HUMAN:FOXM1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FOXM1 (synonyms: FKHL16, HFH11, MPP2, WIN)
Protein Name(s)	Forkhead box protein M1 Forkhead-related protein FKHL16 Hepatocyte nuclear factor 3 forkhead homolog 11 HFH-11 HNF-3/fork-head homolog 11 M-phase phosphoprotein 2 MPM-2 reactive phosphoprotein 2 Transcription factor Trident Winged-helix factor from INS-1 cells
External Links
UniProt	Q08050
EMBL	U74612 U74613 U83113 DQ022289 BC006192 BC006529 BC012863 L16783
CCDS	CCDS8515.1 CCDS8516.1 CCDS8517.1
PIR	B36881
RefSeq	NP_001230017.1 NP_001230018.1 NP_068772.2 NP_973731.1 NP_973732.1
UniGene	Hs.239 Hs.735243
PDB	3G73
PDBsum	3G73
ProteinModelPortal	Q08050
SMR	Q08050
BioGrid	108594
DIP	DIP-36754N
IntAct	Q08050
MINT	MINT-107757
STRING	9606.ENSP00000342307
PhosphoSite	Q08050
DMDM	12644391
MaxQB	Q08050
PaxDb	Q08050
PRIDE	Q08050
DNASU	2305
Ensembl	ENST00000342628 ENST00000359843 ENST00000361953
GeneID	2305
KEGG	hsa:2305
UCSC	uc001qle.3 uc001qlf.3 uc001qlg.3
CTD	2305
GeneCards	GC12M002966
HGNC	HGNC:3818
HPA	CAB017832 HPA029974 HPA029975 HPA029976
MIM	602341
neXtProt	NX_Q08050
PharmGKB	PA28236
eggNOG	COG5025
GeneTree	ENSGT00390000000589
HOGENOM	HOG000112633
HOVERGEN	HBG051652
InParanoid	Q08050
KO	K09406
OMA	QKRPNPE
OrthoDB	EOG7SJD4C
PhylomeDB	Q08050
TreeFam	TF333250
Reactome	REACT_1006 REACT_1857
EvolutionaryTrace	Q08050
GeneWiki	FOXM1
GenomeRNAi	2305
NextBio	9359
PRO	PR:Q08050
Proteomes	UP000005640
Bgee	Q08050
CleanEx	HS_FOXM1 HS_MPP2
ExpressionAtlas	Q08050
Genevestigator	Q08050
GO	GO:0005737 GO:0005654 GO:0005634 GO:0003677 GO:0019901 GO:0043565 GO:0003700 GO:0044212 GO:0007049 GO:0006978 GO:0006281 GO:0000086 GO:0001889 GO:0000278 GO:0090344 GO:0032873 GO:0000122 GO:0045892 GO:0008284 GO:2000781 GO:0045944 GO:0045893 GO:0051726 GO:0071156 GO:0001558 GO:0042127 GO:0046578 GO:2000377 GO:0006355 GO:0006366 GO:0006351 GO:0001570
Gene3D	1.10.10.10
InterPro	IPR001766 IPR018122 IPR011991
Pfam	PF00250
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00657 PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001766	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q61660	F		Seeded From UniProt	complete
involved_in	GO:2000377	regulation of reactive oxygen species metabolic process	PMID:19696738^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071156	regulation of cell cycle arrest	PMID:19696738^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046578	regulation of Ras protein signal transduction	PMID:19696738^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20531406^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20531406^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:20531406^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032873	negative regulation of stress-activated MAPK cascade	PMID:19696738^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:19696738^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20531406^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000036	ECO:0000305	curator inference used in manual assertion	GO:0000122,GO:0000977	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21860419^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(NCBI_Gene:7422)	Seeded From UniProt	complete
involved_in	GO:2000781	positive regulation of double-strand break repair	PMID:17101782^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090344	negative regulation of cell aging	PMID:19696738^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19160488^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17101782^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:19160488^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P53350	F		Seeded From UniProt	complete
involved_in	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	PMID:17101782^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000086	G2/M transition of mitotic cell cycle	PMID:19160488^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10523841^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:10523841^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:9032290^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9032290^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:9032290^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003700	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:9441747^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:9032290^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003700	P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	Reactome:R-HSA-156711	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-4088439 Reactome:R-HSA-4088309 Reactome:R-HSA-4088307 Reactome:R-HSA-4088306 Reactome:R-HSA-4088162 Reactome:R-HSA-4088141 Reactome:R-HSA-4088134 Reactome:R-HSA-4088130 Reactome:R-HSA-4088024	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:9242644^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001558	regulation of cell growth	PMID:10523841^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9441747^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Park, HJ et al. (2009) FoxM1, a critical regulator of oxidative stress during oncogenesis. EMBO J. 28 2908-18 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Lefebvre, C et al. (2010) A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers. Mol. Syst. Biol. 6 377 PubMed GONUTS page
↑ Karadedou, CT et al. (2012) FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer. Oncogene 31 1845-58 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Tan, Y et al. (2007) Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Mol. Cell. Biol. 27 1007-16 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Fu, Z et al. (2008) Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat. Cell Biol. 10 1076-82 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Lüscher-Firzlaff, JM et al. (1999) Interaction of the fork head domain transcription factor MPP2 with the human papilloma virus 16 E7 protein: enhancement of transformation and transactivation. Oncogene 18 5620-30 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Ye, H et al. (1997) Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues. Mol. Cell. Biol. 17 1626-41 PubMed GONUTS page
↑ ^9.0 ^9.1 Korver, W et al. (1997) The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. Genomics 46 435-42 PubMed GONUTS page
↑ Yao, KM et al. (1997) Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain. J. Biol. Chem. 272 19827-36 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:19696738-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Park, HJ et al. (2009) FoxM1, a critical regulator of oxidative stress during oncogenesis. EMBO J. 28 2908-18 PubMed GONUTS page

[PMID:20531406-3] 3.0 ^3.1 ^3.2 ^3.3 Lefebvre, C et al. (2010) A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers. Mol. Syst. Biol. 6 377 PubMed GONUTS page

[PMID:21860419-4] Karadedou, CT et al. (2012) FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer. Oncogene 31 1845-58 PubMed GONUTS page

[PMID:17101782-5] 5.0 ^5.1 ^5.2 Tan, Y et al. (2007) Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Mol. Cell. Biol. 27 1007-16 PubMed GONUTS page

[PMID:19160488-6] 6.0 ^6.1 ^6.2 Fu, Z et al. (2008) Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat. Cell Biol. 10 1076-82 PubMed GONUTS page

[PMID:10523841-7] 7.0 ^7.1 ^7.2 Lüscher-Firzlaff, JM et al. (1999) Interaction of the fork head domain transcription factor MPP2 with the human papilloma virus 16 E7 protein: enhancement of transformation and transactivation. Oncogene 18 5620-30 PubMed GONUTS page

[PMID:9032290-8] 8.0 ^8.1 ^8.2 ^8.3 Ye, H et al. (1997) Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues. Mol. Cell. Biol. 17 1626-41 PubMed GONUTS page

[PMID:9441747-9] 9.0 ^9.1 Korver, W et al. (1997) The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. Genomics 46 435-42 PubMed GONUTS page

[PMID:9242644-10] Yao, KM et al. (1997) Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain. J. Biol. Chem. 272 19827-36 PubMed GONUTS page

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HUMAN:FOXM1

Contents

Annotations

Notes

References

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