N
IntAct	O43524
MINT	MINT-89098
STRING	9606.ENSP00000339527
ChEMBL	CHEMBL5778
PhosphoSite	O43524
MaxQB	O43524
PaxDb	O43524
PRIDE	O43524
DNASU	2309
Ensembl	ENST00000343882 ENST00000406360 ENST00000540898
GeneID	2309
KEGG	hsa:2309
UCSC	uc003psk.2
CTD	2309
GeneCards	GC06P108881
HGNC	HGNC:3821
HPA	CAB004074
MIM	602681
neXtProt	NX_O43524
PharmGKB	PA28239
eggNOG	COG5025
GeneTree	ENSGT00390000000589
HOGENOM	HOG000251635
HOVERGEN	HBG057789
InParanoid	O43524
KO	K09408
OMA	NFTGAKQ
OrthoDB	EOG7R2BJD
PhylomeDB	O43524
TreeFam	TF315583
Reactome	REACT_111057 REACT_12442 REACT_147727
SignaLink	O43524
ChiTaRS	FOXO3
EvolutionaryTrace	O43524
GeneWiki	FOXO3
GenomeRNAi	2309
NextBio	35475594
PRO	PR:O43524
Proteomes	UP000005640
Bgee	O43524
CleanEx	HS_FOXO3
ExpressionAtlas	O43524
Genevestigator	O43524
GO	GO:0005737 GO:0005829 GO:0016020 GO:0005654 GO:0005634 GO:0031490 GO:0001047 GO:0003677 GO:0019901 GO:0043565 GO:0003700 GO:0001547 GO:0034599 GO:0030330 GO:0007173 GO:0097192 GO:0038095 GO:0008543 GO:0042593 GO:0001544 GO:0045087 GO:0000122 GO:0048011 GO:0001556 GO:0001542 GO:0048015 GO:0045648 GO:0043525 GO:0045944 GO:0045893 GO:0006357 GO:0006417 GO:0006351
Gene3D	1.10.10.10
InterPro	IPR001766 IPR018122 IPR011991
Pfam	PF00250
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001766	F		Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WVH4	P		Seeded From UniProt	complete
involved_in	GO:0014737	positive regulation of muscle atrophy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WVH4	P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WVH4	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	PMID:19188590^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:29445193^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006390	mitochondrial transcription	PMID:29445193^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0042149)	Seeded From UniProt	complete
enables	GO:0034246	mitochondrial sequence-specific DNA-binding transcription factor activity	PMID:29445193^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	happens_during:(GO:0042149)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:29445193^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005759	mitochondrial matrix	PMID:29445193^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0042149)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q61660	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:15905404^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35222	F	part_of:(GO:0034599)	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:20371612^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20371612^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000062716)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:20371612^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSG00000062716)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20371612^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15084260^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:15084260^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15084260^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15084260^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23283301^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23283301^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005739	mitochondrion	PMID:23283301^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0042149)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:29445193^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0042149)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:23283301^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0042149)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18787191^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10102273^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10102273^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:10102273^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	PMID:10102273^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WVH4	P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WVH4	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21329882^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8IW41	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:18593906^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11309	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:16751106^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13043	F		Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	PMID:21329882^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WVH4	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21329882^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10102273^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16751106^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22761832^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21329882^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16751106^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10102273^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21329882^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WVH4	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:1891915 PANTHER:PTN002908599 RGD:620283 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	F		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 PANTHER:PTN000215135 UniProtKB:A4L7N3 UniProtKB:P98177 WB:WBGene00000912	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 PANTHER:PTN002908599 UniProtKB:P98177	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:2676586 PANTHER:PTN002908599 RGD:1309196 RGD:1561201 RGD:620283 UniProtKB:A4L7N3 UniProtKB:F1NNE8 UniProtKB:F1RME6 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:2676586 PANTHER:PTN002908599 RGD:1309196 RGD:1561201 RGD:620283 UniProtKB:A4L7N3 UniProtKB:F1RME6 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599 RGD:620283 UniProtKB:O43524 UniProtKB:P98177 WB:WBGene00000912	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2676586 PANTHER:PTN002908599	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002908599 UniProtKB:O43524 WB:WBGene00000912 ZFIN:ZDB-GENE-990708-6	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:14734530^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	PMID:14734530^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25327288^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:14734530^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23640897^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0033554)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:23640897^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000353	positive regulation of endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:1990785	response to water-immersion restraint stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0071548	response to dexamethasone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0071386	cellular response to corticosterone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	C		Seeded From UniProt	complete
enables	GO:0001221	transcription cofactor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	F		Seeded From UniProt	complete
involved_in	GO:0014737	positive regulation of muscle atrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
involved_in	GO:0006390	mitochondrial transcription	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	F		Seeded From UniProt	complete
involved_in	GO:0001556	oocyte maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
involved_in	GO:0001547	antral ovarian follicle growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
involved_in	GO:0001544	initiation of primordial ovarian follicle growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
involved_in	GO:0001542	ovulation from ovarian follicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	F		Seeded From UniProt	complete
involved_in	GO:2000377	regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
involved_in	GO:2000177	regulation of neural precursor cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
involved_in	GO:0097150	neuronal stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	F		Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
enables	GO:0034246	mitochondrial sequence-specific DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	C		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	F		Seeded From UniProt	complete
involved_in	GO:0030330	DNA damage response, signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVH4 ensembl:ENSMUSP00000101141	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-8870566 Reactome:R-HSA-9614562 Reactome:R-HSA-9614414 Reactome:R-HSA-8870628 Reactome:R-HSA-5687126 Reactome:R-HSA-5687101	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-9625758 Reactome:R-NUL-9624615 Reactome:R-NUL-9620900 Reactome:R-NUL-9620857 Reactome:R-NUL-9620806 Reactome:R-HSA-9625375 Reactome:R-HSA-9625091 Reactome:R-HSA-9624976 Reactome:R-HSA-9623415 Reactome:R-HSA-9622668 Reactome:R-HSA-9622630 Reactome:R-HSA-9620532 Reactome:R-HSA-9620515 Reactome:R-HSA-9618021 Reactome:R-HSA-9618004 Reactome:R-HSA-9617996 Reactome:R-HSA-9617972 Reactome:R-HSA-9617840 Reactome:R-HSA-9614662 Reactome:R-HSA-9614414 Reactome:R-HSA-8952226 Reactome:R-HSA-8870628 Reactome:R-HSA-6790036 Reactome:R-HSA-5687126 Reactome:R-HSA-5687095 Reactome:R-HSA-2399992 Reactome:R-HSA-199299 Reactome:R-HSA-1535903	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0170	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Segura, MF et al. (2009) Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. Proc. Natl. Acad. Sci. U.S.A. 106 1814-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Celestini, V et al. (2018) Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy. Cell Death Dis 9 231 PubMed GONUTS page
↑ Essers, MA et al. (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308 1181-4 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Wang, K & Li, PF (2010) Foxo3a regulates apoptosis by negatively targeting miR-21. J. Biol. Chem. 285 16958-66 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Hu, MC et al. (2004) IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117 225-37 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Peserico, A et al. (2013) A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cell. Mol. Life Sci. 70 2015-29 PubMed GONUTS page
↑ Heinke, J et al. (2008) BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. Circ. Res. 103 804-12 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Brunet, A et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96 857-68 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Kress, TR et al. (2011) The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis. Mol. Cell 41 445-57 PubMed GONUTS page
↑ Morishita, D et al. (2008) Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. Cancer Res. 68 5076-85 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Lehtinen, MK et al. (2006) A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125 987-1001 PubMed GONUTS page
↑ Ghosh, AP et al. (2012) CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS ONE 7 e39586 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 ^14.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Bakker, WJ et al. (2004) FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1. J. Cell Biol. 164 175-84 PubMed GONUTS page
↑ Dowdle, WE et al. (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16 1069-79 PubMed GONUTS page
↑ ^17.0 ^17.1 Wang, N et al. (2013) Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism. J. Biol. Chem. 288 18146-61 PubMed GONUTS page

[PMID:19274049-1] Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:19188590-2] Segura, MF et al. (2009) Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. Proc. Natl. Acad. Sci. U.S.A. 106 1814-9 PubMed GONUTS page

[PMID:29445193-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Celestini, V et al. (2018) Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy. Cell Death Dis 9 231 PubMed GONUTS page

[PMID:15905404-4] Essers, MA et al. (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308 1181-4 PubMed GONUTS page

[PMID:20371612-5] 5.0 ^5.1 ^5.2 ^5.3 Wang, K & Li, PF (2010) Foxo3a regulates apoptosis by negatively targeting miR-21. J. Biol. Chem. 285 16958-66 PubMed GONUTS page

[PMID:15084260-6] 6.0 ^6.1 ^6.2 ^6.3 Hu, MC et al. (2004) IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117 225-37 PubMed GONUTS page

[PMID:23283301-7] 7.0 ^7.1 ^7.2 ^7.3 Peserico, A et al. (2013) A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cell. Mol. Life Sci. 70 2015-29 PubMed GONUTS page

[PMID:18787191-8] Heinke, J et al. (2008) BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. Circ. Res. 103 804-12 PubMed GONUTS page

[PMID:10102273-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Brunet, A et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96 857-68 PubMed GONUTS page

[PMID:21329882-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Kress, TR et al. (2011) The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis. Mol. Cell 41 445-57 PubMed GONUTS page

[PMID:18593906-11] Morishita, D et al. (2008) Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. Cancer Res. 68 5076-85 PubMed GONUTS page

[PMID:16751106-12] 12.0 ^12.1 ^12.2 Lehtinen, MK et al. (2006) A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125 987-1001 PubMed GONUTS page

[PMID:22761832-13] Ghosh, AP et al. (2012) CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS ONE 7 e39586 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 ^14.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:14734530-15] 15.0 ^15.1 ^15.2 Bakker, WJ et al. (2004) FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1. J. Cell Biol. 164 175-84 PubMed GONUTS page

[PMID:25327288-16] Dowdle, WE et al. (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16 1069-79 PubMed GONUTS page

[PMID:23640897-17] 17.0 ^17.1 Wang, N et al. (2013) Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism. J. Biol. Chem. 288 18146-61 PubMed GONUTS page

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HUMAN:FOXO3

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