HUMAN:ATF1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ATF1
Protein Name(s)	Cyclic AMP-dependent transcription factor ATF-1 cAMP-dependent transcription factor ATF-1 Activating transcription factor 1 Protein TREB36
External Links
UniProt	P18846
EMBL	X55544 AK299240 AC013244 BC029619 AJ295163
CCDS	CCDS8803.1
PIR	S12560
RefSeq	NP_005162.1
UniGene	Hs.648565
ProteinModelPortal	P18846
SMR	P18846
BioGrid	106956
DIP	DIP-652N
IntAct	P18846
MINT	MINT-142718
STRING	9606.ENSP00000262053
BindingDB	P18846
ChEMBL	CHEMBL3255
DrugBank	DB00852
PhosphoSite	P18846
DMDM	1168542
MaxQB	P18846
PaxDb	P18846
PRIDE	P18846
DNASU	466
Ensembl	ENST00000262053
GeneID	466
KEGG	hsa:466
UCSC	uc001rww.4
CTD	466
GeneCards	GC12P051189
HGNC	HGNC:783
HPA	CAB016222 HPA055069 HPA055406
MIM	123803 612160
neXtProt	NX_P18846
Orphanet	97338
PharmGKB	PA25083
eggNOG	NOG255464
GeneTree	ENSGT00390000008655
HOGENOM	HOG000007365
HOVERGEN	HBG011077
InParanoid	P18846
KO	K09053
OMA	HIAQQMS
PhylomeDB	P18846
TreeFam	TF106464
Reactome	REACT_12524
SignaLink	P18846
ChiTaRS	ATF1
GeneWiki	ATF1
GenomeRNAi	466
NextBio	1921
PRO	PR:P18846
Proteomes	UP000005640
Bgee	P18846
CleanEx	HS_ATF1
ExpressionAtlas	P18846
Genevestigator	P18846
GO	GO:0005654 GO:0005634 GO:0005667 GO:0003705 GO:0000977 GO:0001228 GO:0003700 GO:0043623 GO:0045087 GO:0002755 GO:0002756 GO:0048011 GO:0045740 GO:0010976 GO:0045944 GO:0032025 GO:0014070 GO:0051403 GO:0034166 GO:0034134 GO:0034138 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0035666
InterPro	IPR029825 IPR004827 IPR003102 IPR001630
PANTHER	PTHR22952:SF99
Pfam	PF00170 PF02173
PRINTS	PR00041
SMART	SM00338
PROSITE	PS50217 PS00036 PS50953

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0035326	enhancer binding	PMID:17565989^[1]	ECO:0000314			F		figure 1	complete
	GO:0005515	protein binding	PMID:17565989^[1]	ECO:0000021		UniProtKB:P02794 UniProtKB:Q9Y6X2	F		figure 1, 3	complete
	GO:0016481	negative regulation of transcription	PMID:17565989^[1]	ECO:0000315			P		Fig.2B,C	complete
	GO:0016925	protein sumoylation	PMID:17565989^[1]	ECO:0000314			P		Fig. S1	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001630 InterPro:IPR004827	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P15337	F		Seeded From UniProt	complete
part_of	GO:1990590	ATF1-ATF4 transcription factor complex	PMID:12871976^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0034976)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:1655749^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:24797)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:1655749^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:1655749^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1298366 MGI:MGI:88494 MGI:MGI:88495 PANTHER:PTN001119557 RGD:1307360 RGD:620218	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8798441^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21045134^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P18846	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20102225^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P18846	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7FD47 ensembl:ENSRNOP00000073249	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7FD47 ensembl:ENSRNOP00000073249	P		Seeded From UniProt	complete
involved_in	GO:0045740	positive regulation of DNA replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7FD47 ensembl:ENSRNOP00000073249	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7FD47 ensembl:ENSRNOP00000073249	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7FD47 ensembl:ENSRNOP00000073249	F		Seeded From UniProt	complete
involved_in	GO:0034622	cellular protein-containing complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7FD47 ensembl:ENSRNOP00000073249	P		Seeded From UniProt	complete
involved_in	GO:0032025	response to cobalt ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7FD47 ensembl:ENSRNOP00000073249	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7FD47 ensembl:ENSRNOP00000073249	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7FD47 ensembl:ENSRNOP00000073249	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7FD47 ensembl:ENSRNOP00000073249	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7FD47 ensembl:ENSRNOP00000073249	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7FD47 ensembl:ENSRNOP00000073249	F		Seeded From UniProt	complete
part_of	GO:1990590	ATF1-ATF4 transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81269 ensembl:ENSMUSP00000023769	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81269 ensembl:ENSMUSP00000023769	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81269 ensembl:ENSMUSP00000023769	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001630	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001630 InterPro:IPR004827 InterPro:IPR029825	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001630 InterPro:IPR029825	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001630 InterPro:IPR003102 InterPro:IPR004827	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029825	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029825	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029825	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:2196176^[9] PMID:8401579^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-199910	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
	GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	PMID:24224056^[11]	ECO:0000315			F		Fig 3, using Figure 4 for binding.	complete CACAO 10085
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Iwasaki, K et al. (2007) PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element. J. Biol. Chem. 282 22335-43 PubMed GONUTS page
↑ ^2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Luo, S et al. (2003) Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. J. Biol. Chem. 278 37375-85 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Rehfuss, RP et al. (1991) The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. J. Biol. Chem. 266 18431-4 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ji, L et al. (1996) CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas. J. Biol. Chem. 271 22687-91 PubMed GONUTS page
↑ Ciani, B et al. (2010) Molecular basis of coiled-coil oligomerization-state specificity. Proc. Natl. Acad. Sci. U.S.A. 107 19850-5 PubMed GONUTS page
↑ Reinke, AW et al. (2010) Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays. Biochemistry 49 1985-97 PubMed GONUTS page
↑ Yoshimura, T et al. (1990) Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. EMBO J. 9 2537-42 PubMed GONUTS page
↑ Zucman, J et al. (1993) EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. Nat. Genet. 4 341-5 PubMed GONUTS page
↑ Kato, H et al. (2013) The transcription factors Atf1 and Pcr1 are essential for transcriptional induction of the extracellular maltase Agl1 in fission yeast. PLoS ONE 8 e80572 PubMed GONUTS page

[PMID:17565989-1] 1.0 ^1.1 ^1.2 ^1.3 Iwasaki, K et al. (2007) PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element. J. Biol. Chem. 282 22335-43 PubMed GONUTS page

[PMID:19274049-2] 2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:12871976-3] Luo, S et al. (2003) Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. J. Biol. Chem. 278 37375-85 PubMed GONUTS page

[PMID:1655749-4] 4.0 ^4.1 ^4.2 Rehfuss, RP et al. (1991) The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. J. Biol. Chem. 266 18431-4 PubMed GONUTS page

[PMID:21873635-5] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8798441-6] Ji, L et al. (1996) CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas. J. Biol. Chem. 271 22687-91 PubMed GONUTS page

[PMID:21045134-7] Ciani, B et al. (2010) Molecular basis of coiled-coil oligomerization-state specificity. Proc. Natl. Acad. Sci. U.S.A. 107 19850-5 PubMed GONUTS page

[PMID:20102225-8] Reinke, AW et al. (2010) Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays. Biochemistry 49 1985-97 PubMed GONUTS page

[PMID:2196176-9] Yoshimura, T et al. (1990) Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. EMBO J. 9 2537-42 PubMed GONUTS page

[PMID:8401579-10] Zucman, J et al. (1993) EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. Nat. Genet. 4 341-5 PubMed GONUTS page

[PMID:24224056-11] Kato, H et al. (2013) The transcription factors Atf1 and Pcr1 are essential for transcriptional induction of the extracellular maltase Agl1 in fission yeast. PLoS ONE 8 e80572 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

HUMAN:ATF1

Contents

Annotations

Notes

References

a

c

d

e

h

i

m

n

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools