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HUMAN:AQP1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | AQP1 (synonyms: CHIP28) | |
Protein Name(s) | Aquaporin-1
AQP-1 Aquaporin-CHIP Urine water channel Water channel protein for red blood cells and kidney proximal tubule | |
External Links | ||
UniProt | P29972 | |
EMBL | M77829 U41517 U41518 S73482 AK309608 AY953319 AC004691 AC005155 AB451275 AB451402 CH471073 BC022486 AF480415 | |
CCDS | CCDS5431.1 CCDS55096.1 CCDS55097.1 CCDS55098.1 | |
PIR | A41616 I52366 | |
RefSeq | NP_001171989.1 NP_001171990.1 NP_001171991.1 NP_932766.1 | |
UniGene | Hs.76152 | |
PDB | 1FQY 1H6I 1IH5 | |
PDBsum | 1FQY 1H6I 1IH5 | |
ProteinModelPortal | P29972 | |
SMR | P29972 | |
BioGrid | 106854 | |
DIP | DIP-29607N | |
IntAct | P29972 | |
MINT | MINT-1439356 | |
STRING | 9606.ENSP00000311165 | |
DrugBank | DB00819 | |
GuidetoPHARMACOLOGY | 688 | |
TCDB | 1.A.8.8.1 | |
PhosphoSite | P29972 | |
DMDM | 267412 | |
PaxDb | P29972 | |
PRIDE | P29972 | |
DNASU | 358 | |
Ensembl | ENST00000311813 ENST00000409611 ENST00000409899 ENST00000441328 | |
GeneID | 358 | |
KEGG | hsa:358 | |
UCSC | uc003tbv.2 | |
CTD | 358 | |
GeneCards | GC07P030894 | |
HGNC | HGNC:633 | |
HPA | CAB001707 HPA019206 | |
MIM | 107776 110450 | |
neXtProt | NX_P29972 | |
PharmGKB | PA24918 | |
eggNOG | COG0580 | |
GeneTree | ENSGT00760000119223 | |
HOGENOM | HOG000288286 | |
HOVERGEN | HBG000312 | |
InParanoid | P29972 | |
KO | K09864 | |
OMA | FNNHWIF | |
OrthoDB | EOG7N8ZWD | |
PhylomeDB | P29972 | |
TreeFam | TF312940 | |
Reactome | REACT_121329 REACT_121380 REACT_23826 REACT_24023 | |
ChiTaRS | AQP1 | |
EvolutionaryTrace | P29972 | |
GeneWiki | Aquaporin_1 | |
GenomeRNAi | 358 | |
NextBio | 1497 | |
PRO | PR:P29972 | |
Proteomes | UP000005640 | |
Bgee | P29972 | |
CleanEx | HS_AQP1 | |
ExpressionAtlas | P29972 | |
Genevestigator | P29972 | |
GO | GO:0045177 GO:0016324 GO:0043679 GO:0009925 GO:0016323 GO:0005903 GO:0031526 GO:0005737 GO:0070062 GO:0005887 GO:0031965 GO:0005634 GO:0005886 GO:0042383 GO:0020003 GO:0008519 GO:0035379 GO:0015168 GO:0005223 GO:0030184 GO:0005267 GO:0015079 GO:0022857 GO:0015250 GO:0005372 GO:0072488 GO:0015696 GO:0015701 GO:0048593 GO:0035378 GO:0015670 GO:0098655 GO:0006884 GO:0019725 GO:0071474 GO:0071320 GO:0071280 GO:0071549 GO:0070301 GO:0071456 GO:0071241 GO:0071260 GO:0071288 GO:0071732 GO:0071300 GO:0071472 GO:0033554 GO:0034644 GO:0033326 GO:0006182 GO:0051458 GO:0030950 GO:0003094 GO:0015793 GO:0042538 GO:0021670 GO:0044241 GO:0085018 GO:0072220 GO:0072239 GO:0072232 GO:0072230 GO:0050891 GO:0043066 GO:0043154 GO:0030185 GO:0042476 GO:0030157 GO:0045766 GO:0010634 GO:0048146 GO:0010592 GO:0046878 GO:0071805 GO:0006813 GO:0070295 GO:0003097 GO:0042493 GO:0043627 GO:0033363 GO:0019233 GO:0044281 GO:0035377 GO:0055085 GO:0006833 GO:0042060 | |
Gene3D | 1.20.1080.10 | |
InterPro | IPR023271 IPR023274 IPR000425 IPR022357 | |
PANTHER | PTHR19139 | |
Pfam | PF00230 | |
PRINTS | PR02013 PR00783 | |
SUPFAM | SSF81338 | |
TIGRFAMs | TIGR00861 | |
PROSITE | PS00221 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0085018 |
maintenance of symbiont-containing vacuole by host |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071732 |
cellular response to nitric oxide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071549 |
cellular response to dexamethasone stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071474 |
cellular hyperosmotic response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071472 |
cellular response to salt stress |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071456 |
cellular response to hypoxia |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071320 |
cellular response to cAMP |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071320 |
cellular response to cAMP |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071300 |
cellular response to retinoic acid |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071300 |
cellular response to retinoic acid |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071288 |
cellular response to mercury ion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071288 |
cellular response to mercury ion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071288 |
cellular response to mercury ion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071288 |
cellular response to mercury ion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071288 |
cellular response to mercury ion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071280 |
cellular response to copper ion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071280 |
cellular response to copper ion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071260 |
cellular response to mechanical stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071241 |
cellular response to inorganic substance |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070301 |
cellular response to hydrogen peroxide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050891 |
multicellular organismal water homeostasis |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048146 |
positive regulation of fibroblast proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046878 |
positive regulation of saliva secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046878 |
positive regulation of saliva secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045766 |
positive regulation of angiogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0045177 |
apical part of cell |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0002306) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042493 |
response to drug |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042476 |
odontogenesis |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0042383 |
sarcolemma |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0035379 |
carbon dioxide transmembrane transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035378 |
carbon dioxide transmembrane transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035377 |
transepithelial water transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034644 |
cellular response to UV |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0033326 |
cerebrospinal fluid secretion |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0031526 |
brush border membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030950 |
establishment or maintenance of actin cytoskeleton polarity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030185 |
nitric oxide transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0030184 |
nitric oxide transmembrane transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030157 |
pancreatic juice secretion |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0022857 |
transmembrane transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0021670 |
lateral ventricle development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0020005 |
symbiont-containing vacuole membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0020003 |
symbiont-containing vacuole |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0019725 |
cellular homeostasis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016323 |
basolateral plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016323 |
basolateral plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016323 |
basolateral plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016323 |
basolateral plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016323 |
basolateral plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016323 |
basolateral plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016323 |
basolateral plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0015793 |
glycerol transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0015793 |
glycerol transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0015696 |
ammonium transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0015696 |
ammonium transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0015670 |
carbon dioxide transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0015670 |
carbon dioxide transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0015670 |
carbon dioxide transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0015250 |
water channel activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0015250 |
water channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0015168 |
glycerol transmembrane transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0015168 |
glycerol transmembrane transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0015079 |
potassium ion transmembrane transporter activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0009925 |
basal plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0008519 |
ammonium transmembrane transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006884 |
cell volume homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006833 |
water transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006833 |
water transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006833 |
water transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006833 |
water transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006833 |
water transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006833 |
water transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006833 |
water transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006833 |
water transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006833 |
water transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006813 |
potassium ion transport |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0019934 |
cGMP-mediated signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005903 |
brush border |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005903 |
brush border |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
NOT|part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005372 |
water transmembrane transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005372 |
water transmembrane transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005372 |
water transmembrane transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005372 |
water transmembrane transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005372 |
water transmembrane transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005372 |
water transmembrane transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005372 |
water transmembrane transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005372 |
water transmembrane transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005372 |
water transmembrane transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005267 |
potassium channel activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005223 |
intracellular cGMP-activated cation channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003097 |
renal water transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0035379 |
carbon dioxide transmembrane transporter activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002709505 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035378 |
carbon dioxide transmembrane transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000440666 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG13270 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0015250 |
water channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG13270 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0015168 |
glycerol transmembrane transporter activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002709505 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008519 |
ammonium transmembrane transporter activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002709505 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006972 |
hyperosmotic response |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002709505 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003097 |
renal water transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103201 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0015250 |
water channel activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0015250 |
water channel activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0015250 |
water channel activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0015250 |
water channel activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0015250 |
water channel activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034220 |
ion transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005223 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0015079 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005267 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0072488 |
ammonium transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008519 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0072488 |
ammonium transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008519 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0098655 |
cation transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005223 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0015267 |
channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055085 |
transmembrane transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0015701 |
bicarbonate transport |
Reactome:R-HSA-1247673 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
involved_in |
GO:0006833 |
water transport |
Reactome:R-HSA-432047 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-507870 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0003091 |
renal water homeostasis |
Reactome:R-HSA-432040 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Pisitkun, T et al. (2004) Identification and proteomic profiling of exosomes in human urine. Proc. Natl. Acad. Sci. U.S.A. 101 13368-73 PubMed GONUTS page
- ↑ 4.0 4.1 Radtke, AL & O'Riordan, MX (2008) Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1. Cell. Microbiol. 10 2197-207 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Boassa, D & Yool, AJ (2003) Single amino acids in the carboxyl terminal domain of aquaporin-1 contribute to cGMP-dependent ion channel activation. BMC Physiol. 3 12 PubMed GONUTS page
- ↑ Peng, J et al. (2006) Effect of dexamethasone and aquaporin-1 antisense oligonucleotides on the aquaporin-1 expression in cultured human trabecular meshwork cells. J. Huazhong Univ. Sci. Technol. Med. Sci. 26 137-40 PubMed GONUTS page
- ↑ 7.0 7.1 Umenishi, F & Schrier, RW (2002) Identification and characterization of a novel hypertonicity-responsive element in the human aquaporin-1 gene. Biochem. Biophys. Res. Commun. 292 771-5 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Misawa, T et al. (2008) Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains. Acta Neuropathol. 116 247-60 PubMed GONUTS page
- ↑ 9.0 9.1 Kaneko, K et al. (2008) Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells. Microvasc. Res. 75 297-301 PubMed GONUTS page
- ↑ Belkacemi, L et al. (2008) AQP1 gene expression is upregulated by arginine vasopressin and cyclic AMP agonists in trophoblast cells. Life Sci. 82 1272-80 PubMed GONUTS page
- ↑ Shengbiao Wang, et al. (2007) Cyclic adenosine monophosphate regulation of aquaporin gene expression in human amnion epithelia. Reprod Sci 14 234-40 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 12.4 Jiang, Q et al. (2009) MEK/ERK pathway mediates UVB-induced AQP1 downregulation and water permeability impairment in human retinal pigment epithelial cells. Int. J. Mol. Med. 23 771-7 PubMed GONUTS page
- ↑ 13.0 13.1 Umenishi, F & Schrier, RW (2002) Induction of human aquaporin-1 gene by retinoic acid in human erythroleukemia HEL cells. Biochem. Biophys. Res. Commun. 293 913-7 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 Voigtlaender, J et al. (2002) Transmembrane water influx via aquaporin-1 is inhibited by barbiturates and propofol in red blood cells. Naunyn Schmiedebergs Arch. Pharmacol. 366 209-17 PubMed GONUTS page
- ↑ 15.0 15.1 Singleton, N et al. () Psychiatric morbidity among adults living in private households, 2000. Int Rev Psychiatry 15 65-73 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 16.3 Mulders, SM et al. (1997) Importance of the mercury-sensitive cysteine on function and routing of AQP1 and AQP2 in oocytes. Am. J. Physiol. 273 F451-6 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 17.3 17.4 17.5 Abrami, L et al. (1996) Glycerol permeability of mutant aquaporin 1 and other AQP-MIP proteins: inhibition studies. Pflugers Arch. 431 408-14 PubMed GONUTS page
- ↑ 18.0 18.1 18.2 18.3 18.4 Abrami, L et al. (1995) Evidence for a glycerol pathway through aquaporin 1 (CHIP28) channels. Pflugers Arch. 430 447-58 PubMed GONUTS page
- ↑ 19.0 19.1 Baetz, NW et al. (2009) Role of aquaporin-1 in trabecular meshwork cell homeostasis during mechanical strain. Exp. Eye Res. 89 95-100 PubMed GONUTS page
- ↑ 20.0 20.1 20.2 20.3 20.4 Satoh, J et al. (2007) Human astrocytes express aquaporin-1 and aquaporin-4 in vitro and in vivo. Neuropathology 27 245-56 PubMed GONUTS page
- ↑ 21.0 21.1 Hoque, MO et al. (2006) Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage-independent growth. Am. J. Pathol. 168 1345-53 PubMed GONUTS page
- ↑ Shan, Z et al. (2005) Increased fluid secretion after adenoviral-mediated transfer of the human aquaporin-1 cDNA to irradiated miniature pig parotid glands. Mol. Ther. 11 444-51 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 23.3 23.4 Delporte, C et al. (1997) Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands. Proc. Natl. Acad. Sci. U.S.A. 94 3268-73 PubMed GONUTS page
- ↑ Jouret, F et al. (2004) Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5. Kidney Int. 65 198-208 PubMed GONUTS page
- ↑ Zhang, L et al. (2011) Inhibition of aquaporin-1 expression by RNAi protects against aristolochic acid I-induced apoptosis in human proximal tubular epithelial (HK-2) cells. Biochem. Biophys. Res. Commun. 405 68-73 PubMed GONUTS page
- ↑ Wang, W et al. (2003) Aquaporin expression in developing human teeth and selected orofacial tissues. Calcif. Tissue Int. 72 222-7 PubMed GONUTS page
- ↑ 27.0 27.1 Jimi, T et al. (2006) Aquaporin 1: examination of its expression and localization in normal human skeletal muscle tissue. Cells Tissues Organs (Print) 184 181-7 PubMed GONUTS page
- ↑ 28.0 28.1 28.2 28.3 Endeward, V et al. (2006) Evidence that aquaporin 1 is a major pathway for CO2 transport across the human erythrocyte membrane. FASEB J. 20 1974-81 PubMed GONUTS page
- ↑ 29.0 29.1 29.2 29.3 29.4 Stamer, WD et al. (2003) Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement. Invest. Ophthalmol. Vis. Sci. 44 2803-8 PubMed GONUTS page
- ↑ 30.0 30.1 30.2 30.3 Gömöri, E et al. (2006) Fetal development of membrane water channel proteins aquaporin-1 and aquaporin-4 in the human brain. Int. J. Dev. Neurosci. 24 295-305 PubMed GONUTS page
- ↑ 31.0 31.1 31.2 Maunsbach, AB et al. (1997) Aquaporin-1 water channel expression in human kidney. J. Am. Soc. Nephrol. 8 1-14 PubMed GONUTS page
- ↑ 32.0 32.1 Monzani, E et al. (2009) AQP1 is not only a water channel: it contributes to cell migration through Lin7/beta-catenin. PLoS ONE 4 e6167 PubMed GONUTS page
- ↑ 33.0 33.1 Herrera, M et al. (2006) Aquaporin-1 transports NO across cell membranes. Hypertension 48 157-64 PubMed GONUTS page
- ↑ 34.0 34.1 34.2 34.3 Burghardt, B et al. (2003) Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas. Gut 52 1008-16 PubMed GONUTS page
- ↑ 35.0 35.1 35.2 35.3 Johansson, PA et al. (2005) Aquaporin-1 in the choroid plexuses of developing mammalian brain. Cell Tissue Res. 322 353-64 PubMed GONUTS page
- ↑ Crane, JM & Verkman, AS (2008) Long-range nonanomalous diffusion of quantum dot-labeled aquaporin-1 water channels in the cell plasma membrane. Biophys. J. 94 702-13 PubMed GONUTS page
- ↑ 37.0 37.1 Missner, A et al. (2008) Carbon dioxide transport through membranes. J. Biol. Chem. 283 25340-7 PubMed GONUTS page
- ↑ 38.0 38.1 38.2 Musa-Aziz, R et al. (2009) Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG. Proc. Natl. Acad. Sci. U.S.A. 106 5406-11 PubMed GONUTS page
- ↑ 39.0 39.1 Ripoche, P et al. () Role of RhAG and AQP1 in NH3 and CO2 gas transport in red cell ghosts: a stopped-flow analysis. Transfus Clin Biol 13 117-22 PubMed GONUTS page
- ↑ 40.0 40.1 Preston, GM et al. (1994) Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels. Science 265 1585-7 PubMed GONUTS page
- ↑ 41.0 41.1 Mathai, JC et al. (1996) Functional analysis of aquaporin-1 deficient red cells. The Colton-null phenotype. J. Biol. Chem. 271 1309-13 PubMed GONUTS page
- ↑ 42.0 42.1 42.2 Yool, AJ et al. (2002) Tetraethylammonium block of water flux in Aquaporin-1 channels expressed in kidney thin limbs of Henle's loop and a kidney-derived cell line. BMC Physiol. 2 4 PubMed GONUTS page
- ↑ 43.0 43.1 Zhu, XQ et al. (2009) Expression of aquaporin 1 and aquaporin 3 in fetal membranes and placenta in human term pregnancies with oligohydramnios. Placenta 30 670-6 PubMed GONUTS page
- ↑ Marchini, G et al. () AQP1 and AQP3, psoriasin, and nitric oxide synthases 1-3 are inflammatory mediators in erythema toxicum neonatorum. Pediatr Dermatol 20 377-84 PubMed GONUTS page
- ↑ Kamiie, J et al. (2002) Localization and expression of the aquaporin-1 water channel in mesangial cells in the human glomerulus. Arch. Histol. Cytol. 65 83-90 PubMed GONUTS page
- ↑ Au, CG et al. (2008) Changes in skeletal muscle expression of AQP1 and AQP4 in dystrophinopathy and dysferlinopathy patients. Acta Neuropathol. 116 235-46 PubMed GONUTS page
- ↑ Lazowski, KW et al. (1995) Evidence for the presence of a Hg-inhibitable water-permeability pathway and aquaporin 1 in A5 salivary epithelial cells. J. Cell. Physiol. 164 613-9 PubMed GONUTS page
- ↑ 48.0 48.1 48.2 48.3 48.4 48.5 48.6 48.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Hub, JS & de Groot, BL (2008) Mechanism of selectivity in aquaporins and aquaglyceroporins. Proc. Natl. Acad. Sci. U.S.A. 105 1198-203 PubMed GONUTS page
- ↑ Zeidel, ML et al. (1992) Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein. Biochemistry 31 7436-40 PubMed GONUTS page
- ↑ Tsunoda, SP et al. (2004) Aquaporin-1, nothing but a water channel. J. Biol. Chem. 279 11364-7 PubMed GONUTS page
- ↑ Preston, GM et al. (1992) Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein. Science 256 385-7 PubMed GONUTS page
- ↑ Murata, K et al. (2000) Structural determinants of water permeation through aquaporin-1. Nature 407 599-605 PubMed GONUTS page
- ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
- ↑ Buck, TM et al. (2007) A novel tripartite motif involved in aquaporin topogenesis, monomer folding and tetramerization. Nat. Struct. Mol. Biol. 14 762-9 PubMed GONUTS page
- ↑ Preston, GM & Agre, P (1991) Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family. Proc. Natl. Acad. Sci. U.S.A. 88 11110-4 PubMed GONUTS page
a
b
c
- GO:0035378 ! carbon dioxide transmembrane transport
- GO:0035379 ! carbon dioxide transmembrane transporter activity
- GO:0015670 ! carbon dioxide transport
- Catarrhini
- GO:0019725 ! cellular homeostasis
- GO:0071474 ! cellular hyperosmotic response
- GO:0071260 ! cellular response to mechanical stimulus
- GO:0034644 ! cellular response to UV
- GO:0071732 ! cellular response to nitric oxide
- GO:0071549 ! cellular response to dexamethasone stimulus
- GO:0071472 ! cellular response to salt stress
- GO:0070301 ! cellular response to hydrogen peroxide
- GO:0071456 ! cellular response to hypoxia
- GO:0071320 ! cellular response to cAMP
- GO:0071300 ! cellular response to retinoic acid
- GO:0071288 ! cellular response to mercury ion
- GO:0071280 ! cellular response to copper ion
- GO:0006884 ! cell volume homeostasis
- GO:0033326 ! cerebrospinal fluid secretion
- GO:0019934 ! cGMP-mediated signaling
- GO:0015267 ! channel activity
- Chordata
- Craniata
- GO:0005737 ! cytoplasm
e
g
i
m
n
o
p
- GO:0030157 ! pancreatic juice secretion
- GO:0005886 ! plasma membrane
- GO:0048146 ! positive regulation of fibroblast proliferation
- GO:0046878 ! positive regulation of saliva secretion
- GO:0045766 ! positive regulation of angiogenesis
- GO:0005267 ! potassium channel activity
- GO:0071805 ! potassium ion transmembrane transport
- GO:0015079 ! potassium ion transmembrane transporter activity
- GO:0006813 ! potassium ion transport
- Primates
r
s
t