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HUMAN:BCL6

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) BCL6 (synonyms: BCL5, LAZ3, ZBTB27, ZNF51)
Protein Name(s) B-cell lymphoma 6 protein

BCL-6 B-cell lymphoma 5 protein BCL-5 Protein LAZ-3 Zinc finger and BTB domain-containing protein 27 Zinc finger protein 51

External Links
UniProt P41182
EMBL Z21943
U00115
S67779
EU139066
AC072022
CH471052
CH471052
BC150184
CCDS CCDS3289.1
CCDS46975.1
PIR A48752
I52586
RefSeq NP_001124317.1
NP_001128210.1
NP_001697.2
XP_005247751.1
UniGene Hs.478588
PDB 1R28
1R29
1R2B
2EN2
2EOS
2LCE
2YRM
3BIM
3E4U
3LBZ
4CP3
PDBsum 1R28
1R29
1R2B
2EN2
2EOS
2LCE
2YRM
3BIM
3E4U
3LBZ
4CP3
ProteinModelPortal P41182
SMR P41182
BioGrid 107076
DIP DIP-2651N
IntAct P41182
MINT MINT-158757
STRING 9606.ENSP00000232014
PhosphoSite P41182
DMDM 728952
MaxQB P41182
PaxDb P41182
PRIDE P41182
Ensembl ENST00000232014
ENST00000406870
ENST00000450123
ENST00000621333
GeneID 604
KEGG hsa:604
UCSC uc003frp.3
uc011bsf.1
CTD 604
GeneCards GC03M187439
HGNC HGNC:1001
HPA CAB000307
HPA004899
MIM 109565
neXtProt NX_P41182
Orphanet 545
98839
98838
PharmGKB PA25312
eggNOG COG5048
GeneTree ENSGT00750000117671
HOGENOM HOG000001556
HOVERGEN HBG004831
InParanoid P41182
KO K15618
OMA NECDCRF
OrthoDB EOG7KQ22S
PhylomeDB P41182
TreeFam TF330912
ChiTaRS BCL6
EvolutionaryTrace P41182
GeneWiki BCL6
GenomeRNAi 604
NextBio 2453
PRO PR:P41182
Proteomes UP000005640
Bgee P41182
CleanEx HS_BCL6
ExpressionAtlas P41182
Genevestigator P41182
GO GO:0005634
GO:0003682
GO:0031490
GO:0046872
GO:0000977
GO:0001227
GO:0043565
GO:0003700
GO:0030036
GO:0030183
GO:0000902
GO:0006974
GO:0048821
GO:0002467
GO:0006954
GO:0002903
GO:0030308
GO:0008285
GO:0001953
GO:0048294
GO:0032764
GO:0035024
GO:0045629
GO:0000122
GO:0045892
GO:0043065
GO:0030890
GO:0051272
GO:0000060
GO:0002634
GO:0050776
GO:0050727
GO:0043380
GO:0032319
GO:0007266
GO:0007283
GO:0042092
Gene3D 3.30.160.60
InterPro IPR000210
IPR011333
IPR013069
IPR007087
IPR015880
IPR013087
Pfam PF00651
SMART SM00225
SM00355
SUPFAM SSF54695
PROSITE PS50097
PS00028
PS50157

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:E9Q3T6
UniProtKB:O14978
UniProtKB:O95125
UniProtKB:O95863
UniProtKB:P10071
UniProtKB:P10754
UniProtKB:P17028
UniProtKB:P28698
UniProtKB:P36508
UniProtKB:P41183
UniProtKB:P47806
UniProtKB:P52738
UniProtKB:Q02085
UniProtKB:Q05516
UniProtKB:Q08376
UniProtKB:Q0VDQ9
UniProtKB:Q16600
UniProtKB:Q61967
UniProtKB:Q6DJT9
UniProtKB:Q6NUN9
UniProtKB:Q86UQ0
UniProtKB:Q8CIV7
UniProtKB:Q8K0L9
UniProtKB:Q8K3J5
UniProtKB:Q8NI51
UniProtKB:Q91ZD1
UniProtKB:Q96RE9
UniProtKB:Q99684
UniProtKB:Q9BU19
UniProtKB:Q9ESP5
UniProtKB:Q9GZX5
UniProtKB:Q9H116
UniProtKB:Q9NQX1
UniProtKB:Q9NZL3
UniProtKB:Q9QY31
UniProtKB:Q9UM63
UniProtKB:Q9UPG8
UniProtKB:Q9UQR1
UniProtKB:Q9WTJ2
UniProtKB:Q9Y2X9
UniProtKB:Q9Y473
UniProtKB:Q9Y5A6

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045591

positive regulation of regulatory T cell differentiation

PMID:22387553[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:7795255[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050776

regulation of immune response

PMID:16455075[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:15577913[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:9135990[6]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903464

negative regulation of mitotic cell cycle DNA replication

PMID:10490843[7]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:15577913[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:10490843[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030308

negative regulation of cell growth

PMID:10490843[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:15577913[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0005657

replication fork

PMID:10490843[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10898795[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:15577913[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0002903

negative regulation of B cell apoptotic process

PMID:15577913[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002634

regulation of germinal center formation

PMID:7795255[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:15577913[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050727

regulation of inflammatory response

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107187
PANTHER:PTN000578061

P

Seeded From UniProt

complete

involved_in

GO:0042127

regulation of cell population proliferation

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107187
PANTHER:PTN000578061

P

Seeded From UniProt

complete

involved_in

GO:0042092

type 2 immune response

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107187
PANTHER:PTN000578061

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107187
MGI:MGI:1278332
PANTHER:PTN000578151
UniProtKB:P41182
UniProtKB:Q96JB3

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107187
MGI:MGI:1278332
PANTHER:PTN000578151

F

Seeded From UniProt

complete

enables

GO:0001227

DNA-binding transcription repressor activity, RNA polymerase II-specific

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107187
MGI:MGI:1278332
PANTHER:PTN000578151

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107187
MGI:MGI:1278332
PANTHER:PTN000578151

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11929873[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:12097386[11]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:11929873[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25416956[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P41182

F

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030183

B cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0030036

actin cytoskeleton organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0008104

protein localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0007266

Rho protein signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

F

Seeded From UniProt

complete

involved_in

GO:0002829

negative regulation of type 2 immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0002467

germinal center formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0001953

negative regulation of cell-matrix adhesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

enables

GO:0001227

DNA-binding transcription repressor activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

F

Seeded From UniProt

complete

enables

GO:0001161

intronic transcription regulatory region sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

F

Seeded From UniProt

complete

involved_in

GO:0000902

cell morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:2000773

negative regulation of cellular senescence

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0051272

positive regulation of cellular component movement

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0050727

regulation of inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0048821

erythrocyte development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0048294

negative regulation of isotype switching to IgE isotypes

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0045746

negative regulation of Notch signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0045666

positive regulation of neuron differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0045629

negative regulation of T-helper 2 cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0045596

negative regulation of cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

F

Seeded From UniProt

complete

involved_in

GO:0043380

regulation of memory T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0043087

regulation of GTPase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0042127

regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0042092

type 2 immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0035024

negative regulation of Rho protein signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0032764

negative regulation of mast cell cytokine production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

enables

GO:0031490

chromatin DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

F

Seeded From UniProt

complete

involved_in

GO:0031065

positive regulation of histone deacetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

involved_in

GO:0030890

positive regulation of B cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41183
ensembl:ENSMUSP00000023151

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013087

F

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

Reactome:R-HSA-5633008

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

Reactome:R-HSA-6785807

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-9622627
Reactome:R-HSA-6800250
Reactome:R-HSA-6790036

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0395

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. Chang, CC et al. (2012) Downregulation of inflammatory microRNAs by Ig-like transcript 3 is essential for the differentiation of human CD8(+) T suppressor cells. J. Immunol. 188 3042-52 PubMed GONUTS page
  3. 3.0 3.1 Cattoretti, G et al. (1995) BCL-6 protein is expressed in germinal-center B cells. Blood 86 45-53 PubMed GONUTS page
  4. Pantano, S et al. (2006) Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells. Exp. Cell Res. 312 1312-22 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 Phan, RT & Dalla-Favera, R (2004) The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature 432 635-9 PubMed GONUTS page
  6. Baron, BW et al. (1997) BCL6 can repress transcription from the human immunodeficiency virus type I promoter/enhancer region. Genes Chromosomes Cancer 19 14-21 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Albagli, O et al. (1999) Overexpressed BCL6 (LAZ3) oncoprotein triggers apoptosis, delays S phase progression and associates with replication foci. Oncogene 18 5063-75 PubMed GONUTS page
  8. Huynh, KD et al. (2000) BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev. 14 1810-23 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 9.5 9.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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