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HUMAN:CSK21
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | CSNK2A1 (synonyms: CK2A1) | |
Protein Name(s) | Casein kinase II subunit alpha
CK II alpha | |
External Links | ||
UniProt | P68400 | |
EMBL | J02853 M55265 S53149 X70251 AK302583 BT019792 AB451279 AL049761 CH471133 CH471133 CH471133 CH471133 CH471133 BC011668 BC053532 BC071167 | |
CCDS | CCDS13003.1 CCDS13004.1 | |
PIR | A30319 | |
RefSeq | NP_001886.1 NP_808227.1 NP_808228.1 XP_006723611.1 | |
UniGene | Hs.644056 Hs.654675 Hs.741126 | |
PDB | 1JWH 1NA7 1PJK 2PVR 2ZJW 3AMY 3AT2 3AT3 3AT4 3AXW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE1 3PE2 3PE4 3Q04 3Q9W 3Q9X 3Q9Y 3Q9Z 3QA0 3R0T 3RPS 3TAX 3U4U 3U87 3U9C 3W8L 3WAR 3WIK 3WIL 4BXA 4BXB 4DGL 4FBX 4GRB 4GUB 4GYW 4GYY 4GZ3 4IB5 4KWP 4MD7 4MD8 4MD9 4NH1 | |
PDBsum | 1JWH 1NA7 1PJK 2PVR 2ZJW 3AMY 3AT2 3AT3 3AT4 3AXW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE1 3PE2 3PE4 3Q04 3Q9W 3Q9X 3Q9Y 3Q9Z 3QA0 3R0T 3RPS 3TAX 3U4U 3U87 3U9C 3W8L 3WAR 3WIK 3WIL 4BXA 4BXB 4DGL 4FBX 4GRB 4GUB 4GYW 4GYY 4GZ3 4IB5 4KWP 4MD7 4MD8 4MD9 4NH1 | |
ProteinModelPortal | P68400 | |
SMR | P68400 | |
BioGrid | 107841 | |
DIP | DIP-32682N | |
IntAct | P68400 | |
MINT | MINT-142347 | |
STRING | 9606.ENSP00000217244 | |
BindingDB | P68400 | |
ChEMBL | CHEMBL3629 | |
GuidetoPHARMACOLOGY | 1549 | |
PhosphoSite | P68400 | |
DMDM | 55977123 | |
MaxQB | P68400 | |
PaxDb | P68400 | |
PRIDE | P68400 | |
DNASU | 1457 | |
Ensembl | ENST00000217244 ENST00000349736 ENST00000400217 | |
GeneID | 1457 | |
KEGG | hsa:1457 | |
UCSC | uc002wdw.1 | |
CTD | 1457 | |
GeneCards | GC20M000459 | |
HGNC | HGNC:2457 | |
HPA | CAB020680 | |
MIM | 115440 | |
neXtProt | NX_P68400 | |
PharmGKB | PA26957 | |
eggNOG | COG0515 | |
GeneTree | ENSGT00390000004215 | |
HOGENOM | HOG000233021 | |
HOVERGEN | HBG107282 | |
InParanoid | P68400 | |
KO | K03097 | |
OMA | LYQYIDK | |
OrthoDB | EOG7QG446 | |
PhylomeDB | P68400 | |
TreeFam | TF300483 | |
Reactome | REACT_150260 REACT_200668 REACT_22272 | |
SignaLink | P68400 | |
ChiTaRS | CSNK2A1 | |
EvolutionaryTrace | P68400 | |
GeneWiki | Casein_kinase_2,_alpha_1 | |
GenomeRNAi | 1457 | |
NextBio | 5989 | |
PMAP-CutDB | B4DYS6 | |
PRO | PR:P68400 | |
Proteomes | UP000005640 | |
Bgee | P68400 | |
CleanEx | HS_CSNK2A1 | |
ExpressionAtlas | P68400 | |
Genevestigator | P68400 | |
GO | GO:0005829 GO:0005634 GO:0016581 GO:0005886 GO:0016580 GO:0005524 GO:0051879 GO:0047485 GO:0004674 GO:0007411 GO:0061077 GO:0000278 GO:0071174 GO:0043154 GO:0030307 GO:0008284 GO:0045732 GO:0030177 GO:0006468 GO:0006355 GO:0048511 GO:0007165 GO:0006351 GO:0016055 | |
InterPro | IPR011009 IPR000719 IPR017441 IPR002290 IPR008271 | |
Pfam | PF00069 | |
SMART | SM00220 | |
SUPFAM | SSF56112 | |
PROSITE | PS00107 PS50011 PS00108 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000315 |
F |
Figure three shows CK2 phosphorylates the C terminus of PTEN. |
complete | |||||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_direct_input:(UniProtKB:P25686-1)|has_direct_input:(UniProtKB:P25686-2) |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000059 |
negative regulation of ubiquitin-dependent protein catabolic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016301 |
kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000019) |
Seeded From UniProt |
complete | ||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005956 |
protein kinase CK2 complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0018107 |
peptidyl-threonine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016581 |
NuRD complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016580 |
Sin3 complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:1905818 |
regulation of chromosome separation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0047485 |
protein N-terminus binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045732 |
positive regulation of protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0031519 |
PcG protein complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030307 |
positive regulation of cell growth |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030177 |
positive regulation of Wnt signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2001234 |
negative regulation of apoptotic signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061077 |
chaperone-mediated protein folding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0051879 |
Hsp90 protein binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:1901796 |
regulation of signal transduction by p53 class mediator |
Reactome:R-HSA-5633007 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016236 |
macroautophagy |
Reactome:R-HSA-8934903 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006656 |
phosphatidylcholine biosynthetic process |
Reactome:R-HSA-1483191 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006457 |
protein folding |
Reactome:R-HSA-390466 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-8948039 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-6805061 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048511 |
rhythmic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Torres, J & Pulido, R (2001) The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J. Biol. Chem. 276 993-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Ottaviani, D et al. (2017) Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain. Hum. Mol. Genet. 26 611-623 PubMed GONUTS page
- ↑ 3.0 3.1 Allende-Vega, N et al. (2008) Transcription factor TAFII250 phosphorylates the acidic domain of Mdm2 through recruitment of protein kinase CK2. Mol. Cell. Biochem. 316 99-106 PubMed GONUTS page
- ↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Abbott, KL et al. (2005) Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1. Biochemistry 44 2716-31 PubMed GONUTS page
- ↑ 6.0 6.1 Sun, JM et al. (2007) Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J. Biol. Chem. 282 33227-36 PubMed GONUTS page
- ↑ Sayed, M et al. (2001) Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells. Oncogene 20 6994-7005 PubMed GONUTS page
- ↑ Homma, MK et al. (2002) Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein. Proc. Natl. Acad. Sci. U.S.A. 99 5959-64 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 Hung, MS et al. (2010) Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer. PLoS ONE 5 e11418 PubMed GONUTS page
- ↑ 10.0 10.1 Shin, S et al. (2005) Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8. EMBO J. 24 3532-42 PubMed GONUTS page
- ↑ 11.0 11.1 Vandamme, J et al. (2011) Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Mol. Cell Proteomics 10 M110.002642 PubMed GONUTS page
- ↑ 12.0 12.1 Song, DH et al. (2003) CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling. J. Biol. Chem. 278 24018-25 PubMed GONUTS page
- ↑ Rabellino, A et al. (2012) The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA. Cancer Res. 72 2275-84 PubMed GONUTS page
- ↑ Horejsí, Z et al. (2010) CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Mol. Cell 39 839-50 PubMed GONUTS page
- ↑ Szabó, A et al. (2013) The CK2 kinase stabilizes CLOCK and represses its activity in the Drosophila circadian oscillator. PLoS Biol. 11 e1001645 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 Lozeman, FJ et al. (1990) Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. Biochemistry 29 8436-47 PubMed GONUTS page
- ↑ 17.0 17.1 Bosc, DG et al. (2000) Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2. J. Biol. Chem. 275 14295-306 PubMed GONUTS page
- ↑ 18.0 18.1 Miyata, Y (2009) Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery. Cell. Mol. Life Sci. 66 1840-9 PubMed GONUTS page
c
n
o
p
- GO:0031519 ! PcG protein complex
- GO:0018105 ! peptidyl-serine phosphorylation
- GO:0018107 ! peptidyl-threonine phosphorylation
- GO:0006656 ! phosphatidylcholine biosynthetic process
- GO:0016310 ! phosphorylation
- GO:0005886 ! plasma membrane
- GO:0030177 ! positive regulation of Wnt signaling pathway
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0045732 ! positive regulation of protein catabolic process
- GO:0030307 ! positive regulation of cell growth
- Primates
- GO:0006457 ! protein folding
- GO:0004672 ! protein kinase activity
- GO:0005956 ! protein kinase CK2 complex
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
r