HUMAN:ANXA1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ANXA1 (synonyms: ANX1, LPC1)
Protein Name(s)	Annexin A1 Annexin I Annexin-1 Calpactin II Calpactin-2 Chromobindin-9 Lipocortin I Phospholipase A2 inhibitory protein p35
External Links
UniProt	P04083
EMBL	X05908 BC001275 BC035993
CCDS	CCDS6645.1
PIR	A03080
RefSeq	NP_000691.1
UniGene	Hs.494173
PDB	1AIN 1BO9 1QLS
PDBsum	1AIN 1BO9 1QLS
ProteinModelPortal	P04083
SMR	P04083
BioGrid	106798
DIP	DIP-32875N
IntAct	P04083
MINT	MINT-1212274
STRING	9606.ENSP00000257497
DrugBank	DB00288 DB01234 DB00741
TCDB	1.A.31.1.3
PhosphoSite	P04083
DMDM	113944
DOSAC-COBS-2DPAGE	P04083
REPRODUCTION-2DPAGE	IPI00218918 P04083
UCD-2DPAGE	P04083
MaxQB	P04083
PaxDb	P04083
PeptideAtlas	P04083
PRIDE	P04083
DNASU	301
Ensembl	ENST00000257497 ENST00000376911
GeneID	301
KEGG	hsa:301
UCSC	uc004ajf.1
CTD	301
GeneCards	GC09P075766
HGNC	HGNC:533
HPA	CAB013023 CAB035987 CAB058693 HPA011271 HPA011272
MIM	151690
neXtProt	NX_P04083
PharmGKB	PA24823
eggNOG	NOG282829
HOGENOM	HOG000158803
HOVERGEN	HBG061815
InParanoid	P04083
KO	K17091
OMA	MNDIKAC
OrthoDB	EOG74XS72
PhylomeDB	P04083
TreeFam	TF105452
Reactome	REACT_18283 REACT_19231 REACT_21264
SignaLink	P04083
ChiTaRS	ANXA1
EvolutionaryTrace	P04083
GeneWiki	Annexin_A1
GenomeRNAi	301
NextBio	1213
PRO	PR:P04083
Proteomes	UP000005640
Bgee	P04083
CleanEx	HS_ANXA1
ExpressionAtlas	P04083
Genevestigator	P04083
GO	GO:0016323 GO:0009986 GO:0005929 GO:0001533 GO:0005737 GO:0005768 GO:0005576 GO:0005615 GO:0070062 GO:0005925 GO:0042629 GO:0031966 GO:0005634 GO:0005886 GO:0043234 GO:0042383 GO:0031982 GO:0036310 GO:0005509 GO:0005544 GO:0048306 GO:0033676 GO:0004386 GO:0019834 GO:0005543 GO:0030674 GO:0005102 GO:0003697 GO:0003727 GO:0005198 GO:0046632 GO:0050482 GO:0007166 GO:0006928 GO:0071385 GO:0070301 GO:0032508 GO:0036292 GO:0031018 GO:0042063 GO:0070365 GO:0006954 GO:0030073 GO:0030216 GO:0043066 GO:2000483 GO:1900138 GO:0097350 GO:0001780 GO:0018149 GO:1900087 GO:0033031 GO:0031394 GO:0031340 GO:0070459 GO:0030850 GO:0042127 GO:0042493 GO:0032355 GO:0070555 GO:0043434 GO:0010165 GO:0007165
Gene3D	1.10.220.10
InterPro	IPR001464 IPR018502 IPR018252 IPR002388
PANTHER	PTHR10502:SF17
Pfam	PF00191
PRINTS	PR00196 PR00197
SMART	SM00335
PROSITE	PS00223

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045727	positive regulation of translation	PMID:21420379^[1]	ECO:0000314			P		Fig. 3	complete CACAO 6731
	GO:0019534	toxin transporter activity	PMID:22792315^[2]	ECO:0000316		UniProtKB:P07355	F		FIg. 1 B and C	complete CACAO 6737
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28344315^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002371)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28675934^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0003688)\|part_of:(UBERON:0001911)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001155)	Seeded From UniProt	complete
colocalizes_with	GO:0005884	actin filament	PMID:22773844^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002618) exists_during:(GO:0035924)	Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:22773844^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	PMID:22773844^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618) part_of:(GO:0035924)	Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:25468996^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0098641	cadherin binding involved in cell-cell adhesion	PMID:25468996^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032743	positive regulation of interleukin-2 production	PMID:17008549^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	PMID:17008549^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045629	negative regulation of T-helper 2 cell differentiation	PMID:17008549^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045627	positive regulation of T-helper 1 cell differentiation	PMID:17008549^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0019898	extrinsic component of membrane	PMID:17008549^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:17008549^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17008549^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19625660^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045920	negative regulation of exocytosis	PMID:19625660^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046883	regulation of hormone secretion	PMID:19625660^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:19625660^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031232	extrinsic component of external side of plasma membrane	PMID:19625660^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	PMID:25664854^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090303	positive regulation of wound healing	PMID:25664854^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:25664854^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:25664854^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	PMID:15187149^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	PMID:15187149^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071621	granulocyte chemotaxis	PMID:15187149^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002548	monocyte chemotaxis	PMID:15187149^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	PMID:15187149^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19619	C		Seeded From UniProt	complete
part_of	GO:0031313	extrinsic component of endosome membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19619	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19619	F		Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10107	C		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10107	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10107	C		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10107	P		Seeded From UniProt	complete
involved_in	GO:0032652	regulation of interleukin-1 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10107	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10107	P		Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10107	P		Seeded From UniProt	complete
involved_in	GO:0002685	regulation of leukocyte migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10107	P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[12]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	PMID:19190083^[13]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002202)	Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:18767904^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[15]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:2000483	negative regulation of interleukin-8 secretion	PMID:22056994^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:22056994^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000775)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22056994^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22056994^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[17]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[18]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:23580065^[19]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001827)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:22664934^[20]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001827)	Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	PMID:15226301^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01023	F	inhibited_by:(CHEBI:60888)	Seeded From UniProt	complete
involved_in	GO:0097350	neutrophil clearance	PMID:21957127^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002092)	Seeded From UniProt	complete
involved_in	GO:0071385	cellular response to glucocorticoid stimulus	PMID:2936963^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046632	alpha-beta T cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10107	P		Seeded From UniProt	complete
enables	GO:0019834	phospholipase A2 inhibitor activity	PMID:2936963^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001780	neutrophil homeostasis	PMID:21957127^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002092)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:21362503^[24]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002367)	Seeded From UniProt	complete
involved_in	GO:0031340	positive regulation of vesicle fusion	PMID:2138016^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030216	keratinocyte differentiation	PMID:10908733^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019834	phospholipase A2 inhibitor activity	PMID:3013422^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0018149	peptide cross-linking	PMID:10908733^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	PMID:2138016^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0001533	cornified envelope	PMID:10908733^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000483	negative regulation of interleukin-8 secretion	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
enables	GO:1990814	DNA/DNA annealing activity	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	F		Seeded From UniProt	complete
involved_in	GO:1900138	negative regulation of phospholipase A2 activity	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0097350	neutrophil clearance	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0090303	positive regulation of wound healing	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0071621	granulocyte chemotaxis	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0071385	cellular response to glucocorticoid stimulus	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794 RGD:2118 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0070459	prolactin secretion	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052711 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0070365	hepatocyte differentiation	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0050482	arachidonic acid secretion	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	F		Seeded From UniProt	complete
involved_in	GO:0046883	regulation of hormone secretion	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0046632	alpha-beta T cell differentiation	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0045920	negative regulation of exocytosis	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0045629	negative regulation of T-helper 2 cell differentiation	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0045627	positive regulation of T-helper 1 cell differentiation	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0044849	estrous cycle	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052711 PANTHER:PTN000052715	P		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0042063	gliogenesis	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
enables	GO:0033676	double-stranded DNA-dependent ATPase activity	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	F		Seeded From UniProt	complete
involved_in	GO:0033031	positive regulation of neutrophil apoptotic process	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0032743	positive regulation of interleukin-2 production	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0032652	regulation of interleukin-1 production	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0031394	positive regulation of prostaglandin biosynthetic process	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0031340	positive regulation of vesicle fusion	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	F		Seeded From UniProt	complete
involved_in	GO:0030216	keratinocyte differentiation	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
enables	GO:0019834	phospholipase A2 inhibitor activity	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118 UniProtKB:P04083	F		Seeded From UniProt	complete
involved_in	GO:0014839	myoblast migration involved in skeletal muscle regeneration	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0010165	response to X-ray	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794 RGD:2118 UniProtKB:P04083	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118 UniProtKB:P04083	C		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083 UniProtKB:P19619	F		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	F		Seeded From UniProt	complete
contributes_to	GO:0003727	single-stranded RNA binding	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	F		Seeded From UniProt	complete
contributes_to	GO:0003697	single-stranded DNA binding	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	F		Seeded From UniProt	complete
involved_in	GO:0002685	regulation of leukocyte migration	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0002548	monocyte chemotaxis	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098641	P		Seeded From UniProt	complete
enables	GO:1990814	DNA/DNA annealing activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	F		Seeded From UniProt	complete
involved_in	GO:1900138	negative regulation of phospholipase A2 activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	C		Seeded From UniProt	complete
involved_in	GO:0071385	cellular response to glucocorticoid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0070459	prolactin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0070365	hepatocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0050709	negative regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	F		Seeded From UniProt	complete
part_of	GO:0042629	mast cell granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	C		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0042063	gliogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
enables	GO:0033676	double-stranded DNA-dependent ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	C		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	C		Seeded From UniProt	complete
involved_in	GO:0031960	response to corticosteroid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0031394	positive regulation of prostaglandin biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
enables	GO:0019834	phospholipase A2 inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	F		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0010165	response to X-ray	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	C		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	F		Seeded From UniProt	complete
enables	GO:0003727	single-stranded RNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	F		Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	F		Seeded From UniProt	complete
involved_in	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	P		Seeded From UniProt	complete
involved_in	GO:0071385	cellular response to glucocorticoid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	P		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	P		Seeded From UniProt	complete
involved_in	GO:0050482	arachidonic acid secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	P		Seeded From UniProt	complete
involved_in	GO:0046632	alpha-beta T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	P		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	C		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	P		Seeded From UniProt	complete
involved_in	GO:0033031	positive regulation of neutrophil apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	P		Seeded From UniProt	complete
involved_in	GO:0032652	regulation of interleukin-1 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	P		Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	C		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	C		Seeded From UniProt	complete
involved_in	GO:0014839	myoblast migration involved in skeletal muscle regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	P		Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	C		Seeded From UniProt	complete
involved_in	GO:0002685	regulation of leukocyte migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	P		Seeded From UniProt	complete
involved_in	GO:0001780	neutrophil homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10107 ensembl:ENSMUSP00000025561	P		Seeded From UniProt	complete
enables	GO:0004859	phospholipase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002388	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001464 InterPro:IPR002388 InterPro:IPR018252 InterPro:IPR018502 InterPro:IPR037104	F		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001464 InterPro:IPR002388 InterPro:IPR018252 InterPro:IPR018502 InterPro:IPR037104	F		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:10882119^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:10882119^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:2967291^[30]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:2967291^[30]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:10882119^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:16130169^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:16130169^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16130169^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-749452 Reactome:R-HSA-749448 Reactome:R-HSA-6785895 Reactome:R-HSA-444476 Reactome:R-HSA-391913 Reactome:R-HSA-380073 Reactome:R-HSA-379048	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0019834	phospholipase A2 inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0593	F		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0111	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0466	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0026	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0153	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0112	C		Seeded From UniProt	complete
part_of	GO:0001891	phagocytic cup	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0473	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kang, JH et al. (2011) Proteomics analysis of starved cells revealed Annexin A1 as an important regulator of autophagic degradation. Biochem. Biophys. Res. Commun. 407 581-6 PubMed GONUTS page
↑ Tcatchoff, L et al. (2012) Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin. PLoS ONE 7 e40429 PubMed GONUTS page
↑ Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page
↑ Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
↑ ^5.0 ^5.1 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Pin, AL et al. (2012) Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression. J. Biol. Chem. 287 30541-51 PubMed GONUTS page
↑ ^7.0 ^7.1 Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 D'Acquisto, F et al. (2007) Annexin-1 modulates T-cell activation and differentiation. Blood 109 1095-102 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 McArthur, S et al. (2009) Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization. FASEB J. 23 4000-10 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Leoni, G et al. (2015) Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J. Clin. Invest. 125 1215-27 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Ernst, S et al. (2004) An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family. J. Immunol. 172 7669-76 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Kesimer, M et al. (2009) Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. FASEB J. 23 1858-68 PubMed GONUTS page
↑ Pons, V et al. (2008) Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biol. 6 e214 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Iwasa, T et al. (2012) Suppression of MIP-2 or IL-8 production by annexins A1 and A4 during coculturing of macrophages with late apoptotic human peripheral blood neutrophils. Biochim. Biophys. Acta 1822 204-11 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page
↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
↑ Ling, TY et al. (2004) Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1. J. Biol. Chem. 279 38736-48 PubMed GONUTS page
↑ ^22.0 ^22.1 Dalli, J et al. (2012) Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow. FASEB J. 26 387-96 PubMed GONUTS page
↑ ^23.0 ^23.1 Wallner, BP et al. () Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. Nature 320 77-81 PubMed GONUTS page
↑ Stamer, WD et al. (2011) Protein profile of exosomes from trabecular meshwork cells. J Proteomics 74 796-804 PubMed GONUTS page
↑ ^25.0 ^25.1 Blackwood, RA & Ernst, JD (1990) Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins. Biochem. J. 266 195-200 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Lee, CH et al. (2000) Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes. FEBS Lett. 477 268-72 PubMed GONUTS page
↑ Huang, KS et al. (1986) Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase. Cell 46 191-9 PubMed GONUTS page
↑ ^28.00 ^28.01 ^28.02 ^28.03 ^28.04 ^28.05 ^28.06 ^28.07 ^28.08 ^28.09 ^28.10 ^28.11 ^28.12 ^28.13 ^28.14 ^28.15 ^28.16 ^28.17 ^28.18 ^28.19 ^28.20 ^28.21 ^28.22 ^28.23 ^28.24 ^28.25 ^28.26 ^28.27 ^28.28 ^28.29 ^28.30 ^28.31 ^28.32 ^28.33 ^28.34 ^28.35 ^28.36 ^28.37 ^28.38 ^28.39 ^28.40 ^28.41 ^28.42 ^28.43 ^28.44 ^28.45 ^28.46 ^28.47 ^28.48 ^28.49 ^28.50 ^28.51 ^28.52 ^28.53 ^28.54 ^28.55 ^28.56 ^28.57 ^28.58 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Walther, A et al. (2000) A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol. Cell 5 831-40 PubMed GONUTS page
↑ ^30.0 ^30.1 Kaplan, R et al. (1988) Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein. J. Biol. Chem. 263 8037-43 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page

[PMID:21420379-1] Kang, JH et al. (2011) Proteomics analysis of starved cells revealed Annexin A1 as an important regulator of autophagic degradation. Biochem. Biophys. Res. Commun. 407 581-6 PubMed GONUTS page

[PMID:22792315-2] Tcatchoff, L et al. (2012) Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin. PLoS ONE 7 e40429 PubMed GONUTS page

[PMID:28344315-3] Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page

[PMID:28675934-4] Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page

[PMID:25037231-5] 5.0 ^5.1 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page

[PMID:22773844-6] 6.0 ^6.1 ^6.2 Pin, AL et al. (2012) Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression. J. Biol. Chem. 287 30541-51 PubMed GONUTS page

[PMID:25468996-7] 7.0 ^7.1 Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:17008549-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 D'Acquisto, F et al. (2007) Annexin-1 modulates T-cell activation and differentiation. Blood 109 1095-102 PubMed GONUTS page

[PMID:19625660-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 McArthur, S et al. (2009) Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization. FASEB J. 23 4000-10 PubMed GONUTS page

[PMID:25664854-10] 10.0 ^10.1 ^10.2 ^10.3 Leoni, G et al. (2015) Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J. Clin. Invest. 125 1215-27 PubMed GONUTS page

[PMID:15187149-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Ernst, S et al. (2004) An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family. J. Immunol. 172 7669-76 PubMed GONUTS page

[PMID:23533145-12] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19190083-13] Kesimer, M et al. (2009) Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. FASEB J. 23 1858-68 PubMed GONUTS page

[PMID:18767904-14] Pons, V et al. (2008) Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biol. 6 e214 PubMed GONUTS page

[PMID:21423176-15] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:22056994-16] 16.0 ^16.1 ^16.2 ^16.3 Iwasa, T et al. (2012) Suppression of MIP-2 or IL-8 production by annexins A1 and A4 during coculturing of macrophages with late apoptotic human peripheral blood neutrophils. Biochim. Biophys. Acta 1822 204-11 PubMed GONUTS page

[PMID:19199708-17] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:19056867-18] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:23580065-19] Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page

[PMID:22664934-20] Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page

[PMID:15226301-21] Ling, TY et al. (2004) Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1. J. Biol. Chem. 279 38736-48 PubMed GONUTS page

[PMID:21957127-22] 22.0 ^22.1 Dalli, J et al. (2012) Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow. FASEB J. 26 387-96 PubMed GONUTS page

[PMID:2936963-23] 23.0 ^23.1 Wallner, BP et al. () Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. Nature 320 77-81 PubMed GONUTS page

[PMID:21362503-24] Stamer, WD et al. (2011) Protein profile of exosomes from trabecular meshwork cells. J Proteomics 74 796-804 PubMed GONUTS page

[PMID:2138016-25] 25.0 ^25.1 Blackwood, RA & Ernst, JD (1990) Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins. Biochem. J. 266 195-200 PubMed GONUTS page

[PMID:10908733-26] 26.0 ^26.1 ^26.2 Lee, CH et al. (2000) Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes. FEBS Lett. 477 268-72 PubMed GONUTS page

[PMID:3013422-27] Huang, KS et al. (1986) Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase. Cell 46 191-9 PubMed GONUTS page

[PMID:21873635-28] 28.00 ^28.01 ^28.02 ^28.03 ^28.04 ^28.05 ^28.06 ^28.07 ^28.08 ^28.09 ^28.10 ^28.11 ^28.12 ^28.13 ^28.14 ^28.15 ^28.16 ^28.17 ^28.18 ^28.19 ^28.20 ^28.21 ^28.22 ^28.23 ^28.24 ^28.25 ^28.26 ^28.27 ^28.28 ^28.29 ^28.30 ^28.31 ^28.32 ^28.33 ^28.34 ^28.35 ^28.36 ^28.37 ^28.38 ^28.39 ^28.40 ^28.41 ^28.42 ^28.43 ^28.44 ^28.45 ^28.46 ^28.47 ^28.48 ^28.49 ^28.50 ^28.51 ^28.52 ^28.53 ^28.54 ^28.55 ^28.56 ^28.57 ^28.58 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10882119-29] 29.0 ^29.1 ^29.2 Walther, A et al. (2000) A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol. Cell 5 831-40 PubMed GONUTS page

[PMID:2967291-30] 30.0 ^30.1 Kaplan, R et al. (1988) Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein. J. Biol. Chem. 263 8037-43 PubMed GONUTS page

[PMID:16130169-31] 31.0 ^31.1 ^31.2 Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page

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HUMAN:ANXA1

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