GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:12417656
| Citation |
Ceriani, MF, Hogenesch, JB, Yanovsky, M, Panda, S, Straume, M and Kay, SA (2002) Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. J. Neurosci. 22:9305-19 |
|---|---|
| Abstract |
In Drosophila, a number of key processes such as emergence from the pupal case, locomotor activity, feeding, olfaction, and aspects of mating behavior are under circadian regulation. Although we have a basic understanding of how the molecular oscillations take place, a clear link between gene regulation and downstream biological processes is still missing. To identify clock-controlled output genes, we have used an oligonucleotide-based high-density array that interrogates gene expression changes on a whole genome level. We found genes regulating various physiological processes to be under circadian transcriptional regulation, ranging from protein stability and degradation, signal transduction, heme metabolism, detoxification, and immunity. By comparing rhythmically expressed genes in the fly head and body, we found that the clock has adapted its output functions to the needs of each particular tissue, implying that tissue-specific regulation is superimposed on clock control of gene expression. Finally, taking full advantage of the fly as a model system, we have identified and characterized a cycling potassium channel protein as a key step in linking the transcriptional feedback loop to rhythmic locomotor behavior. |
| Links | |
| Keywords |
Animals; Behavior, Animal/physiology; Biological Clocks/genetics; Blotting, Northern; Circadian Rhythm/genetics; Drosophila/genetics; Drosophila Proteins; Gene Expression Profiling; Gene Expression Regulation/physiology; Genome; Heme/metabolism; Large-Conductance Calcium-Activated Potassium Channels; Motor Activity/genetics; Mutation; Oligonucleotide Array Sequence Analysis; Photoperiod; Potassium Channels/genetics; Potassium Channels/metabolism; Potassium Channels, Calcium-Activated/genetics; Potassium Channels, Calcium-Activated/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Transcription, Genetic/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
