EMENI:CREA

Species (Taxon ID)	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL194 / M139) (Aspergillus nidulans). (227321)
Gene Name(s)	creA
Protein Name(s)	DNA-binding protein creA Carbon catabolite repressor A
External Links
UniProt	Q01981
EMBL	AY219921 AACD01000105 BN001301
PIR	A41694
RefSeq	XP_663799.1
ProteinModelPortal	Q01981
STRING	162425.CADANIAP00006813
EnsemblFungi	[example_ID CADANIAT00006813]
GeneID	2870784
KEGG	ani:AN6195.2
eggNOG	COG5048
HOGENOM	HOG000164217
InParanoid	Q01981
KO	K09467
OMA	RIHSNPN
OrthoDB	EOG7K0ZMS
Proteomes	UP000000560
GO	GO:0005737 GO:0005634 GO:0046872 GO:0043565 GO:0003700 GO:0044212 GO:0071277 GO:0006338 GO:0048315 GO:0075308 GO:0045892 GO:0016584 GO:0009051 GO:0070798 GO:0070795 GO:0051094 GO:0033246 GO:0043941 GO:0010914 GO:1900854 GO:0043609 GO:0075306 GO:0006357 GO:0043935 GO:0009847 GO:0000909 GO:0006351
Gene3D	3.30.160.60
InterPro	IPR007087 IPR015880 IPR013087
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:18420433^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043609	regulation of carbon utilization	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002934191 UniProtKB:Q01981	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002934191 PomBase:SPBC1D7.02c SGD:S000003003 UniProtKB:Q01981	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002934191 PomBase:SPBC1D7.02c SGD:S000003003 UniProtKB:Q01981	C	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002934191 SGD:S000003003	F	Seeded From UniProt	complete
involved_in	GO:0000433	carbon catabolite repression of transcription from RNA polymerase II promoter by glucose	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002934191 PomBase:SPBC1D7.02c SGD:S000003003	P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:9829933^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:8753653^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:8483416^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:8143847^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:10079330^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043609	regulation of carbon utilization	PMID:15158274^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043609	regulation of carbon utilization	PMID:12920487^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016584	nucleosome positioning	PMID:14871945^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009051	pentose-phosphate shunt, oxidative branch	PMID:16000711^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:15813742^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23800192^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23800192^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18063396^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Tamayo, EN et al. (2008) CreA mediates repression of the regulatory gene xlnR which controls the production of xylanolytic enzymes in Aspergillus nidulans. Fungal Genet. Biol. 45 984-93 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Stemple, CJ et al. (1998) The facC gene of Aspergillus nidulans encodes an acetate-inducible carnitine acetyltransferase. J. Bacteriol. 180 6242-51 PubMed GONUTS page
↑ Reymond-Cotton, P et al. (1996) Expression of the Sclerotinia sclerotiorum polygalacturonase pg1 gene: possible involvement of CREA in glucose catabolite repression. Curr. Genet. 30 240-5 PubMed GONUTS page
↑ Kulmburg, P et al. (1993) Specific binding sites in the alcR and alcA promoters of the ethanol regulon for the CREA repressor mediating carbon catabolite repression in Aspergillus nidulans. Mol. Microbiol. 7 847-57 PubMed GONUTS page
↑ Espeso, EA & Peñalva, MA (1994) In vitro binding of the two-finger repressor CreA to several consensus and non-consensus sites at the ipnA upstream region is context dependent. FEBS Lett. 342 43-8 PubMed GONUTS page
↑ Dzikowska, A et al. (1999) Cloning, characterisation and regulation of the ornithine transaminase (otaA) gene of Aspergillus nidulans. Curr. Genet. 35 118-26 PubMed GONUTS page
↑ Ilyés, H et al. (2004) CreA-mediated carbon catabolite repression of beta-galactosidase formation in Aspergillus nidulans is growth rate dependent. FEMS Microbiol. Lett. 235 147-51 PubMed GONUTS page
↑ Prathumpai, W et al. (2004) The effect of CreA in glucose and xylose catabolism in Aspergillus nidulans. Appl. Microbiol. Biotechnol. 63 748-53 PubMed GONUTS page
↑ García, I et al. (2004) Chromatin rearrangements in the prnD-prnB bidirectional promoter: dependence on transcription factors. Eukaryotic Cell 3 144-56 PubMed GONUTS page
↑ David, H et al. (2005) CreA influences the metabolic fluxes of Aspergillus nidulans during growth on glucose and xylose. Microbiology (Reading, Engl.) 151 2209-21 PubMed GONUTS page
↑ Mathieu, M et al. (2005) Patterns of nucleosomal organization in the alc regulon of Aspergillus nidulans: roles of the AlcR transcriptional activator and the CreA global repressor. Mol. Microbiol. 56 535-48 PubMed GONUTS page
↑ ^13.0 ^13.1 Brown, NA et al. (2013) Functional characterisation of the non-essential protein kinases and phosphatases regulating Aspergillus nidulans hydrolytic enzyme production. Biotechnol Biofuels 6 91 PubMed GONUTS page
↑ Roy, P et al. (2008) CreA-mediated repression in Aspergillus nidulans does not require transcriptional auto-regulation, regulated intracellular localisation or degradation of CreA. Fungal Genet. Biol. 45 657-70 PubMed GONUTS page

[PMID:18420433-1] Tamayo, EN et al. (2008) CreA mediates repression of the regulatory gene xlnR which controls the production of xylanolytic enzymes in Aspergillus nidulans. Fungal Genet. Biol. 45 984-93 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9829933-3] Stemple, CJ et al. (1998) The facC gene of Aspergillus nidulans encodes an acetate-inducible carnitine acetyltransferase. J. Bacteriol. 180 6242-51 PubMed GONUTS page

[PMID:8753653-4] Reymond-Cotton, P et al. (1996) Expression of the Sclerotinia sclerotiorum polygalacturonase pg1 gene: possible involvement of CREA in glucose catabolite repression. Curr. Genet. 30 240-5 PubMed GONUTS page

[PMID:8483416-5] Kulmburg, P et al. (1993) Specific binding sites in the alcR and alcA promoters of the ethanol regulon for the CREA repressor mediating carbon catabolite repression in Aspergillus nidulans. Mol. Microbiol. 7 847-57 PubMed GONUTS page

[PMID:8143847-6] Espeso, EA & Peñalva, MA (1994) In vitro binding of the two-finger repressor CreA to several consensus and non-consensus sites at the ipnA upstream region is context dependent. FEBS Lett. 342 43-8 PubMed GONUTS page

[PMID:10079330-7] Dzikowska, A et al. (1999) Cloning, characterisation and regulation of the ornithine transaminase (otaA) gene of Aspergillus nidulans. Curr. Genet. 35 118-26 PubMed GONUTS page

[PMID:15158274-8] Ilyés, H et al. (2004) CreA-mediated carbon catabolite repression of beta-galactosidase formation in Aspergillus nidulans is growth rate dependent. FEMS Microbiol. Lett. 235 147-51 PubMed GONUTS page

[PMID:12920487-9] Prathumpai, W et al. (2004) The effect of CreA in glucose and xylose catabolism in Aspergillus nidulans. Appl. Microbiol. Biotechnol. 63 748-53 PubMed GONUTS page

[PMID:14871945-10] García, I et al. (2004) Chromatin rearrangements in the prnD-prnB bidirectional promoter: dependence on transcription factors. Eukaryotic Cell 3 144-56 PubMed GONUTS page

[PMID:16000711-11] David, H et al. (2005) CreA influences the metabolic fluxes of Aspergillus nidulans during growth on glucose and xylose. Microbiology (Reading, Engl.) 151 2209-21 PubMed GONUTS page

[PMID:15813742-12] Mathieu, M et al. (2005) Patterns of nucleosomal organization in the alc regulon of Aspergillus nidulans: roles of the AlcR transcriptional activator and the CreA global repressor. Mol. Microbiol. 56 535-48 PubMed GONUTS page

[PMID:23800192-13] 13.0 ^13.1 Brown, NA et al. (2013) Functional characterisation of the non-essential protein kinases and phosphatases regulating Aspergillus nidulans hydrolytic enzyme production. Biotechnol Biofuels 6 91 PubMed GONUTS page

[PMID:18063396-14] Roy, P et al. (2008) CreA-mediated repression in Aspergillus nidulans does not require transcriptional auto-regulation, regulated intracellular localisation or degradation of CreA. Fungal Genet. Biol. 45 657-70 PubMed GONUTS page

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EMENI:CREA

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