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PMID:10949039
| Citation |
Chantalat, L, Skoufias, DA, Kleman, JP, Jung, B, Dideberg, O and Margolis, RL (2000) Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions. Mol. Cell 6:183-9 |
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| Abstract |
Survivin is a mitotic spindle-associated protein involved in linking mitotic spindle function to activation of apoptosis in mammalian cells. The structure of the full-length human survivin has been determined by X-ray crystallography to 2.7 A. Strikingly, the structure forms a very unusual bow tie-shaped dimer. It does not dimerize through a C-terminal coiled-coil, contrary to sequence analysis prediction. The C-terminal helices contain hydrophobic clusters with the potential for protein-protein interactions. The unusual shape and dimensions of survivin suggest it serves an adaptor function through its alpha-helical extensions. |
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| Keywords |
Amino Acid Sequence; Apoptosis/physiology; Crystallography, X-Ray; Dimerization; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Models, Molecular; Molecular Sequence Data; Neoplasm Proteins; Protein Structure, Quaternary; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins/chemistry; Proteins/genetics; Proteins/physiology; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Sequence Homology, Amino Acid |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0008270: zinc ion binding |
ECO:0000303: author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803: protein homodimerization activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0050897: cobalt ion binding |
ECO:0000303: author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803: protein homodimerization activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0050897: cobalt ion binding |
ECO:0000303: author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270: zinc ion binding |
ECO:0000303: author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
See also
References
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