HUMAN:BIRC5

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BIRC5 (synonyms: API4, IAP4)
Protein Name(s)	Baculoviral IAP repeat-containing protein 5 Apoptosis inhibitor 4 Apoptosis inhibitor survivin
External Links
UniProt	O15392
EMBL	U75285 AF077350 AB154416 AY830084 AB028869 AY927772 DQ227257 DQ310375 DQ310376 DQ310377 DQ310378 DQ310379 CR541740 AK223428 AK311917 AY795969 AC087645 CH471099 BC008718 BC034148 BC065497
CCDS	CCDS11755.1 CCDS32751.1 CCDS32752.1
RefSeq	NP_001012270.1 NP_001012271.1 NP_001159.2
UniGene	Hs.744872
PDB	1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N
PDBsum	1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N
ProteinModelPortal	O15392
SMR	O15392
BioGrid	106829
DIP	DIP-34662N
IntAct	O15392
MINT	MINT-147138
STRING	9606.ENSP00000301633
BindingDB	O15392
ChEMBL	CHEMBL5989
MEROPS	I32.005
PhosphoSite	O15392
MaxQB	O15392
PaxDb	O15392
PRIDE	O15392
DNASU	332
Ensembl	ENST00000374948 ENST00000590449 ENST00000590925 ENST00000592734
GeneID	332
KEGG	hsa:332
UCSC	uc002jvg.3 uc002jvh.3
CTD	332
GeneCards	GC17P076210
HGNC	HGNC:593
HPA	CAB004270 HPA002830
MIM	603352
neXtProt	NX_O15392
PharmGKB	PA25362
eggNOG	NOG271140
GeneTree	ENSGT00510000047537
HOVERGEN	HBG050690
InParanoid	O15392
KO	K08731
Reactome	REACT_150425 REACT_150471 REACT_682
SignaLink	O15392
ChiTaRS	BIRC5
EvolutionaryTrace	O15392
GeneWiki	Survivin
GenomeRNAi	332
NextBio	1369
PRO	PR:O15392
Proteomes	UP000005640
Bgee	O15392
CleanEx	HS_BIRC5
ExpressionAtlas	O15392
Genevestigator	O15392
GO	GO:0005814 GO:0032133 GO:0000775 GO:0000777 GO:0005737 GO:0005881 GO:0005829 GO:0031021 GO:0005874 GO:0030496 GO:0000228 GO:0005634 GO:0005819 GO:0005876 GO:0051087 GO:0050897 GO:0048037 GO:0004869 GO:0043027 GO:0019899 GO:0042802 GO:0046872 GO:0008017 GO:0046982 GO:0042803 GO:0008536 GO:0015631 GO:0008270 GO:0006915 GO:0051301 GO:0007059 GO:0000910 GO:0051303 GO:0000086 GO:0000278 GO:0007067 GO:0043066 GO:0043154 GO:0045892 GO:0008284 GO:0031536 GO:0045931 GO:0031503 GO:0006468 GO:0031577 GO:0006351
Gene3D	1.10.1170.10
InterPro	IPR001370
Pfam	PF00653
SMART	SM00238
PROSITE	PS50143

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0007605	sensory perception of sound	PMID:20627126^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20627126^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20627126^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:20627126^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21364656^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21364656^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21364656^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
	GO:0006302	double-strand break repair	PMID:20394854^[3]	ECO:0000315			P	Figure 3a. siRNA-Survivin knock down is shown to increase gamma-H2AX which means "survivin attenuation impairs double strand DNA repair capacities" (page 233, left column, bottom of 2nd paragraph). This is IMP because the use of siRNA to change the phenotype. It is not annotated further because this paper does not show evidence for a mechanism.	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000054	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
	GO:0031954	positive regulation of protein autophosphorylation	PMID:20394854^[3]	ECO:0000315			P	Figure 4b row 2 (DNA-PKcs S2056) and row 4 (survivin). When survivin is knocked down by siRNA (column 1 vs. 2) the phosphorylation (which DNA-PKcs autophosphorylates) of S2056 of DNA-PKcs is inhibited. "DNA-PKcs (auto)phosphorylation at Serine 2056 and observed an impaired detection of phosphoS2056 DNA-PKcs." (page 233, right column, first paragraph) It is IMP because of the use of siRNA	complete
enables	GO:0051087	chaperone binding	PMID:18086682^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10809	F	Seeded From UniProt	complete
	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	PMID:20394854^[3]	ECO:0000315			P	Figure 4b row 1 (DNA-PKcs T2609). In this figure, "decreased T2609 phosphoryltion of the DNA-PKcs moecule" was observed when survivin was knocked down. (page 229, left column, first paagraph) In the presence of survivin the T2609 is phosphorylated meaning the survivin is involved in the positive regulation of this. This is an IMP because si-RNA is used to change the phenotype.	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:20826784^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21536684^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032133	chromosome passenger complex	PMID:18591255^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q53HL2	C	Seeded From UniProt	complete
part_of	GO:0032133	chromosome passenger complex	PMID:18591255^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96GD4	C	Seeded From UniProt	complete
part_of	GO:0032133	chromosome passenger complex	PMID:15260989^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q53HL2	C	Seeded From UniProt	complete
involved_in	GO:0031503	protein-containing complex localization	PMID:16239925^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:15665297^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:16322459^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q93008	F	Seeded From UniProt	complete
enables	GO:0008536	Ran GTPase binding	PMID:18591255^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P62826	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21252625^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18591255^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20826784^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15665297^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000777	condensed chromosome kinetochore	PMID:15665297^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	PMID:16322459^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000228	nuclear chromosome	PMID:16322459^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0090307	mitotic spindle assembly	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005168 ZFIN:ZDB-GENE-030826-2	P	Seeded From UniProt	complete
part_of	GO:0005876	spindle microtubule	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005168 UniProtKB:O15392	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260635 MGI:MGI:107572 MGI:MGI:1203517 PANTHER:PTN000005166 RGD:620692 UniProtKB:O15392 UniProtKB:P98170 UniProtKB:Q13489 UniProtKB:Q13490 UniProtKB:Q96CA5	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260635 PANTHER:PTN000005166 PomBase:SPCC962.02c RGD:620690 RGD:620692 UniProtKB:O15392 UniProtKB:P98170 UniProtKB:Q13489 UniProtKB:Q13490 UniProtKB:Q96CA5	C	Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:11084331^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	PMID:11084331^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23251006^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15392	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17099693^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15392	F	Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004869	P	Seeded From UniProt	complete
involved_in	GO:0051303	establishment of chromosome localization	PMID:12805209^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	PMID:12805209^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0050897	cobalt ion binding	PMID:10949039^[18]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0048037	cofactor binding	PMID:12773388^[19]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:16291752^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	PMID:16291752^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:9859993^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:12773388^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:9256286^[22]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10626797^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:12773388^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	PMID:9859993^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:16291752^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15392-1	F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:10949039^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:10876248^[24]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007094	mitotic spindle assembly checkpoint	PMID:12805209^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031536	positive regulation of exit from mitosis	PMID:12805209^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031021	interphase microtubule organizing center	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:11069302^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:16291752^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:10876248^[24]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:10949039^[18]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005881	cytoplasmic microtubule	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005876	spindle microtubule	PMID:11069302^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005876	spindle microtubule	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:12773388^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005814	centriole	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9256286^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	PMID:12805209^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	PMID:11516652^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	PMID:16291752^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000086	G2/M transition of mitotic cell cycle	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16291752^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15392-1	F	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0043027	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:16291752^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10626797^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16291752^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:16344111^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:21536684^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	Reactome:R-HSA-5633008	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8956026 Reactome:R-HSA-5666169 Reactome:R-HSA-5666160 Reactome:R-HSA-5666129 Reactome:R-HSA-4655355 Reactome:R-HSA-375302 Reactome:R-HSA-2484822 Reactome:R-HSA-2468287 Reactome:R-HSA-2467811 Reactome:R-HSA-2467809 Reactome:R-HSA-1638821 Reactome:R-HSA-1638803 Reactome:R-HSA-141439 Reactome:R-HSA-141431 Reactome:R-HSA-141422 Reactome:R-HSA-141409	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6797763 Reactome:R-HSA-6790036 Reactome:R-HSA-4655355	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0159	P	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0995	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0030414	peptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	F	Seeded From UniProt	complete
enables	GO:0004869	cysteine-type endopeptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0789	F	Seeded From UniProt	complete
involved_in	GO:0010466	negative regulation of peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	P	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P	Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137 UniProtKB-SubCell:SL-0047	C	Seeded From UniProt	complete
part_of	GO:0000777	condensed chromosome kinetochore	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0149	C	Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C	Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0469	C	Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:16291752^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Habtemichael, N et al. (2010) Expression analysis suggests a potential cytoprotective role of Birc5 in the inner ear. Mol. Cell. Neurosci. 45 297-305 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Knauer, SK et al. (2010) An otoprotective role for the apoptosis inhibitor protein survivin. Cell Death Dis 1 e51 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Capalbo, G et al. (2010) Radiation-induced survivin nuclear accumulation is linked to DNA damage repair. Int. J. Radiat. Oncol. Biol. Phys. 77 226-34 PubMed GONUTS page
↑ Ghosh, JC et al. (2008) Hsp60 regulation of tumor cell apoptosis. J. Biol. Chem. 283 5188-94 PubMed GONUTS page
↑ ^5.0 ^5.1 Wang, H et al. (2010) Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity. J. Biol. Chem. 285 36129-37 PubMed GONUTS page
↑ ^6.0 ^6.1 Pavlyukov, MS et al. (2011) Survivin monomer plays an essential role in apoptosis regulation. J. Biol. Chem. 286 23296-307 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Xia, F et al. (2008) A survivin-ran complex regulates spindle formation in tumor cells. Mol. Cell. Biol. 28 5299-311 PubMed GONUTS page
↑ Sampath, SC et al. (2004) The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell 118 187-202 PubMed GONUTS page
↑ Vader, G et al. (2006) Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. EMBO Rep. 7 85-92 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Samuel, T et al. (2005) cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. Cancer Res. 65 210-8 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Vong, QP et al. (2005) Chromosome alignment and segregation regulated by ubiquitination of survivin. Science 310 1499-504 PubMed GONUTS page
↑ Barrett, RM et al. (2011) Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro. Cell Cycle 10 538-48 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^14.0 ^14.1 Uren, AG et al. (2000) Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. Curr. Biol. 10 1319-28 PubMed GONUTS page
↑ Guvenc, H et al. (2013) Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex. Clin. Cancer Res. 19 631-42 PubMed GONUTS page
↑ Knauer, SK et al. (2006) The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function. EMBO Rep. 7 1259-65 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 Lens, SM et al. (2003) Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J. 22 2934-47 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Chantalat, L et al. (2000) Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions. Mol. Cell 6 183-9 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Marusawa, H et al. (2003) HBXIP functions as a cofactor of survivin in apoptosis suppression. EMBO J. 22 2729-40 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 ^20.7 ^20.8 Noton, EA et al. (2006) Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis. J. Biol. Chem. 281 1286-95 PubMed GONUTS page
↑ ^21.00 ^21.01 ^21.02 ^21.03 ^21.04 ^21.05 ^21.06 ^21.07 ^21.08 ^21.09 ^21.10 Li, F et al. (1998) Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 396 580-4 PubMed GONUTS page
↑ ^22.0 ^22.1 Ambrosini, G et al. (1997) A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med. 3 917-21 PubMed GONUTS page
↑ ^23.0 ^23.1 Mahotka, C et al. (1999) Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties. Cancer Res. 59 6097-102 PubMed GONUTS page
↑ ^24.0 ^24.1 Verdecia, MA et al. (2000) Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. Nat. Struct. Biol. 7 602-8 PubMed GONUTS page
↑ ^25.0 ^25.1 O'Connor, DS et al. (2000) Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc. Natl. Acad. Sci. U.S.A. 97 13103-7 PubMed GONUTS page
↑ Wheatley, SP et al. (2001) INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Curr. Biol. 11 886-90 PubMed GONUTS page
↑ Wheatley, SP & McNeish, IA (2005) Survivin: a protein with dual roles in mitosis and apoptosis. Int. Rev. Cytol. 247 35-88 PubMed GONUTS page

[PMID:20627126-1] 1.0 ^1.1 ^1.2 ^1.3 Habtemichael, N et al. (2010) Expression analysis suggests a potential cytoprotective role of Birc5 in the inner ear. Mol. Cell. Neurosci. 45 297-305 PubMed GONUTS page

[PMID:21364656-2] 2.0 ^2.1 ^2.2 Knauer, SK et al. (2010) An otoprotective role for the apoptosis inhibitor protein survivin. Cell Death Dis 1 e51 PubMed GONUTS page

[PMID:20394854-3] 3.0 ^3.1 ^3.2 Capalbo, G et al. (2010) Radiation-induced survivin nuclear accumulation is linked to DNA damage repair. Int. J. Radiat. Oncol. Biol. Phys. 77 226-34 PubMed GONUTS page

[PMID:18086682-4] Ghosh, JC et al. (2008) Hsp60 regulation of tumor cell apoptosis. J. Biol. Chem. 283 5188-94 PubMed GONUTS page

[PMID:20826784-5] 5.0 ^5.1 Wang, H et al. (2010) Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity. J. Biol. Chem. 285 36129-37 PubMed GONUTS page

[PMID:21536684-6] 6.0 ^6.1 Pavlyukov, MS et al. (2011) Survivin monomer plays an essential role in apoptosis regulation. J. Biol. Chem. 286 23296-307 PubMed GONUTS page

[PMID:18591255-7] 7.0 ^7.1 ^7.2 ^7.3 Xia, F et al. (2008) A survivin-ran complex regulates spindle formation in tumor cells. Mol. Cell. Biol. 28 5299-311 PubMed GONUTS page

[PMID:15260989-8] Sampath, SC et al. (2004) The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell 118 187-202 PubMed GONUTS page

[PMID:16239925-9] Vader, G et al. (2006) Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. EMBO Rep. 7 85-92 PubMed GONUTS page

[PMID:15665297-10] 10.0 ^10.1 ^10.2 Samuel, T et al. (2005) cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. Cancer Res. 65 210-8 PubMed GONUTS page

[PMID:16322459-11] 11.0 ^11.1 ^11.2 Vong, QP et al. (2005) Chromosome alignment and segregation regulated by ubiquitination of survivin. Science 310 1499-504 PubMed GONUTS page

[PMID:21252625-12] Barrett, RM et al. (2011) Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro. Cell Cycle 10 538-48 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11084331-14] 14.0 ^14.1 Uren, AG et al. (2000) Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. Curr. Biol. 10 1319-28 PubMed GONUTS page

[PMID:23251006-15] Guvenc, H et al. (2013) Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex. Clin. Cancer Res. 19 631-42 PubMed GONUTS page

[PMID:17099693-16] Knauer, SK et al. (2006) The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function. EMBO Rep. 7 1259-65 PubMed GONUTS page

[PMID:12805209-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 Lens, SM et al. (2003) Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J. 22 2934-47 PubMed GONUTS page

[PMID:10949039-18] 18.0 ^18.1 ^18.2 Chantalat, L et al. (2000) Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions. Mol. Cell 6 183-9 PubMed GONUTS page

[PMID:12773388-19] 19.0 ^19.1 ^19.2 ^19.3 Marusawa, H et al. (2003) HBXIP functions as a cofactor of survivin in apoptosis suppression. EMBO J. 22 2729-40 PubMed GONUTS page

[PMID:16291752-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 ^20.7 ^20.8 Noton, EA et al. (2006) Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis. J. Biol. Chem. 281 1286-95 PubMed GONUTS page

[PMID:9859993-21] 21.00 ^21.01 ^21.02 ^21.03 ^21.04 ^21.05 ^21.06 ^21.07 ^21.08 ^21.09 ^21.10 Li, F et al. (1998) Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 396 580-4 PubMed GONUTS page

[PMID:9256286-22] 22.0 ^22.1 Ambrosini, G et al. (1997) A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med. 3 917-21 PubMed GONUTS page

[PMID:10626797-23] 23.0 ^23.1 Mahotka, C et al. (1999) Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties. Cancer Res. 59 6097-102 PubMed GONUTS page

[PMID:10876248-24] 24.0 ^24.1 Verdecia, MA et al. (2000) Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. Nat. Struct. Biol. 7 602-8 PubMed GONUTS page

[PMID:11069302-25] 25.0 ^25.1 O'Connor, DS et al. (2000) Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc. Natl. Acad. Sci. U.S.A. 97 13103-7 PubMed GONUTS page

[PMID:11516652-26] Wheatley, SP et al. (2001) INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Curr. Biol. 11 886-90 PubMed GONUTS page

[PMID:16344111-27] Wheatley, SP & McNeish, IA (2005) Survivin: a protein with dual roles in mitosis and apoptosis. Int. Rev. Cytol. 247 35-88 PubMed GONUTS page

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HUMAN:BIRC5

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