DROME:PER

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	per
Protein Name(s)	Period circadian protein Protein clock-6 CLK-6
External Links
UniProt	P07663
EMBL	M30114 M30114 M30114 AF033029 X03636 AE014298 AL024485 AL024485 AL024485 AL024485 AY575847 L07817 L07818 L07819 L07821 L07823 L07825 AB029194 AB029195 AB029196 AB029222 AB029223 AB029224 AB029250 AB029251 AB029252 D00009 AF251241 AY047980 AY047981 AY047982 AY047983 AY047984 AY047985 AY047986 AY047987 AY047988 AY047989 AY047990 AY047991 AY047992 AY047993 AY047994 AY047995 AY047996 AY047997 AY047998 AY047999 AY048000 AY048001 AY048002 AY048003 AY048004 AY048005 AY048006 AY048007 AY048008 AY048009 AY048010 AY048011 AY048012 AY048013 AY048014 AY048015 AY048016 AY048017 AY048018 AY048019 AY048020 AY048021 AY048022 AY048023 AY048024 AY048025 AY048026 AY048027 AY048028 AY048029 AY048030 AY048031 AY048032 AY048033 AY048034 AY048035 AY048036 AY048037 AY048038 AY048040 AY048041 AY048042
PIR	A23932 A26427 A26588 B26427 C26427 S52943
RefSeq	NP_001259194.1 NP_525056.2
UniGene	Dm.65
PDB	1WA9 3GEC 3RTY
PDBsum	1WA9 3GEC 3RTY
ProteinModelPortal	P07663
SMR	P07663
BioGrid	57782
DIP	DIP-29426N
MINT	MINT-1327740
PaxDb	P07663
GeneID	31251
KEGG	dme:Dmel_CG2647
CTD	31251
FlyBase	FBgn0003068
eggNOG	NOG253593
InParanoid	P07663
KO	K02633
OrthoDB	EOG7TMZRC
Reactome	REACT_180268 REACT_239233
EvolutionaryTrace	P07663
GenomeRNAi	31251
NextBio	772671
Proteomes	UP000000803
Bgee	P07663
ExpressionAtlas	P07663
GO	GO:0005737 GO:0005634 GO:0048471 GO:0046982 GO:0042803 GO:0004871 GO:0003712 GO:0003714 GO:0008134 GO:0001306 GO:0048148 GO:0048512 GO:0007623 GO:0042745 GO:0060086 GO:0007620 GO:0007619 GO:0008340 GO:0008062 GO:0009649 GO:0043153 GO:0045475 GO:0007616 GO:0045433 GO:0007617 GO:0000122 GO:2000678 GO:0045892 GO:0042752 GO:0045187 GO:0009416 GO:0006979 GO:0009266 GO:0007622
InterPro	IPR001610 IPR000014 IPR013767
Pfam	PF00989
SMART	SM00086 SM00091
SUPFAM	SSF55785
PROSITE	PS50112

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0048512	circadian behavior	PMID:8134384^[1]	ECO:0000315			P	Figure 3	complete CACAO 3475
involved_in	GO:0048512	circadian behavior	PMID:8134384^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043153	entrainment of circadian clock by photoperiod	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003068 MGI:MGI:1098283 PANTHER:PTN000138364 ZFIN:ZDB-GENE-011220-2	P	Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003068 MGI:MGI:1098283 MGI:MGI:1195265 PANTHER:PTN000138364 UniProtKB:O15534 ZFIN:ZDB-GENE-000804-1	P	Seeded From UniProt	complete
involved_in	GO:0009416	response to light stimulus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1098283 PANTHER:PTN000138364 ZFIN:ZDB-GENE-011220-2 ZFIN:ZDB-GENE-040419-1	P	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003068 MGI:MGI:1098283 MGI:MGI:1195265 PANTHER:PTN000138364	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003068 MGI:MGI:1195265 PANTHER:PTN000138364 UniProtKB:O15534 UniProtKB:P56645	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003068 MGI:MGI:1098283 MGI:MGI:1195265 PANTHER:PTN000138364 RGD:61945 RGD:727863 UniProtKB:O15055 UniProtKB:P56645	C	Seeded From UniProt	complete
enables	GO:0001222	transcription corepressor binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1195265 PANTHER:PTN000138364	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1098283 MGI:MGI:1195265 PANTHER:PTN000138364	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003068 MGI:MGI:1098283 MGI:MGI:1195265 MGI:MGI:1277134 PANTHER:PTN000138364 RGD:61945 UniProtKB:P56645	P	Seeded From UniProt	complete
involved_in	GO:1904059	regulation of locomotor rhythm	PMID:24086144^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	PMID:24086144^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060086	circadian temperature homeostasis	PMID:22981774^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	PMID:22323813^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001306	age-dependent response to oxidative stress	PMID:20157575^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:20157575^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19223210^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:19402744^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19402744^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19402744^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	PMID:19402744^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	PMID:19402744^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:19402744^[8]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0003068	F	Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	PMID:19139270^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:18666831^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:18627767^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	PMID:18044989^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17578908^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17369364^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17369364^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17578907^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:17452449^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	PMID:17452449^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	PMID:17452449^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043153	entrainment of circadian clock by photoperiod	PMID:16361445^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:16319317^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16410523^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16410523^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15930393^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009649	entrainment of circadian clock	PMID:16085487^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:11178250^[22]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	PMID:15522971^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15356209^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15356209^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007620	copulation	PMID:15324667^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12944510^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12944510^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:12944510^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:12417656^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12015613^[28]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	PMID:12015613^[28]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12015613^[28]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:12015613^[28]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045187	regulation of circadian sleep/wake cycle, sleep	PMID:12015603^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007619	courtship behavior	PMID:11715043^[30]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048148	behavioral response to cocaine	PMID:11715043^[30]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:11715043^[30]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008062	eclosion rhythm	PMID:11715043^[30]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	PMID:11715043^[30]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	PMID:11715043^[30]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007617	mating behavior	PMID:11470898^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008062	eclosion rhythm	PMID:11264660^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	PMID:11264660^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045433	male courtship behavior, veined wing generated song production	PMID:11092827^[33]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:11092827^[33]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048512	circadian behavior	PMID:10677013^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:10409723^[35]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0023076	F	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:10409723^[35]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0023076	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10409723^[35]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000678	negative regulation of transcription regulatory region DNA binding	PMID:10409723^[35]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045187	regulation of circadian sleep/wake cycle, sleep	PMID:25325457^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:27489346^[37]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:29174887^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0044297	cell body	PMID:26082158^[39]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26082158^[39]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013767	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19402751^[40]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P07663-1	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19402744^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P07663-1	F	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	Reactome:R-DME-432626 PMID:11178250^[22] PMID:15312644^[41] PMID:12154068^[42]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-DME-538835 Reactome:R-DME-538832 Reactome:R-DME-538824 Reactome:R-DME-538822 Reactome:R-DME-432647 Reactome:R-DME-432590 Reactome:R-DME-432559 Reactome:R-DME-432556 Reactome:R-DME-432544 Reactome:R-DME-432535 Reactome:R-DME-432464 Reactome:R-DME-432411 Reactome:R-DME-432361	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-DME-538904 Reactome:R-DME-538900 Reactome:R-DME-538891 Reactome:R-DME-432544 Reactome:R-DME-432527 Reactome:R-DME-432513 Reactome:R-DME-432483 Reactome:R-DME-432455 Reactome:R-DME-432371	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:11178250^[22] PMID:12486701^[43]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:15312644^[41]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045433	male courtship behavior, veined wing generated song production	PMID:12486700^[44]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12626480^[45] PMID:12486701^[43]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12626480^[45]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009266	response to temperature stimulus	PMID:12626480^[45]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008062	eclosion rhythm	PMID:12626480^[45] PMID:12486701^[43] PMID:12111533^[46] PMID:12015613^[28]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009416	response to light stimulus	PMID:12626480^[45]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	PMID:12626480^[45]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:12486701^[43]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007622	rhythmic behavior	PMID:12486701^[43]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042745	circadian sleep/wake cycle	PMID:12111533^[46]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Edery, I et al. (1994) Temporal phosphorylation of the Drosophila period protein. Proc. Natl. Acad. Sci. U.S.A. 91 2260-4 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Garbe, DS et al. (2013) Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila. PLoS Genet. 9 e1003749 PubMed GONUTS page
↑ Kaneko, H et al. (2012) Circadian rhythm of temperature preference and its neural control in Drosophila. Curr. Biol. 22 1851-7 PubMed GONUTS page
↑ Chen, CC et al. (2012) Visualizing long-term memory formation in two neurons of the Drosophila brain. Science 335 678-85 PubMed GONUTS page
↑ ^6.0 ^6.1 Krishnan, N et al. (2009) The circadian clock gene period extends healthspan in aging Drosophila melanogaster. Aging (Albany NY) 1 937-48 PubMed GONUTS page
↑ Kotwica, J et al. (2009) Developmental profiles of PERIOD and DOUBLETIME in Drosophila melanogaster ovary. J. Insect Physiol. 55 419-25 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Landskron, J et al. (2009) A role for the PERIOD:PERIOD homodimer in the Drosophila circadian clock. PLoS Biol. 7 e3 PubMed GONUTS page
↑ Yu, W et al. (2009) DOUBLETIME plays a noncatalytic role to mediate CLOCK phosphorylation and repress CLOCK-dependent transcription within the Drosophila circadian clock. Mol. Cell. Biol. 29 1452-8 PubMed GONUTS page
↑ Kivimäe, S et al. (2008) Activating PER repressor through a DBT-directed phosphorylation switch. PLoS Biol. 6 e183 PubMed GONUTS page
↑ Krishnan, N et al. (2008) Circadian regulation of response to oxidative stress in Drosophila melanogaster. Biochem. Biophys. Res. Commun. 374 299-303 PubMed GONUTS page
↑ Picot, M et al. (2007) Light activates output from evening neurons and inhibits output from morning neurons in the Drosophila circadian clock. PLoS Biol. 5 e315 PubMed GONUTS page
↑ Matsumoto, A et al. (2007) A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock. Genes Dev. 21 1687-700 PubMed GONUTS page
↑ ^14.0 ^14.1 Fernández, MP et al. (2007) Impaired clock output by altered connectivity in the circadian network. Proc. Natl. Acad. Sci. U.S.A. 104 5650-5 PubMed GONUTS page
↑ Kadener, S et al. (2007) Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component. Genes Dev. 21 1675-86 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Kim, EY et al. (2007) A DOUBLETIME kinase binding domain on the Drosophila PERIOD protein is essential for its hyperphosphorylation, transcriptional repression, and circadian clock function. Mol. Cell. Biol. 27 5014-28 PubMed GONUTS page
↑ Collins, BH et al. (2005) Disruption of Cryptochrome partially restores circadian rhythmicity to the arrhythmic period mutant of Drosophila. Proc. Natl. Acad. Sci. U.S.A. 102 19021-6 PubMed GONUTS page
↑ Lin, JM et al. (2005) In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD. J. Neurosci. 25 11175-83 PubMed GONUTS page
↑ ^19.0 ^19.1 Meyer, P et al. (2006) PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock. Science 311 226-9 PubMed GONUTS page
↑ Cyran, SA et al. (2005) The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period. J. Neurosci. 25 5430-7 PubMed GONUTS page
↑ Glaser, FT & Stanewsky, R (2005) Temperature synchronization of the Drosophila circadian clock. Curr. Biol. 15 1352-63 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Hardin, PE (2000) From biological clock to biological rhythms. Genome Biol. 1 REVIEWS1023 PubMed GONUTS page
↑ Sakai, T et al. (2004) A clock gene, period, plays a key role in long-term memory formation in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 101 16058-63 PubMed GONUTS page
↑ ^24.0 ^24.1 Lin, Y et al. (2004) The neuropeptide pigment-dispersing factor coordinates pacemaker interactions in the Drosophila circadian system. J. Neurosci. 24 7951-7 PubMed GONUTS page
↑ Beaver, LM & Giebultowicz, JM (2004) Regulation of copulation duration by period and timeless in Drosophila melanogaster. Curr. Biol. 14 1492-7 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Ashmore, LJ et al. (2003) Novel insights into the regulation of the timeless protein. J. Neurosci. 23 7810-9 PubMed GONUTS page
↑ Ceriani, MF et al. (2002) Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. J. Neurosci. 22 9305-19 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 ^28.4 Panda, S et al. (2002) Circadian rhythms from flies to human. Nature 417 329-35 PubMed GONUTS page
↑ Shaw, PJ et al. (2002) Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature 417 287-91 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 ^30.3 ^30.4 ^30.5 Sokolowski, MB (2001) Drosophila: genetics meets behaviour. Nat. Rev. Genet. 2 879-90 PubMed GONUTS page
↑ Sakai, T & Ishida, N (2001) Circadian rhythms of female mating activity governed by clock genes in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 98 9221-5 PubMed GONUTS page
↑ ^32.0 ^32.1 Blanchardon, E et al. (2001) Defining the role of Drosophila lateral neurons in the control of circadian rhythms in motor activity and eclosion by targeted genetic ablation and PERIOD protein overexpression. Eur. J. Neurosci. 13 871-88 PubMed GONUTS page
↑ ^33.0 ^33.1 Greenspan, RJ & Ferveur, JF (2000) Courtship in Drosophila. Annu. Rev. Genet. 34 205-232 PubMed GONUTS page
↑ Kaneko, M et al. (2000) Involvement of the period gene in developmental time-memory: effect of the perShort mutation on phase shifts induced by light pulses delivered to Drosophila larvae. J. Biol. Rhythms 15 13-30 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 ^35.3 Lee, C et al. (1999) PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription. Mol. Cell. Biol. 19 5316-25 PubMed GONUTS page
↑ Cao, W & Edery, I (2015) A novel pathway for sensory-mediated arousal involves splicing of an intron in the period clock gene. Sleep 38 41-51 PubMed GONUTS page
↑ Lee, E et al. (2016) Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation. Proc. Natl. Acad. Sci. U.S.A. 113 E4904-13 PubMed GONUTS page
↑ Li, Q et al. (2017) Fbxl4 Serves as a Clock Output Molecule that Regulates Sleep through Promotion of Rhythmic Degradation of the GABA Receptor. Curr. Biol. 27 3616-3625.e5 PubMed GONUTS page
↑ ^39.0 ^39.1 Venkatesan, A et al. (2015) A Doubletime Nuclear Localization Signal Mediates an Interaction with Bride of Doubletime to Promote Circadian Function. J. Biol. Rhythms 30 302-17 PubMed GONUTS page
↑ Hennig, S et al. (2009) Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2. PLoS Biol. 7 e94 PubMed GONUTS page
↑ ^41.0 ^41.1 Emery, P & Reppert, SM (2004) A rhythmic Ror. Neuron 43 443-6 PubMed GONUTS page
↑ Glossop, NR & Hardin, PE (2002) Central and peripheral circadian oscillator mechanisms in flies and mammals. J. Cell. Sci. 115 3369-77 PubMed GONUTS page
↑ ^43.0 ^43.1 ^43.2 ^43.3 ^43.4 Stanewsky, R (2003) Genetic analysis of the circadian system in Drosophila melanogaster and mammals. J. Neurobiol. 54 111-47 PubMed GONUTS page
↑ Emmons, SW & Lipton, J (2003) Genetic basis of male sexual behavior. J. Neurobiol. 54 93-110 PubMed GONUTS page
↑ ^45.0 ^45.1 ^45.2 ^45.3 ^45.4 ^45.5 Hendricks, JC (2003) Invited review: Sleeping flies don't lie: the use of Drosophila melanogaster to study sleep and circadian rhythms. J. Appl. Physiol. 94 1660-72; discussion 1673 PubMed GONUTS page
↑ ^46.0 ^46.1 Stanewsky, R (2002) Clock mechanisms in Drosophila. Cell Tissue Res. 309 11-26 PubMed GONUTS page

[PMID:8134384-1] 1.0 ^1.1 Edery, I et al. (1994) Temporal phosphorylation of the Drosophila period protein. Proc. Natl. Acad. Sci. U.S.A. 91 2260-4 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24086144-3] 3.0 ^3.1 Garbe, DS et al. (2013) Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila. PLoS Genet. 9 e1003749 PubMed GONUTS page

[PMID:22981774-4] Kaneko, H et al. (2012) Circadian rhythm of temperature preference and its neural control in Drosophila. Curr. Biol. 22 1851-7 PubMed GONUTS page

[PMID:22323813-5] Chen, CC et al. (2012) Visualizing long-term memory formation in two neurons of the Drosophila brain. Science 335 678-85 PubMed GONUTS page

[PMID:20157575-6] 6.0 ^6.1 Krishnan, N et al. (2009) The circadian clock gene period extends healthspan in aging Drosophila melanogaster. Aging (Albany NY) 1 937-48 PubMed GONUTS page

[PMID:19223210-7] Kotwica, J et al. (2009) Developmental profiles of PERIOD and DOUBLETIME in Drosophila melanogaster ovary. J. Insect Physiol. 55 419-25 PubMed GONUTS page

[PMID:19402744-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Landskron, J et al. (2009) A role for the PERIOD:PERIOD homodimer in the Drosophila circadian clock. PLoS Biol. 7 e3 PubMed GONUTS page

[PMID:19139270-9] Yu, W et al. (2009) DOUBLETIME plays a noncatalytic role to mediate CLOCK phosphorylation and repress CLOCK-dependent transcription within the Drosophila circadian clock. Mol. Cell. Biol. 29 1452-8 PubMed GONUTS page

[PMID:18666831-10] Kivimäe, S et al. (2008) Activating PER repressor through a DBT-directed phosphorylation switch. PLoS Biol. 6 e183 PubMed GONUTS page

[PMID:18627767-11] Krishnan, N et al. (2008) Circadian regulation of response to oxidative stress in Drosophila melanogaster. Biochem. Biophys. Res. Commun. 374 299-303 PubMed GONUTS page

[PMID:18044989-12] Picot, M et al. (2007) Light activates output from evening neurons and inhibits output from morning neurons in the Drosophila circadian clock. PLoS Biol. 5 e315 PubMed GONUTS page

[PMID:17578908-13] Matsumoto, A et al. (2007) A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock. Genes Dev. 21 1687-700 PubMed GONUTS page

[PMID:17369364-14] 14.0 ^14.1 Fernández, MP et al. (2007) Impaired clock output by altered connectivity in the circadian network. Proc. Natl. Acad. Sci. U.S.A. 104 5650-5 PubMed GONUTS page

[PMID:17578907-15] Kadener, S et al. (2007) Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component. Genes Dev. 21 1675-86 PubMed GONUTS page

[PMID:17452449-16] 16.0 ^16.1 ^16.2 Kim, EY et al. (2007) A DOUBLETIME kinase binding domain on the Drosophila PERIOD protein is essential for its hyperphosphorylation, transcriptional repression, and circadian clock function. Mol. Cell. Biol. 27 5014-28 PubMed GONUTS page

[PMID:16361445-17] Collins, BH et al. (2005) Disruption of Cryptochrome partially restores circadian rhythmicity to the arrhythmic period mutant of Drosophila. Proc. Natl. Acad. Sci. U.S.A. 102 19021-6 PubMed GONUTS page

[PMID:16319317-18] Lin, JM et al. (2005) In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD. J. Neurosci. 25 11175-83 PubMed GONUTS page

[PMID:16410523-19] 19.0 ^19.1 Meyer, P et al. (2006) PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock. Science 311 226-9 PubMed GONUTS page

[PMID:15930393-20] Cyran, SA et al. (2005) The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period. J. Neurosci. 25 5430-7 PubMed GONUTS page

[PMID:16085487-21] Glaser, FT & Stanewsky, R (2005) Temperature synchronization of the Drosophila circadian clock. Curr. Biol. 15 1352-63 PubMed GONUTS page

[PMID:11178250-22] 22.0 ^22.1 ^22.2 Hardin, PE (2000) From biological clock to biological rhythms. Genome Biol. 1 REVIEWS1023 PubMed GONUTS page

[PMID:15522971-23] Sakai, T et al. (2004) A clock gene, period, plays a key role in long-term memory formation in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 101 16058-63 PubMed GONUTS page

[PMID:15356209-24] 24.0 ^24.1 Lin, Y et al. (2004) The neuropeptide pigment-dispersing factor coordinates pacemaker interactions in the Drosophila circadian system. J. Neurosci. 24 7951-7 PubMed GONUTS page

[PMID:15324667-25] Beaver, LM & Giebultowicz, JM (2004) Regulation of copulation duration by period and timeless in Drosophila melanogaster. Curr. Biol. 14 1492-7 PubMed GONUTS page

[PMID:12944510-26] 26.0 ^26.1 ^26.2 Ashmore, LJ et al. (2003) Novel insights into the regulation of the timeless protein. J. Neurosci. 23 7810-9 PubMed GONUTS page

[PMID:12417656-27] Ceriani, MF et al. (2002) Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. J. Neurosci. 22 9305-19 PubMed GONUTS page

[PMID:12015613-28] 28.0 ^28.1 ^28.2 ^28.3 ^28.4 Panda, S et al. (2002) Circadian rhythms from flies to human. Nature 417 329-35 PubMed GONUTS page

[PMID:12015603-29] Shaw, PJ et al. (2002) Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature 417 287-91 PubMed GONUTS page

[PMID:11715043-30] 30.0 ^30.1 ^30.2 ^30.3 ^30.4 ^30.5 Sokolowski, MB (2001) Drosophila: genetics meets behaviour. Nat. Rev. Genet. 2 879-90 PubMed GONUTS page

[PMID:11470898-31] Sakai, T & Ishida, N (2001) Circadian rhythms of female mating activity governed by clock genes in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 98 9221-5 PubMed GONUTS page

[PMID:11264660-32] 32.0 ^32.1 Blanchardon, E et al. (2001) Defining the role of Drosophila lateral neurons in the control of circadian rhythms in motor activity and eclosion by targeted genetic ablation and PERIOD protein overexpression. Eur. J. Neurosci. 13 871-88 PubMed GONUTS page

[PMID:11092827-33] 33.0 ^33.1 Greenspan, RJ & Ferveur, JF (2000) Courtship in Drosophila. Annu. Rev. Genet. 34 205-232 PubMed GONUTS page

[PMID:10677013-34] Kaneko, M et al. (2000) Involvement of the period gene in developmental time-memory: effect of the perShort mutation on phase shifts induced by light pulses delivered to Drosophila larvae. J. Biol. Rhythms 15 13-30 PubMed GONUTS page

[PMID:10409723-35] 35.0 ^35.1 ^35.2 ^35.3 Lee, C et al. (1999) PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription. Mol. Cell. Biol. 19 5316-25 PubMed GONUTS page

[PMID:25325457-36] Cao, W & Edery, I (2015) A novel pathway for sensory-mediated arousal involves splicing of an intron in the period clock gene. Sleep 38 41-51 PubMed GONUTS page

[PMID:27489346-37] Lee, E et al. (2016) Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation. Proc. Natl. Acad. Sci. U.S.A. 113 E4904-13 PubMed GONUTS page

[PMID:29174887-38] Li, Q et al. (2017) Fbxl4 Serves as a Clock Output Molecule that Regulates Sleep through Promotion of Rhythmic Degradation of the GABA Receptor. Curr. Biol. 27 3616-3625.e5 PubMed GONUTS page

[PMID:26082158-39] 39.0 ^39.1 Venkatesan, A et al. (2015) A Doubletime Nuclear Localization Signal Mediates an Interaction with Bride of Doubletime to Promote Circadian Function. J. Biol. Rhythms 30 302-17 PubMed GONUTS page

[PMID:19402751-40] Hennig, S et al. (2009) Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2. PLoS Biol. 7 e94 PubMed GONUTS page

[PMID:15312644-41] 41.0 ^41.1 Emery, P & Reppert, SM (2004) A rhythmic Ror. Neuron 43 443-6 PubMed GONUTS page

[PMID:12154068-42] Glossop, NR & Hardin, PE (2002) Central and peripheral circadian oscillator mechanisms in flies and mammals. J. Cell. Sci. 115 3369-77 PubMed GONUTS page

[PMID:12486701-43] 43.0 ^43.1 ^43.2 ^43.3 ^43.4 Stanewsky, R (2003) Genetic analysis of the circadian system in Drosophila melanogaster and mammals. J. Neurobiol. 54 111-47 PubMed GONUTS page

[PMID:12486700-44] Emmons, SW & Lipton, J (2003) Genetic basis of male sexual behavior. J. Neurobiol. 54 93-110 PubMed GONUTS page

[PMID:12626480-45] 45.0 ^45.1 ^45.2 ^45.3 ^45.4 ^45.5 Hendricks, JC (2003) Invited review: Sleeping flies don't lie: the use of Drosophila melanogaster to study sleep and circadian rhythms. J. Appl. Physiol. 94 1660-72; discussion 1673 PubMed GONUTS page

[PMID:12111533-46] 46.0 ^46.1 Stanewsky, R (2002) Clock mechanisms in Drosophila. Cell Tissue Res. 309 11-26 PubMed GONUTS page

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