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Uren, AG, Wong, L, Pakusch, M, Fowler, KJ, Burrows, FJ, Vaux, DL and Choo, KH (2000) Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. Curr. Biol. 10:1319-28
Survivin is a mammalian protein that carries a motif typical of the inhibitor of apoptosis (IAP)proteins, first identified in baculoviruses. Although baculoviral IAP proteins regulate cell death, the yeast Survivin homolog Bir1 is involved in cell division. To determine the function of Survivin in mammals, we analyzed the pattern of localization of Survivin protein during the cell cycle, and deleted its gene by homologous recombination in mice.
Amino Acid Sequence; Animals; Autoantigens; Cell Cycle; Cell Nucleus/metabolism; Centromere/metabolism; Centromere Protein B; Chromosomal Proteins, Non-Histone/genetics; Chromosomal Proteins, Non-Histone/metabolism; Chromosomes/metabolism; Cytoskeletal Proteins/metabolism; DNA-Binding Proteins/metabolism; Embryo, Mammalian/metabolism; Fluorescent Dyes; Gene Deletion; Genotype; HeLa Cells; Humans; Inhibitor of Apoptosis Proteins; Mice; Microscopy, Fluorescence; Microtubule-Associated Proteins; Microtubules/drug effects; Microtubules/metabolism; Mitosis; Molecular Sequence Data; Neoplasm Proteins; Proteins/genetics; Proteins/metabolism; Sequence Alignment; Tubulin/metabolism
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