DROME:RB27C

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Hrb27C (synonyms: hrp48, Rbp7)
Protein Name(s)	Heterogeneous nuclear ribonucleoprotein 27C Hrb27-C HRP48.1 hnRNP 48
External Links
UniProt	P48809
EMBL	X62639 DQ062784 AE014134 AE014134 AE014134 AY069699 AY128430 S51720
PIR	D41732
RefSeq	NP_001162897.1 NP_001162898.1 NP_001245917.1 NP_001245918.1 NP_001245919.1 NP_476869.1 NP_723228.1 NP_723229.1
UniGene	Dm.1997
ProteinModelPortal	P48809
SMR	P48809
BioGrid	60119
IntAct	P48809
STRING	7227.FBpp0297875
iPTMnet	P48809
PaxDb	P48809
PRIDE	P48809
EnsemblMetazoa	FBtr0079346 FBtr0079347 FBtr0079348 FBtr0301403 FBtr0301404 FBtr0307030 FBtr0307031 FBtr0307032
GeneID	33968
KEGG	dme:Dmel_CG10377
UCSC	CG10377-RB
CTD	33968
FlyBase	FBgn0004838
eggNOG	KOG4205 ENOG410YA8Z
GeneTree	ENSGT00900000140835
InParanoid	P48809
KO	K14411
OMA	ALENGPH
OrthoDB	EOG091G1CPI
PhylomeDB	P48809
ChiTaRS	Hrb27C
GenomeRNAi	33968
PRO	PR:P48809
Proteomes	UP000000803
Bgee	FBgn0004838
ExpressionAtlas	P48809
Genevisible	P48809
GO	GO:0005737 GO:0030529 GO:0005654 GO:0005634 GO:0043186 GO:0043234 GO:0003730 GO:0048027 GO:0003729 GO:0003697 GO:0007411 GO:0007298 GO:0007319 GO:0045451 GO:0045727 GO:0048024
CDD	cd12574 cd12327
Gene3D	3.30.70.330
InterPro	IPR034134 IPR034131 IPR012677 IPR035979 IPR000504
Pfam	PF00076
SMART	SM00360
SUPFAM	SSF54928
PROSITE	PS50102

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0030371	translation repressor activity	PMID:29635389^[1]	ECO:0000315			F	They depleted Hrp48 from SL2 cells and tested the ability of exogenous SXL to inhibit the translation of a reporter containing full-length msl-2 5′ and 3′ UTRs (Figure 3A). Depletion of Hrp48 indeed reduced the capacity of SXL to inhibit translation of the reporter (Figure 3B). The results of this paper support a model where a repressor complex composed of SXL, UNR and Hrp48 assembles at the 3′ UTR of msl-2 mRNA; Hrp48 then contributes to inhibit ribosome recruitment by targeting eIF3d.(Figure 8)	complete CACAO 13242
part_of	GO:1990904	ribonucleoprotein complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001215 FB:FBgn0004237 FB:FBgn0004838 MGI:MGI:1916394 PANTHER:PTN002689974 UniProtKB:P09651 UniProtKB:P19338 UniProtKB:P22626 UniProtKB:Q14103 UniProtKB:Q96EP5 UniProtKB:Q99729	C	Seeded From UniProt	complete
involved_in	GO:0048026	positive regulation of mRNA splicing, via spliceosome	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1917498 PANTHER:PTN002689981	P	Seeded From UniProt	complete
enables	GO:0034046	poly(G) binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002689981 UniProtKB:Q96EP5	F	Seeded From UniProt	complete
enables	GO:0008266	poly(U) RNA binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002689981 UniProtKB:Q96EP5	F	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1917498 PANTHER:PTN001924359	P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004838 PANTHER:PTN002689978 UniProtKB:O14979 UniProtKB:Q14103 UniProtKB:Q96EP5 UniProtKB:Q99729	C	Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004838 PANTHER:PTN002689981	F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104819 MGI:MGI:1330294 MGI:MGI:893588 MGI:MGI:97286 PANTHER:PTN002689974 RGD:1306751 RGD:1310403 RGD:1310906 RGD:3153 RGD:69234 SGD:S000003391 SGD:S000005483 TAIR:locus:2019622 TAIR:locus:2076096 TAIR:locus:2079874 TAIR:locus:2083810 TAIR:locus:2122009 TAIR:locus:2159401 TAIR:locus:2179939 UniProtKB:P19338 UniProtKB:P22626 UniProtKB:P38159 UniProtKB:P62995 UniProtKB:Q03250 UniProtKB:Q13148 UniProtKB:Q14103 UniProtKB:Q9SVM8	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24292889^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24292889^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:18516287^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043186	P granule	PMID:18590813^[5]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0003891	C	Seeded From UniProt	complete
part_of	GO:0043186	P granule	PMID:18590813^[5]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0283442	C	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:19013444^[6]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0259139	C	Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	PMID:17890223^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	PMID:17890223^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	PMID:17890223^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1903688	positive regulation of border follicle cell migration	PMID:17483425^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048024	regulation of mRNA splicing, via spliceosome	PMID:15937219^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045451	pole plasm oskar mRNA localization	PMID:15130488^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0048027	mRNA 5'-UTR binding	PMID:11131516^[11]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:10908586^[12]	ECO:0000250	sequence similarity evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
part_of	GO:0005737	cytoplasm	PMID:7867926^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	PMID:1730753^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
NOT\|part_of	GO:0005730	nucleolus	PMID:1730753^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	PMID:1730753^[14]	ECO:0000250	sequence similarity evidence used in manual assertion	HGNC:5031	C	Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	PMID:1730753^[14]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0263396	C	Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	PMID:1730753^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:1730753^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000504 InterPro:IPR035979	F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034131 InterPro:IPR034134	F	Seeded From UniProt	complete
involved_in	GO:0007319	negative regulation of oskar mRNA translation	PMID:11700288^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	PMID:11700288^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0048027	mRNA 5'-UTR binding	PMID:11700288^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Szostak, E et al. (2018) Hrp48 and eIF3d contribute to msl-2 mRNA translational repression. Nucleic Acids Res. PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Lee, SY et al. (2014) Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10. Cell. Mol. Life Sci. 71 2747-58 PubMed GONUTS page
↑ Berger, J et al. (2008) Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. PLoS Genet. 4 e1000085 PubMed GONUTS page
↑ ^5.0 ^5.1 Thomson, T et al. () Isolation of new polar granule components in Drosophila reveals P body and ER associated proteins. Mech. Dev. 125 865-73 PubMed GONUTS page
↑ Kalifa, Y et al. (2009) Glorund interactions in the regulation of gurken and oskar mRNAs. Dev. Biol. 326 68-74 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Nelson, MR et al. (2007) A multiprotein complex that mediates translational enhancement in Drosophila. J. Biol. Chem. 282 34031-8 PubMed GONUTS page
↑ Mathieu, J et al. (2007) A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila. Genetics 176 1579-90 PubMed GONUTS page
↑ Blanchette, M et al. (2005) Global analysis of positive and negative pre-mRNA splicing regulators in Drosophila. Genes Dev. 19 1306-14 PubMed GONUTS page
↑ Huynh, JR et al. (2004) The Drosophila hnRNPA/B homolog, Hrp48, is specifically required for a distinct step in osk mRNA localization. Dev. Cell 6 625-35 PubMed GONUTS page
↑ Mahowald, AP (2001) Assembly of the Drosophila germ plasm. Int. Rev. Cytol. 203 187-213 PubMed GONUTS page
↑ Lasko, P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J. Cell Biol. 150 F51-6 PubMed GONUTS page
↑ Siebel, CW et al. (1995) Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing. Genes Dev. 9 269-83 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Matunis, MJ et al. (1992) Isolation of hnRNP complexes from Drosophila melanogaster. J. Cell Biol. 116 245-55 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Johnstone, O & Lasko, P (2001) Translational regulation and RNA localization in Drosophila oocytes and embryos. Annu. Rev. Genet. 35 365-406 PubMed GONUTS page

[PMID:29635389-1] Szostak, E et al. (2018) Hrp48 and eIF3d contribute to msl-2 mRNA translational repression. Nucleic Acids Res. PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24292889-3] 3.0 ^3.1 Lee, SY et al. (2014) Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10. Cell. Mol. Life Sci. 71 2747-58 PubMed GONUTS page

[PMID:18516287-4] Berger, J et al. (2008) Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. PLoS Genet. 4 e1000085 PubMed GONUTS page

[PMID:18590813-5] 5.0 ^5.1 Thomson, T et al. () Isolation of new polar granule components in Drosophila reveals P body and ER associated proteins. Mech. Dev. 125 865-73 PubMed GONUTS page

[PMID:19013444-6] Kalifa, Y et al. (2009) Glorund interactions in the regulation of gurken and oskar mRNAs. Dev. Biol. 326 68-74 PubMed GONUTS page

[PMID:17890223-7] 7.0 ^7.1 ^7.2 Nelson, MR et al. (2007) A multiprotein complex that mediates translational enhancement in Drosophila. J. Biol. Chem. 282 34031-8 PubMed GONUTS page

[PMID:17483425-8] Mathieu, J et al. (2007) A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila. Genetics 176 1579-90 PubMed GONUTS page

[PMID:15937219-9] Blanchette, M et al. (2005) Global analysis of positive and negative pre-mRNA splicing regulators in Drosophila. Genes Dev. 19 1306-14 PubMed GONUTS page

[PMID:15130488-10] Huynh, JR et al. (2004) The Drosophila hnRNPA/B homolog, Hrp48, is specifically required for a distinct step in osk mRNA localization. Dev. Cell 6 625-35 PubMed GONUTS page

[PMID:11131516-11] Mahowald, AP (2001) Assembly of the Drosophila germ plasm. Int. Rev. Cytol. 203 187-213 PubMed GONUTS page

[PMID:10908586-12] Lasko, P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J. Cell Biol. 150 F51-6 PubMed GONUTS page

[PMID:7867926-13] Siebel, CW et al. (1995) Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing. Genes Dev. 9 269-83 PubMed GONUTS page

[PMID:1730753-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Matunis, MJ et al. (1992) Isolation of hnRNP complexes from Drosophila melanogaster. J. Cell Biol. 116 245-55 PubMed GONUTS page

[PMID:11700288-15] 15.0 ^15.1 ^15.2 Johnstone, O & Lasko, P (2001) Translational regulation and RNA localization in Drosophila oocytes and embryos. Annu. Rev. Genet. 35 365-406 PubMed GONUTS page

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DROME:RB27C

Contents

Annotations

Notes

References

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