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PMID:14561230

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Citation

Boassa, D and Yool, AJ (2003) Single amino acids in the carboxyl terminal domain of aquaporin-1 contribute to cGMP-dependent ion channel activation. BMC Physiol. 3:12

Abstract

Aquaporin-1 (AQP1) functions as an osmotic water channel and a gated cation channel. Activation of the AQP1 ion conductance by intracellular cGMP was hypothesized to involve the carboxyl (C-) terminus, based on amino acid sequence alignments with cyclic-nucleotide-gated channels and cGMP-selective phosphodiesterases.

Links

PubMed PMC269983 Online version:10.1186/1472-6793-3-12

Keywords

Amino Acid Sequence/physiology; Amino Acids/genetics; Amino Acids/metabolism; Animals; Aquaporin 1; Aquaporins/biosynthesis; Aquaporins/chemistry; Aquaporins/genetics; Aquaporins/physiology; Blood Group Antigens; Conserved Sequence/physiology; Cyclic GMP/biosynthesis; Cyclic GMP/physiology; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Female; Humans; Ion Channels/chemistry; Ion Channels/drug effects; Ion Channels/metabolism; Ion Channels/physiology; Membrane Potentials/drug effects; Membrane Potentials/genetics; Membrane Potentials/physiology; Mutagenesis, Site-Directed/genetics; Mutagenesis, Site-Directed/physiology; Nitric Oxide Donors/pharmacology; Nitroprusside/pharmacology; Oocytes/chemistry; Oocytes/cytology; Oocytes/metabolism; Osmotic Pressure; Patch-Clamp Techniques/methods; Peptides/physiology; Protein Structure, Tertiary/physiology; Xenopus laevis/embryology; Xenopus laevis/genetics; Xenopus laevis/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:AQP1

enables

GO:0005372: water transmembrane transporter activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:AQP1

enables

GO:0005223: intracellular cGMP-activated cation channel activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:AQP1

involved_in

GO:0071732: cellular response to nitric oxide

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:AQP1

involved_in

GO:0071241: cellular response to inorganic substance

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:AQP1

involved_in

GO:0006833: water transport

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:AQP1

involved_in

GO:0019934: cGMP-mediated signaling

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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