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HUMAN:BCL6
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | BCL6 (synonyms: BCL5, LAZ3, ZBTB27, ZNF51) | |
Protein Name(s) | B-cell lymphoma 6 protein
BCL-6 B-cell lymphoma 5 protein BCL-5 Protein LAZ-3 Zinc finger and BTB domain-containing protein 27 Zinc finger protein 51 | |
External Links | ||
UniProt | P41182 | |
EMBL | Z21943 U00115 S67779 EU139066 AC072022 CH471052 CH471052 BC150184 | |
CCDS | CCDS3289.1 CCDS46975.1 | |
PIR | A48752 I52586 | |
RefSeq | NP_001124317.1 NP_001128210.1 NP_001697.2 XP_005247751.1 | |
UniGene | Hs.478588 | |
PDB | 1R28 1R29 1R2B 2EN2 2EOS 2LCE 2YRM 3BIM 3E4U 3LBZ 4CP3 | |
PDBsum | 1R28 1R29 1R2B 2EN2 2EOS 2LCE 2YRM 3BIM 3E4U 3LBZ 4CP3 | |
ProteinModelPortal | P41182 | |
SMR | P41182 | |
BioGrid | 107076 | |
DIP | DIP-2651N | |
IntAct | P41182 | |
MINT | MINT-158757 | |
STRING | 9606.ENSP00000232014 | |
PhosphoSite | P41182 | |
DMDM | 728952 | |
MaxQB | P41182 | |
PaxDb | P41182 | |
PRIDE | P41182 | |
Ensembl | ENST00000232014 ENST00000406870 ENST00000450123 ENST00000621333 | |
GeneID | 604 | |
KEGG | hsa:604 | |
UCSC | uc003frp.3 uc011bsf.1 | |
CTD | 604 | |
GeneCards | GC03M187439 | |
HGNC | HGNC:1001 | |
HPA | CAB000307 HPA004899 | |
MIM | 109565 | |
neXtProt | NX_P41182 | |
Orphanet | 545 98839 98838 | |
PharmGKB | PA25312 | |
eggNOG | COG5048 | |
GeneTree | ENSGT00750000117671 | |
HOGENOM | HOG000001556 | |
HOVERGEN | HBG004831 | |
InParanoid | P41182 | |
KO | K15618 | |
OMA | NECDCRF | |
OrthoDB | EOG7KQ22S | |
PhylomeDB | P41182 | |
TreeFam | TF330912 | |
ChiTaRS | BCL6 | |
EvolutionaryTrace | P41182 | |
GeneWiki | BCL6 | |
GenomeRNAi | 604 | |
NextBio | 2453 | |
PRO | PR:P41182 | |
Proteomes | UP000005640 | |
Bgee | P41182 | |
CleanEx | HS_BCL6 | |
ExpressionAtlas | P41182 | |
Genevestigator | P41182 | |
GO | GO:0005634 GO:0003682 GO:0031490 GO:0046872 GO:0000977 GO:0001227 GO:0043565 GO:0003700 GO:0030036 GO:0030183 GO:0000902 GO:0006974 GO:0048821 GO:0002467 GO:0006954 GO:0002903 GO:0030308 GO:0008285 GO:0001953 GO:0048294 GO:0032764 GO:0035024 GO:0045629 GO:0000122 GO:0045892 GO:0043065 GO:0030890 GO:0051272 GO:0000060 GO:0002634 GO:0050776 GO:0050727 GO:0043380 GO:0032319 GO:0007266 GO:0007283 GO:0042092 | |
Gene3D | 3.30.160.60 | |
InterPro | IPR000210 IPR011333 IPR013069 IPR007087 IPR015880 IPR013087 | |
Pfam | PF00651 | |
SMART | SM00225 SM00355 | |
SUPFAM | SSF54695 | |
PROSITE | PS50097 PS00028 PS50157 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0005556 |
multiple sequence alignment evidence used in manual assertion |
UniProtKB:E9Q3T6 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045591 |
positive regulation of regulatory T cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050776 |
regulation of immune response |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1903464 |
negative regulation of mitotic cell cycle DNA replication |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030308 |
negative regulation of cell growth |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0005657 |
replication fork |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002903 |
negative regulation of B cell apoptotic process |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002634 |
regulation of germinal center formation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050727 |
regulation of inflammatory response |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107187 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042127 |
regulation of cell population proliferation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107187 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042092 |
type 2 immune response |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107187 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107187 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107187 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107187 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107187 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030183 |
B cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030036 |
actin cytoskeleton organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008104 |
protein localization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007283 |
spermatogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007266 |
Rho protein signal transduction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003682 |
chromatin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002829 |
negative regulation of type 2 immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002467 |
germinal center formation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001953 |
negative regulation of cell-matrix adhesion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0001161 |
intronic transcription regulatory region sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000902 |
cell morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000773 |
negative regulation of cellular senescence |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051272 |
positive regulation of cellular component movement |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050727 |
regulation of inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048821 |
erythrocyte development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048294 |
negative regulation of isotype switching to IgE isotypes |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045746 |
negative regulation of Notch signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045666 |
positive regulation of neuron differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045629 |
negative regulation of T-helper 2 cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045596 |
negative regulation of cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043380 |
regulation of memory T cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043087 |
regulation of GTPase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042127 |
regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042092 |
type 2 immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035024 |
negative regulation of Rho protein signal transduction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032764 |
negative regulation of mast cell cytokine production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0031490 |
chromatin DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031065 |
positive regulation of histone deacetylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030890 |
positive regulation of B cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41183 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042981 |
regulation of apoptotic process |
Reactome:R-HSA-5633008 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
Reactome:R-HSA-6785807 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-9622627 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
- ↑ Chang, CC et al. (2012) Downregulation of inflammatory microRNAs by Ig-like transcript 3 is essential for the differentiation of human CD8(+) T suppressor cells. J. Immunol. 188 3042-52 PubMed GONUTS page
- ↑ 3.0 3.1 Cattoretti, G et al. (1995) BCL-6 protein is expressed in germinal-center B cells. Blood 86 45-53 PubMed GONUTS page
- ↑ Pantano, S et al. (2006) Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells. Exp. Cell Res. 312 1312-22 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Phan, RT & Dalla-Favera, R (2004) The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature 432 635-9 PubMed GONUTS page
- ↑ Baron, BW et al. (1997) BCL6 can repress transcription from the human immunodeficiency virus type I promoter/enhancer region. Genes Chromosomes Cancer 19 14-21 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Albagli, O et al. (1999) Overexpressed BCL6 (LAZ3) oncoprotein triggers apoptosis, delays S phase progression and associates with replication foci. Oncogene 18 5063-75 PubMed GONUTS page
- ↑ Huynh, KD et al. (2000) BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev. 14 1810-23 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 10.0 10.1 Lemercier, C et al. (2002) Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor. J. Biol. Chem. 277 22045-52 PubMed GONUTS page
- ↑ Arima, M et al. (2002) A putative silencer element in the IL-5 gene recognized by Bcl6. J. Immunol. 169 829-36 PubMed GONUTS page
- ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
c
d
i
n
- GO:0043066 ! negative regulation of apoptotic process
- GO:0035024 ! negative regulation of Rho protein signal transduction
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:2000773 ! negative regulation of cellular senescence
- GO:0045629 ! negative regulation of T-helper 2 cell differentiation
- GO:0002903 ! negative regulation of B cell apoptotic process
- GO:0030308 ! negative regulation of cell growth
- GO:1903464 ! negative regulation of mitotic cell cycle DNA replication
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0045596 ! negative regulation of cell differentiation
- GO:0032764 ! negative regulation of mast cell cytokine production
- GO:0001953 ! negative regulation of cell-matrix adhesion
- GO:0008285 ! negative regulation of cell population proliferation
- GO:0048294 ! negative regulation of isotype switching to IgE isotypes
- GO:0002829 ! negative regulation of type 2 immune response
- GO:0045746 ! negative regulation of Notch signaling pathway
- GO:0003676 ! nucleic acid binding
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
o
p
r
- GO:0042981 ! regulation of apoptotic process
- GO:0002634 ! regulation of germinal center formation
- GO:0050727 ! regulation of inflammatory response
- GO:0006357 ! regulation of transcription by RNA polymerase II
- GO:0043380 ! regulation of memory T cell differentiation
- GO:0050776 ! regulation of immune response
- GO:0043087 ! regulation of GTPase activity
- GO:0042127 ! regulation of cell population proliferation
- GO:0005657 ! replication fork
- GO:0007266 ! Rho protein signal transduction
- GO:0000977 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding