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PMID:14675051

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Citation

Jouret, F, Igarashi, T, Gofflot, F, Wilson, PD, Karet, FE, Thakker, RV and Devuyst, O (2004) Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5. Kidney Int. 65:198-208

Abstract

The renal chloride channel ClC-5, which is responsible for Dent's disease, is coexpressed with the vacuolar H+-ATPase in proximal tubules (PT) and alpha-type intercalated cells (IC) of the mature kidney. Neonatal cases of Dent's disease suggest that ClC-5 distribution must be acquired before birth. However, the ontogeny of ClC-5, and its processing and segmental distribution with respect to related proteins during nephrogenesis remain unknown.

Links

PubMed Online version:10.1111/j.1523-1755.2004.00360.x

Keywords

Animals; Antibodies, Monoclonal; Aquaporin 1; Aquaporins/metabolism; Blood Group Antigens; Carbonic Anhydrases/metabolism; Chloride Channels/genetics; Chloride Channels/immunology; Chloride Channels/metabolism; Gene Expression Regulation, Developmental; Glycosylation; Humans; Immunohistochemistry; Kidney/embryology; Kidney/physiology; Kidney Diseases/genetics; Mice; Mice, Inbred Strains; Phenotype; Proton-Translocating ATPases/metabolism; RNA, Messenger/analysis

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:CAH2

located_in

GO:0045177: apical part of cell

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:AQP1

located_in

GO:0045177: apical part of cell

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:CLCN5

located_in

GO:0016020: membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:CLCN5

located_in

GO:0045177: apical part of cell

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:CLCN5

located_in

GO:0016020: membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:VPP4

located_in

GO:0045177: apical part of cell

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:VPP4

located_in

GO:0045177: apical part of cell

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:CLCN5

located_in

GO:0045177: apical part of cell

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:CAH2

part_of

GO:0045177: apical part of cell

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:AQP1

part_of

GO:0045177: apical part of cell

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

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