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PMID:9441747
| Citation |
Korver, W, Roose, J, Heinen, K, Weghuis, DO, de Bruijn, D, van Kessel, AG and Clevers, H (1997) The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. Genomics 46:435-42 |
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| Abstract |
We recently identified the winged-helix/fork head transcription factor Trident in mouse and described its expression in cycling cells. Here we report the isolation and characterization of the human TRIDENT (HGMW-approved symbol FKHL16) cDNA and gene. Homology between the human and the mouse Trident proteins was 79%. The gene consists of 10 exons and is located on chromosome 12 band p13. The winged-helix DNA-binding domain is encoded on three exons. Analysis of the promoter in synchronized Rat-1 fibroblasts revealed a fragment of 300 bases responsible for the cell cycle-specific expression of the TRIDENT gene. |
| Links |
PubMed Online version:10.1006/geno.1997.5065 |
| Keywords |
Amino Acid Sequence; Animals; Base Sequence; Chromosome Mapping; Chromosomes, Human, Pair 12; DNA, Complementary; Forkhead Transcription Factors; Humans; Mice; Molecular Sequence Data; Promoter Regions, Genetic; Sequence Homology, Amino Acid; Transcription Factors/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0042127: regulation of cell population proliferation |
ECO:0000303: author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700: DNA-binding transcription factor activity |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
See also
References
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