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HUMAN:CSK21

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CSNK2A1 (synonyms: CK2A1)
Protein Name(s) Casein kinase II subunit alpha

CK II alpha

External Links
UniProt P68400
EMBL J02853
M55265
S53149
X70251
AK302583
BT019792
AB451279
AL049761
CH471133
CH471133
CH471133
CH471133
CH471133
BC011668
BC053532
BC071167
CCDS CCDS13003.1
CCDS13004.1
PIR A30319
RefSeq NP_001886.1
NP_808227.1
NP_808228.1
XP_006723611.1
UniGene Hs.644056
Hs.654675
Hs.741126
PDB 1JWH
1NA7
1PJK
2PVR
2ZJW
3AMY
3AT2
3AT3
3AT4
3AXW
3BQC
3C13
3FWQ
3H30
3JUH
3MB6
3MB7
3NGA
3NSZ
3OWJ
3OWK
3OWL
3PE1
3PE2
3PE4
3Q04
3Q9W
3Q9X
3Q9Y
3Q9Z
3QA0
3R0T
3RPS
3TAX
3U4U
3U87
3U9C
3W8L
3WAR
3WIK
3WIL
4BXA
4BXB
4DGL
4FBX
4GRB
4GUB
4GYW
4GYY
4GZ3
4IB5
4KWP
4MD7
4MD8
4MD9
4NH1
PDBsum 1JWH
1NA7
1PJK
2PVR
2ZJW
3AMY
3AT2
3AT3
3AT4
3AXW
3BQC
3C13
3FWQ
3H30
3JUH
3MB6
3MB7
3NGA
3NSZ
3OWJ
3OWK
3OWL
3PE1
3PE2
3PE4
3Q04
3Q9W
3Q9X
3Q9Y
3Q9Z
3QA0
3R0T
3RPS
3TAX
3U4U
3U87
3U9C
3W8L
3WAR
3WIK
3WIL
4BXA
4BXB
4DGL
4FBX
4GRB
4GUB
4GYW
4GYY
4GZ3
4IB5
4KWP
4MD7
4MD8
4MD9
4NH1
ProteinModelPortal P68400
SMR P68400
BioGrid 107841
DIP DIP-32682N
IntAct P68400
MINT MINT-142347
STRING 9606.ENSP00000217244
BindingDB P68400
ChEMBL CHEMBL3629
GuidetoPHARMACOLOGY 1549
PhosphoSite P68400
DMDM 55977123
MaxQB P68400
PaxDb P68400
PRIDE P68400
DNASU 1457
Ensembl ENST00000217244
ENST00000349736
ENST00000400217
GeneID 1457
KEGG hsa:1457
UCSC uc002wdw.1
CTD 1457
GeneCards GC20M000459
HGNC HGNC:2457
HPA CAB020680
MIM 115440
neXtProt NX_P68400
PharmGKB PA26957
eggNOG COG0515
GeneTree ENSGT00390000004215
HOGENOM HOG000233021
HOVERGEN HBG107282
InParanoid P68400
KO K03097
OMA LYQYIDK
OrthoDB EOG7QG446
PhylomeDB P68400
TreeFam TF300483
Reactome REACT_150260
REACT_200668
REACT_22272
SignaLink P68400
ChiTaRS CSNK2A1
EvolutionaryTrace P68400
GeneWiki Casein_kinase_2,_alpha_1
GenomeRNAi 1457
NextBio 5989
PMAP-CutDB B4DYS6
PRO PR:P68400
Proteomes UP000005640
Bgee P68400
CleanEx HS_CSNK2A1
ExpressionAtlas P68400
Genevestigator P68400
GO GO:0005829
GO:0005634
GO:0016581
GO:0005886
GO:0016580
GO:0005524
GO:0051879
GO:0047485
GO:0004674
GO:0007411
GO:0061077
GO:0000278
GO:0071174
GO:0043154
GO:0030307
GO:0008284
GO:0045732
GO:0030177
GO:0006468
GO:0006355
GO:0048511
GO:0007165
GO:0006351
GO:0016055
InterPro IPR011009
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00069
SMART SM00220
SUPFAM SSF56112
PROSITE PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004674

protein serine/threonine kinase activity

PMID:11035045[1]

ECO:0000315

F

Figure three shows CK2 phosphorylates the C terminus of PTEN.

complete
CACAO 2098

enables

GO:0004674

protein serine/threonine kinase activity

PMID:28031292[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P19784,UniProtKB:P67870

F

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:28031292[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(UniProtKB:P25686-1)|has_direct_input:(UniProtKB:P25686-2)

Seeded From UniProt

complete

involved_in

GO:2000059

negative regulation of ubiquitin-dependent protein catabolic process

PMID:28031292[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P19784,UniProtKB:P25686,UniProtKB:P67870

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:18548200[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

PMID:18548200[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:11035045[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21630459[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:15723517[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005956

protein kinase CK2 complex

PMID:15723517[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0018107

peptidyl-threonine phosphorylation

PMID:15723517[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016581

NuRD complex

PMID:17827154[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016580

Sin3 complex

PMID:17827154[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1905818

regulation of chromosome separation

PMID:11704824[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0047485

protein N-terminus binding

PMID:11972058[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P25054

F

Seeded From UniProt

complete

involved_in

GO:0045732

positive regulation of protein catabolic process

PMID:20625391[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16193064[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0031519

PcG protein complex

PMID:21282530[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030307

positive regulation of cell growth

PMID:20625391[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030177

positive regulation of Wnt signaling pathway

PMID:12700239[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:20625391[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:20625391[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:22406621[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21282530[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:12700239[12]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:16193064[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:20625391[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:20864032[14]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:24013921[15]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P68400

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

involved_in

GO:2001234

negative regulation of apoptotic signaling pathway

PMID:28031292[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:2174700[16]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:2174700[16]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:10799509[17]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10799509[17]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0061077

chaperone-mediated protein folding

PMID:19387550[18]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051879

Hsp90 protein binding

PMID:19387550[18]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:2174700[16]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1901796

regulation of signal transduction by p53 class mediator

Reactome:R-HSA-5633007

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

Reactome:R-HSA-8934903

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006656

phosphatidylcholine biosynthetic process

Reactome:R-HSA-1483191

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006457

protein folding

Reactome:R-HSA-390466

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8948039
Reactome:R-HSA-8873929
Reactome:R-HSA-8850945
Reactome:R-HSA-6814409
Reactome:R-HSA-392752
Reactome:R-HSA-2529020
Reactome:R-HSA-201717

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-6805061
Reactome:R-HSA-6805059

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

involved_in

GO:0048511

rhythmic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0090

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Torres, J & Pulido, R (2001) The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J. Biol. Chem. 276 993-8 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Ottaviani, D et al. (2017) Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain. Hum. Mol. Genet. 26 611-623 PubMed GONUTS page
  3. 3.0 3.1 Allende-Vega, N et al. (2008) Transcription factor TAFII250 phosphorylates the acidic domain of Mdm2 through recruitment of protein kinase CK2. Mol. Cell. Biochem. 316 99-106 PubMed GONUTS page
  4. de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
  5. 5.0 5.1 5.2 Abbott, KL et al. (2005) Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1. Biochemistry 44 2716-31 PubMed GONUTS page
  6. 6.0 6.1 Sun, JM et al. (2007) Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J. Biol. Chem. 282 33227-36 PubMed GONUTS page
  7. Sayed, M et al. (2001) Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells. Oncogene 20 6994-7005 PubMed GONUTS page
  8. Homma, MK et al. (2002) Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein. Proc. Natl. Acad. Sci. U.S.A. 99 5959-64 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 Hung, MS et al. (2010) Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer. PLoS ONE 5 e11418 PubMed GONUTS page
  10. 10.0 10.1 Shin, S et al. (2005) Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8. EMBO J. 24 3532-42 PubMed GONUTS page
  11. 11.0 11.1 Vandamme, J et al. (2011) Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Mol. Cell Proteomics 10 M110.002642 PubMed GONUTS page
  12. 12.0 12.1 Song, DH et al. (2003) CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling. J. Biol. Chem. 278 24018-25 PubMed GONUTS page
  13. Rabellino, A et al. (2012) The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA. Cancer Res. 72 2275-84 PubMed GONUTS page
  14. Horejsí, Z et al. (2010) CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Mol. Cell 39 839-50 PubMed GONUTS page
  15. Szabó, A et al. (2013) The CK2 kinase stabilizes CLOCK and represses its activity in the Drosophila circadian oscillator. PLoS Biol. 11 e1001645 PubMed GONUTS page
  16. 16.0 16.1 16.2 Lozeman, FJ et al. (1990) Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. Biochemistry 29 8436-47 PubMed GONUTS page
  17. 17.0 17.1 Bosc, DG et al. (2000) Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2. J. Biol. Chem. 275 14295-306 PubMed GONUTS page
  18. 18.0 18.1 Miyata, Y (2009) Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery. Cell. Mol. Life Sci. 66 1840-9 PubMed GONUTS page