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HUMAN:FOXM1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) FOXM1 (synonyms: FKHL16, HFH11, MPP2, WIN)
Protein Name(s) Forkhead box protein M1

Forkhead-related protein FKHL16 Hepatocyte nuclear factor 3 forkhead homolog 11 HFH-11 HNF-3/fork-head homolog 11 M-phase phosphoprotein 2 MPM-2 reactive phosphoprotein 2 Transcription factor Trident Winged-helix factor from INS-1 cells

External Links
UniProt Q08050
EMBL U74612
U74613
U83113
DQ022289
BC006192
BC006529
BC012863
L16783
CCDS CCDS8515.1
CCDS8516.1
CCDS8517.1
PIR B36881
RefSeq NP_001230017.1
NP_001230018.1
NP_068772.2
NP_973731.1
NP_973732.1
UniGene Hs.239
Hs.735243
PDB 3G73
PDBsum 3G73
ProteinModelPortal Q08050
SMR Q08050
BioGrid 108594
DIP DIP-36754N
IntAct Q08050
MINT MINT-107757
STRING 9606.ENSP00000342307
PhosphoSite Q08050
DMDM 12644391
MaxQB Q08050
PaxDb Q08050
PRIDE Q08050
DNASU 2305
Ensembl ENST00000342628
ENST00000359843
ENST00000361953
GeneID 2305
KEGG hsa:2305
UCSC uc001qle.3
uc001qlf.3
uc001qlg.3
CTD 2305
GeneCards GC12M002966
HGNC HGNC:3818
HPA CAB017832
HPA029974
HPA029975
HPA029976
MIM 602341
neXtProt NX_Q08050
PharmGKB PA28236
eggNOG COG5025
GeneTree ENSGT00390000000589
HOGENOM HOG000112633
HOVERGEN HBG051652
InParanoid Q08050
KO K09406
OMA QKRPNPE
OrthoDB EOG7SJD4C
PhylomeDB Q08050
TreeFam TF333250
Reactome REACT_1006
REACT_1857
EvolutionaryTrace Q08050
GeneWiki FOXM1
GenomeRNAi 2305
NextBio 9359
PRO PR:Q08050
Proteomes UP000005640
Bgee Q08050
CleanEx HS_FOXM1
HS_MPP2
ExpressionAtlas Q08050
Genevestigator Q08050
GO GO:0005737
GO:0005654
GO:0005634
GO:0003677
GO:0019901
GO:0043565
GO:0003700
GO:0044212
GO:0007049
GO:0006978
GO:0006281
GO:0000086
GO:0001889
GO:0000278
GO:0090344
GO:0032873
GO:0000122
GO:0045892
GO:0008284
GO:2000781
GO:0045944
GO:0045893
GO:0051726
GO:0071156
GO:0001558
GO:0042127
GO:0046578
GO:2000377
GO:0006355
GO:0006366
GO:0006351
GO:0001570
Gene3D 1.10.10.10
InterPro IPR001766
IPR018122
IPR011991
Pfam PF00250
PRINTS PR00053
SMART SM00339
PROSITE PS00657
PS00658
PS50039

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR001766

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:Q61660

F

Seeded From UniProt

complete

involved_in

GO:2000377

regulation of reactive oxygen species metabolic process

PMID:19696738[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071156

regulation of cell cycle arrest

PMID:19696738[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046578

regulation of Ras protein signal transduction

PMID:19696738[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20531406[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:20531406[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:20531406[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032873

negative regulation of stress-activated MAPK cascade

PMID:19696738[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:19696738[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:20531406[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0001227

DNA-binding transcription repressor activity, RNA polymerase II-specific

GO_REF:0000036

ECO:0000305

curator inference used in manual assertion

GO:0000122,GO:0000977

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:21860419[4]

ECO:0000314

direct assay evidence used in manual assertion

F

has_regulation_target:(NCBI_Gene:7422)

Seeded From UniProt

complete

involved_in

GO:2000781

positive regulation of double-strand break repair

PMID:17101782[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090344

negative regulation of cell aging

PMID:19696738[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:19160488[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:17101782[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:19160488[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P53350

F

Seeded From UniProt

complete

involved_in

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

PMID:17101782[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000086

G2/M transition of mitotic cell cycle

PMID:19160488[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR018122
InterPro:IPR030456

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR018122
InterPro:IPR030456

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR018122
InterPro:IPR030456

F

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:10523841[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:10523841[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006366

transcription by RNA polymerase II

PMID:9032290[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:9032290[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:9032290[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003700

P

Seeded From UniProt

complete

involved_in

GO:0042127

regulation of cell population proliferation

PMID:9441747[9]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:9032290[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003700

P

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

Reactome:R-HSA-156711

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-4088439
Reactome:R-HSA-4088309
Reactome:R-HSA-4088307
Reactome:R-HSA-4088306
Reactome:R-HSA-4088162
Reactome:R-HSA-4088141
Reactome:R-HSA-4088134
Reactome:R-HSA-4088130
Reactome:R-HSA-4088024

ECO:0000304

author statement supported by traceable reference used in manual assertion









C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:9242644[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001558

regulation of cell growth

PMID:10523841[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:9441747[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Park, HJ et al. (2009) FoxM1, a critical regulator of oxidative stress during oncogenesis. EMBO J. 28 2908-18 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Lefebvre, C et al. (2010) A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers. Mol. Syst. Biol. 6 377 PubMed GONUTS page
  4. Karadedou, CT et al. (2012) FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer. Oncogene 31 1845-58 PubMed GONUTS page
  5. 5.0 5.1 5.2 Tan, Y et al. (2007) Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Mol. Cell. Biol. 27 1007-16 PubMed GONUTS page
  6. 6.0 6.1 6.2 Fu, Z et al. (2008) Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat. Cell Biol. 10 1076-82 PubMed GONUTS page
  7. 7.0 7.1 7.2 Lüscher-Firzlaff, JM et al. (1999) Interaction of the fork head domain transcription factor MPP2 with the human papilloma virus 16 E7 protein: enhancement of transformation and transactivation. Oncogene 18 5620-30 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Ye, H et al. (1997) Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues. Mol. Cell. Biol. 17 1626-41 PubMed GONUTS page
  9. 9.0 9.1 Korver, W et al. (1997) The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. Genomics 46 435-42 PubMed GONUTS page
  10. Yao, KM et al. (1997) Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain. J. Biol. Chem. 272 19827-36 PubMed GONUTS page